Ola Didrik Saugstad

Pediatrisk forskningsinstitutt

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E-post o.d.saugstad@medisin.uio.no

Rom D1.2029

Brukernavn

Besøksadresse Sognsvannsveien 20 OUS Rikshospitalet 0372 Oslo

Postadresse Postboks 4950 Nydalen OUS, Rikshospitalet 0424 Oslo

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Faglige interesser

Ola Didrik Saugstad er professor emeritus ved Universitetet i Oslo. Han er en barnelege, forsker og debattant i spørsmål om medisinsk etikk. Han var overlege i neonatologi (nyfødtmedisin) og bestyrer ved Pediatrisk forskningsinstitutt på Rikshospitalet. Han var også avdelingsleder ved Avdeling for Kvinne og Barnehelse, Kvinne og Barnklinikken, Oslo Universitetssykehus. Fra 1991-2010 var han leder for den norske nyfødtscreeningen.

Saugstad har siden 1970-tallet forsket på gjenopplivning av nyfødte, og har vært banebrytende i å få endret praksis på området fra bruk av ren oksygen, som hadde vært praksis de siste 200 år, til bruk av vanlig luft. Forskningen har vist en nedgang i dødsraten på 30 prosent ved bruk av luft, og flere hundre tusen barn kan dermed reddes hvert år. I 2010 ble luft anbefalt i internasjonale retningslinjer, basert på Saugstads og kollegenes forskning. Denne forskningen har lagt grunnlaget for nye resusiteringsprogram for nyfødte i lavinntektsland.

Bakgrunn

1991-2007 - Forfatter av «Når Barnet er Født for Tidlig» (1991,1999, 2009) som er oversatt til Svensk, Dansk, Russisk og Spansk og «Barnets første leveår» (2007).
1986-1991 - Ble overlege i 1986 og professor i 1991
1985 - Sammen med Gösta Rooth er han redaktør og bidragsyter til «The Roots of Perinatal Medicine» og sammen med Sigmund Vaage «Helse for den svake»
1977 - Tok doktorgraden
1974 - 1976 stipendiat med midler fra Norges forskningsråd ved Institutt for kirurgisk forskning ved Rikshospitalet i Norge
fra 1974 - Arbeidet som stipendiat ved universitetssykehuset i Uppsala
1973 - Tok den medisinske embedseksamen
Han har publisert over 400 artikler i medisinske tidsskrifter og en rekke bokkapitler i internasjonale fagbøker

Priser og utmerkelse

2014 - Æresprofessor ved Moskva Statsuniversitet; Æresdoktor ved Universitetet i Athen
2012 - ME prisen; SalusAnsvar Nordic Medical Award
2011 - Bjørnsonprisen, American Academy of Pediatrics Landmark Award; Æresmedlem American Pediatric Society
2010 - Ridder av 1. klasse av St. Olavs Orden
2007 - Livsvernprisen
2005 - Æresmedlem av den finske perinatalmedisinske foreningen
2001 - The Virginia Apgar Prize; Æresmedlem av Norsk perinatalmedisinsk forening
2000 - Æresmedlem av den ungarske barnelegeforeningen
1997 - The Arvo Ylppo Medal in Neonatology (Universitetet i Helsingfors)
1995 - The Laerdal Award in Acute Medicine (Universitetet i Oslo)
Medlem av Det Norske Videskaps-akademi
Märta Philipson Award for Progress in Pediatrics (Universitetet i Stockholm)
Innvalgt (en av 30) medlem av International Academy of Perinatal Medicine

Verv

2012-2015 - Han var medlem at WHOs ekspertutvalg for Basic Newborn Care (2012) og Guidelines for Handling of Preterm Infants (2015).
1996-2006 - I perioden 1996 til 2006 var han styremedlem og fra 2002-2004 president for European Association of Perinatal Medicine.
2001-2004 - Styremedlem i International Pediatric Foundation
1997-2001 - Han var rådgiver for Helseministeren
1990-1993 - Leder av ESPRs nyfødtgruppe
1987-1989 - Grunnlegger og den første leder av Norsk Perinatalmedisinsk Forening
1987-1990 Styremedlem i European Society of Pediatric Research (ESPR)
Han er eller har vært medlem av redaksjonskollegiet og redaktør i 8 medisinske tidsskrift.
Han har også vært referee for mer enn tredve tidsskrifter.
Han har skrevet en rekke avisartikler og kronikker om medisinsk etiske emner knyttet til bioetikk spesielt relatert til foster og nyfødte og forsknings og helsepolitikk.

Undervisning

Ola Didrik Saugstad underviste i pediatri MEDSEM9 - 9.semester i medisin på Universitetet i Oslo. I tillegg holdt han flere æresforelesninger i pediatri rundt om i verden og mer enn 300 inviterte foredrag ved alle store kongresser i faget og andre fora i alle verdensdeler.

