mathor

• Wortinger, Laura Anne ; Barth, Claudia; Nerland, Stener; Jørgensen, Kjetil Nordbø; Shadrin, Alexey & Szabo, Attila [Vis alle 11 forfattere av denne artikkelen] (2021). Association of Birth Asphyxia With Regional White Matter Abnormalities Among Patients With Schizophrenia and Bipolar Disorders. JAMA Network Open. ISSN 2574-3805. 4(12). doi: 10.1001/jamanetworkopen.2021.39759. Vis sammendrag

  Importance: White matter (WM) abnormalities are commonly reported in psychiatric disorders. Whether peripartum insufficiencies in brain oxygenation, known as birth asphyxia, are associated with WM of patients with severe mental disorders is unclear. Objective: To examine the association between birth asphyxia and WM in adult patients with schizophrenia and bipolar disorders (BDs) compared with healthy adults. Design, setting, and participants: In this case-control study, all individuals participating in the ongoing Thematically Organized Psychosis project were linked to the Medical Birth Registry of Norway (MBRN), where a subset of 271 patients (case group) and 529 healthy individuals (control group) had undergone diffusion-weighted imaging (DWI). Statistical analyses were performed from June 16, 2020, to March 9, 2021. Exposures: Birth asphyxia was defined based on measures from standardized reporting at birth in the MBRN. Main outcomes and measures: Associations between birth asphyxia and WM regions of interest diffusion metrics, ie, fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD), were compared between groups using analysis of covariance, adjusted for age, age squared, and sex. Results: Of the 850 adults included in the study, 271 were in the case group (140 [52%] female individuals; mean [SD] age, 28.64 [7.43] years) and 579 were in the control group (245 [42%] female individuals; mean [SD] age, 33.54 [8.31] years). Birth asphyxia measures were identified in 15% to 16% of participants, independent of group. The posterior limb of the internal capsule (PLIC) showed a significant diagnostic group × birth asphyxia interaction (F(1, 843) = 11.46; P = .001), reflecting a stronger association between birth asphyxia and FA in the case group than the control group. RD, but not AD, also displayed a significant diagnostic group × birth asphyxia interaction (F(1, 843) = 9.28; P = .002) in the PLIC, with higher values in patients with birth asphyxia and similar effect sizes as observed for FA. Conclusions and relevance: In this case-control study, abnormalities in the PLIC of adult patients with birth asphyxia may suggest a greater susceptibility to hypoxia in patients with severe mental illness, which could lead to myelin damage or impeded brain development. Echoing recent early-stage schizophrenia studies, abnormalities of the PLIC are relevant to psychiatric disorders, as the PLIC contains important WM brain pathways associated with language, cognitive function, and sensory function, which are impaired in schizophrenia and BDs.

• Spencer, Arthur P.C.; Brooks, Jonathan C.W.; Masuda, Naoki; Byrne, Hollie; Lee-Kelland, Richard & Jary, Sally [Vis alle 10 forfattere av denne artikkelen] (2021). Motor function and white matter connectivity in children cooled for neonatal encephalopathy. NeuroImage: Clinical. ISSN 2213-1582. 32. doi: 10.1016/j.nicl.2021.102872.
• Bjertnaes, Lars J.; Hauge, Anton; Thoresen, Marianne & Walløe, Lars (2021). Prioritized brain circulation during ergometer cycling with apnea and face immersion in ice-cold water: A case report. International Medical Case Reports Journal. ISSN 1179-142X. 14, s. 675–681. doi: 10.2147/IMCRJ.S317404. Fulltekst i vitenarkiv
• Phillips, Thomas; Menassa, David; Grant, Simon; Cohen, Nicki & Thoresen, Marianne (2021). The effects of Xenon gas inhalation on neuropathology in a placental-induced brain injury model in neonates: A pilot study. Acta Paediatrica. ISSN 0803-5253. 110(1), s. 119–122. doi: 10.1111/apa.15486. Fulltekst i vitenarkiv
• Wood, Thomas Ragnar; Gundersen, Julia Kristine; Falck, Mari; Maes, Elke; Osredkar, Damjan & Løberg, Else Marit [Vis alle 9 forfattere av denne artikkelen] (2020). Variability and sex-dependence of hypothermic neuroprotection in a rat model of neonatal hypoxic–ischaemic brain injury: a single laboratory meta-analysis. Scientific Reports. ISSN 2045-2322. 10:10833, s. 1–13. doi: 10.1038/s41598-020-67532-2. Fulltekst i vitenarkiv
• Dingley, John; Okano, Satomi; Lee-Kelland, Richard; Scull-Brown, Emma; Thoresen, Marianne & Chakkarapani, Ela (2020). Closed circuit xenon delivery for 72h in neonatal piglets following hypoxic insult using an ambient pressure automated control system: Development, technical evaluation and pulmonary effects. PLOS ONE. ISSN 1932-6203. doi: 10.1371/journal.pone.0224447. Fulltekst i vitenarkiv
• Frikstad, Kari-Anne; Molinari, Elisa; Thoresen, Marianne; Ramsbottom, Simon A; Hughes, Frances & Letteboer, Stef J.F. [Vis alle 16 forfattere av denne artikkelen] (2019). A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling. Cell reports. ISSN 2211-1247. 28(7), s. 1907–1922.e6. doi: 10.1016/j.celrep.2019.07.025.
