Julie Elisabeth Heggelund

Image of Julie Elisabeth Heggelund
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Visiting address Sognsvannsveien 20 Rikshospitalet 0372 Oslo
Postal address Postboks 4950 Nydalen OUS HF Rikshospitalet 0424 Oslo
Other affiliations Department for Informatics (Student)

Academic interests

I'm currently part of a multidisciplinary project on celiac disease at IMMI at Rikshospitalet. We aim to decipher the immunological mechanisms behind the development of the disease. My part of the project consists of studying the binding between gluten peptides from food and antibodies produced by the body, using methods such as X-ray crystallography, phage display and electron microscopy.

My postdoc project focused on membrane proteins involved in multiresistant tuberculosis. The project was a FRIPRO mobility project financed by the Research Council of Norway. I spent the first two years at the University of Leeds, UK, and the last year in the Økstad group at the Department of Pharmacy, including a collaboration with the Luecke group at NCMM.

My PhD project focused on the X-ray crystallographic studies of the cholera toxin (from V. cholerae) and the heat-labile enterotoxin (from ETEC). In addition, I have investigated the binding of different ligands to the toxins using the methods SPR, ELISA, NMR and MST, including cell biology work. My main findings include five X-ray structures of the cholera toxin binding different blood-group oligosaccharides, complemented by SPR and STD-NMR data (Heggelund et al., PLOS Pathogens, 2016). The PhD project was supervised by Professor Ute Krengel. For more information, visit the Bacterial toxins webpage.

LinkedIn: no.linkedin.com/in/jeheggelund

Teaching

Lecturer in KJM1140 Autumn 2019 and Spring 2022 - Biochemistry 1 for chemists

Group teacher in the following subjects:

Speaker at the following popular science events:

  • Unveiling of the Hassel exhibition, Department of Chemistry, 2019
  • Realistforeningens REALfrokost, 2016
  • The new Life Science building exhibition, 2014
  • Faglig pedagogisk dag, 2012/2013
  • Kjemi1-dagen, 2013/2014
  • Kjemi Grand Prix, 2012

Co-supervisor of students:

  • Helene, Master student, 60 stp, 2016
  • Tobias, KJM3020 - Undergraduate research, 20 stp, 2015
  • Victoria, KJM2020 - Undergraduate research, 20 stp, 2014 
  • Daniel, Master student, 60 stp, 2015
  • Njáll, KJM2020, Undergraduate research, 20 stp, 2012
  • Aleksandra, ERASMUS project, 30 stp, 2012
  • Przemysław, ERASMUS project, 30 stp, 2011

Background

  • PhD in Structural biology, Department of Chemistry, UiO - 2015
    • PhD thesis "Cholera toxin - carbohydrate interaction as the basis for cholera blood-group dependence" supervised by Prof. Ute Krengel
  • MSc in Molecular biosciences, IBV, UiO - 2011
    • Master thesis "Human Endonuclease V - Cloning, expression, purification and biochemical characterization" supervised by Dr. Bjørn Dalhus, OUS.
  • BSc in Molecular biology and biological chemistry, IBV, UiO - 2009
Tags: Chemistry, Biological chemistry, Life Science, Antibiotic resistance