Robbins, Mary E. & Saugstad, Ola Didrik (2023). Oxygen for newborn resuscitation: a narrative review. Pediatric Medicine. ISSN 2617-5428. 6, s. 1–11. doi: 10.21037/pm-21-110. Fulltekst i vitenarkiv
Aagaard, Ellisiv Nerdrum; Solevåg, Anne Lee & Saugstad, Ola Didrik (2023). Significance of Neonatal Heart Rate in the Delivery Room—A Review. Children. ISSN 2227-9067. 10(9). doi: 10.3390/children10091551. Fulltekst i vitenarkiv
Lawn, Joy E; Bhutta, Zulfiqar A.; Ezeaka, Chinyere & Saugstad, Ola Didrik (2023). Ending Preventable Neonatal Deaths: Multicountry Evidence to Inform Accelerated Progress to the Sustainable Development Goal by 2030. Neonatology. ISSN 1661-7800. 120(4), s. 491–499. doi: 10.1159/000530496. Fulltekst i vitenarkiv
Katheria, Anup; Schmölzer, Georg M.; Janvier, Annie; Kapadia, Vishal; Saugstad, Ola Didrik & Vento, Maximo [Vis alle 10 forfattere av denne artikkelen] (2023). A Narrative Review of the Rationale for Conducting Neonatal Emergency Studies with a Waived or Deferred Consent Approach. Neonatology. ISSN 1661-7800. 120(3), s. 344–352. doi: 10.1159/000530257.
Saugstad, Ola Didrik & Kirpalani, Haresh (2023). Searching for evidence in neonatology. Acta Paediatrica. ISSN 0803-5253. 112(8), s. 1648–1652. doi: 10.1111/apa.16815. Fulltekst i vitenarkiv
Sweet, David G.; Carnielli, Virgilio P.; Greisen, Gorm; Hallman, Mikko; Klebermass-Schrehof, Katrin & Ozek, Eren [Vis alle 15 forfattere av denne artikkelen] (2023). European Consensus Guidelines on the Management of Respiratory Distress Syndrome: 2022 Update. Neonatology. ISSN 1661-7800. 120(1), s. 3–23. doi: 10.1159/000528914. Fulltekst i vitenarkiv
Myrhaug, Hilde Tinderholt; Kaasen, Anne; Pay, Aase Serine Devold; Henriksen, Lena; Smedslund, Geir & Saugstad, Ola Didrik [Vis alle 7 forfattere av denne artikkelen] (2023). Umbilical cord blood acid–base analysis at birth and long-term neurodevelopmental outcomes in children: a systematic review and meta-analysis. BJOG: An International Journal of Obstetrics and Gynaecology. ISSN 1470-0328. 130(10), s. 1156–1166. doi: 10.1111/1471-0528.17480. Fulltekst i vitenarkiv
Dotinga, Baukje M.; Bao, Mian; Solberg, Rønnaug; Saugstad, Ola Didrik; Hulscher, Jan B. F. & Bos, Arend F. [Vis alle 8 forfattere av denne artikkelen] (2023). Gene expression in the intestine of newborn piglets after hypoxia-reoxygenation. Pediatric Research. ISSN 0031-3998. 94, s. 1365–1372. doi: 10.1038/s41390-023-02657-4.
Tune, Benedicte Grebstad; Melheim, Maria; Atneosen-Åsegg, Monica; Dotinga, Baukje; Saugstad, Ola Didrik & Solberg, Rønnaug [Vis alle 7 forfattere av denne artikkelen] (2023). Long Non-Coding RNAs in Hypoxia and Oxidative Stress: Novel Insights Investigating a Piglet Model of Perinatal Asphyxia. Biology (Basel). ISSN 2079-7737. 12(4). doi: 10.3390/biology12040549. Fulltekst i vitenarkiv
Stenersen, Eydis Oddsdottir; Olsen, Annette; Melheim, Maria; Solberg, Rønnaug; Dannevig, Ingrid & Schmölzer, Georg [Vis alle 11 forfattere av denne artikkelen] (2023). A Piglet Perinatal Asphyxia Model to Study Cardiac Injury and Hemodynamics after Cardiac Arrest, Resuscitation, and the Return of Spontaneous Circulation. Journal of Visualized Experiments. ISSN 1940-087X. 2023(191). doi: 10.3791/64788. Fulltekst i vitenarkiv Vis sammendrag
Neonatal piglets have been extensively used as translational models for perinatal asphyxia. In 2007, we adapted a well-established piglet asphyxia model by introducing cardiac arrest. This enabled us to study the impact of severe asphyxia on key outcomes, including the time taken for the return of spontaneous circulation (ROSC), as well as the effect of chest compressions according to alternative protocols for cardiopulmonary resuscitation. Due to the anatomical and physiological similarities between piglets and human neonates, piglets serve as good models in studies of cardiopulmonary resuscitation and hemodynamic monitoring. In fact, this cardiac arrest model has provided evidence for guideline development through research on resuscitation protocols, pathophysiology, biomarkers, and novel methods for hemodynamic monitoring. Notably, the incidental finding that a substantial fraction of piglets have pulseless electrical activity (PEA) during cardiac arrest may increase the applicability of the model (i.e., it may be used to study pathophysiology extending beyond the perinatal period). However, the model generation is technically challenging and requires various skill sets, dedicated personnel, and a fine balance of the measures, including the surgical protocols and the use of sedatives/analgesics, to ensure a reasonable rate of survival. In this paper, the protocol is described in detail, as well as experiences with adaptations to the protocol over the years.
Haavaldsen, Camilla; Morken, Nils-Halvdan; Saugstad, Ola Didrik & Eskild, Anne (2022). Is the increasing prevalence of labor induction accompanied by changes in pregnancy outcomes? An observational study of all singleton births at gestational weeks 37–42 in Norway during 1999–2019. Acta Obstetricia et Gynecologica Scandinavica. ISSN 0001-6349. s. 1–16. doi: 10.1111/aogs.14489. Fulltekst i vitenarkiv
Rajar, Polona; Dhariwal, Achal; Salvadori Da Silva, Gabriela; Junges, Roger; Åmdal, Heidi Aarø & Berild, Dag [Vis alle 12 forfattere av denne artikkelen] (2022). Microbial DNA extraction of high-host content and low biomass samples: Optimized protocol for nasopharynx metagenomic studies. Frontiers in Microbiology. ISSN 1664-302X. 13, s. 1–15. doi: 10.3389/fmicb.2022.1038120. Fulltekst i vitenarkiv
