Ingrid Melle

• Davies, Gail; Lam, Max; Harris, Sarah E.; Trampush, Joey W.; Luciano, Michelle; Hill, W. David; Hagenaars, Saskia P.; Ritchie, Stuart J.; Marioni, Riccardo E.; Fawns-Ritchie, Chloe; Liewald, David C.M.; Okely, Judith A.; Ahola-Olli, Ari V.; Barnes, Catriona L.K.; Bertram, Lars; Bis, Joshua C.; Burdick, Katherine E.; Christoforou, Andrea; Derosse, Pamela; Djurovic, Srdjan; Espeseth, Thomas; Giakoumaki, Stella; Giddaluru, Sudheer; Gustavson, Daniel E.; Hayward, Caroline; Hofer, Edith; Ikram, M. Arfan; Karlsson, Robert; Knowles, Emma; Lahti, Jari; Leber, Markus; Li, Shuo; Mather, Karen A.; Melle, Ingrid; Morris, Derek; Oldmeadow, Christopher; Palviainen, Teemu; Payton, Antony; Pazoki, Raha; Petrovic, Katja; Reynolds, Chandra A.; Sargurupremraj, Muralidharan; Scholz, Markus; Smith, Jennifer A.; Smith, Albert V.; Terzikhan, Natalie; Thalamuthu, Anbupalam; Trompet, Stella; van der Lee, Sven J.; Ware, Erin B.; Windham, B. Gwen; Wright, Margaret J.; Yang, Jingyun; Yu, Jin; Ames, David; Amin, Najaf; Amouyel, Philippe; Andreassen, Ole Andreas; Armstrong, Nicola J.; Assareh, Amelia A; Attia, John R.; Attix, Deborah; Avramopoulos, Dimitrios; Bennett, David A.; Böhmer, Anne C.; Boyle, Patricia A.; Brodaty, Henry; Campbell, Harry; Cannon, Tyrone D.; Cirulli, Elizabeth T.; Congdon, Eliza; Conley, Emily Drabant; Corley, Janie; Cox, Simon R.; Dale, Anders; Dehghan, Abbas; Dick, Danielle; Dickinson, Dwight; Eriksson, Johan G.; Evangelou, Evangelos; Faul, Jessica D.; Ford, Ian; Freimer, Nelson A.; Gao, He; Giegling, Ina; Gillespie, Nathan A.; Gordon, Scott D.; Gottesman, Rebecca F.; Griswold, Michael E.; Gudnason, Vilmundur; Harris, Tamara B.; Hartmann, Annette M.; Hatzimanolis, Alex; Heiss, Gerardo; Holliday, Elizabeth G.; Joshi, Peter K.; Kähönen, Mika; Kardia, Sharon L.R.; Karlsson, Ida; Kleineidam, Luca; Knopman, David S.; Kochan, Nicole A.; Konte, Bettina; Kwok, John B.; Le Hellard, Stephanie; Lee, Teresa; Lehtimäki, Terho; Li, Shu-Chen; Liu, Tian; Koini, Marisa; London, Edythe; Longstreth, Will T.; Lopez, Oscar L.; Loukola, Anu; Luck, Tobias; Lundervold, Astri; Lundquist, Anders; Lyytikäinen, Leo-Pekka; Martin, Nicholas G.; Montgomery, Grant W.; Murray, Alison D.; Need, Anna C.; Noordam, Raymond; Nyberg, Lars; Ollier, William; Papenberg, Göran; Pattie, Alison; Polasek, Ozren; Poldrack, Russell A.; Psaty, Bruce M.; Reppermund, Simone; Riedel-Heller, Steffi G.; Rose, Richard J.; Rotter, Jerome I.; Roussos, Panos; Rovio, Suvi P.; Saba, Yasaman; Sabb, Fred W.; Sachdev, Perminder S.; Satizabal, Claudia L.; Schmid, Matthias; Scott, Rodney J.; Scult, Matthew A.; Simino, Jeannette; Slagboom, P. Eline; Smyrnis, Nikolaos; Soumaré, Aïcha; Stefanis, Nikos C.; Stott, David J.; Straub, Richard E.; Sundet, Kjetil Søren; Taylor, Adele M.; Taylor, Kent D.; Tzoulaki, Ioanna; Tzourio, Christophe; Uitterlinden, André; Vitart, Veronique; Voineskos, Aristotle N.; Kaprio, Jaakko; Wagner, Michael; Wagner, Holger; Weinhold, Leonie; Wen, K. Hoyan; Widén, Elisabeth; Yang, Qiong; Zhao, Wei; Adams, Hieab H.H.; Arking, Dan E.; Bilder, Robert M.; Bitsios, Panos; Boerwinkle, Eric; Chiba-Falek, Ornit; Corvin, Aiden; De Jager, Philip L.; Debette, Stéphanie; Donohoe, Gary; Elliott, Paul; Fitzpatrick, Annette L.; Gill, Michael; Glahn, David C.; Hägg, Sara; Hansell, Narelle K.; Hariri, Ahmad; Ikram, M. Kamran; Jukema, J. Wouter; Vuoksimaa, Eero; Keller, Matthew C.; Kremen, William S.; Launer, Lenore; Lindenberger, Ulman; Palotie, Aarno; Pedersen, Nancy L.; Pendleton, Neil; Porteous, David J.; Räikkönen, Katri; Raitakari, Olli T.; Ramirez, Alfredo; Reinvang, Ivar; Rudan, Igor; Rujescu, Dan; Schmidt, Reinhold; Schmidt, Helena; Schofield, Peter W.; Schofield, Peter R.; Starr, John M.; Steen, Vidar Martin; Trollor, Julian N.; Turner, Steven T.; Van Duijn, Cornelia M.; Villringer, Arno; Weinberger, Daniel R.; Weir, David R.; Wilson, James F.; Malhotra, Anil; McIntosh, Andrew M.; Gale, Catharine R.; Seshadri, Sudha; Mosley, Thomas H.; Bressler, Jan; Lencz, Todd & Deary, Ian J. (2018). Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature Communications.  ISSN 2041-1723.  9:2098, s 1- 16 . doi: 10.1038/s41467-018-04362-x
• Demmo, Christine; Lagerberg, Trine Vik; Kvitland, Levi Røstad; Aminoff, Sofie Ragnhild; Hellvin, Tone; Simonsen, Carmen Elisabeth; Haatveit, Beathe Almenning; Andreassen, Ole Andreas; Melle, Ingrid & Ueland, Torill (2018). Neurocognitive functioning, clinical course and functional outcome in first-treatment bipolar I disorder patients with and without clinical relapse: A 1-year follow-up study. Bipolar Disorders.  ISSN 1398-5647.  20(3), s 228- 237 . doi: 10.1111/bdi.12569 Vis sammendrag

  OBJECTIVES: Due to limited research on the association between recurrence of mood episodes and the longitudinal course of neurocognitive functioning in early phase bipolar I disorder (BD I), the impact of recurrence on neurocognition remains unclear. Further, a strong correlation between neurocognitive impairment and functional impairment has been demonstrated. The longitudinal relationship between neurocognitive impairment and functional outcome in relation to recurrence is, however, not established. METHODS: The current study investigated the longitudinal relationship between neurocognition, recurrence of mood episodes and functional outcome in a sample of first-treatment (FT) BD I patients (N = 42), with and without relapse, during a 1-year follow-up period. The longitudinal course of neurocognitive functioning in the patients was also compared to that of a group of healthy controls (N = 143). RESULTS: Compared to both patients with relapse and healthy controls, no-relapse patients showed neurocognitive improvements. The polarity of the relapse episodes was mostly depressive, and for the no-relapse patients, reduction of symptoms was associated with neurocognitive improvement. No-relapse patients showed better global and occupational functioning. CONCLUSIONS: The current study found different neurocognitive and functional trajectories in FT BD I patients with and without relapse, with differences at follow-up to some degree being mediated by current symptoms. The current findings highlight the importance of treatment focusing on neurocognition and symptom states with the aim of improving functional recovery.

