Trine Finnes

• Dahl, Jesper; Holvik, Kristin; Heldal, Einar; Grimnes, Guri; Hoff, Mari; Finnes, Trine; Apalset, Ellen Margrete & Meyer, Haakon E (2020). Individual Variation in Adaptive Immune Responses and Risk of Hip Fracture-A NOREPOS Population-Based Cohort Study. Journal of Bone and Mineral Research.  ISSN 0884-0431. . doi: 10.1002/jbmr.4135 Fulltekst i vitenarkiv.
• Sævik, Åse Bjorvatn; Åkerman, Anna-Karin; Methlie, Paal; Quinkler, Marcus; Jørgensen, Anders Palmstrøm; Høybye, Charlotte; Debowska, Aleksandra; Nedrebø, Bjørn Gunnar; Dahle, Anne Lise; Carlsen, Siri; Tomkowicz, Aneta; Sollid, Stina Therese; Nermoen, Ingrid; Grønning, Kaja; Dahlqvist, Per; Grimnes, Guri; Skov, Jakob; Finnes, Trine Elisabeth; Valland, Susanna Fonneland; Wahlberg, Jeanette; Holte, Synnøve Emblem; Simunkova, Katerina; Kämpe, Olle; Husebye, Eystein Sverre; Bensing, Sophie & Øksnes, Marianne (2020). Residual Corticosteroid Production in Autoimmune Addison Disease. Journal of Clinical Endocrinology and Metabolism.  ISSN 0021-972X.  105(7) . doi: doi:10.1210/clinem/dgaa256 Vis sammendrag

  Design: Two-staged, cross-sectional clinical study in 17 centers (Norway, Sweden, and Germany). Residual glucocorticoid (GC) production was defined as quantifiable serum cortisol and 11-deoxycortisol and residual mineralocorticoid (MC) production as quantifiable serum aldosterone and corticosterone after > 18 hours of medication fasting. Corticosteroids were analyzed by liquid chromatography–tandem mass spectrometry. Clinical variables included frequency of adrenal crises and quality of life. Peak cortisol response was evaluated by a standard 250 µg cosyntropin test. Results: Fifty-eight (30.2%) of 192 patients had residual GC production, more common in men (n = 33; P < 0.002) and in shorter disease duration (median 6 [0-44] vs 13 [0-53] years; P < 0.001). Residual MC production was found in 26 (13.5%) patients and associated with shorter disease duration (median 5.5 [0.5-26.0] vs 13 [0-53] years; P < 0.004), lower fludrocortisone replacement dosage (median 0.075 [0.050-0.120] vs 0.100 [0.028-0.300] mg; P < 0.005), and higher plasma renin concentration (median 179 [22-915] vs 47.5 [0.6-658.0] mU/L; P < 0.001). There was no significant association between residual production and frequency of adrenal crises or quality of life. None had a normal cosyntropin response, but peak cortisol strongly correlated with unstimulated cortisol (r = 0.989; P < 0.001) and plasma adrenocorticotropic hormone (ACTH; r = –0.487; P < 0.001). Conclusion: In established AAD, one-third of the patients still produce GCs even decades after diagnosis. Residual production is more common in men and in patients with shorter disease duration but is not associated with adrenal crises or quality of life. (J Clin Endocrinol Metab 105: 1–12, 2020) Key words: Adrenal failure; adrenal steroids; Autoimmune Addison disease; cortisol; primary adrenal insufficiency; residual function