Ueland, Marthe; Hajdarevic, Riad; Mella, Olav; Strand, Elin Bolle; Daysi Duarte, Sosa & Saugstad, Ola Didrik [Vis alle 9 forfattere av denne artikkelen] (2022). No replication of previously reported association with genetic variants in the T cell receptor alpha (TRA) locus for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Translational Psychiatry. ISSN 2158-3188. 12:277, s. 1–5. doi: 10.1038/s41398-022-02046-1. Fulltekst i vitenarkiv Vis sammendrag
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease with a variety of symptoms such as post-exertional malaise, fatigue, and pain, but where aetiology and pathogenesis are unknown. An increasing number of studies have implicated the involvement of the immune system in ME/CFS. Furthermore, a hereditary component is suggested by the reported increased risk for disease in relatives, and genetic association studies are being performed to identify potential risk variants. We recently reported an association with the immunologically important human leucocyte antigen (HLA) genes HLA-C and HLA-DQB1 in ME/ CFS. Furthermore, a genome-wide genetic association study in 42 ME/CFS patients reported significant association signals with two variants in the T cell receptor alpha (TRA) locus (P value <5 × 10−8 ). As the T cell receptors interact with the HLA molecules, we aimed to replicate the previously reported findings in the TRA locus using a large Norwegian ME/CFS cohort (409 cases and 810 controls) and data from the UK biobank (2105 cases and 4786 controls). We investigated numerous SNPs in the TRA locus, including the two previously ME/CFS-associated variants, rs11157573 and rs17255510. No associations were observed in the Norwegian cohort, and there was no significant association with the two previously reported SNPs in any of the cohorts. However, other SNPs showed signs of association (P value <0.05) in the UK Biobank cohort and meta-analyses of Norwegian and UK biobank cohorts, but none survived correction for multiple testing. Hence, our research did not identify any reliable associations with variants in the TRA locus.
Sankaran, Deepika; Lakshminrusimha, Satyan & Saugstad, Ola Didrik (2022). Physiology of neonatal resuscitation: Giant strides with small breaths. Seminars in Perinatology. ISSN 0146-0005. 46(6). doi: 10.1016/j.semperi.2022.151620.
Sotiropoulos, James Xavier; Vento, Maximo; Saugstad, Ola Didrik & Oei, Ju Lee (2022). The quest for optimum oxygenation during newborn delivery room resuscitation: Is it the baby or is it us? Seminars in Perinatology. ISSN 0146-0005. 46(6). doi: 10.1016/j.semperi.2022.151622.
Saugstad, Ola Didrik (2022). Oxygenation of the newborn. The impact of one molecule on newborn lives. Journal of Perinatal Medicine. ISSN 0300-5577. 51(1), s. 20–26. doi: 10.1515/jpm-2022-0259. Fulltekst i vitenarkiv
Oei, Ju Lee; Kapadia, Vishal; Rabi, Yacov; Saugstad, Ola Didrik; Rook, Denise & Vermeulen, Marijn J. [Vis alle 15 forfattere av denne artikkelen] (2022). Neurodevelopmental outcomes of preterm infants after randomisation to initial resuscitation with lower (FiO2 <0.3) or higher (FiO2 >0.6) initial oxygen levels. An individual patient meta-analysis. Archives of Disease in Childhood: Fetal and Neonatal Edition. ISSN 1359-2998. 107(4), s. 386–392. doi: 10.1136/archdischild-2021-321565.
Trivedi, Shamik; Eger, Siw Helen & Saugstad, Ola Didrik (2022). Resuscitation of the Newborn Development of Algorithms, Present Status and Future Perspectives. I Moreira de Sá, R.A. & Fonseca, E.B. (Red.), Perinatology: Evidence-based Best Practices in Perinatal Medicine, Volume II. Springer Nature. ISSN 978-3-030-83433-3. s. 1269–1288. doi: 10.1007/978-3-030-83434-0_67.
Bruckner, Marlies; Lista, Gianluca; Saugstad, Ola Didrik & Schmölzer, Georg M. (2021). Delivery room management of asphyxiated term and near-term infants. Neonatology. ISSN 1661-7800. 118(4), s. 487–499. doi: 10.1159/000516429. Fulltekst i vitenarkiv
Sotiropoulos, James X.; Kapadia, Vishal; Vento, Maximo; Rabi, Yacov; Saugstad, Ola Didrik & Kumar, R. Kishore [Vis alle 16 forfattere av denne artikkelen] (2021). Oxygen for the delivery room respiratory support of moderate-to-late preterm infants. An international survey of clinical practice from 21 countries. Acta Paediatrica. ISSN 0803-5253. 110(12), s. 3261–3268. doi: 10.1111/apa.16091.
Kapadia, Vishal; Oei, Ju Lee; Finer, Neil; Rich, Wade; Rabi, Yacov & Wright, Ian M. [Vis alle 14 forfattere av denne artikkelen] (2021). Outcomes of delivery room resuscitation of bradycardic preterm infants: A retrospective cohort study of randomised trials of high vs low initial oxygen concentration and an individual patient data analysis. Resuscitation. ISSN 0300-9572. 167, s. 209–217. doi: 10.1016/j.resuscitation.2021.08.023.
Shah, Malika D. & Saugstad, Ola Didrik (2021). Newborns at risk of Covid-19 - Lessons from the last year. Journal of Perinatal Medicine. ISSN 0300-5577. 49(6), s. 643–649. doi: 10.1515/jpm-2021-0258.
Saugstad, Ola Didrik; Kapadia, Vishal & Oei, Ju Lee (2021). Oxygen in the First Minutes of Life in Very Preterm Infants. Neonatology. ISSN 1661-7800. 118(2), s. 218–224. doi: 10.1159/000516261.
Solevåg, Anne Lee & Saugstad, Ola Didrik (2021). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Noninvasive Blood Pressure Measurement in Neonates. Journal of Pediatrics. ISSN 0022-3476. 235. doi: 10.1016/j.jpeds.2021.05.004.
Mathias, Maxwell; Chang, Jill; Perez, Marta & Saugstad, Ola (2021). Supplemental oxygen in the newborn: Historical perspective and current trends. Antioxidants. ISSN 2076-3921. 10(12), s. 1–13. doi: 10.3390/antiox10121879. Fulltekst i vitenarkiv
