Anne Margrethe Myhre

• Barth, Claudia; Kelly, Sinead; Nerland, Stener; Jahanshad, Neda; Alloza, Clara & Ambrogi, Sonia [Vis alle 44 forfattere av denne artikkelen] (2022). In vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis. Molecular Psychiatry. ISSN 1359-4184. s. 1–11. doi: 10.1038/s41380-022-01901-3. Fulltekst i vitenarkiv Vis sammendrag

  Emerging evidence suggests brain white matter alterations in adolescents with early-onset psychosis (EOP; age of onset <18 years). However, as neuroimaging methods vary and sample sizes are modest, results remain inconclusive. Using harmonized data processing protocols and a mega-analytic approach, we compared white matter microstructure in EOP and healthy controls using diffusion tensor imaging (DTI). Our sample included 321 adolescents with EOP (median age = 16.6 years, interquartile range (IQR) = 2.14, 46.4% females) and 265 adolescent healthy controls (median age = 16.2 years, IQR = 2.43, 57.7% females) pooled from nine sites. All sites extracted mean fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) for 25 white matter regions of interest per participant. ComBat harmonization was performed for all DTI measures to adjust for scanner differences. Multiple linear regression models were fitted to investigate case-control differences and associations with clinical variables in regional DTI measures. We found widespread lower FA in EOP compared to healthy controls, with the largest effect sizes in the superior longitudinal fasciculus (Cohen’s d = 0.37), posterior corona radiata (d = 0.32), and superior fronto‐occipital fasciculus (d = 0.31). We also found widespread higher RD and more localized higher MD and AD. We detected significant effects of diagnostic subgroup, sex, and duration of illness, but not medication status. Using the largest EOP DTI sample to date, our findings suggest a profile of widespread white matter microstructure alterations in adolescents with EOP, most prominently in male individuals with early-onset schizophrenia and individuals with a shorter duration of illness.