Publications

  • Heggelund, Julie Elisabeth; Das, Saykat; Stamnæs, Jorunn; Iversen, Rasmus & Sollid, Ludvig Magne (2023). Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3. Nature Communications. ISSN 2041-1723. 14:6216 (1), p. 1–11. doi: 10.1038/s41467-023-42004-z. Full text in Research Archive
  • Heim, Joel Benjamin; Hodnik, Vesna; Heggelund, Julie Elisabeth; Anderluh, Gregor & Krengel, Ute (2019). Crystal structures of cholera toxin in complex with fucosylated receptors point to importance of secondary binding site. Scientific Reports. ISSN 2045-2322. 9 . doi: 10.1038/s41598-019-48579-2. Full text in Research Archive
  • Heggelund, Julie Elisabeth; Heim, Joel Benjamin; Bajc, Gregor; Hodnik, Vesna; Anderluh, Gregor & Krengel, Ute (2019). Specificity of Escherichia coli heat-Labile enterotoxin investigated by single-site mutagenesis and crystallography. International Journal of Molecular Sciences. ISSN 1661-6596. 20(3). doi: 10.3390/ijms20030703. Full text in Research Archive
  • Bjerregaard-Andersen, Kaare; Johannesen, Hedda; Abdel-Rahman, Noha Mansour Hassan; Heggelund, Julie Elisabeth; Hoås, Helene Mykland & Abraha, Fana [Show all 13 contributors for this article] (2018). Crystal structure of an L chain optimised 14F7 anti-ganglioside Fv suggests a unique tumour- specificity through an unusual H-chain CDR3 architecture. Scientific Reports. ISSN 2045-2322. 8:10836, p. 1–11. doi: 10.1038/s41598-018-28918-5. Full text in Research Archive
  • Heggelund, Julie Elisabeth; Varrot, Annabelle; Imberty, Anne & Krengel, Ute (2017). Histo-blood group antigens as mediators of infections. Current Opinion in Structural Biology. ISSN 0959-440X. 44, p. 190–200. doi: 10.1016/j.sbi.2017.04.001.
  • Heggelund, Julie Elisabeth; Mackenzie, Alasdair; Martinsen, Tobias; Heim, Joël Benjamin; Cheshev, Pavel & Bernardi, Anna [Show all 7 contributors for this article] (2017). Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics. Scientific Reports. ISSN 2045-2322. 7(2326). doi: 10.1038/s41598-017-02179-0. Full text in Research Archive
  • Hatlem, Daniel; Heggelund, Julie Elisabeth; Burschowsky, Daniel; Krengel, Ute & Kristiansen, Per Eugen (2017). 1H, 13C, 15N backbone assignment of the human heat-labile enterotoxin B-pentamer and chemical shift mapping of neolactotetraose binding. Biomolecular NMR Assignments. ISSN 1874-2718. 11(1), p. 99–104. doi: 10.1007/s12104-017-9728-9. Full text in Research Archive
  • Heggelund, Julie Elisabeth; Burschowsky, Daniel; Bjørnestad, Victoria Ariel; Hodnik, Vesna; Anderluh, Gregor & Krengel, Ute (2016). High-Resolution Crystal Structures Elucidate the Molecular Basis of Cholera Blood Group Dependence. PLoS Pathogens. ISSN 1553-7366. 12(4). doi: 10.1371/journal.ppat.1005567. Full text in Research Archive
  • Heggelund, Julie Elisabeth; Bjørnestad, Victoria Ariel & Krengel, Ute (2015). Vibrio cholerae and Escherichia coli heat-labile enterotoxins and beyond. In Alouf, Joseph E; Ladant, Daniel & Popoff, Michel R (Ed.), The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition. Elsevier. ISSN 978-0-12-800188-2. p. 195–229. doi: 10.1016/B978-0-12-800188-2.00007-0.
  • Vasile, Francesca; Reina, José J.; Potenza, Donatella; Heggelund, Julie Elisabeth; Mackenzie, Alasdair & Krengel, Ute [Show all 7 contributors for this article] (2014). Comprehensive analysis of blood group antigen binding to classical and El Tor cholera toxin B-pentamers by NMR. Glycobiology. ISSN 0959-6658. 24(8), p. 766–778. doi: 10.1093/glycob/cwu040.
  • Fladeby, Cathrine; Vik, Erik Sebastian; Lærdahl, Jon Kristen; Neurauter, Christine Gran; Heggelund, Julie Elisabeth & Thorgaard, Eirik [Show all 10 contributors for this article] (2012). The Human Homolog of Escherichia coli Endonuclease V Is a Nucleolar Protein with Affinity for Branched DNA Structures. PLOS ONE. ISSN 1932-6203. 7(11). doi: 10.1371/journal.pone.0047466.
  • Heggelund, Julie Elisabeth; Haugen, Espen; Lygren, Birgitte; Mackenzie, Alasdair; Roclöv, Åsa Holmner & Vasile, Francesca [Show all 9 contributors for this article] (2012). Both El Tor and classical cholera toxin bind blood group determinants. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 418(4), p. 731–735. doi: 10.1016/j.bbrc.2012.01.089.