• Sævik, Åse Bjorvatn; Åkerman, Anna Karin; Grønning, Kaja; Nermoen, Ingrid; Valland, Susanna Fonneland; Finnes, Trine Elisabeth; Isaksson, Magnus; Dahlqvist, Per; Bergthórsdóttir, Ragnhildur; Ekwall, Olov; Skov, Jakob; Nedrebø, Bjørn Gunnar; Hulting, Anne Lena; Wahlberg, Jeanette; Svartberg, Johan; Höybye, Charlotte; Bleskestad, Inger Hjørdis; Jørgensen, Anders Palmstrøm; Kämpe, Olle; Øksnes, Marianne; Bensing, Sophie & Husebye, Eystein Sverre (2017). Clues for early detection of autoimmune Addison's disease - myths and realities. Journal of Internal Medicine.  ISSN 0954-6820.  283(2), s 190- 199 . doi: 10.1111/joim.12699
• Finnes, Trine Elisabeth; Lofthus, Cathrine Marie; Meyer, Haakon E; Søgaard, Anne-Johanne; Tell, Grethe Seppola; Apalset, Ellen M; Gjesdal, Clara Gram; Grimnes, Guri; Schei, Berit; Blomhoff, Rune; Samuelsen, Sven Ove & Holvik, Kristin (2016). A combination of low serum concentrations of vitamins K1 and D is associated with increased risk of hip fractures in elderly Norwegians: a NOREPOS study. Osteoporosis International.  ISSN 0937-941X.  27(4), s 1645- 1652 . doi: 10.1007/s00198-015-3435-0
• Finnes, Trine Elisabeth; Lofthus, Cathrine Marie; Meyer, Haakon E.; Eriksen, Erik Fink; Apalset, Ellen M; Tell, Grethe S; Torjesen, Peter A; Samuelsen, Sven Ove & Holvik, Kristin (2014). Procollagen type 1 amino-terminal propeptide (P1NP) and risk of hip fractures in elderly Norwegian men and women. A NOREPOS study. Bone.  ISSN 8756-3282.  64, s 1- 7 . doi: 10.1016/j.bone.2014.03.010 Vis sammendrag

  The current study aimed to assess a possible association between the bone turnover marker procollagen type 1 amino-terminal propeptide (P1NP) and future hip fractures in elderly Norwegian men and women and to elucidate the relation between P1NP, bone mineral density and 25-hydroxyvitamin D (25(OH)D). Men and women aged 71 to 77 from two population based health studies in Norway (1999-2001) were followed for a median period of 7.3years with respect to hip fractures. The study was designed as a case-cohort study. P1NP and 25(OH)D were analysed in frozen serum samples obtained at baseline in hip fracture patients (n=340) and in randomly selected sex stratified sub-cohorts. Bone mineral density was measured by dual-energy X-ray absorptiometry (DXA) in a subset of participants. Cox proportional hazards regression with inverse probability weighting and robust variance was performed. No significant correlation between 25(OH)D and P1NP was found. A negative correlation between P1NP and BMD was observed in women (Rho=-0.36, p=0.001). A similar trend was observed in men. No association between quartiles of P1NP and rate of subsequent hip fractures was found. Spline analyses suggested a higher rate of hip fracture at P1NP levels above 60μg/L in both men and women. A higher hip fracture rate, which was independent of BMD, was also indicated in women with very low levels of P1NP.

• Finnes, Trine Elisabeth; Meyer, Haakon E; Falch, Jan Arvid; Medhus, Asle Wilhelm; Wentzel-Larsen, Tore & Lofthus, Cathrine Marie (2013). Secular reduction of excess mortality in hip fracture patients > 85 years. BMC Geriatrics.  ISSN 1471-2318.  13 . doi: 10.1186/1471-2318-13-25 Fulltekst i vitenarkiv.