• Færden, Ann; Lyngstad, Siv Hege; Simonsen, Carmen Elisabeth; Ringen, Petter Andreas; Papsuev, Oleg; Dieset, Ingrid; Andreassen, Ole Andreas; Agartz, Ingrid; Marder, Stephen R. & Melle, Ingrid (2018). Reliability and validity of the self-report version of the apathy evaluation scale in first-episode Psychosis: Concordance with the clinical version at baseline and 12 months follow-up. Psychiatry Research.  ISSN 0165-1781.  267, s 140- 147 . doi: 10.1016/j.psychres.2018.05.065
• Gjerde, Priyanthi Borgen; Dieset, Ingrid; Simonsen, Carmen Elisabeth; Hoseth, Eva Zsuzsanna; Iversen, Trude Seselie Jahr; Lagerberg, Trine Vik; Lyngstad, Siv Hege; Mørch, Ragni Helene; Skrede, Silje; Andreassen, Ole Andreas; Melle, Ingrid & Steen, Vidar Martin (2018). Increase in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis. Schizophrenia Research.  ISSN 0920-9964.  197, s 253- 260 . doi: 10.1016/j.schres.2017.10.042 Fulltekst i vitenarkiv. Vis sammendrag

  Background A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug related effects on lipid biosynthesis. We examined whether changes in serum lipids are associated with alleviation of psychosis symptoms after one year of antipsychotic drug treatment in a cohort of first-episode psychosis (FEP) patients. Methods A total of 132 non-affective antipsychotic-treated FEP patients were included through the Norwegian Thematically Organized Psychosis (TOP) project. Data on antipsychotic usage, serum lipids (total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol and triglycerides (TG)), body mass index (BMI) and clinical state were obtained at baseline and after 12 months. The Positive and Negative Syndrome Scale (PANSS) was used to assess psychotic symptoms. Mixed-effects models were employed to examine the relationship between serum lipids and psychotic symptoms while controlling for potential confounders including BMI. Results An increase in HDL during one year of antipsychotic treatment was associated with reduction in PANSS negative subscores (B = − 0.48, p = 0.03). This relationship was not affected by concurrent change in BMI (adjusted HDL: B = − 0.54, p = 0.02). No significant associations were found between serum lipids, BMI and PANSS positive subscores. Conclusion We found that an increase in HDL level during antipsychotic treatment is associated with improvement in negative symptoms in FEP. These findings warrant further investigation to clarify the interaction between lipid pathways and psychosis.

• Hartberg, Cecilie Bhandari; Lange, Elisabeth Heffermehl; Lagerberg, Trine Vik; Haukvik, Unn Kristin H.; Andreassen, Ole Andreas; Melle, Ingrid & Agartz, Ingrid (2018). Cortical thickness, cortical surface area and subcortical volumes in schizophrenia and bipolar disorder patients with cannabis use. European Neuropsychopharmacology.  ISSN 0924-977X.  28(1), s 37- 47 . doi: 10.1016/j.euroneuro.2017.11.019
• Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas & Ueland, Thor (2018). Attenuated Notch signaling in schizophrenia and bipolar disorder. Scientific Reports.  ISSN 2045-2322.  8:5349, s 1- 8 . doi: 10.1038/s41598-018-23703-w
• Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas & Ueland, Thor (2018). Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder. Translational psychiatry.  ISSN 2158-3188.  8:55, s 1- 10 . doi: 10.1038/s41398-018-0102-1
• Iversen, Trude Seselie Jahr; Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Mørch, Ragni Helene; Gardsjord, Erlend Strand; Jørgensen, Kjetil Nordbø; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2018). Side effect burden of antipsychotic drugs in real life - Impact of gender and polypharmacy. Progress in Neuro-psychopharmacology and Biological Psychiatry.  ISSN 0278-5846.  82, s 263- 271 . doi: 10.1016/j.pnpbp.2017.11.004
• Savage, Jeanne E.; Jansen, Philip R.; Stringer, Sven; Watanabe, Kyoko; Bryois, Julien; de Leeuw, Christiaan A.; Nagel, Mats; Awasthi, Swapnil; Barr, Peter B.; Coleman, Jonathan R.I.; Grasby, Katrina L.; Hammerschlag, Anke R.; Kaminski, Jakob A.; Karlsson, Robert; Krapohl, Eva; Lam, Max; Nygaard, Marianne; Reynolds, Chandra A.; Trampush, Joey W.; Young, Hannah; Zabaneh, Delilah; Hägg, Sara; Hansell, Narelle K.; Karlsson, Ida K.; Linnarsson, Sten; Montgomery, Grant W.; Muñoz-Manchado, Ana B.; Quinlan, Erin B.; Schumann, Gunter; Skene, Nathan G.; Webb, Bradley T.; White, Tonya; Arking, Dan E.; Avramopoulos, Dimitrios; Bilder, Robert M.; Bitsios, Panos; Burdick, Katherine E.; Cannon, Tyrone D.; Chiba-Falek, Ornit; Christoforou, Andrea; Cirulli, Elizabeth T.; Congdon, Eliza; Corvin, Aiden; Davies, Gail; Deary, Ian J.; DeRosse, Pamela; Dickinson, Dwight; Djurovic, Srdjan; Donohoe, Gary; Conley, Emily Drabant; Eriksson, Johan G.; Espeseth, Thomas; Freimer, Nelson A.; Giakoumaki, Stella; Giegling, Ina; Gill, Michael; Glahn, David C.; Hariri, Ahmad; Hatzimanolis, Alex; Keller, Matthew C.; Knowles, Emma; Koltai, Deborah; Konte, Bettina; Lahti, Jari; Le Hellard, Stephanie; Lencz, Todd; Liewald, David C.; London, Edythe; Lundervold, Astri; Malhotra, Anil K.; Melle, Ingrid; Morris, Derek; Need, Anna C.; Ollier, William; Palotie, Aarno; Payton, Antony; Pendleton, Neil; Poldrack, Russell A.; Räikkönen, Katri; Reinvang, Ivar; Roussos, Panos; Rujescu, Dan; Sabb, Fred W.; Scult, Matthew A; Smeland, Olav Bjerkehagen; Smyrnis, Nikolaos; Starr, John M; Steen, Vidar Martin; Stefanis, Nikos C.; Straub, Richard E.; Sundet, Kjetil Søren; Tiemeier, Henning; Voineskos, Aristotle N.; Weinberger, Daniel R.; Widén, Elisabeth; Yu, Jin; Abecasis, Goncalo; Andreassen, Ole Andreas; Breen, Gerome; Christiansen, Lene; Debrabant, Birgit; Dick, Danielle M.; Heinz, Andreas; Hjerling-Leffler, Jens; Ikram, M. Arfan; Kendler, Kenneth S.; Martin, Nicholas G.; Medland, Sarah E.; Pedersen, Nancy L.; Plomin, Robert; Polderman, Tinca J.C.; Ripke, Stephan; van der Sluis, Sophie; Sullivan, Patrick F.; Vrieze, Scott I; Wright, Margaret J. & Posthuma, Daniëlle (2018). Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. Nature Genetics.  ISSN 1061-4036.  50, s 912- 919 . doi: 10.1038/s41588-018-0152-6
• Simonsen, Carmen Elisabeth; Faerden, Ann; Ueland, Torill; Vaskinn, Anja; Bjella, Thomas; Andreassen, Ole Andreas; Romm, Kristin Lie & Melle, Ingrid (2018). Self-rated disability in first treated episode of psychosis: A 1-year follow-up study. Comprehensive Psychiatry.  ISSN 0010-440X.  85, s 48- 54 . doi: 10.1016/j.comppsych.2018.06.004
• Svendsen, Ingrid Hartveit; Øie, Merete Glenne; Møller, Paul; Nelson, Barnaby; Melle, Ingrid & Haug, Elisabeth (2018). Stability in basic self-disturbances and diagnosis in a first treated psychosis: A seven year follow-up study. Schizophrenia Research.  ISSN 0920-9964.