• Chakkarapani, Ela & Thoresen, Marianne (2019). Brain and whole body cooling, MacDonald's Atlas of Procedures in Neonatology. Lamy, Wolters Kluwer. ISSN 9781496394255.
• Walløe, Lars; Hjort, Nils Lid & Thoresen, Marianne (2019). Why results from Bayesian Statistical analyses of clinical trials with a strong prior and small sample sixes may be misleading. Acta Paediatrica. ISSN 0803-5253. s. 1190–1191. doi: 10.1111/apa.14800. Fulltekst i vitenarkiv
• Gunn, Alistair J & Thoresen, Marianne (2019). Neonatal encephalopathy and hypoxic-ischemic encephalopathy. Handbook of Clinical Neurology. ISSN 0072-9752. 162, s. 217–237. doi: 10.1016/B978-0-444-64029-1.00010-2.
• Lee-Kelland, Richard; Jary, Sally; Tonks, James; Cowan, Frances Mary; Thoresen, Marianne & Chakkarapani, Ela (2019). School-age outcomes of children without cerebral palsy cooled for neonatal hypoxic-ischaemic encephalopathy in 2008-2010. Archives of Disease in Childhood: Fetal and Neonatal Edition. ISSN 1359-2998. doi: 10.1136/archdischild-2018-316509.
• Jary, Sally; Lee-Kelland, Richard; Tonks, James; Cowan, Frances Mary; Thoresen, Marianne & Chakkarapani, Elavazhagan (2019). Motor performance and cognitive correlates in children cooled for neonatal encephalopathy without cerebral palsy at school age. Acta Paediatrica. ISSN 0803-5253. doi: 10.1111/apa.14780.
• Walløe, Lars; Hjort, Nils Lid & Thoresen, Marianne (2019). Start cooling as soon as possible. Acta Paediatrica. ISSN 0803-5253. 108(4), s. 771–771. doi: 10.1111/apa.14710.
• Tonks, James; Cloke, Grace; Lee-Kelland, Richard; Jary, Sally; Thoresen, Marianne & Cowan, Frances [Vis alle 7 forfattere av denne artikkelen] (2019). Attention and visuo-spatial function in children without cerebral palsy who were cooled for neonatal encephalopathy: a case-control study. Journal of Building Performance Simulation. ISSN 1940-1493. 33(7), s. 894–898. doi: 10.1080/02699052.2019.1597163. Vis sammendrag

  Attention and visuo-spatial function in children without cerebral palsy who were cooled for neonatal encephalopathy: a case-Control study

• Wassink, Guido; Davidson, Joanne O.; Dhillon, Simerdeep K.; Zhou, Kelly; Bennet, Laura & Thoresen, Marianne [Vis alle 7 forfattere av denne artikkelen] (2019). Therapeutic hypothermia in neonatal hypoxic-ischemic encephalopathy. Current Neurology and Neuroscience Reports. ISSN 1528-4042. 19:2(2), s. 1–10. doi: 10.1007/s11910-019-0916-0.