• Mørch-Johnsen, Lynn Egeland; Smelror, Runar; Andreou, Dimitrios; Barth, Claudia; Johannessen, Cecilie Haggag & Wedervang-Resell, Kirsten [Vis alle 15 forfattere av denne artikkelen] (2022). Negative Symptom Domains Are Associated With Verbal Learning in Adolescents With Early Onset Psychosis. Frontiers in Psychiatry. ISSN 1664-0640. 12. doi: 10.3389/fpsyt.2021.825681. Fulltekst i vitenarkiv
• Andreou, Dimitrios; Steen, Nils Eiel; Jørgensen, Kjetil Nordbø; Smelror, Runar; Wedervang-Resell, Kirsten & Nerland, Stener [Vis alle 25 forfattere av denne artikkelen] (2021). Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness. Psychological Medicine. ISSN 0033-2917. s. 1–10. doi: 10.1017/S0033291721003056. Fulltekst i vitenarkiv
• Andreou, Dimitrios; Jørgensen, Kjetil Nordbø; Nerland, Stener; Smelror, Runar; Wedervang-Resell, Kirsten & Johannessen, Cecilie Haggag [Vis alle 11 forfattere av denne artikkelen] (2021). Lower plasma total tau in adolescent psychosis: Involvement of the orbitofrontal cortex. Journal of Psychiatric Research. ISSN 0022-3956. 144, s. 255–261. doi: 10.1016/j.jpsychires.2021.10.031. Fulltekst i vitenarkiv
• Smelror, Runar; Johannessen, Cecilie Haggag; Wedervang-Resell, Kirsten; Jørgensen, Kjetil Nordbø; Barth, Claudia & Andreou, Dimitrios [Vis alle 11 forfattere av denne artikkelen] (2021). Cognitive Impairment Profile in Adolescent Early-Onset Psychosis Usingthe MATRICS Battery: Age and Sex Effects. Neuropsychology. ISSN 0894-4105. 35(3), s. 300–309. doi: 10.1037/neu0000723.
• Engen, Kristine; Wortinger, Laura Anne ; Jørgensen, Kjetil Nordbø; Lundberg, Mathias; Bohman, Hannes & Smelror, Runar [Vis alle 10 forfattere av denne artikkelen] (2020). Autoantibodies to the N-methyl-D-aspartate receptor in adolescents with early onset psychosis and healthy controls. Frontiers in Psychiatry. ISSN 1664-0640. 11:666, s. 1–7. doi: 10.3389/fpsyt.2020.00666. Fulltekst i vitenarkiv
• Gurholt, Tiril Pedersen; Lonning, Vera Louise Hiorth; Nerland, Stener; Jørgensen, Kjetil Nordbø; Haukvik, Unn Kristin H. & Alloza, Clara [Vis alle 41 forfattere av denne artikkelen] (2020). Intracranial and subcortical volumes in adolescents with early‐onset psychosis: A multisite mega‐analysis from the ENIGMA consortium. Human Brain Mapping. ISSN 1065-9471. s. 373–384. doi: 10.1002/hbm.25212. Fulltekst i vitenarkiv
• Wedervang-Resell, Kirsten; Ueland, Thor; Aukrust, Pål; Friis, Svein; Holven, Kirsten Bjørklund & Johannessen, Cecilie Haggag [Vis alle 13 forfattere av denne artikkelen] (2020). Reduced levels of circulating adhesion molecules in adolescents with early-onset psychosis. Nature NPJ Schizophrenia. ISSN 2334-265X. 6, s. 1–8. doi: 10.1038/s41537-020-00112-5. Fulltekst i vitenarkiv
• Barth, Claudia; Lonning, Vera Louise Hiorth; Gurholt, Tiril Pedersen; Andreassen, Ole Andreas; Myhre, Anne Margrethe & Agartz, Ingrid (2020). Exploring white matter microstructure and the impact of antipsychotics in adolescent-onset psychosis. PLOS ONE. ISSN 1932-6203. doi: 10.1371/journal.pone.0233684. Fulltekst i vitenarkiv
• Smelror, Runar; Rund, Bjørn Rishovd; Lonning, Vera Louise Hiorth; Jørgensen, Kjetil Nordbø; Wedervang-Resell, Kirsten & Andreassen, Ole Andreas [Vis alle 9 forfattere av denne artikkelen] (2020). Negative and disorganized symptoms mediate the relationship between verbal learning and global functioning in adolescents with early-onset psychosis. European Child and Adolescent Psychiatry. ISSN 1018-8827. doi: 10.1007/s00787-020-01479-7. Fulltekst i vitenarkiv
• Wedervang-Resell, Kirsten; Friis, Svein; Lonning, Vera Louise Hiorth; Smelror, Runar; Johannessen, Cecilie Haggag & Agartz, Ingrid [Vis alle 10 forfattere av denne artikkelen] (2019). Lipid alterations in adolescents with early-onset psychosis may be independent of antipsychotic medication. Schizophrenia Research. ISSN 0920-9964. s. 1–7. doi: 10.1016/j.schres.2019.11.039. Fulltekst i vitenarkiv
• Wedervang-Resell, Kirsten; Friis, Svein; Lonning, Vera Louise Hiorth; Smelror, Runar; Johannessen, Cecilie Haggag & Reponen, Elina Johanna [Vis alle 13 forfattere av denne artikkelen] (2019). Increased interleukin 18 activity in adolescents with early-onset psychosis is associated with cortisol and depressive symptoms. Psychoneuroendocrinology. ISSN 0306-4530. 112:104513, s. 1–7. doi: 10.1016/j.psyneuen.2019.104513. Fulltekst i vitenarkiv
• Wikenius, Ellen; Myhre, Anne Margrethe; Page, Christian Magnus; Moe, Vibeke; Smith, Lars & Heiervang, Einar [Vis alle 8 forfattere av denne artikkelen] (2019). Prenatal maternal depressive symptoms and infant DNA methylation: a longitudinal epigenome-wide study. Nordic Journal of Psychiatry. ISSN 0803-9488. 73(4-5), s. 257–263. doi: 10.1080/08039488.2019.1613446. Fulltekst i vitenarkiv
• Smelror, Runar; Jørgensen, Kjetil Nordbø; Lonning, Vera Louise Hiorth; Kelleher, Ian; Cannon, Mary & DeRosse, Pamela [Vis alle 16 forfattere av denne artikkelen] (2018). Healthy adolescent performance with standardized scoring tables for the MATRICS Consensus Cognitive Battery: A multisite study. Schizophrenia Bulletin. ISSN 0586-7614. 45(4), s. 773–783. doi: 10.1093/schbul/sby131.
• Wikenius, Ellen; Bekkhus, Mona; Martinsen, Pål Gunnar & Myhre, Anne Margrethe (2017). Betydningen av stress tidlig i livet for epigenetisk variasjon : hva vet vi, og hva betyr det? Tidsskrift for Norsk Psykologforening. ISSN 0332-6470. 54(7), s. 626–636.
• Bendiksen, Bothild; Svensson, Elisabeth; Aase, Heidi; Reichborn-Kjennerud, Ted; Friis, Svein & Myhre, Anne Margrethe [Vis alle 7 forfattere av denne artikkelen] (2017). Co-Occurrence of ODD and CD in Preschool Children With Symptoms of ADHD. Journal of Attention Disorders. ISSN 1087-0547. 21(9), s. 741–752. doi: 10.1177/1087054714538655.
• Wikenius, Ellen; Moe, Vibeke; Malde, Marian Kjellevold; Smith, Lars; Lyle, Robert & Waagbø, Rune [Vis alle 8 forfattere av denne artikkelen] (2016). The association between hair cortisol and self-reported symptoms of depression in pregnant women. PLOS ONE. ISSN 1932-6203. 11(9). doi: 10.1371/journal.pone.0161804. Vis sammendrag