• Van Erp, Theo G.M.; Walton, Esther; Hibar, Derrek; Schmaal, Lianne; Jiang, Wenhao; Glahn, David C.; Pearlson, Godfrey D.; Yao, Nailin; Fukunaga, Masaki; Hashimoto, Ryota; Okada, Naohiro; Yamamori, Hidenaga; Bustillo, Juan R.; Clark, Vincent P.; Agartz, Ingrid; Mueller, Bryon A.; Cahn, Wiepke; de Zwarte, Sonja M.C.; Hulshoff Pol, Hilleke E.; Kahn, René S.; Ophoff, Roel A.; van Haren, Neeltje E.M.; Andreassen, Ole Andreas; Dale, Anders; Doan, Nhat Trung; Gurholt, Tiril Pedersen; Hartberg, Cecilie Bhandari; Haukvik, Unn Kristin H.; Jørgensen, Kjetil Nordbø; Lagerberg, Trine Vik; Melle, Ingrid; Westlye, Lars Tjelta; Gruber, Oliver; Kraemer, Bernd; Richter, Anja; Zilles, David; Calhoun, Vince D.; Crespo-Facorro, Benedicto; Roiz-Santiañez, Roberto; Tordesillas-Gutiérrez, Diana; Loughland, Carmel; Carr, Vaughan J.; Catts, Stanley; Cropley, Vanessa L.; Fullerton, Janice M.; Green, Melissa J.; Henskens, Frans A.; Jablensky, Assen; Lenroot, Rhoshel K.; Mowry, Bryan J.; Michie, Patricia T.; Pantelis, Christos; Quide, Yann; Schall, Ulrich; Scott, Rodney J.; Cairns, Murray J.; Seal, Marc; Tooney, Paul A.; Rasser, Paul E.; Cooper, Gavin; Shannon Weickert, Cynthia; Weickert, Thomas W.; Morris, Derek W.; Hong, Elliot; Kochunov, Peter; Beard, Lauren M.; Gur, Raquel E.; Gur, Ruben C.; Satterthwaite, Theodore D; Wolf, Daniel H.; Belger, Aysenil; Brown, Gregory G.; Ford, Judith M.; Macciardi, Fabio; Mathalon, Daniel H.; O'Leary, Daniel S.; Potkin, Steven G.; Preda, Adrian; Voyvodic, James; Lim, Kelvin O.; McEwen, Sarah; Yang, Fude; Tan, Yunlong; Tan, Shuping; Wang, Zhiren; Fan, Fengmei; Chen, Jingxu; Xiang, Hong; Tang, Shiyou; Guo, Hua; Wan, Ping; Wei, Dong; Bockholt, Henry J.; Ehrlich, Stefan; Wolthusen, Rick P.F.; King, Margaret D.; Shoemaker, Jody M.; Sponheim, Scott R.; De Haan, Lieuwe; Koenders, Laura; Machielsen, Marise W.; van Amelsvoort, Therese; Veltman, Dick J.; Assogna, Francesca; Banaj, Nerisa; de Rossi, Pietro; Iorio, Mariangela; Piras, Fabrizio; Spalletta, Gianfranco; McKenna, Peter J.; Pomarol-Clotet, Edith; Salvador, Raymond; Corvin, Aiden; Donohoe, Gary; Kelly, Sinead; Whelan, Christopher D.; Dickie, Erin W.; Rotenberg, David; Voineskos, Aristotle N.; Ciufolini, Simone; Radua, Joaquim; Dazzan, Paola; Murray, Robin; Reis Marques, Tiago; Simmons, Andrew; Borgwardt, Stefan; Egloff, Laura; Harrisberger, Fabienne; Riecher-Rössler, Anita; Smieskova, Renata; Alpert, Kathryn I.; Wang, Lei; Jönsson, Erik Gunnar; Koops, Sanne; Sommer, Iris Else Clara; Bertolino, Alessandro; Bonvino, Aurora; Di Giorgio, Annabella; Neilson, Emma; Mayer, Andrew R.; Stephen, Julia M.; Kwon, Jun Soo; Yun, Je-Yeon; Cannon, Dara M.; McDonald, Colm; Lebedeva, Irina; Tomyshev, Alexander S.; Akhadov, Tolibjohn; Kaleda, Vasily; Fatouros-Bergman, Helena & Flyckt, Lena (2018). Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium. Biological Psychiatry.  ISSN 0006-3223. . doi: 10.1016/j.biopsych.2018.04.023
• Walton, E; Hibar, Derrek; Van Erp, Theo G M; Potkin, Steven G; Roiz-Santiañez, Roberto; Crespo-Facorro, B; Suarez-Pinilla, Paula; van Haren, Neeltje E.M.; de Zwarte, Sonja M.C.; Kahn, René S; Cahn, Wiepke; Doan, Nhat Trung; Jørgensen, Kjetil Nordbø; Gurholt, Tiril Pedersen; Agartz, Ingrid; Andreassen, Ole Andreas; Westlye, Lars Tjelta; Melle, Ingrid; Berg, Akiah Ottesen; Mørch-Johnsen, Lynn Egeland; Færden, Ann; Flyckt, Lena; Fatouros-Bergman, Helena; Jönsson, Erik Gunnar; Hashimoto, Ryota; Yamamori, Hidenaga; Fukunaga, Masaki; Jahanshad, Neda; De Rossi, Pietro; Piras, Fabrizio; Banaj, Nerisa; Spalletta, Gianfranco; Gur, Raquel E; Gur, Ruben C; Wolf, Daniel H.; Satterthwaite, TD; Beard, Lauren M.; Sommer, Iris E; Koops, Sanne; Gruber, Oliver; Richter, A; Krämer, Bernhard; Kelly, S; Donohoe, G; McDonald, C; Cannon, Dara M; Corvin, Aiden; Gill, M; Di Giorgio, Annabella; Bertolino, A; Lawrie, Stephen M; Nickson, Thomas; Whalley, Heather Clare; Neilson, Emma; Calhoun, Vince D.; Thompson, Paul Murray; Turner, J A & Ehrlich, S (2018). Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium. Psychological Medicine.  ISSN 0033-2917.  48(1), s 82- 94 . doi: 10.1017/S0033291717001283
• Aas, Monica; Dieset, Ingrid; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Mørch, Ragni Helene; Reponen, Elina Johanna; Steen, Nils Eiel; Anderssen, Jannicke Fjæra; Ueland, Thor; Aukrust, Pål; Agartz, Ingrid; Andreassen, Ole Andreas & Melle, Ingrid (2017). Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses. Brain, behavior, and immunity.  ISSN 0889-1591.  65, s 342- 349 . doi: 10.1016/j.bbi.2017.06.005
• Aas, Monica; Henry, C.; Bellivier, F; Lajnef, M; Gard, S; Kahn, J-P; Lagerberg, Trine Vik; Aminoff, Sofie Ragnhild; Bjella, Thomas; Leboyer, M; Andreassen, Ole Andreas; Melle, Ingrid & Etain, B (2017). Affective lability mediates the association between childhood trauma and suicide attempts, mixed episodes and co-morbid anxiety disorders in bipolar disorders. Psychological Medicine.  ISSN 0033-2917.  47(5), s 902- 912 . doi: 10.1017/S0033291716003081
• Aas, Monica; Kauppi, Karolina; Brandt, Christine Lycke; Tesli, Martin Steen; Kaufmann, Tobias; Steen, Nils Eiel; Agartz, Ingrid; Westlye, Lars Tjelta; Andreassen, Ole Andreas & Melle, Ingrid (2017). Childhood trauma is associated with increased brain responses to emotionally negative as compared with positive faces in patients with psychotic disorders. Psychological Medicine.  ISSN 0033-2917.  47(4), s 669- 679 . doi: 10.1017/S0033291716002762