• El-Dib, Mohamed; Terrie, E; Inder, Terrie E; Chalak, Lina F; Massaro, An N & Thoresen, Marianne [Vis alle 7 forfattere av denne artikkelen] (2018). Should therapeutic hypothermia be offered to babies With mild neonatal encephalopathy in the first 6 hours after birth? Pediatric Research. ISSN 0031-3998. doi: 10.1038/s41390-019-0291-1. Fulltekst i vitenarkiv
• Walløe, Lars; Hjort, Nils Lid & Thoresen, Marianne (2018). Major concerns about late hypothermia study. Acta Paediatrica. ISSN 0803-5253. doi: 10.1111/apa.14640. Fulltekst i vitenarkiv
• Falck, Mari; Osredkar, Damjan; Maes, Elke; Flatebø, Torun; Wood, Thomas Ragnar & Walløe, Lars [Vis alle 8 forfattere av denne artikkelen] (2018). Hypothermia is neuroprotective after severe hypoxic-ischaemic brain injury in neonatal rats pre-exposed to PAM3CSK4. Developmental Neuroscience. ISSN 0378-5866. 40(3), s. 189–197. doi: 10.1159/000487798. Vis sammendrag

  BACKGROUND: Preclinical research on the neuroprotective effect of hypothermia (HT) after perinatal asphyxia has shown variable results, depending on comorbidities and insult severity. Exposure to inflammation increases vulnerability of the neonatal brain to hypoxic-ischaemic (HI) injury, and could be one explanation for those neonates whose injury is unexpectedly severe. Gram-negative type inflammatory exposure by lipopolysaccharide administration prior to a mild HI insult results in moderate brain injury, and hypothermic neuroprotection is negated. However, the neuroprotective effect of HT is fully maintained after gram-positive type inflammatory exposure by PAM3CSK4 (PAM) pre-administration in the same HI model. Whether HT is neuroprotective in severe brain injury with gram-positive inflammatory pre-exposure has not been investigated. METHODS: 59 seven-day-old rat pups were subjected to a unilateral HI insult, with left carotid artery ligation followed by 90-min hypoxia (8% O2 at Trectal 36°C). An additional 196 pups received intraperitoneal 0.9% saline (control) or PAM1 mg/kg, 8 h before undergoing the same HI insult. After randomisation to 5 h normothermia (NT37°C) or HT32°C, pups survived 1 week before they were sacrificed by perfusion fixation. Brains were harvested for hemispheric and hippocampal area loss analyses at postnatal day 14, as well as immunostaining for neuron count in the HIP CA1 region. RESULTS: Normothermic PAM animals (PAM-NT) had a comparable median area loss (hemispheric: 60% [95% CI 33-66]; hippocampal: 61% [95% CI 29-67]) to vehicle animals (Veh-NT) (hemispheric: 58% [95% CI 11-64]; hippocampal: 60% [95% CI 19-68]), which is defined as severe brain injury. Furthermore, mortality was low and similar in the two groups (Veh-NT 4.5% vs. PAM-NT 6.6%). HT reduced hemispheric and hippocampal injury in the Veh group by 13 and 28%, respectively (hemispheric: p = 0.048; hippocampal: p = 0.042). HT also provided neuroprotection in the PAM group, reducing hemispheric injury by 22% (p = 0.03) and hippocampal injury by 37% (p = 0.027). CONCLUSION: In these experiments with severe brain injury, Toll-like receptor-2 triggering prior to HI injury does not have an additive injurious effect, and there is a small but significant neuroprotective effect of HT. HT appears to be neuroprotective over a continuum of injury severity in this model, and the effect size tapers off with increasing area loss. Our results indicate that gram-positive inflammatory exposure prior to HI injury does not negate the neuroprotective effect of HT in severe brain injury.

• Sabir, Hemmen; Dingley, John; Scull-Brown, Emma; Chakkarapani, Ela & Thoresen, Marianne (2018). Fentanyl induces cerebellar internal granular cell layer apoptosis in healthy newborn pigs. Frontiers in Neurology. ISSN 1664-2295. 9(MAY). doi: 10.3389/fneur.2018.00294. Fulltekst i vitenarkiv
• Falck, Mari; Osredkar, Damjan; Wood, Thomas Ragnar; Maes, Elke; Flatebø, Torun & Sabir, Hemmen [Vis alle 7 forfattere av denne artikkelen] (2018). Neonatal Systemic Inflammation Induces Inflammatory Reactions and Brain Apoptosis in a Pathogen-Specific Manner. Neonatology. ISSN 1661-7800. 113(3), s. 212–220. doi: 10.1159/000481980.
