About the project
Stroke is a major global health challenge, causing severe disability. A stroke is caused by a thrombosis (blood clot) or hemorrhage (bleeding) in the brain, and this disruption in blood supply leads to death of brain tissue. Unfortunately, such a brain damage cannot be easily repaired, since the adult human brain has limited ability to generate new neurons.Â
In this project, we are exploring the use of brain organoids, which are three-dimensional neural structures grown from stem cells, to replace lost neurons and repair the brain in a mouse model of stroke. We will implant organoids into the stroke-injured brain area and use different means to stimulate appropriate neural connections between the implanted organoid and the host brain. The aim is that these external cells can mature into neurons and effectively become part of the damaged brain, potentially restoring lost function.