  Depression has been linked to an imbalance in cortisol. Until recently, cortisol has been studied by measuring concentrations at single time points in blood or saliva samples. Cortisol concentrations vary with circadian rhythm and experiences, from time point to time point. The measurement of hair cortisol concentration (HCC) is a new method of accessing mean, long-term cortisol concentrations. Recent studies show positive associations between depression and HCC, and prenatal maternal cortisol is thought to influence the developing fetus. We therefore examined the association between HCC and self-reported symptoms of depression in second trimester pregnant women. Participants were 181 women, recruited between September 2011 and October 2013 to the Little-in-Norway (LiN)-study. These women answered the Edinburgh Postnatal Depression Rating Scale (EPDS) on self-reported symptoms of depression, and one cm maternal scalp hair was collected and analyzed for cortisol concentrations. Multiple regression analyses did not show depressive symptoms as a predictor for HCC in our selection of pregnant women, while gestational age was significantly related. In conclusion, our study indicated that symptoms of depression during pregnancy did not predict HCC, but further studies of clinically depressed, pregnant women using gestational age as an adjustment variable are warranted.

• Gjevik, Elen; Sandstad, Berit; Andreassen, Ole Andreas; Myhre, Anne Margrethe & Sponheim, Eili (2015). Exploring the agreement between questionnaire information and DSM-IV diagnoses of comorbid psychopathology in children with autism spectrum disorders. Autism. ISSN 1362-3613. doi: 10.1177/1362361314526003.
• Gjevik, Elen; Sandstad, Berit; Andreassen, Ole Andreas; Myhre, Anne Margrethe & Sponheim, Eili (2014). Exploring the agreement between questionnaire information and DSM-IV diagnoses of comorbid psychopathology in children with autism spectrum disorders. Autism. ISSN 1362-3613. 19(4), s. 433–442. doi: 10.1177/1362361314526003.
• Bendiksen, Bothild; Aase, Heidi; Svensson, Elisabeth; Friis, Svein; Myhre, Anne Margrethe & Reichborn-Kjennerud, Ted [Vis alle 7 forfattere av denne artikkelen] (2014). Impairment in young preschool children with symptoms of attention-deficit/hyperactivity disorder and co-occurring oppositional defiant disorder and conduct disorder. Scandinavian Journal of Child and Adolescent Psychiatry and Psychology. ISSN 2245-8875. 2(3), s. 95–105. doi: 10.21307/sjcapp-2014-014. Fulltekst i vitenarkiv
• Øvergaard, Kristin Romvig; Aase, Heidi; Torgersen, Svenn; Reichborn-Kjennerud, Ted; Ørbeck, Beate & Myhre, Anne Margrethe [Vis alle 7 forfattere av denne artikkelen] (2014). Continuity in features of anxiety and attention deficit/hyperactivity disorder in young preschool children. European Child and Adolescent Psychiatry. ISSN 1018-8827. 23(9), s. 743–752. doi: 10.1007/s00787-014-0538-7. Fulltekst i vitenarkiv Vis sammendrag