• Tann, Cally J.; Martinello, KA; Sadoo, S; Lawn, JN; Seale, AC & Vega-Poblete, M [Vis alle 22 forfattere av denne artikkelen] (2017). Neonatal encephalopathy With goup B streptpococcal disease worldwide: Systematic review, investigator Group datasets and Meta-analysis. Clinical Infectious Diseases. ISSN 1058-4838. s. 173–189. doi: 10.1093/cid/cix662.
• Liu, Xun; Jary, Sally; Cowan, Frances & Thoresen, Marianne (2017). Reduced infancy and childhood epilepsy following hypothermia-treated neonatal encephalopathy. Epilepsia. ISSN 0013-9580. 58(11), s. 1902–1911. doi: 10.1111/epi.13914.
• Skranes, Janne Helen; Løhaugen, Gro; Schumacher, Eva Margrethe; Osredkar, Damjan; Server, Andrés & Cowan, Frances Mary [Vis alle 9 forfattere av denne artikkelen] (2017). Amplitude-Integrated Electroencephalography Improves the Identification of Infants with Encephalopathy for Therapeutic Hypothermia and Predicts Neurodevelopmental Outcomes at 2 Years of Age. Journal of Pediatrics. ISSN 0022-3476. 187, s. 34–42. doi: 10.1016/j.jpeds.2017.04.041.
• Falck, Mari; Osredkar, Damjan; Maes, Elke; Flatebø, Torun; Wood, Thomas Ragnar & Sabir, Hemmen [Vis alle 7 forfattere av denne artikkelen] (2017). Hypothermic neuronal rescue from infection-sensitised hypoxic-ischaemic brain injury is pathogen dependent. Developmental Neuroscience. ISSN 0378-5866. 39(1-4), s. 238–247. doi: 10.1159/000455838.
• Wood, Thomas Ragnar; Hobbs, C; Brun, AC; Falck, Mari; Løberg, Else Marit & Thoresen, Marianne (2017). Rectal temperature in the first five hours after hypoxia-ischaemia critically affetcs neuropathological outcomes in neonatale rats. Pediatric Research. ISSN 0031-3998. doi: 10.1038/pr.2017.51.
• Thoresen, Marianne; Gunn, A J; Robertson, Nicola J; Laptook, Abbot R; Barks, J D & Wassink, Guido [Vis alle 7 forfattere av denne artikkelen] (2017). Therapeutic hypothermia translates from ancient history in to practice. Pediatric Research. ISSN 0031-3998. 81(1-2), s. 202–209. doi: 10.1038/pr.2016.198.
• Kochanek, P; Kitagawa, RS; Batchelor, P & Thoresen, Marianne (2016). Central Nervous System Injury and Temperature Management. Therapeutic Hypothermia and Temperature Management. ISSN 2153-7658. 6(3), s. 112–115. doi: 10.1089/ther.2016.29014.pjk.
• Sabir, Hemmen; Osredkar, Damjan; Maes, Elke; Wood, Thomas Ragnar & Thoresen, Marianne (2016). Xenon combined with therapeutic hypothermia is not neuroprotective after severe hypoxia-ischemia in neonatal rats. PLOS ONE. ISSN 1932-6203. 11(6). doi: 10.1371/journal.pone.0156759.
• Elstad, Maja; Liu, Xun & Thoresen, Marianne (2016). Heart rate response to therapeutic hypothermia in infants with hypoxic–ischaemic encephalopathy. Resuscitation. ISSN 0300-9572. 106, s. 53–57. doi: 10.1016/j.resuscitation.2016.06.023.