Dotinga, Baukje M.; Solberg, Rønnaug; Saugstad, Ola Didrik; Bos, Arend F. & Kooi, Elisabeth M. W. (2021). Splanchnic oxygen saturation during reoxygenation with 21% or 100% O<inf>2</inf> in newborn piglets. Pediatric Research. ISSN 0031-3998. doi: 10.1038/s41390-021-01819-6.
Hajdarevic, Riad; Lande, Asgeir; Rekeland, Ingrid Gurvin; Rydland, Anne; Strand, Elin Bolle & Sosa , Daysi Duarte [Vis alle 13 forfattere av denne artikkelen] (2021). Fine mapping of the major histocompatibility complex (MHC) in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suggests involvement of both HLA class I and class II loci. Brain, Behavior, and Immunity. ISSN 0889-1591. 98, s. 101–109. doi: 10.1016/j.bbi.2021.08.219. Fulltekst i vitenarkiv
Gottimukkala, Sasi Bhushan; Sotiropoulos, James Xavier; Lorente-Pozo, Sheila; Monti Sharma, Abhineet; Vento, Maximo & Saugstad, Ola Didrik [Vis alle 7 forfattere av denne artikkelen] (2021). Oxygen saturation (SpO2) targeting for newborn infants at delivery: Are we reaching for an impossible unknown? Seminars in Fetal & Neonatal Medicine. ISSN 1744-165X. 26(2), s. 1–8. doi: 10.1016/j.siny.2021.101220.
Solevåg, Anne Lee & Saugstad, Ola Didrik (2021). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Diagnostic Utility of the Newborn Electrocardiogram. Journal of Pediatrics. ISSN 0022-3476. 229, s. 32–32. doi: 10.1016/j.jpeds.2020.08.073.
Saugstad, Ola Didrik; Robertson, Nicola J. & Vento, Maximo (2021). A critical review of the 2020 International Liaison Committee on Resuscitation treatment recommendations for resuscitating the newly born infant. Acta Paediatrica. ISSN 0803-5253. 110(4), s. 1107–1112. doi: 10.1111/apa.15754. Fulltekst i vitenarkiv
Omer, Murwan; Melo, Ashanty Maggvie; Kelly, Lynne; Mac Dermott, Emma Jane; Leahy, Timothy Ronan & Killeen, Orla [Vis alle 9 forfattere av denne artikkelen] (2020). Emerging Role of the NLRP3 Inflammasome and Interleukin-1β in Neonates. Neonatology. ISSN 1661-7800. 117(5), s. 545–554. doi: 10.1159/000507584.
Haumont, Dominique; Modi, Neena; Saugstad, Ola Didrik; Antetere, Rosine; NguyenBa, Cuong & Turner, Mark [Vis alle 8 forfattere av denne artikkelen] (2020). Evaluating preterm care across Europe using the eNewborn European Network database. Pediatric Research. ISSN 0031-3998. 88(3), s. 484–495. doi: 10.1038/s41390-020-0769-x.
Zasada, Magdalena; Madetko-Talowska, Anna; Revhaug, Cecilie; Rognlien, Anne Gro Wesenberg; Baumbusch, Lars Oliver & Książek, Teofila [Vis alle 12 forfattere av denne artikkelen] (2020). Transcriptome analysis reveals dysregulation of genes involved in oxidative phosphorylation in a murine model of retinopathy of prematurity. Pediatric Research. ISSN 0031-3998. 88(3), s. 391–397. doi: 10.1038/s41390-020-0793-x.
Innerdal, Mari; Simaga, I.; Diall, H.; Eielsen, M.; Niermeyer, Susan & Eielsen, Olav V [Vis alle 7 forfattere av denne artikkelen] (2020). Reduction in perinatal mortality after implementation of HBB training at a district hospital in Mali. Journal of Tropical Pediatrics. ISSN 0142-6338. 66(3), s. 315–321. doi: 10.1093/tropej/fmz072.
Saugstad, Ola Didrik (2020). Acetaminophen and the Developing Brain: Reason for Concern? Neonatology. ISSN 1661-7800. 117(2), s. 245–248. doi: 10.1159/000505954.
Saugstad, Ola Didrik (2020). What did I learn as a neonatologist over 40 years and what impact did Napoleon have on modern newborn medicine? Acta Paediatrica. ISSN 0803-5253. 109(5), s. 877–879. doi: 10.1111/apa.15170.
Dypvik, Johanne; Larsen, Sandra; Haavaldsen, Camilla; Saugstad, Ola Didrik & Eskild, Anne (2020). Placental Weight and Risk of Neonatal Death. JAMA pediatrics. ISSN 2168-6203. 174(2), s. 197–199. doi: 10.1001/jamapediatrics.2019.4556.
Rajar, Polona; Saugstad, Ola Didrik; Berild, Dag; Dutta, Anirban; Greisen, Gorm & Lausten-Thomsen, Ulrik [Vis alle 11 forfattere av denne artikkelen] (2020). Antibiotic stewardship in premature infants: a systematic review. Neonatology. ISSN 1661-7800. 117(6), s. 673–686. doi: 10.1159/000511710. Fulltekst i vitenarkiv
Lande, Asgeir; Fluge, Øystein; Strand, Elin Bolle; Flåm, Siri Tennebø; Daysi Duarte, Sosa & Mella, Olav [Vis alle 10 forfattere av denne artikkelen] (2020). Human Leukocyte Antigen Alleles Associated With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Scientific Reports. ISSN 2045-2322. 10:5267(1), s. 1–8. doi: 10.1038/s41598-020-62157-x. Fulltekst i vitenarkiv
Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2020). Oxygen metabolism and oxygenation of the newborn. Seminars in Fetal & Neonatal Medicine. ISSN 1744-165X. 25:101078(2), s. 1–5. doi: 10.1016/j.siny.2020.101078. Fulltekst i vitenarkiv
Marshall, Stephanie; Lang, Astri Maria; Perez, Marta & Saugstad, Ola Didrik (2019). Delivery room handling of the newborn. Journal of Perinatal Medicine. ISSN 0300-5577. 48(1), s. 1–10. doi: 10.1515/jpm-2019-0304. Fulltekst i vitenarkiv
Zasada, Magdalena; Suski, Maciej; Bokiniec, Renata; Szwarc-Duma, Monika; Borszewska-Kornacka, Maria Katarzyna & Madej, Józef [Vis alle 13 forfattere av denne artikkelen] (2019). Comparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasia. The Italian Journal of Pediatrics. ISSN 1720-8424. 45(112), s. 1–9. doi: 10.1186/s13052-019-0676-0. Fulltekst i vitenarkiv
Rajar, Polona; Atneosen-Åsegg, Monica; Saugstad, Ola Didrik; Solberg, Rønnaug & Baumbusch, Lars Oliver (2019). Quantification of circulating cell-free DNA (cfDNA) in urine using a newborn piglet model of asphyxia. PLOS ONE. ISSN 1932-6203. 14 (12), s. 1–14. doi: 10.1371/journal.pone.0227066. Fulltekst i vitenarkiv