View all works in Cristin

  • Heggelund, Julie Elisabeth (2023). Structural studies of transglutaminase 3.
  • Heggelund, Julie Elisabeth (2023). Poster: Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3.
  • Heggelund, Julie Elisabeth (2022). Structural studies of Transglutaminase 3.
  • Heggelund, Julie Elisabeth (2022). Phage display to improve the lives of celiac disease patients.
  • Heggelund, Julie Elisabeth (2022). Poster: Phage display to improve the lives of celiac disease patients.
  • Heggelund, Julie Elisabeth (2020). Development of inhibitors of drug-efflux transporters to fight antibiotic resistance.
  • Heggelund, Julie Elisabeth (2020). Development of inhibitors of drug-efflux transporters to fight antibiotic resistance.
  • Heggelund, Julie Elisabeth (2020). Legemidler mot sykdommer i sentralnervesystemet kan hjelpe mot antibiotikaresistens. www.mn.uio.no/farmasi.
  • Heggelund, Julie Elisabeth (2020). Tuberkulose-vaksine i kampen mot SARS-CoV-2. www.mn.uio.no/farmasi.
  • Heggelund, Julie Elisabeth; Heim, Joel Benjamin & Krengel, Ute (2019). Cholera blood group association elucidated with synchrotron radiation.
  • Heggelund, Julie Elisabeth (2019). Development of inhibitors of drug-efflux transporters to fight antibiotic resistance (IBA).
  • Heggelund, Julie Elisabeth (2019). High-resolution crystal structures elucidate the molecular basis of cholera blood group dependence.
  • Heggelund, Julie Elisabeth (2019). Development of inhibitors of drug-efflux transporters to fight antibiotic resistance.
  • Johannesen, Hedda; Bjerregaard-Andersen, Kaare; Heggelund, Julie Elisabeth; Løset, Geir Åge & Krengel, Ute (2019). 14F7 - A tumour specific antibody .
  • Heggelund, Julie Elisabeth (2018). LCP-krystallisering på synkrotronen. www.mn.uio.no/farmasi.
  • Johannesen, Hedda; Bjerregaard-Andersen, Kaare; Heggelund, Julie Elisabeth; Løset, Geir Åge & Krengel, Ute (2018). NeuGc GM3 - a cancer-specific ganglioside that is recognised by the antibody 14F7.
  • Heggelund, Julie Elisabeth (2018). The constant threat from infectious disease: From cholera to antibiotic resistance.
  • Heggelund, Julie Elisabeth; Hausvik, Emil; Carvalho, Luiz; Økstad, Ole Andreas Løchen; Martinez, Aurora & Goldman, Adrian (2018). Targeting MFS transporters to switch off antibiotic resistance in tuberculosis.
  • Johannesen, Hedda; Mykland hoås, Helene; Heggelund, Julie Elisabeth; Bjerregaard-Andersen, Kaare; Løset, Geir Åge & Krengel, Ute (2018). 14F7, An anti-ganglioside scFv for cancer therapies.
  • Johannesen, Hedda; Mykland Hoås, Helene; Heggelund, Julie Elisabeth; Bjerregaard-Andersen, Kaare; Løset, Geir Åge & Krengel, Ute (2018). 14F7, an antibody that recognises a tumour-specific ganglioside with high specificity .
  • Heggelund, Julie Elisabeth (2018). Combatting antibiotic resistance: Targeting MFS transporters from Mycobacterium tuberculosis.
  • Johannesen, Hedda; Hoås Mykland, Helene; Heggelund, Julie Elisabeth; Bjerregaard-Andersen, Kaare; Løset, Geir Åge & Krengel, Ute (2018). An anti-ganglioside scFv for cancer therapies.
  • Heggelund, Julie Elisabeth (2017). Selvlysende tuberkuloseproteiner. www.mn.uio.no/farmasi.
  • Heggelund, Julie Elisabeth (2017). Bakterier sender antibiotika ut av cellene før de rekker å virke. www.mn.uio.no/farmasi.
  • Tonjum, Tone; Krengel, Ute & Heggelund, Julie Elisabeth (2017). 5 alternativer til antibiotika.
  • Heggelund, Julie Elisabeth (2017). Crystal structures of bacterial enterotoxins in complex with GM1 inhibitors: towards new cholera prophylactics and treatment .
  • Heim, Joël Benjamin; Heggelund, Julie Elisabeth & Krengel, Ute (2016). Cholera blood-group dependence and role of secretor status.
  • Heim, Joël Benjamin; Heggelund, Julie Elisabeth & Krengel, Ute (2016). Cholera blood-group dependence and role of secretor status.
  • Heggelund, Julie Elisabeth (2016). REALfrokost: Kolera rammer mennesker med blodtype 0 hardest.
  • Heggelund, Julie Elisabeth & Manna, Dipankar (2016). Proteiner fra sopp kan drepe kreftceller. Titan.uio.no.