• Aas, Monica; Melle, Ingrid; Bettella, Francesco; Djurovic, Srdjan; Le Hellard, Stephanie; Bjella, Thomas; Ringen, Petter Andreas; Lagerberg, Trine Vik; Smeland, Olav Bjerkehagen; Agartz, Ingrid; Andreassen, Ole Andreas & Tesli, Martin Steen (2017). Psychotic patients who used cannabis frequently before illness onset have higher genetic predisposition to schizophrenia than those who did not. Psychological Medicine.  ISSN 0033-2917.  48(1), s 43- 49 . doi: 10.1017/S0033291717001209
• Aleman, André; Lincoln, Tania M.; Bruggeman, Richard; Melle, Ingrid; Arends, Johan; Arango, Celso & Knegtering, Henderikus (2017). Treatment of negative symptoms: Where do we stand, and where do we go?. Schizophrenia Research.  ISSN 0920-9964.  186, s 55- 62 . doi: 10.1016/j.schres.2016.05.015
• Bauer, Michael; Glenn, T; Alda, M; Aleksandrovich, MA; Andreassen, Ole Andreas; Angelopoulos, E; Ardau, R; Ayhan, Y; Baethge, C; Bharathram, SR; Bauer, R; Baune, BT; Becerra-Palars, C; Bellivier, F; Belmaker, RH; Berk, M; Bersudsky, Y; Bicakci, Ş; Birabwa-Oketcho, H; Bjella, Thomas; Bossini, L; Cabrera, J; Cheung, EYW; Del Zompo, M; Dodd, S; Donix, M; Etain, B; Fagiolini, A; Fountoulakis, KN; Frye, MA; Gonzalez-Pinto, A; Gottlieb, JF; Grof, P; Harima, H; Henry, C; Isometsa, ET; Janno, S; Kapczinski, F; Kardell, M; Khaldi, S; Kliwicki, S; König, B; Kot, TL; Krogh, R; Kunz, M; Lafer, B; Landen, M; Larsen, ER; Lewitzka, U; Licht, RW; Lopez-Jaramillo, C; MacQueen, G; Manchia, M; Marsh, W; Martinez-Cengotitabengoa, M; Melle, Ingrid; Meza-Urzua, F; Yee Ming, M; Monteith, S; Morken, Gunnar; Mosca, E; Munoz, R; Mythri, SV; Nacef, F; Nadella, RK; Nery, FG; Nielsen, RE; O'Donovan, C; Omrani, A; Osher, Y; Østermark Sørensen, H; Ouali, U; Pica Ruiz, Y; Pilhatsch, M; Pinna, M; da Ponte, FDR; Quiroz, D; Ramesar, R; Rasgon, N; Reddy, MS; Reif, A; Ritter, P; Rybakowski, JK; Sagduyu, K; Scippa, ÂM; Severus, E; Simhandl, C; Stein, DJ; Strejilevich, S; Subramaniam, M; Sulaiman, AH; Suominen, K; Tagata, H; Tatebayashi, Y; Tondo, L; Torrent, C; Vaaler, Arne; Veeh, J; Vieta, E; Viswanath, B; Yoldi-Negrete, M; Zetin, M; Zgueb, Y & Whybrow, Peter C. (2017). Solar insolation in springtime influences age of onset of bipolar I disorder. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  136(6), s 571- 582 . doi: 10.1111/acps.12772
• Berg, Akiah Ottesen; Melle, Ingrid; Zuber, Verena; Simonsen, Carmen Elisabeth; Nerhus, Mari; Ueland, Torill; Andreassen, Ole Andreas; Sundet, Kjetil Søren & Vaskinn, Anja (2017). Modelling difficulties in abstract thinking in psychosis: the importance of socio-developmental background. Cognitive Neuropsychiatry.  ISSN 1354-6805.  22(1), s 39- 52 . doi: 10.1080/13546805.2016.1259998
• Bjørnestad, Jone Ravndal; Davidson, Larry; Joa, Inge; Larsen, Tor Ketil; Hegelstad, Wenche; Langeveld, Johannes H.; Veseth, Marius; Melle, Ingrid; Johannessen, Jan Olav & Brønnick, Kolbjørn Selvåg (2017). Antipsychotic treatment: experiences of fully recovered service users. Journal of Mental Health.  ISSN 0963-8237.  26(3), s 264- 270 . doi: 10.1080/09638237.2017.1294735
• Bjørnestad, Jone Ravndal; Hegelstad, Wenche; Joa, Inge; Davidson, Larry; Larsen, Tor Ketil; Melle, Ingrid; Veseth, Marius; Johannessen, Jan Olav & Brønnick, Kolbjørn Selvåg (2017). "With a little help from my friends" social predictors of clinical recovery in first-episode psychosis. Psychiatry Research.  ISSN 0165-1781.  255, s 209- 214 . doi: 10.1016/j.psychres.2017.05.041
• Church, Chelsea; Andreassen, Ole Andreas; Lorentzen, Steinar; Melle, Ingrid & Aas, Monica (2017). Childhood trauma and minimization/denial in people with and without a severe mental disorder. Frontiers in Psychology.  ISSN 1664-1078.  8 . doi: 10.3389/fpsyg.2017.01276
• Doan, Nhat Trung; Kaufmann, Tobias; Bettella, Francesco; Jørgensen, Kjetil Nordbø; Brandt, Christine Lycke; Moberget, Torgeir; Alnæs, Dag; Douaud, Gwenaëlle; Duff, Eugene; Djurovic, Srdjan; Melle, Ingrid; Ueland, Torill; Agartz, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Distinct multivariate brain morphological patterns and their added predictive value with cognitive and polygenic risk scores in mental disorders. NeuroImage: Clinical.  ISSN 2213-1582.  15, s 719- 731 . doi: 10.1016/j.nicl.2017.06.014
• Gardsjord, Erlend Strand; Romm, Kristin Lie; Røssberg, Jan Ivar; Friis, Svein; Barder, Helene; Evensen, Julie Horgen; Haahr, Ulrik; Hegelstad, Wenche; Joa, Inge; Johannessen, Jan Olav; Langeveld, Johannes H.; Larsen, Tor Ketil; Ilner, Stein E. Opjordsmoen; Rund, Bjørn Rishovd; Simonsen, Erik; Vaglum, Per Jørgen Wiggen; McGlashan, Thomas & Melle, Ingrid (2017). Is going into stable symptomatic remission associated with a more positive development of life satisfaction? A 10-year follow-up study of first episode psychosis. Schizophrenia Research.  ISSN 0920-9964.  193, s 364- 369 . doi: 10.1016/j.schres.2017.07.006
• Haug, Elisabeth; Øie, Merete Glenne; Andreassen, Ole Andreas; Bratlien, Unni; Barnaby, Nelson; Melle, Ingrid & Møller, Paul (2017). High levels of anomalous self-experience are associated with longer duration of untreated psychosis. Early Intervention in Psychiatry.  ISSN 1751-7885.  11(2), s 133- 138 . doi: 10.1111/eip.12220 Fulltekst i vitenarkiv.