• Wood, Thomas Ragnar; Smit, Elisa; Maes, Elke; Osredkar, Damjan; Falck, Mari & Elstad, Maja [Vis alle 7 forfattere av denne artikkelen] (2016). Monitoring of cerebral blood flow during hypoxia-ischemia and resuscitation in the neonatal rat using laser speckle imaging. Physiological Reports. ISSN 2051-817X. 4(7), s. 1–14. doi: 10.14814/phy2.12749. Fulltekst i vitenarkiv
• Wood, Thomas Ragnar; Osredkar, Damjan; Puchades, Maja Amedjkouh; Maes, Elke; Falck, Mari & Flatebø, Torun [Vis alle 9 forfattere av denne artikkelen] (2016). Treatment temperature and insult severity influence the neuroprotective effects of therapeutic hypothermia. Scientific Reports. ISSN 2045-2322. 6. doi: 10.1038/srep23430. Fulltekst i vitenarkiv
• Hemmen, Sabir; Wood, Thomas Ragnar; Gill, Hannah; Liu, Xun; Dingley, John & Thoresen, Marianne (2016). Xenon depresses aEEG background voltage activity whilst maintaining cardiovascular stability in sedated healthy newborn pigs. Journal of the Neurological Sciences. ISSN 0022-510X. 363, s. 140–144. doi: 10.1016/j.jns.2016.02.051. Fulltekst i vitenarkiv
• Whitelaw, Andrew; Osredkar, Damjan & Thoresen, Marianne (2015). Neurological & Neuromuscular Disorders. I MacDonald, Mhairi G. & Seshia, Mary M. K. (Red.), Avery's Neonatology: Pathophysiology and Management of the Newborn (Seventh Edition). Lippincott Williams & Wilkins. ISSN 9781451192681. s. 994–1016.
• Aquilina, Kristian & Thoresen, Marianne (2015). A newborn piglet survival model of post-hemorrhagic ventricular dilatation. I Yager, Jerome Y. (Red.), Animal Models of Neurodevelopmental Disorders. Humana Press. ISSN 978-1-4939-2708-1. doi: 10.1007/978-1-4939-2709-8_10.
• Chakkarapani, Elavazhagan & Thoresen, Marianne (2015). The Newborn Pig Global Hypoxic-Ischemic Model of Perinatal Brain and Organ Injury. I Yager, Jerome Y. (Red.), Animal Models of Neurodevelopmental Disorders. Humana Press. ISSN 978-1-4939-2708-1. doi: 10.1007/978-1-4939-2709-8_12.
• Jary, Sally; Smit, Elisa; Liu, Xun; Cowan, Frances & Thoresen, Marianne (2015). Less severe cerebral palsy outcomes in infants treated with therapeutic hypothermia. Acta Paediatrica. ISSN 0803-5253. 104(12), s. 1241–1247. doi: 10.1111/apa.13146.
• Smit, Elisa; Liu, Xun; Gill, Hannah; Jary, Sally; Wood, Thomas Ragnar & Thoresen, Marianne (2015). The effect of resuscitation in 100% oxygen on brain injury in a newborn rat model of severe hypoxic-ischaemic encephalopathy. Resuscitation. ISSN 0300-9572. 96, s. 214–219. doi: 10.1016/j.resuscitation.2015.07.050.
• Thoresen, Marianne & Sabir, Hemmen (2015). Epilepsy: Neonatal seizures still lack safe and effective treatment. Nature Reviews Neurology. ISSN 1759-4758. 11(6), s. 311–312. doi: 10.1038/nrneurol.2015.74.
• Osredkar, Damjan; Sabir, Hemmen; Falck, Mari; Wood, Thomas Ragnar; Maes, Elke & Flatebø, Torun [Vis alle 8 forfattere av denne artikkelen] (2015). Hypothermia Does Not Reverse Cellular Responses Caused by Lipopolysaccharide in Neonatal Hypoxic-Ischaemic Brain Injury. Developmental Neuroscience. ISSN 0378-5866. 37(4-5), s. 390–397. doi: 10.1159/000430860.
• Gunn, Alistair J & Thoresen, Marianne (2015). Animal studies of neonatal hypothermic neuroprotection have translated well in to practice. Resuscitation. ISSN 0300-9572. 97, s. 88–90. doi: 10.1016/j.resuscitation.2015.03.026.
• Skranes, Janne Helen; Cowan, Frances; Stiris, Tom; Fugelseth, Drude; Thoresen, Marianne & SERVER, ANDRES (2015). Brain imaging in cooled encephalopathic neonates does not differ between four and 11 days after birth. Acta Paediatrica. ISSN 0803-5253. 104(8), s. 752–758. doi: 10.1111/apa.13016.
• Dingley, John; Liu, Xun; Gill, Hannah; Smit, Elisa; Sabir, Hemmen & Tooley, James [Vis alle 9 forfattere av denne artikkelen] (2015). The feasibility of using a portable xenon delivery device to permit earlier xenon ventilation with therapeutic cooling of neonates during ambulance retrieval. Anesthesia and Analgesia. ISSN 0003-2999. 120(6), s. 1331–1336. doi: 10.1213/ANE.0000000000000693.