Revhaug, Cecilie; Bik-Multanowski, Miroslaw; Zasada, Magdalena; Rognlien, Anne Gro Wesenberg; Günther, Clara-Cecilie & Ksiazek, Teofila [Vis alle 13 forfattere av denne artikkelen] (2019). Immune System Regulation Affected by a Murine Experimental Model of Bronchopulmonary Dysplasia: Genomic and Epigenetic Findings. Neonatology. ISSN 1661-7800. 116, s. 269–277. doi: 10.1159/000501461. Fulltekst i vitenarkiv Vis sammendrag
Background: Bronchopulmonary dysplasia (BPD) is a common cause of abrupted lung development after preterm birth. BPD may lead to increased rehospitalization, more severe and frequent respiratory infections, and life-long reduced lung function. The gene regulation in lungs with BPD is complex, with various genetic and epigenetic factors involved. Objectives: The aim of this study was to examine the regulatory relation between gene expression and the epigenome (DNA methylation) relevant for the immune system after hyperoxia followed by a recovery period in air using a mouse model of BPD. Methods: Newborn mice pups were subjected to an immediate hyperoxic condition from birth and kept at 85% O2 levels for 14 days followed by a 14-day period in room air. Next, mice lung tissue was used for RNA and DNA extraction with subsequent microarray-based assessment of lung transcriptome and supplementary methylome analysis. Results:The immune system-related transcriptomeregulation was affected in mouse lungs after hyperoxia. A high proportion of genes relevant in the immune system exhibited significant expression alterations, e.g., B cell-specific genes central to the cytokine-cytokine receptor interaction, the PI3K-AKT, and the B cell receptor signaling pathways. The findings were accompanied by significant DNA hypermethylation observed in the PI3K-AKT pathway and immune system-relevant genes. Conclusions: Oxygen damage could be partly responsible for the increased susceptibility and abnormal response to respiratory viruses and infections seen in premature babies with BPD through dysregulated genes.
Zasada, Magdalena; Madetko-Talowska, Anna; Revhaug, Cecilie; Rognlien, Anne Gro Wesenberg; Baumbusch, Lars Oliver & Książek, Teofila [Vis alle 12 forfattere av denne artikkelen] (2019). Short- and long-term impact of hyperoxia on the blood and retinal cells' transcriptome in a mouse model of oxygen-induced retinopathy. Pediatric Research. ISSN 0031-3998. 87, s. 485–493. doi: 10.1038/s41390-019-0598-y. Fulltekst i vitenarkiv
Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2019). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Positive Pressure Ventilation in the Newborn Infant: The Use of a Face Mask. Journal of Pediatrics. ISSN 0022-3476. doi: 10.1016/j.jpeds.2019.08.054.
Vento, Máximo & Saugstad, Ola Didrik (2019). Targeting oxygen in term and preterm infants starting at birth. Clinics in Perinatology. ISSN 0095-5108. 46(3), s. 459–473. doi: 10.1016/j.clp.2019.05.013.
Ystgaard, Martin Bogale; Scheffler, Katja; Suganthan, Rajikala; Bjørås, Magnar; Ranheim, Trine & Sagen, Ellen Lund [Vis alle 9 forfattere av denne artikkelen] (2019). Neuromodulatory effect of NLRP3 and ASC in neonatal hypoxic ischemic encephalopathy. Neonatology. ISSN 1661-7800. 115(4), s. 355–362. doi: 10.1159/000497200. Fulltekst i vitenarkiv Vis sammendrag
Background: Following birth asphyxia there is a robust inflammatory response. NLRP3 is a receptor of the innate immune system. Upon activation, NLRP3 forms an inflammasome together with ASC and procaspase-1 to mediate release of IL-1β and IL-18. NLRP3 has previously been shown to be upregulated following neonatal hypoxic-ischemic (HI) brain injury in mice, but with no early effect on brain injury. Objective: We aimed to evaluate if deficiency of NLRP3 or ASC protects against neonatal HI brain damage 7 days after hypoxia-ischemia. Methods: C57BL/6J, NLRP3–/–, and ASC–/– mice were subjected to unilateral common carotid artery ligation followed by hypoxia at P9. Brain infarction, apoptosis, and microglial response were evaluated, as well as total RNA sequencing and examination of plasma levels of systemic proinflammatory cytokines. Results: NLRP3–/– mice showed significantly increased brain infarction volumes compared to wild-type (Wt) mice, while ASC–/– mice showed reduced brain infarction volumes after neonatal hypoxia-ischemia. The amount of activated microglia was increased in NLRP3–/– mice, while decreased in ASC–/– mice compared to Wt mice. Total RNA sequencing showed an impaired inflammatory transcriptional response in the hippocampus of NLRP3–/– mice. Plasma levels of IL-1β and IL-18 were not affected, but TNF was lower in NLRP3–/– and ASC–/– mice compared to Wt mice. Conclusion: ASC deficiency is neuroprotective in neonatal HI brain damage in mice, while NLRP3 deficiency increases brain damage.
Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2019). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Polycythemia in Small for Gestational Age Infants. Journal of Pediatrics. ISSN 0022-3476. 214, s. 140–140. doi: 10.1016/j.jpeds.2019.04.038.
Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2019). 50 Years Ago in The Journal of Pediatrics: Intrauterine Growth of Live-Born Caucasian Infants at Sea Level: Standards Obtained from Measurements in 7 Dimensions of Infants Born between 25 and 44 Weeks of Gestation. Journal of Pediatrics. ISSN 0022-3476. 209. doi: 10.1016/j.jpeds.2018.12.035.