• Hibar, Derrek; Adams, Hieab H.H.; Jahanshad, Neda; Chauhan, Ganesh; Stein, Jason L.; Hofer, Edith; Renteriá, Miguel E.; Bis, Joshua C.; Arias-Vasquez, Alejandro; Ikram, M. Kamran; Desrivières, Sylvane; Vernooij, Meike W; Abramovic, Lucija; Alhusaini, Saud; Amin, Najaf; Andersson, Micael; Arfanakis, Konstantinos; Aribisala, Benjamin S.; Armstrong, Nicola J.; Athanasiu, Lavinia; Axelsson, Tomas; Beecham, Ashley H.; Beiser, Alexa; Bernard, Manon; Blanton, Susan H.; Bohlken, Marc M.; Boks, Marco P.; Bralten, Janita; Brickman, Adam M.; Carmichael, Owen; Chakravarty, M. Mallar; Chen, Qiang; Ching, Christopher R.K.; Chouraki, Vincent; Cuellar-Partida, Gabriel; Crivello, Fabrice; Den Braber, Anouk; Doan, Nhat Trung; Ehrlich, Stefan; Giddaluru, Sudheer; Goldman, Aaron L; Gottesman, Rebecca F.; Grimm, Oliver; Griswold, Michael E.; Guadalupe, Tulio; Gutman, Boris A.; Hass, Johanna; Haukvik, Unn Kristin H.; Hoehn, David; Holmes, Avram J.; Hoogman, Martine; Janowitz, Deborah; Jia, Tianye; Jørgensen, Kjetil Nordbø; Karbalai, Nazanin; Kasperaviciute, Dalia; Kim, Sungeun; Klein, Marieke; Kraemer, Bernd; Lee, Phil H.; Liewald, David C.M.; Lopez, Lorna M.; Luciano, Michelle; MacAre, Christine; Marquand, André F.; Matarin, Mar; Mather, Karen A.; Mattheisen, Manuel; McKay, David R.; Milaneschi, Yuri; Muñoz Maniega, Susana; Nho, Kwangsik; Nugent, Allison C.; Nyquist, Paul; Loohuis, Loes M. Olde; Oosterlaan, Jaap; Papmeyer, Martina; Pirpamer, Lukas; Pütz, Benno; Ramasamy, Adaikalavan; Richards, Jennifer S.; Risacher, Shannon L.; Roiz-Santiañez, Roberto; Rommelse, Nanda; Ropele, Stefan; Rose, Emma J.; Royle, Natalie A.; Rundek, Tatjana; Sämann, Philipp G.; Saremi, Arvin; Satizabal, Claudia L.; Schmaal, Lianne; Schork, Andrew J.; Shen, Li; Shin, Jean; Shumskaya, Elena; Smith, Albert V.; Sprooten, Emma; Strike, Lachlan T.; Teumer, Alexander; Tordesillas-Gutierrez, Diana; Toro, Roberto; Trabzuni, Daniah; Trompet, Stella; Vaidya, Dhananjay; Van Der Grond, Jeroen; Van Der Lee, Sven J.; Van Der Meer, Dennis; van Donkelaar, Marjolein M.J.; Van Eijk, Kristel R.; Van Erp, Theo G.M.; Van Rooij, Daan; Walton, Esther; Westlye, Lars Tjelta; Whelan, Christopher D.; Windham, Beverly G.; Winkler, Anderson M.; Wittfeld, Katharina; Woldehawariat, Girma; Wolf, Christiane; Wolfers, Thomas; Yanek, Lisa R.; Yang, Jingyun; Zijdenbos, Alex; Zwiers, Marcel P.; Agartz, Ingrid; Almasy, Laura; Ames, David; Amouyel, Philippe; Andreassen, Ole Andreas; Arepalli, Sampath; Assareh, Amelia A.; Barral, Sandra; Bastin, Mark E.; Becker, Diane M.; Becker, James T.; Bennett, David A.; Blangero, John; Van Bokhoven, Hans; Boomsma, Dorret I.; Brodaty, Henry; Brouwer, Rachel M.; Brunner, Han G.; Buckner, Randy L.; Buitelaar, Jan K.; Bulayeva, Kazima B.; Cahn, Wiepke; Calhoun, Vince D.; Cannon, Dara M.; Cavalleri, Gianpiero L.; Cheng, Ching-Yu; Cichon, Sven; Cookson, Mark R.; Corvin, Aiden; Crespo-Facorro, Benedicto; Curran, Joanne E.; Czisch, Michael; Dale, Anders; Davies, Gareth E.; de Craen, Anton J.M.; de Geus, Eco J.C.; De Jager, Philip L.; de Zubicaray, Greig I.; Deary, Ian J.; Debette, Stéphanie; Decarli, Charles; Delanty, Norman; Depondt, Chantal; Destefano, Anita; Dillman, Allissa; Djurovic, Srdjan; Donohoe, Gary; Drevets, Wayne C.; Duggirala, Ravi; Dyer, Thomas D.; Enzinger, Christian; Erk, Susanne; Espeseth, Thomas; Fedko, Iryna O.; Fernandéz, Guillén; Ferrucci, Luigi; Fisher, Simon E.; Fleischman, Debra A.; Ford, Ian; Fornage, Myriam; Foroud, Tatiana M.; Fox, Peter T.; Francks, Clyde; Fukunaga, Masaki; Gibbs, J. Raphael; Glahn, David C.; Gollub, Randy L.; Göring, Harald H.H.; Green, Robert C.; Gruber, Oliver; Gudnason, Vilmundur; Guelfi, Sebastian; Håberg, Asta; Hansell, Narelle K.; Hardy, John; Hartman, Catharina A.; Hashimoto, Ryota; Hegenscheid, Katrin; Heinz, Andreas; Le Hellard, Stephanie; Hernandez, Dena G.; Heslenfeld, Dirk J.; Ho, Beng-Choon; Hoekstra, Pieter J.; Hoffmann, Wolfgang; Hofman, Albert; Holsboer, Florian; Homuth, Georg; Hosten, Norbert; Hottenga, Jouke-Jan; Huentelman, Matthew; Pol, Hilleke E. Hulshoff; Ikeda, Masashi; Jack, Clifford R.; Jenkinson, Mark; Johnson, Robert; Jönsson, Erik Gunnar; Jukema, J. Wouter; Kahn, René S.; Kanai, Ryota; Kloszewska, Iwona; Knopman, David S.; Kochunov, Peter; Kwok, John B.; Lawrie, Stephen M.; Lemaître, Hervé; Liu, Xinmin; Longo, Dan L.; Lopez, Oscar L.; Lovestone, Simon; Martinez, Oliver; Martinot, Jean-Luc; Mattay, Venkata S.; McDonald, Colm; McIntosh, Andrew M.; McMahon, Francis J.; McMahon, Katie L.; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Mohnke, Sebastian; Montgomery, Grant W.; Morris, Derek W.; Mosley, Thomas H.; Mühleisen, Thomas W.; Müller-Myhsok, Bertram; Nalls, Michael A.; Nauck, Matthias; Nichols, Thomas E.; Niessen, Wiro J.; Nöthen, Markus M.; Nyberg, Lars; Ohi, Kazutaka; Olvera, Rene L.; Ophoff, Roel A.; Pandolfo, Massimo; Paus, Tomas; Pausova, Zdenka; Penninx, Brenda W.J.H.; Pike, G. Bruce; Potkin, Steven G.; Psaty, Bruce