• Thoresen, Marianne (2015). Who should we cool after perinatal asphyxia? Seminars in Fetal & Neonatal Medicine. ISSN 1744-165X. 20(2), s. 66–71. doi: 10.1016/j.siny.2015.01.002.
• Hoque, Nicholas; Liu, Xun; Chakkarapani, Elavazhagan & Thoresen, Marianne (2015). Minimal systemic hypothermia combined with selective head cooling evaluated in a pig model of hypoxia-ischemia. Pediatric Research. ISSN 0031-3998. 77(5), s. 674–680. doi: 10.1038/pr.2015.31.
• Wood, Thomas Ragnar & Thoresen, Marianne (2015). Physiological responses to hypothermia. Seminars in Fetal & Neonatal Medicine. ISSN 1744-165X. 20(2), s. 87–96. doi: 10.1016/j.siny.2014.10.005.
• Liu, Xun; Dingley, John; Scull-Brown, Emma & Thoresen, Marianne (2015). Adding 5 hours delayed xenon to delayed hypothermia treatment improves long term function in neonatal rats surviving to adulthood. Pediatric Research. ISSN 0031-3998. 77, s. 779–783. doi: 10.1038/pr.2015.49.
• Smit, Elisa; Liu, Xun; Jary, Sally; Cowan, Frances & Thoresen, Marianne (2015). Cooling neonates who do not fulfil the standard cooling criteria - short and long term outcomes. Acta Paediatrica. ISSN 0803-5253. 104(2), s. 138–145. doi: 10.1111/apa.12784.

Se alle arbeider i Cristin

• Thoresen, Marianne & Chakkarapani, Ela (2020). Association between neonatal neuroimaging, 18month cognitive and school-age full-scale IQ scores in children without cerebral palsy, cooled for neonatal encephalopathy .
• Thoresen, Marianne; Wood, TR; Gundersen, J; Falck, Mari; Maes, Elke & Osredkar, Damjan [Vis alle 9 forfattere av denne artikkelen] (2020). Variability and sex-dependence of hypothermic neuroprotection in a rat model of neonatal hypoxic-ischaemic brain injury: a single laboratory meta-analysis .
• Thoresen, Marianne; van Bel, Frank; Murray, D; Saliba, E; Buonocore, G & Hellstrøm-Westas, L [Vis alle 7 forfattere av denne artikkelen] (2018). Postnatal management of newborn infants with hypoxic ischaemic encephalopathy (HIE).
• Thoresen, Marianne (2018). The past and future of Neonatal Neuroprotection.
• Thoresen, Marianne (2018). <li value="209"> Thoresen M. On BBC 11th July 2018: http://www.bristolhealthpartners.org.uk/blog/2018/06/26/i-pushed-all-i-could-out-came-a-baby-who-was-pale-limp-and-did-not-cry/1102 . [TV]. BBC.
• Hollung, Sandra Julsen & Thoresen, Marianne (2018). Forekomsten og alvorlighetsgraden av cerebral parese har gått ned. [TV]. NRK Dagsrevyen.
• Thoresen, Marianne (2018). Combining two good treatments makes it worse. (Commentary on Interaction between hypothermia and delayed mesenchymal stem cell therapy in neonatal hypoxic-ischemic brain injury). Brain, behavior, and immunity. ISSN 0889-1591. doi: 10.1016/j.bbi.2018.04.008.
• Thoresen, Marianne (2018). Hva oppnår vi ved nedkjøling av nyfødte med oksygenmangel.
• Thoresen, Marianne (2017). Targeted Temperature management in the very young.
• Thoresen, Marianne (2017). Entry criteria for Therapeutic are drifting - does it matter?
• Thoresen, Marianne (2017). Gases for the brain.
• Thoresen, Marianne (2017). Are small brains different from adults - why is therapeutic hypothermia so effective in newborns?
• Thoresen, Marianne (2017). Selection Criteria for 3 days of Therapeutic Hypothermia (TH) treatment after newborn asphyxia is based on aEEG depression. At 2 years, only 2% of TH infants have seizures needing regular AED treatment in a large SWE cohort'.