  Anxiety disorders and Attention Deficit / Hyperactivity Disorder (ADHD) develop before school age, but little is known about early developmental pathways. Here we test two hypotheses: first, that early signs of anxiety and ADHD at 18 months predict symptoms of anxiety and ADHD at age 3½ years; second, that emotional dysregulation at 18 months predicts the outcome of co-occurring anxiety and ADHD at age 3½ years. The study was part of the prospective Norwegian Mother and Child Cohort Study (MoBa) at the Norwegian Institute of Public Health. The 628 participants were clinically assessed at 3½ years. Questionnaire data collected at 18 months were categorized into early behavioural scales of anxiety, ADHD, and emotional dysregulation. We investigated continuity in features of anxiety and ADHD from 18 months to 3½ years of age through logistic regression analyses. Anxiety symptoms at 3½ years were predicted by early signs of anxiety (Odds ratio [OR] = 1.41, CI = 1.15-1.73) and emotional dysregulation (OR = 1.33, CI = 1.15-1.54). ADHD symptoms at 3½ years were predicted by early signs of ADHD (OR = 1.51, CI = 1.30-1.76) and emotional dysregulation (OR = 1.31, CI = 1.13-1.51). Co-occurring Anxiety and ADHD symptoms at 3½ years were predicted by early signs of anxiety (OR = 1.43, CI = 1.13-1.84), ADHD (OR = 1.30, CI = 1.11-1.54), and emotional dysregulation (OR = 1.34, CI = 1.13-1.58). We conclude that there were modest continuities in features of anxiety and ADHD through early preschool years, while emotional dysregulation at age 18 months was associated with symptoms of anxiety, ADHD, and co-occurring anxiety and ADHD at age 3 ½ years.

• MØRDRE, MARIANNE; Grøholt, Berit; Sandstad, Berit & Myhre, Anne Margrethe (2012). The impact of ADHD symptoms and global impairment in childhood on working disability in mid-adulthood: a 28-year follow-up study using official disability pension records in a high-risk in-patient population. BMC Psychiatry. ISSN 1471-244X. 12(174). doi: 10.1186/1471-244X-12-174.
• MØRDRE, MARIANNE; Grøholt, Berit; Kjelsberg, Ellen; Sandstad, Berit & Myhre, Anne Margrethe (2011). The impact of ADHD and conduct disorder in childhood on adult delinquency: A 30 years follow-up study using official crime records. BMC Psychiatry. ISSN 1471-244X. 11. doi: 10.1186/1471-244X-11-57.
• MØRDRE, MARIANNE; Grøholt, Berit; Knudsen, Ann Kristin; Sponheim, Eili; Mykletun, Arnstein & Myhre, Anne Margrethe (2011). Is long-term prognosis for pervasive developmental disorder not otherwise specified different from prognosis for autistic disorder? Findings from a 30-year follow-up study. Journal of Autism and Developmental Disorders. ISSN 0162-3257. doi: 10.1007/s10803-011-1319-5.
• Sponheim, Eili; Myhre, Anne Margrethe; Reichelt, Karl Ludvig & Aalen, Odd Olai (2006). Peptidmønstre i urin hos barn med mildere former for autisme. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 126(11), s. 1475–1477.
• Balstad, Trude Rakel; Holven, Kirsten Bjørklund; Ottestad, I.O.; Otterdal, Kari; Halvorsen, Bente & Myhre, Anne Margrethe [Vis alle 8 forfattere av denne artikkelen] (2005). Altered composition of HDL3 in FH subjects causing a HDL subfraction with less atheroprotective function. Clinica Chimica Acta. ISSN 0009-8981. 359(1-2), s. 171–178. doi: 10.1016/j.cccn.2005.03.050.

Se alle arbeider i Cristin

• Bendiksen, Bothild; Zeiner, Pål; Aase, Heidi; Svensson, Elisabeth & Myhre, Anne Margrethe (2011). Impairment in Preschoolers with Symptoms of Attention Deficit Hyperactivity Disorder and Anxiety.
• Skirbekk, Anne Benedicte; Kristensen, Hanne & Myhre, Anne Margrethe (2012). Neurodevelopmental Problems in a Clinical Sample of Children with Anxiety Disorders. Universitetet i Oslo. ISSN 978-82-8264-353-5.

Se alle arbeider i Cristin