M.; Reppermund, Simone; Rietschel, Marcella; Roffman, Joshua L.; Romanczuk-Seiferth, Nina; Rotter, Jerome I.; Ryten, Mina; Sacco, Ralph L.; Sachdev, Perminder S.; Saykin, Andrew J.; Schmidt, Reinhold; Schmidt, Helena; Schofield, Peter R.; Sigursson, Sigurdur; Simmons, Andrew; Singleton, Andrew; Sisodiya, Sanjay M.; Smith, Colin; Smoller, Jordan W.; Soininen, Hilkka; Steen, Vidar Martin; Stott, David J.; Sussmann, Jessika E; Thalamuthu, Anbupalam; Toga, Arthur W.; Traynor, Bryan J.; Troncoso, Juan; Tsolaki, Magda; Tzourio, Christophe; Uitterlinden, André G.; Hernández, Maria C. Valdés; Van Der Brug, Marcel; Van Der Lugt, Aad; Van Der Wee, Nic J.A.; van Haren, Neeltje E.M.; Van 'T Ent, Dennis; Van Tol, Marie-Jose; Vardarajan, Badri N.; Vellas, Bruno; Veltman, Dick J.; Völzke, Henry; Walter, Henrik; Wardlaw, Joanna M.; Wassink, Thomas H.; Weale, Michael E.; Weinberger, Daniel R.; Weiner, Michael W.; Wen, Wei; Westman, Eric; White, Tonya; Wong, Tien Y.; Wright, Clinton B.; Zielke, Ronald H.; Zonderman, Alan B.; Martin, Nicholas G.; Van Duijn, Cornelia M.; Wright, Margaret J.; Longstreth, William T.; Schumann, Gunter; Grabe, Hans J.; Franke, Barbara; Launer, Lenore J.; Medland, Sarah E.; Seshadri, Sudha; Thompson, Paul M. & Ikram, M. Arfan (2017). Novel genetic loci associated with hippocampal volume. Nature Communications.  ISSN 2041-1723.  8:13624, s 1- 12 . doi: 10.1038/ncomms13624 Fulltekst i vitenarkiv.
• Hoseth, Eva Zsuzsanna; Ueland, Thor; Dieset, Ingrid; Birnbaum, Rebecca; Shin, Joo Heon; Kleinman, Joel Edward; Hyde, Thomas Michael; Mørch, Ragni Helene; Hope, Sigrun; Lekva, Tove; Abraityte, Judita Aurelija; Michelsen, Annika; Melle, Ingrid; Westlye, Lars Tjelta; Ueland, Torill; Djurovic, Srdjan; Aukrust, Pål; Weinberger, Daniel R. & Andreassen, Ole Andreas (2017). A study of TNF pathway activation in schizophrenia and bipolar disorder in plasma and brain tissue. Schizophrenia Bulletin.  ISSN 0586-7614.  43(4), s 881- 890 . doi: 10.1093/schbul/sbw183
• Jørgensen, Kjetil Nordbø; Nesvåg, Ragnar; Nerland, Stener; Mørch-Johnsen, Lynn; Westlye, Lars Tjelta; Lange, Elisabeth; Haukvik, Unn Kristin H.; Hartberg, Cecilie Bhandari; Melle, Ingrid; Andreassen, Ole Andreas & Agartz, Ingrid (2017). Brain volume change in first-episode psychosis: an effect of antipsychotic medication independent of BMI change. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  135(2), s 117- 126 . doi: 10.1111/acps.12677
• Kaufmann, Tobias; Alnæs, Dag; Brandt, Christine Lycke; Doan, Nhat Trung; Kauppi, Karolina; Bettella, Francesco; Lagerberg, Trine Vik; Berg, Akiah Ottesen; Djurovic, Srdjan; Agartz, Ingrid; Melle, Ingrid; Ueland, Torill; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Task modulations and clinical manifestations in the brain functional connectome in 1615 fMRI datasets. NeuroImage.  ISSN 1053-8119.  147, s 243- 252 . doi: 10.1016/j.neuroimage.2016.11.073
• Lagerberg, Trine Vik; Aminoff, Sofie Ragnhild; Aas, Monica; Bjella, Thomas; Henry, Chantal; Leboyer, Marion; Pedersen, Geir Feigum; Bellivier, Frank; Icick, Romain; Andreassen, Ole Andreas; Etain, Bruno & Melle, Ingrid (2017). Alcohol use disorders are Associated With increased effective lability in bipolar disorder. Journal of Affective Disorders.  ISSN 0165-0327.  208, s 316- 324 . doi: 10.1016/j.jad.2016.09.062
• Lam, Max; Trampush, Joey W.; Yu, Jin; Knowles, Emma; Davies, Gail; Liewald, David C.; Starr, John M.; Djurovic, Srdjan; Melle, Ingrid; Sundet, Kjetil Søren; Christoforou, Andrea; Reinvang, Ivar; DeRosse, Pamela; Lundervold, Astri; Steen, Vidar Martin; Espeseth, Thomas; Räikkönen, Katri; Widén, Elisabeth; Palotie, Aarno; Eriksson, Johan G.; Giegling, Ina; Konte, Bettina; Roussos, Panos; Giakoumaki, Stella; Burdick, Katherine E.; Payton, Antony; Ollier, William; Chiba-Falek, Ornit; Attix, Deborah K.; Need, Anna C.; Cirulli, Elizabeth Trilby; Voineskos, Aristotle N.; Stefanis, Nikos C.; Avramopoulos, Dimitrios A.; Hatzimanolis, Alex; Arking, Dan E.; Smyrnis, Nikolaos; Bilder, Robert M.; Freimer, Nelson A.; Cannon, Tyrone D.; London, Edythe D; Poldrack, Russell A.; Sabb, Fred W.; Congdon, Eliza L.; Conley, Emily Drabant; Scult, Matthew A.; Dickinson, Dwight; Straub, Richard E.; Donohoe, Gary; Morris, Derek; Corvin, Aiden; Gill, Michael; Hariri, Ahmad R.; Weinberger, Daniel R.; Pendleton, Neil; Bitsios, Panos; Rujescu, Dan; Lahti, Jari; Le Hellard, Stephanie; Keller, Matthew C.; Andreassen, Ole Andreas; Deary, Ian J.; Glahn, David C.; Malhotra, Anil K. & Lencz, Todd (2017). Large-scale cognitive GWAS meta-analysis reveals tissue-specific neural expression and potential nootropic drug targets. Cell reports.  ISSN 2211-1247.  21(9), s 2597- 2613 . doi: 10.1016/j.celrep.2017.11.028
• Lange, Elisabeth; Nerland, Stener; Jørgensen, Kjetil Nordbø; Mørch-Johnsen, Lynn; Nesvåg, Ragnar; Hartberg, Cecilie Bhandari; Haukvik, Unn Kristin H.; Osnes, Kåre; Melle, Ingrid; Andreassen, Ole Andreas & Agartz, Ingrid (2017). Alcohol use is associated with thinner cerebral cortex and larger ventricles in schizophrenia, bipolar disorder and healthy controls. Psychological Medicine.  ISSN 0033-2917.  47(4), s 655- 668 . doi: 10.1017/S0033291716002920