  • Heggelund, Julie Elisabeth (2016). Kolera rammer mennesker med blodtype 0 hardest . Forskning.no. ISSN 1891-635X.
  • Heggelund, Julie Elisabeth (2016). Derfor rammes de med blodtype 0 hardest av kolera. Titan.uio.no.
  • Heggelund, Julie Elisabeth (2016). High-Resolution Crystal Structures Elucidate the Molecular Basis of Cholera Blood Group Dependence.
  • Heim, Joël Benjamin; Heggelund, Julie Elisabeth & Krengel, Ute (2016). How does blood group secretor status protect from cholera intoxication? – Structure and interaction analysis of carbohydrate binding.
  • Heggelund, Julie Elisabeth (2016). Siste nytt fra proteinkrystallografiens høyborg. NBS-nytt. ISSN 0801-3535. 1, p. 36–37.
  • Heggelund, Julie Elisabeth (2015). Blood group oligosaccharide binding to cholera toxin revealed by X-ray crystallography.
  • Heggelund, Julie Elisabeth (2015). Blood group oligosaccharide binding to cholera toxin revealed by X-ray crystallography.
  • Heggelund, Julie Elisabeth (2015). High-resolution X-ray structures reveal the cholera toxin binding to blood group oligosaccharides.
  • Heggelund, Julie Elisabeth (2015). Cholera blood-group dependence and protection by human milk elucidated by SPR and X-ray crystallography.
  • Heggelund, Julie Elisabeth (2014). Mine drømmer om det nye livsvitenskapsbygget.
  • Heggelund, Julie Elisabeth (2014). Cholera blood-group dependence elucidated by X-ray crystallography, ELISA and SPR.
  • Heggelund, Julie Elisabeth (2014). Cholera’s blood-group dependence elucidated by X-ray crystallography and ELISA.
  • Hatlem, Daniel; Heggelund, Julie Elisabeth; Burschowsky, Daniel; Kristiansen, Per Eugen & Krengel, Ute (2014). Characterization of Lipopolysaccharide Binding to the E.coli Heat-labile Enterotoxin.
  • Heggelund, Julie Elisabeth; Prydz, Kristian & Krengel, Ute (2014). Cholera blood-group dependence investigated by X-ray crystallography, CaCo-2 cells and ELISA.
  • Heggelund, Julie Elisabeth (2013). Kolera på atomnivå 2.
  • Heggelund, Julie Elisabeth & Krengel, Ute (2013). Kolera og blodgrupper.
  • Hatlem, Daniel; Heggelund, Julie Elisabeth; Burschowsky, Daniel; Kristiansen, Per Eugen & Krengel, Ute (2013). Characterization of Lipopolysaccharide binding to E.coli Heat-labile Enterotoxin.
  • Heggelund, Julie Elisabeth; Prydz, Kristian & Krengel, Ute (2013). Cholera toxin's blood-group dependence investigated with CaCo-2 cells and ELISA.
  • Heggelund, Julie Elisabeth (2013). Cholera toxin - and binding to blood group glycans.
  • Heggelund, Julie Elisabeth & Krengel, Ute (2013). Exploring Cholera Toxin and Heat-Labile Enterotoxin Binding Specificity using SPR and Protein NMR.
  • Krengel, Ute & Heggelund, Julie Elisabeth (2012). Årets Nobelpris i kjemi er en gullgruve for legemiddelindustrien. [Newspaper]. Dagens Næringsliv.
  • Krengel, Ute; Heggelund, Julie Elisabeth & Jemterud, Torkild (2012). Interview om Nobel pris i Kjemi 2012. [Radio]. NRK (podcast Ekko viten).
  • Heggelund, Julie Elisabeth & Krengel, Ute (2012). Kjemi Grand Prix - Molecular basis of cholera blood group dependence.
  • Heggelund, Julie Elisabeth (2012). Kolera - Røntgenstråler og blodtyper.
  • Heggelund, Julie Elisabeth (2012). Kolera på atomnivå.
  • Heggelund, Julie Elisabeth & Krengel, Ute (2012). Molecular basis of cholera blood group dependence.
  • Heggelund, Julie Elisabeth (2012). Molecular basis of cholera blood group dependence.
  • Vogt, Yngve; Krengel, Ute & Heggelund, Julie Elisabeth (2012). Røntgenkjemiker løser koleragåte. [Newspaper]. Apollon.
  • Heggelund, Julie Elisabeth & Krengel, Ute (2012). From heat-labile enterotoxin to cholera toxin - residue by residue.
  • Heggelund, Julie Elisabeth (2011). Human Endonuclease V has specific affinity for branched DNA.
  • Heggelund, Julie Elisabeth; Krengel, Ute & Prydz, Kristian (2015). Cholera toxin – carbohydrate interaction as the basis for cholera blood-group dependence. Akademika publishing. ISSN 1501-7710.

View all works in Cristin

Published Aug. 25, 2020 11:41 AM - Last modified Feb. 11, 2022 3:59 PM