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Saugstad, Ola Didrik (2022). Oxygen – kampen om luft. Cayenne. ISBN 9789198730616. 260 s.

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Aagaard, Ellisiv Nerdrum; Solevåg, Anne Lee & Saugstad, Ola Didrik (2024). Correction to: Significance of Neonatal Heart Rate in the Delivery Room—A Review (Children, (2023), 10, 9, (1551), 10.3390/children10091551). Children. ISSN 2227-9067. 11(1). doi: 10.3390/children11010120.
Volstad, K; Melheim, Maria; Saugstad, Ola Didrik; Stiris, Tom; Baumbusch, Lars Oliver & Andresen, Jannicke Hanne (2023). Effect of nicotine on brain-derived neurotrophic factor and brain-derived neurotrophic factor antisense in newborn asphyxiated piglets.
Saugstad, Ola Didrik; Modi, Neena; Moretti, Corrado; Obladen, Michael; Vento, Maximo & Speer, Christian P. (2023). Newborns and Children in War and Terror. Neonatology. ISSN 1661-7800. doi: 10.1159/000535401.
Saugstad, Ola Didrik (2023). Oxygen to the newborn—too little or too much? Pediatric Medicine. ISSN 2617-5428. 6. doi: 10.21037/PM-22-60.
Saugstad, Ola Didrik (2023). Automated oxygen control for routine use in the NICU—Are we there? Acta Paediatrica. ISSN 0803-5253. 112(6), s. 1142–1144. doi: 10.1111/apa.16751.
Lakshminrusimha, Satyan; Saugstad, Ola Didrik & Vento, Maximo (2023). Lung Aeration During Deferred Cord Clamping—No Additional Benefits in Infants Born Preterm? Journal of Pediatrics. ISSN 0022-3476. doi: 10.1016/j.jpeds.2022.11.029.
Rajar, Polona; Dhariwal, Achal; Salvadori, Gabriela ; Junges, Roger; Åmdal, Heidi Aarø & Berild, Dag [Vis alle 12 forfattere av denne artikkelen] (2022). Microbial DNA extraction of high-host content and low biomass samples: optimized protocol for nasopharynx metagenomic studies. Vis sammendrag
Low microbial biomass and high human DNA content in nasopharyngeal aspirate samples hinder comprehensive characterization of microbiota and resistome. We obtained samples from premature infants, a group with increased risk of developing respiratory disorders and infections, and consequently frequent exposure to antibiotics. Our aim was to devise an optimal protocol for handling nasopharyngeal aspirates from premature infants, focusing on host DNA depletion and microbiome and resistome characterization. Three depletion and three DNA extraction protocols were compared, using RT-PCR and whole metagenome sequencing to determine the efficiency of human DNA removal, taxonomic profiling and assignment of antibiotic resistance genes. Protocols were tested using mock communities, as well as pooled and individual patient samples. The only extraction protocol to retrieve the expected DNA yield from mock community samples was based on a lytic method to improve Gram positive recovery (MasterPure™). Only samples depleted with MolYsis™ showed satisfactory, but varied reduction in host DNA content, in both pooled and individual patient samples, allowing for microbiome and resistome characterisation (host DNA content from 15% to 98%). PCR results were indicative of achieved microbial enrichment. Despite high human DNA and low microbial biomass content in nasopharynx aspirates of preterm infants, we were able to reduce host DNA content to levels compatible with downstream shotgun metagenomic analysis, including bacterial species identification and coverage of antibiotic resistance genes. Whole metagenomic sequencing of microbes colonizing the nasopharynx may contribute to explaining the possible role of airway microbiota in respiratory conditions and reveal carriage of antibiotic resistance genes.
Saugstad, Ola Didrik (2022). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Fatal Genetic Newborn Lung Disease. Journal of Pediatrics. ISSN 0022-3476. 244, s. 114–114. doi: 10.1016/j.jpeds.2022.02.020.
Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2022). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Recoarctation of the Aorta. Journal of Pediatrics. ISSN 0022-3476. 244. doi: 10.1016/j.jpeds.2022.02.024.
Solevåg, Anne Lee & Saugstad, Ola Didrik (2022). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Umbilical Arterial Catheter and Umbilical Vessel Catheterization Use and Complications. Journal of Pediatrics. ISSN 0022-3476. 244. doi: 10.1016/j.jpeds.2022.02.023.
Solevåg, Anne Lee; Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2022). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Iron Supplementation in Infants Born at Term. Journal of Pediatrics. ISSN 0022-3476. 245. doi: 10.1016/j.jpeds.2022.03.020.
Sotiropoulos, James X.; Oei, Ju Lee; Schmölzer, Georg M.; Hunter, Kylie E.; Williams, Jonathan G. & Webster, Angela C. [Vis alle 15 forfattere av denne artikkelen] (2022). NET work M eta-analysis of T rials of i nitial O xygen in preterm N ewborns (NETMOTION): A Protocol for Systematic Review and Individual Participant Data Network Meta-Analysis of Preterm Infants <32 Weeks' Gestation Randomized to Initial Oxygen Concentration for Resuscitation. Neonatology. ISSN 1661-7800. 119(4), s. 517–524. doi: 10.1159/000525127.
Solberg, Rønnaug & Saugstad, Ola Didrik (2022). Oxygen toxicity. I Donn, Steven M.; Mammel, Mark C. & van Kaam, Anton (Red.), Manual of Neonatal Respiratory Care. Springer. ISSN 978-3-030-93996-0. s. 77–82. doi: 10.1007/978-3-030-93997-7_7.
Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2022). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Maternal Cytomegalovirus Infection. Journal of Pediatrics. ISSN 0022-3476. 241. doi: 10.1016/j.jpeds.2021.11.027. Vis sammendrag
Monif et al reported their investigation of the correlation between maternal cytomegalovirus (CMV) infection andneonatal disease in The Journal 50 years ago. They took serum samples from pregnant women at the time of prenatal registration—identifying CMV-negative subjects; they followed them to find seroconversion, indicating maternal CMV infection. The neonates were tested after birth, with CMV IgM in cord blood, and direct virus detection in urine. Of the 664 CMV-negative pregnancies, there were 2 seroconversions during the second and 2 during the third trimester. The neonates infected during the second trimester showed microcephaly and hepatosplenomegaly; the ne- onates infected later were asymptomatic. All the neonates had positive urine samples and positive CMV IgM. The au- thors questioned if maternal CMV infection during gestation leads to dissemination of the virus to the fetus, regardless of gestation, and they concluded that CMV infection in the fetus is not related to the timing of the maternal infection. The majority of neonates with congenital CMV infection are normal at birth and do well, but approximately 15% will have long-term sequelae presenting as hearing loss, problems with vision, cognition, and motor function. CMV is transmitted to the fetus in approximately 20% of cases in first-trimester infections but leads to more severe symptoms and long-term outcome. In the third trimester, the rate of fetal infection is approximately 75%, and the neonates are asymptomatic.1 Monif et al conclude that neonatal infection can occur at any period of gestation and that severity is related to longer duration. It is, however, not the duration of the infection, but the vulnerability of the fetus at earlier gestations, that decides the severity of the infection. Congenital CMV preventative measures are of unknown impact, and a vaccine is not available. Studies on antiviral drugs and immunoglobulins show some effect, but their use is still not routinely recommended. CMV still is as hot a topic today as it was 50 years ago.
Landsverk, Hans Christian Erichsen; Almaas, Runar & Saugstad, Ola Didrik (2022). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Hemiallogeneic Stem Cell Transplantation—from Last Resort to a Viable Treatment Option. Journal of Pediatrics. ISSN 0022-3476. 243, s. 213–213. doi: 10.1016/j.jpeds.2021.12.064.
Solevåg, Anne Lee & Saugstad, Ola Didrik (2022). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Birth Weight Versus Gestational Age as Outcome Predictors. Journal of Pediatrics. ISSN 0022-3476. 243. doi: 10.1016/j.jpeds.2021.12.061.
Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2021). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Neonatal Herpes Virus Infection in the Preacyclovir Era. Journal of Pediatrics. ISSN 0022-3476. 236, s. 61–81. doi: 10.1016/j.jpeds.2021.05.055.
Saugstad, Ola Didrik & Vento, Maximo (2021). Potential Value of Maternal Oxygen Supplementation. JAMA pediatrics. ISSN 2168-6203. 175(7), s. 749–750. doi: 10.1001/jamapediatrics.2021.0364.
Rønning, Rolf & Saugstad, Ola Didrik (2021). https://www.aftenposten.no/meninger/kronikk/i/KzG2Xy/me-pasientene-fikk-rett. Aftenposten (morgenutg. : trykt utg.). ISSN 0804-3116.
Solevåg, Anne Lee & Saugstad, Ola Didrik (2021). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Early-Onset Neonatal Sepsis. Journal of Pediatrics. ISSN 0022-3476. 238. doi: 10.1016/j.jpeds.2021.08.044.
Almaas, Runar & Saugstad, Ola Didrik (2021). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Diagnosis of Self-Mutilation and Hyperuricemia. Journal of Pediatrics. ISSN 0022-3476. 237, s. 86–86. doi: 10.1016/j.jpeds.2021.07.034.
Lee Solevåg, Anne & Saugstad, Ola Didrik (2021). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Fetal Heart Rate Patterns and Umbilical Cord Base Deficit. Journal of Pediatrics. ISSN 0022-3476. 236. doi: 10.1016/j.jpeds.2021.05.054.
Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2021). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Neonatal Platelet Aggregation: Effects of Antenatal Aspirin. Journal of Pediatrics. ISSN 0022-3476. 235. doi: 10.1016/j.jpeds.2021.04.064.
Lee Solevåg, Anne; Andresen, Jannicke H. & Saugstad, Ola Didrik (2021). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Neonatal Anemia Prevention and Treatment. Journal of Pediatrics. ISSN 0022-3476. 234, s. 1–1. doi: 10.1016/j.jpeds.2021.03.060.
Almaas, Runar & Saugstad, Ola Didrik (2021). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Pregnancy in Women with Galactosemia. Journal of Pediatrics. ISSN 0022-3476. 233. doi: 10.1016/j.jpeds.2021.02.032.
Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2021). 50 Years Ago in THE JOURNAL OF PEDIATRICS: The Oxygen Dilemma. Journal of Pediatrics. ISSN 0022-3476. 231, s. 1–1. doi: 10.1016/j.jpeds.2020.11.036.