• Thoresen, Marianne (2017). Tackling perinatal asphyxia. Does keeping the newborn brain cold after lack of oxygen always reduce brain injury?
• Thoresen, Marianne (2017). Reduced sub-cortical grey matter volume is Associated With functional outcome at 6-8 years in children without cerebral palsy, who were cooled for neonatal encephalopathy.
• Thoresen, Marianne; Falck, Mari & Maes, Elke (2017). Pathogen specific changes in core temperature and neuroinflammation in the neonatal rat.
• Thoresen, Marianne (2017). Epilepsy and the need for drug treatment in infancy and early school years after perinatal asphyxia and therapeutic hypothermia.
• Thoresen, Marianne (2017). CARDIOVASCULAR RESPONSE AND SEIZURE FREQUENCY OF 78 HOURS XENON INHALATION WITH HYPOTHERMIA FOLLOWING GLOBAL HYPOXIC-ISCHAEMIA: FEASIBILITY.
• Thoresen, Marianne & Falck, Mari (2017). Hypothermia plus human Umbilical-Cord Blood Cells is neuroprotective in a severe neonatal hypoxicischaemic brain injury model.
• Thoresen, Marianne (2016). 'Lille Tobias var i ferd med å dø - da gjorde lege Marianne noe ingen hadde gjort før'. [TV]. http://www.tv2.no/a/8732302.
• Thoresen, Marianne; Basu, S K; Kaiser, J R; Guffey, D; Minard, C G & Guillet, Ronnie [Vis alle 7 forfattere av denne artikkelen] (2016). Hypoglycaemia and hyperglycaemia are associated with unfavourable outcome in infants with hypoxic ischaemic encephalopathy: a post hoc analysis of the CoolCap Study. Archives of Disease in Childhood: Fetal and Neonatal Edition. ISSN 1359-2998. s. 149–155. doi: 10.1136/archdischild-2015-308733.
• Thoresen, Marianne (2016). Cooling the right children with the optimal protocol using valid short and long term outcome examinations - are we getting any better?
• Thoresen, Marianne (2016). Xenon and hypothermia in neonates.
• Thoresen, Marianne (2016). Hypothermia and beyond. (Perinatal Asphyxia).
• Steinsland, Tonje & Thoresen, Marianne (2016). Vårt lille land : 'Cooling babies'.
• Thoresen, Marianne & Herefordshire & Worcester, BBC Radio (2016). Interview following-up on progress of a baby who had been enrolled in a clinical trial.
• Falck, Mari; Maes, Elke; Flatebo, Torun; Wood, Thomas Ragnar; Sabir, Hemmen & Osredkar, Damjan [Vis alle 7 forfattere av denne artikkelen] (2016). Gram-positive Septicemia Sensitises The Neonatal Brain To Hypoxic-ischemic Injury, Without Inhibiting The Neuroprotective Effect Of Hypothermia.
• Chakkarapani, Ela & Thoresen, Marianne (2016). C-Reactive Protein Response in Infants Cooled for Neonatal Encephalopathy Is Delayed in Females More Than Males.
• Lee-Kelland, Richard; Dingley, John; Okano, S; Scull-Brown, Emma; Thoresen, Marianne & Chakkarapani, Ela (2016). Xenon as Neuroprotection: A Demonstration of an Automated Delivery System.
• Wood, Thomas Ragnar; Skranes, Janne Helen; Falck, Mari; Lohaugen, GC; Stiris, Tom & Loberg, EM [Vis alle 8 forfattere av denne artikkelen] (2016). Core Temperature After Neonatal Hypoxia-Ischaemia Predicts Long-term Cerebral Injury.
• Smit, Elisa; Wood, Thomas Ragnar; Elstad, Maja; Liu, Xun & Thoresen, Marianne (2016). The effect of resuscitation in 100% Oxygen on cerebral blood flow and neuropathology in a newborn rat model of hypoxia-ischaemia.
• Thoresen, Marianne (2015). Optimal hypothermia treatment: an update from experimental and clinical research.
• Thoresen, Marianne (2015). Who should we cool, for how long and at what temperature?
• Thoresen, Marianne (2015). Hypothermia after perinatal asphyxia; do we select and cool the right babies with the optimal cooling protocol and follow up agreements?
