Julie Elisabeth Heggelund

Image of Julie Elisabeth Heggelund
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Visiting address Sognsvannsveien 20 Rikshospitalet 0372 Oslo
Postal address OUS HF Rikshospitalet Postboks 4950 Nydalen 0424 Oslo

Academic interests

I'm currently part of a multidisciplinary project on celiac disease at IMMI at Rikshospitalet. We aim to decipher the immunological mechanisms behind the development of the disease. My part of the project consists of studying the binding between gluten peptides from food and antibodies produced by the body, using methods such as X-ray crystallography, phage display and electron microscopy.

My postdoc project focused on membrane proteins involved in multiresistant tuberculosis. The project was a FRIPRO mobility project financed by the Research Council of Norway. I spent the first two years at the University of Leeds, UK, and the last year in the Økstad group at the Department of Pharmacy, including a collaboration with the Luecke group at NCMM.

My PhD project focused on the X-ray crystallographic studies of the cholera toxin (from V. cholerae) and the heat-labile enterotoxin (from ETEC). In addition, I have investigated the binding of different ligands to the toxins using the methods SPR, ELISA, NMR and MST, including cell biology work. My main findings include five X-ray structures of the cholera toxin binding different blood-group oligosaccharides, complemented by SPR and STD-NMR data (Heggelund et al., PLOS Pathogens, 2016). The PhD project was supervised by Professor Ute Krengel. For more information, visit the Bacterial toxins webpage.

LinkedIn: no.linkedin.com/in/jeheggelund

Teaching

Main lecturer in KJM1140 Autumn 2019 - Biochemistry 1 for chemists

Group teacher in the following subjects:

Speaker at the following popular science events:

  • Unveiling of the Hassel exhibition, Department of Chemistry, 2019
  • Realistforeningens REALfrokost, 2016
  • The new Life Science building exhibition, 2014
  • Faglig pedagogisk dag, 2012/2013
  • Kjemi1-dagen, 2013/2014
  • Kjemi Grand Prix, 2012

Co-supervisor of students:

  • Helene, Master student, 60 stp, 2016
  • Tobias, KJM3020 - Undergraduate research, 20 stp, 2015
  • Victoria, KJM2020 - Undergraduate research, 20 stp, 2014 
  • Daniel, Master student, 60 stp, 2015
  • Njáll, KJM2020, Undergraduate research, 20 stp, 2012
  • Aleksandra, ERASMUS project, 30 stp, 2012
  • Przemysław, ERASMUS project, 30 stp, 2011

Background

  • PhD in Structural biology, Department of Chemistry, UiO - 2015
    • PhD thesis "Cholera toxin - carbohydrate interaction as the basis for cholera blood-group dependence" supervised by Prof. Ute Krengel
  • MSc in Molecular biosciences, IBV, UiO - 2011
    • Master thesis "Human Endonuclease V - Cloning, expression, purification and biochemical characterization" supervised by Dr. Bjørn Dalhus, OUS.
  • BSc in Molecular biology and biological chemistry, IBV, UiO - 2009
Tags: Chemistry, Biological chemistry, Life Science, Antibiotic resistance
Published Aug. 25, 2020 11:41 AM - Last modified Dec. 8, 2020 12:26 PM