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• Dahl, Jesper; Holvik, Kristin; Heldal, Einar; Grimnes, Guri; Hoff, Mari; Finnes, Trine Elisabeth; Apalset, Ellen Margrete & Meyer, Haakon E (2019). Individual variation in adaptive immune responses and risk of hip fracture – A NOREPOS population-based cohort study. Journal of Bone and Mineral Research.  ISSN 0884-0431.  34(suppl.)(2019 Annual Meeting of the ASBMR), s 247- 247 Vis sammendrag

  T-cell mediated immune responses may affect bone homeostasis, and subsequently the risk of fracture, through multiple pathways. Little is known about how individual variation in these responses contributes to the risk of fracture on a population-level. Tuberculin skin tests (TST) are likely one of the few tests directly reflecting in vivo T-cell responses to have been conducted on a population-scale, as part of the effort to prevent the spread of tuberculosis. The aim of this study was to estimate the impact of individual variation in these immune responses on the risk of hip fracture in the general population. The hypothesis was that individuals with a tendency towards pro-inflammatory responses have an increased risk of fracture.We used data from the compulsory nationwide Norwegian mass tuberculosis screening and BCG vaccination programme during 1963-1975, which covered an estimated 80-85% of the population. This data included results from standardized TST, as well as timing and status of BCG vaccination. Individuals aged 14-30 years at the time of TST measurement and born 1940-1960 were included in the current analysis. All included individuals had a negative TST followed by BCG vaccination in the past, and had no signs of tuberculosis upon examination. TST results at the screening were recorded in millimetres, and later categorized according to clinical guidelines (positive/negative). Our cohort constitutes 248 551 individuals who were alive and living in Norway at the start of the NORHIP database in 1994. This database includes records on all hospitalizations due to hip fractures in Norway during 1994-2013 (follow-up). Risk estimates were adjusted for county, BMI, age and time between BCG-TST, using Cox regression models. There were 3580 incident hip fractures during follow-up (first fractures), with a median age at the time of fracture of 61 years (range 36-73). Men with a positive TST had a 22% (HR 1.22, 95% CI 1.02-1.44) increased adjusted risk of hip fracture compared to men with a negative TST. This association was strengthened in sensitivity analyses limited to either those born 1945-1960 (post WW2) or aged 11-14 years at BCG vaccination (school vaccination). No clear association was observed in women. We conclude that men with a negative tuberculin skin test after BCG vaccination have a reduced risk of hip fracture decades later. Women do not demonstrate similar associations, potentially due to sex specific differences in immune responses.

• Finnes, Trine Elisabeth; Lofthus, Cathrine Marie; Søgaard, Anne-Johanne; Tell, Grethe Seppola; Apalset, Ellen M; Gjesdal, Clara Gram; Grimnes, Guri; Schei, Berit; Blomhoff, Rune; Samuelsen, Sven Ove; Meyer, Haakon E & Holvik, Kristin (2015). Low serum vitamin K1 increases the risk of hip fractures only at low vitamin D status. A NOREPOS study. European Geriatric Medicine.  ISSN 1878-7649.  6, s S17- S17
• Dahl, Cecilie; Søgaard, Anne Johanne; Tell, Grethe S; Flaten, Trond Peder; Hongve, Dag; Omsland, Tone Kristin; Holvik, Kristin; Meyer, Haakon E; Finnes, Trine Elisabeth & Aamodt, Geir (2013). Do cadmium and lead in drinking water increase the risk of hip fracture? A NOREPOS study.
• Finnes, Trine Elisabeth; Lofthus, Cathrine Marie; Meyer, Haakon E; Eriksen, Erik Fink; Apalset, Ellen M; Tell, Grethe S & Holvik, Kristin (2013). Serum Levels of Procollagen type 1 Amino-terminal Propeptide and Risk of Hip Fracture in Elderly Men. Norwegian Epidemiologic Osteoporosis Studies (NOREPOS).
• Finnes, Trine Elisabeth; Meyer, Haakon E; Falch, Jan Arvid; Medhus, Asle Wilhelm; Wentzel-Larsen, Tore & Lofthus, Cathrine Marie (2012). DURATION OF EXCESS MORTALITY AFTER HIP FRACTURES IN OSLO, NORWAY: A LONG TERM FOLLOW UP. Osteoporosis International.  ISSN 0937-941X.  23, s S123- S124

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