Solevåg, Anne Lee & Saugstad, Ola Didrik (2021). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Vigorous and Repeated Nasopharyngeal Suctioning. Journal of Pediatrics. ISSN 0022-3476. 230, s. 99–99. doi: 10.1016/j.jpeds.2020.10.052.
Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2021). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Sixth Cranial Nerve Palsy in the Neonate. Journal of Pediatrics. ISSN 0022-3476. 230, s. 125–125. doi: 10.1016/j.jpeds.2020.10.054.
Almaas, Runar & Saugstad, Ola Didrik (2021). 50 years ago in THE JOURNAL OF PEDIATRICS: Hepatopulmonary syndrome: Transplantation Is the big difference. Journal of Pediatrics. ISSN 0022-3476. 229, s. 69–69. doi: 10.1016/j.jpeds.2020.08.074.
Solevåg, Anne Lee & Saugstad, Ola Didrik (2021). 50 Years Ago in THE JOURNAL OF PEDIATRICS: The Newborn Electrocardiogram. Journal of Pediatrics. ISSN 0022-3476. 228, s. 52–52. doi: 10.1016/j.jpeds.2020.07.074.
Branche, Tonia; Perez, Marta & Saugstad, Ola Didrik (2020). The first golden minute — Is it relevant? Resuscitation. ISSN 0300-9572. 156, s. 284–285. doi: 10.1016/j.resuscitation.2020.08.128.
Dypvik, Johanne; Saugstad, Ola Didrik & Eskild, Anne (2020). More details needed on association of placental weight with risk of neonatal death - Reply. JAMA pediatrics. ISSN 2168-6203. 174(9), s. 905–906. doi: 10.1001/jamapediatrics.2020.0975.
Shah, Malika D. & Saugstad, Ola Didrik (2020). Newborns at risk of COVID-19. Journal of Perinatal Medicine. ISSN 0300-5577. 48(5), s. 423–425. doi: 10.1515/jpm-2020-0170.
Saugstad, Ola Didrik (2020). Myalgic Encephalomyelitis (ME) in the Young. Time to Repent. Acta Paediatrica. ISSN 0803-5253. 109(4), s. 645–646. doi: 10.1111/apa.15084.
Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2020). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Developmental Outcome for Trisomy 21 Mosaicism. Journal of Pediatrics. ISSN 0022-3476. 221, s. 38–38. doi: 10.1016/j.jpeds.2019.12.011.
Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2020). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Wilson-Mikity Syndrome. Journal of Pediatrics. ISSN 0022-3476. 222, s. 173–173. doi: 10.1016/j.jpeds.2020.01.037.
Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2020). 50 Years Ago in THE JOURNAL OF PEDIATRICS: When the Lung Ruptures - 50 Years Ago and Today. Journal of Pediatrics. ISSN 0022-3476. 219. doi: 10.1016/j.jpeds.2019.10.004.
Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2020). 50 Years Ago in THE JOURNAL OF PEDIATRICS: When the Newborn Remains Blue. Journal of Pediatrics. ISSN 0022-3476. 224, s. 78–78. doi: 10.1016/j.jpeds.2020.03.030.
Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2020). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Birth Weight Is More Important than Gestational Age for Long-Term Intellectual Outcome. Journal of Pediatrics. ISSN 0022-3476. 220. doi: 10.1016/j.jpeds.2019.11.024.
Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2020). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Chromosome Studies in Full Term, Low Birth Weight, Mentally Retarded Patients. Journal of Pediatrics. ISSN 0022-3476. 218. doi: 10.1016/j.jpeds.2019.09.032.
Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2020). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Magnesium and birth asphyxia. Journal of Pediatrics. ISSN 0022-3476. 227, s. 190–190. doi: 10.1016/j.jpeds.2020.10.015.
Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2020). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Umbilical Catheters—Then and Now. Journal of Pediatrics. ISSN 0022-3476. 227. doi: 10.1016/j.jpeds.2020.06.082.
Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2020). 50 Years Ago in THE JOURNAL OF PEDIATRICS: The Oxygen-Hemoglobin Equilibrium Curve and Tissue Oxygen Release. Journal of Pediatrics. ISSN 0022-3476. 227. doi: 10.1016/j.jpeds.2020.06.085.
Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2020). 50 Years Ago in THE JOURNAL OF PEDIATRICS: Wolf-Hirschorn Versus Cri-du-Chat Syndrome. Journal of Pediatrics. ISSN 0022-3476. 226. doi: 10.1016/j.jpeds.2020.06.015.
Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2020). 50 Years Ago in The Journal of Pediatrics: Neonatal Seizures: 50 Years of Progress. Journal of Pediatrics. ISSN 0022-3476. 225. doi: 10.1016/j.jpeds.2020.04.014.
Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2020). 50 Years Ago in The Journal of Pediatrics: Human Chromosomal Deletion: Two Patients with the 4p–Syndrome. Journal of Pediatrics. ISSN 0022-3476. 216. doi: 10.1016/j.jpeds.2019.07.020.
Andresen, Jannicke Hanne & Saugstad, Ola Didrik (2020). 50 years ago in THE JOURNAL OF PEDIATRICS: Light exposure to the immature eye. Journal of Pediatrics. ISSN 0022-3476. 223, s. 119–119. doi: 10.1016/j.jpeds.2020.02.011.
Konduri, Girija G.; Lagatta, Joanne; Lakshminrusimha, Satyan & Saugstad, Ola Didrik (2019). Finally, A Tool to Address Extubation Anxiety! Journal of Perinatology. ISSN 0743-8346. 39(12), s. 1581–1583. doi: 10.1038/s41372-019-0525-4.
Stensvold, Hans Jørgen & Saugstad, Ola Didrik (2019). The oxygen dilemma: oxygen saturation targets in preterm infants. Acta Paediatrica. ISSN 0803-5253. 108(9), s. 1556–1558. doi: 10.1111/apa.14852.

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Publisert 13. apr. 2011 11:44 - Sist endret 28. sep. 2022 14:42