• Falck, Mari; Osredkar, Damjan; Maes, Elke; Wood, Thomas Ragnar; Puchades, Maja Amedjkouh & Sabir, Hemmen [Vis alle 7 forfattere av denne artikkelen] (2015). Systemic Inflammation Negates Hypothermic Neuroprotection in a Neonatal HIE-model.
• Wood, Thomas Ragnar; Osredkar, Damjan; Flatebø, Torun; Falck, Mari; Maes, Elke & Thoresen, Marianne (2015). Temperature Dependence Of Hypothermic Neuroprotection in a Rat Model of Neonatal Hypoxic Ischaemic Enchephopathy.
• Thoresen, Marianne (2015). Optimal resuscitation followed by optimal hypothermia with and without added xenon inhalation.
• Sabir, Hemmen; Osredkar, Damjan; Maes, Elke; Wood, Thomas Ragnar & Thoresen, Marianne (2015). Therapeutic Hypothermia Combined With Inhaled Xenon in Newborn Rats: the Ongoing Challenge following severe hypoxicischemic brain injury.
• Lee-Kelland, Richard; Chakkarapani, Ela; Jary, Sally; Liu, Xun & Thoresen, Marianne (2015). Temperature Instability Post Rewarming in Neonates Who Have Received Therapeutic Hypothermia.
• Chakkarapani, Ela; Aquilina, Julian; Lee-Kelland, Richard; Jary, Sally; Liu, Xun & Thoresen, Marianne (2015). Morphine exposure and neurodevelopment outcome in cooled neonatal encephalopathy infants with mild cerebral dysfunction.
• Sabir, Hemmen; Maes, Elke; Liu, Xun; Dingley, John & Thoresen, Marianne (2015). Fentanyl induces cerebellar internal granular cell layer apoptosis in healthy newborn pigs.
• Wood, Thomas Ragnar; Osredkar, Damjan; Flatebø, Torun; Falck, Mari; Maes, Elke & Thoresen, Marianne (2015). Temperature Dependence Of Hypothermic Neuroprotection In A R Model Of Neonatal Hypoxic Ischaemic Encephalopathy.
• Thoresen, Marianne; Chakkarapani, Ela; Walløe, Lars; Løberg, Else Marit; Maes, Elke & Liu, Xun [Vis alle 7 forfattere av denne artikkelen] (2015). No cardiac protection from hypothermia or xenon inhalation after hypoxia-ischemia in newborn pigs.
• Falck, Mari; Osredkar, Damjan & Thoresen, Marianne (2015). Hypothermia does not reverse cellular responses caused by lipopolysaccharide in neonatal hypoxic ischemic brain injury.
• Thoresen, Marianne (2015). Editorial: Cooling after perinatal asphyxia. Seminars in Fetal & Neonatal Medicine. ISSN 1744-165X. 20(2). doi: 10.1016/j.siny.2015.01.003.
• Thoresen, Marianne (2014). The David Hardy Lecture - Neuroprotection: Past, present and future.
• Thoresen, Marianne (2014). Intervju om nedkjøling av nyfødte. [TV]. TV 2 Nyhetskanalen.
• Thoresen, Marianne (2014). Intervju om nedkjøling av nyfødte. [TV]. God Morgen Norge, TV 2.
• Thoresen, Marianne (2014). Professor: – Xenon kan være livsfarlig. [TV]. TV 2 Nyhetene.
• Thoresen, Marianne (2021). Corpus callosum morphology, microstructure and outcomes in children without cerebral palsy cooled for neonatal hypoxic-ischemic encephalopathy. Abstract ID: 3538308. Pediatric Academic Society.
• Thoresen, Marianne & Jary, Sally (2021). Motor correlates of brain structural connectivity in school-age children treated with therapeutic hypothermia for neonatal encephalopathy. Abstract ID: 3539104. Pediatric Academic Society.
• Thoresen, Marianne & Gundersen, Julie K (2021). Morphine and fentanyl exposure during therapeutic hypothermia do not affect neurodevelopmental outcome at 18-24 months of age. Abstract ID: 3539552. Pediatric Academic Society.
• Thoresen, Marianne (2018). European Standards of Care for Newborn Health:Postnatal management of newborn infants with hypoxic ischaemic encephalopathy (HIE). Issued by: European Foundation for the Care of Newborn Infants (EFCNI). November 2018. European standard of care for newborn health.

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