• Langeveld, Johannes H.; Bjørkly, Stål; Evensen, Julie Horgen; Joa, Inge; Johannessen, Jan Olav; Larsen, Tor Ketil; Melle, Ingrid; Ilner, Stein E. Opjordsmoen; Røssberg, Jan Ivar; Rund, Bjørn Rishovd; Simonsen, Erik; Vaglum, Per Jørgen Wiggen; Hegelstad, Wenche; McGlashan, Tom & Friis, Svein (2017). A 10-year follow-up study of violent victimization in first episode psychosis : risk and protective factors. Psychiatry Research.  ISSN 0165-1781.  259(January), s 545- 549 . doi: 10.1016/j.psychres.2017.11.013 Vis sammendrag

  Violent victimization in persons with severe mental illness has long-term adverse consequences. Little is known about the long-term prevalence of victimization in first episode psychosis, or about factors affecting victimization throughout the course of illness. To assess the prevalence of violent victimization during a 10-year follow-up period in a group of first episode psychosis (FEP) patients, and to identify early predictors and risk factors for victimization. A prospective design was used with comprehensive assessments of violent victimization, treatment variables and functioning at baseline and during 10-year follow-up. A clinical epidemiological sample of FEP patients (n= 298) was studied. FEP patients in our study were at a 3.5 times greater risk of victimization as compared to the normal population. During the 10-year follow-up period, 23% of subjects fell victim to one or more violent assaults. Victimized patients were younger and reported less occupational activity. At 10-year follow-up, victimization was associated with more concomitant drug use, alcohol misuse and violent behavior, but not with a worse clinical or functional outcome. Treatment programs should focus on risk factors for victimization and develop behavioral alternatives to mitigate risk in FEP patients.

• Le Hellard, Stephanie; Wang, Yunpeng; Witoelar, Aree; Zuber, Verena; Bettella, Francesco; Hugdahl, Kenneth; Espeseth, Thomas; Steen, Vidar Martin; Melle, Ingrid; Desikan, Rahul S.; Schork, Andrew J.; Thompson, Wesley Kurt; Dale, Anders; Djurovic, Srdjan & Andreassen, Ole Andreas (2017). Identification of gene loci that overlap between schizophrenia and educational attainment. Schizophrenia Bulletin.  ISSN 0586-7614.  43(3), s 654- 664 . doi: 10.1093/schbul/sbw085
• Marshall, Christian R.; Howrigan, Daniel P.; Merico, Daniele; Thiruvahindrapuram, Bhooma; Wu, Wenting; Greer, Douglas S.; Antaki, Danny; Shetty, Aniket; Holmans, Peter A.; Pinto, Dalila; Gujral, Madhusudan; Brandler, William M.; Malhotra, Dheeraj; Wang, Zhouzhi; Fuentes Fajarado, Karin V.; Maile, Michelle S.; Ripke, Stephan; Agartz, Ingrid; Albus, Margot; Alexander, Madeline; Amin, Farooq; Atkins, Joshua; Bacanu, Silviu A.; Belliveau, Richard A.; Bergen, Sarah E.; Bertalan, Marcelo; Bevilacqua, Elizabeth; Bigdeli, Tim B.; Black, Donald W.; Bruggeman, Richard; Buccola, Nancy G.; Buckner, Randy L.; Bulik-Sullivan, Brendan; Byerley, William; Cahn, Wiepke; Cai, Guiqing; Cairns, Murray J.; Campion, Dominique; Cantor, Rita M.; Carr, Vaughan J.; Carrera, Noa; Catts, Stanley V.; Chambert, Kimberly D.; Cheng, Wei; Cloninger, C. Robert; Cohen, David; Cormican, Paul; Craddock, Nick; Crespo-Facorro, Benedicto; Crowley, James J.; Curtis, David; Davidson, Michael; Davis, Kenneth L.; Degenhardt, Franziska; Del Favero, Jurgen; DeLisi, Lynn E.; Dikeos, Dimitris; Dinan, Timothy; Djurovic, Srdjan; Donohoe, Gary; Drapeau, Elodie; Duan, Jubao; Dudbridge, Frank; Eichhammer, Peter; Eriksson, Johan; Escott-Price, Valentina; Essioux, Laurent; Fanous, Ayman H.; Farh, Kai-How; Farrell, Martilias S.; Frank, Josef; Franke, Lude; Freedman, Robert; Freimer, Nelson B.; Friedman, Joseph I.; Forstner, Andreas J.; Fromer, Menachem; Genovese, Giulio; Georgieva, Lyudmila; Gershon, Elliot S.; Giegling, Ina; Giusti-Rodriguez, Paola; Godard, Stephanie; Goldstein, Jacqueline I.; Gratten, Jacob; De Haan, Lieuwe; Hamshere, Marian L.; Hansen, Mark; Hansen, Thomas; Haroutunian, Vahram; Hartmann, Annette M.; Henskens, Frans A.; Herms, Stefan; Hirschhorn, Joel N.; Hoffmann, Per; Hofman, Andrea; Huang, Hailiang; Ikeda, Masashi; Joa, Inge; Kähler, Anna Katarina; Kahn, René S.; Kalaydjieva, Luba; Karjalainen, Juha; Kavanagh, David; Keller, Matthew C.; Kelly, Brian J.; Kennedy, James L.; Kim, Yunjung; Knowles, James A.; Konte, Bettina; Laurent, Claudine; Lee, Phil; Lee, S. Hong; Legge, Sophie E.; Lerer, Bernard; Levy, Deborah L.; Liang, Kung-Yee; Lieberman, Jeffrey; Lonnqvist, Jouko; Loughland, Carmel M.; Magnusson, Patrik K.E.; Maher, Brion S.; Maier, Wolfgang; Mallet, Jacques; Mattheisen, Manuel; Mattingsdal, Morten; McCarley, Robert W.; McDonald, Colm; McIntosh, Andrew M.; Meier, Sandra; Meijer, Carin J.; Melle, Ingrid; Mesholam-Gately, Raquelle I.; Metspalu, Andres; Michie, Patricia T.; Milani, Lili; Milanova, Vihra; Mokrab, Younes; Morris, Derek W.; Muller-Myhsok, Bertram; Murphy, Kieran C.; Murray, Robin M.; Myin-Germeys, Inez; Nenadic, Igor; Nertney, Deborah A.; Nestadt, Gerald; Nicodemus, Kristin K.; Nisenbaum, Laura; Nordin, Annelie; O'Callaghan, Eadbhard; O'Dushlaine, Colm; Oh, Sang-Yun; Olincy, Ann; Olsen, Line; O'Neill, F. Anthony; Van Os, Jim; Pantelis, Christos; Papadimitriou, George N.; Parkhomenko, Elena; Pato, Michele T.; Paunio, Tiina; Perkins, Diana O.; Pers, Tune H.; Pietilainen, Olli; Pimm, Jonathan; Pocklington, Andrew J.; Powell, John; Price, Alkes; Pulver, Ann E.; Purcell, Shaun M.; Quested, Digby; Rasmussen, Henrik B.; Reichenberg, Abraham; Reimers, Mark A.; Richards, Alexander L.; Roffman, Joshua L.; Roussos, Panos; Ruderfer, Douglas M.; Salomaa, Veikko; Sanders, Alan R.; Savitz, Adam; Schall, Ulrich; Schulze, Thomas G.; Schwab, Sibylle G.; Scolnick, Edward M.; Scott, Rodney J.; Seidman, Larry J.; Shi, Jianxin; Silverman, Jeremy M.; Smoller, Jordan W.; Söderman, Erik; Spencer, Chris CA; Stahl, Eli A.; Strengman, Eric; Strohmaier, Jana; Stroup, T. Scott; Suvisaari, Jaana; Svrakic, Dragan M.; Szatkiewicz, Jin P.; Thirumalai, Srinivas; Tooney, Paul A.; Veijola, Juha; Visscher, Peter M.; Waddington, John; Walsh, Dermot; Webb, Bradley T.; Weiser, Mark; Wildenauer, Dieter B.; Williams, Nigel M.; Williams, Stephanie; Witt, Stephanie H.; Wolen, Aaron R.; Wormley, Brandon K.; Wray, Naomi R.; Wu, Jing Qin; Zai, Clement C.; Adolfsson, Rolf; Andreassen, Ole Andreas; Blackwood, Douglas H.R.; Bramon, Elvira; Buxbaum, Joseph D.; Cichon, Sven; Collier, David A.; Corvin, Aiden; Daly, Mark J.; Darvasi, Ariel; Domenici, Enrico; Esko, Tonu; Gejman, Pablo V.; Gill, Michael; Gurling, Hugh; Hultman, Christina M.; Iwata, Nakao; Jablensky, Assen V.; Jönsson, Erik Gunnar; Kendler, Kenneth S.; Kirov, George; Knight, Jo; Levinson, Douglas F.; Li, Qingqin S.; McCarroll, Steven A.; McQuillin, Andrew; Moran, Jennifer L.; Mowry, Bryan J.; Nöthen, Markus M.; Ophoff, Roel A.; Owen, Michael J.; Palotie, Aarno; Pato, Carlos N.; Petryshen, Tracey L.; Posthuma, Danielle; Rietschel, Marcella; Riley, Brien P.; Rujescu, Dan; Sklar, Pamela; St. Clair, David; Walters, James T.R.; Werge, Thomas; Sullivan, Patrick F.; O'Donovan, Michael C.; Scherer, Stephen W.; Neale, Benjamin M. & Sebat, Jonathan (2017). Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nature Genetics.  ISSN 1061-4036.  49, s 27- 35 . doi: 10.1038/ng.3725
• McLaughlin, Russell L.; Schijven, Dick; Van Rheenen, Wouter; Van Eijk, Kristel R.; O'Brien, Margaret; Kahn, René S.; Ophoff, Roel A.; Goris, An; Bradley, Daniel G.; Al-Chalabi, Ammar; van den Berg, Leonard H.; Luykx, Jurjen J.; Hardiman, Orla; Veldink, Jan H.; Agartz, Ingrid; Djurovic, Srdjan; Joa, Inge; Mattingsdal, Morten; Melle, Ingrid & Andreassen, Ole Andreas (2017). Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. Nature Communications.  ISSN 2041-1723.  8:14774, s 1- 12 . doi: 10.1038/ncomms14774
• Melle, Ingrid; Johannessen, Jan Olav; Haahr, Ulrik H.; Hegelstad, Wenche; Joa, Inge; Langeveld, Johannes H.; Larsen, Tor Ketil; Ilner, Stein E. Opjordsmoen; Qin, Ping; Røssberg, Jan Ivar; Rund, Bjørn Rishovd; Simonsen, Erik; Vaglum, Per Jørgen Wiggen; McGlashan, Thomas H. & Friis, Svein (2017). Causes and predictors of premature death in first-episode schizophrenia spectrum disorders. World Psychiatry.  ISSN 1723-8617.  16(2), s 217- 218 . doi: 10.1002/wps.20431
• Mellerup, Erling; Andreassen, Ole Andreas; Bennike, Bente; Dam, H; Djurovic, Srdjan; Jorgensen, Martin Balslev; Kessing, Lars Vedel; Koefoed, Pernille; Melle, Ingrid; Mors, Ole & Moeller, GL (2017). Combinations of genetic variants associated with bipolar disorder.. PLoS ONE.  ISSN 1932-6203.  12(12) . doi: 10.1371/journal.pone.0189739
• Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Hope, Sigrun; Aas, Monica; Nerhus, Mari; Gardsjord, Erlend Strand; Haram, Marit; Falk, Ragnhild Sørum; Joa, Inge; Morken, Gunnar; Agartz, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Melle, Ingrid; Ueland, Thor & Andreassen, Ole Andreas (2017). Persistent increase in TNF and IL-1 markers in severe mental disorders suggests trait-related inflammation: a one year follow-up study. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  136(4), s 400- 408 . doi: 10.1111/acps.12783
• Nerhus, Mari; Berg, Akiah Ottesen; Simonsen, Carmen Elisabeth; Haram, Marit; Haatveit, Beathe Christin; Dahl, Sandra Rinne; Gurholt, Tiril Pedersen; Bjella, Thomas; Ueland, Torill; Andreassen, Ole Andreas & Melle, Ingrid (2017). Vitamin D deficiency associated with cognitive functioning in psychotic disorders. Journal of Clinical Psychiatry.  ISSN 0160-6689.  78(7), s e750- e757 . doi: 10.4088/JCP.16m10880
• Nesvåg, Ragnar; Jönsson, Erik Gunnar; Bakken, Inger Johanne; Knudsen, Gun Peggy; Bjella, Thomas; Reichborn-Kjennerud, Ted; Melle, Ingrid & Andreassen, Ole Andreas (2017). The quality of severe mental disorder diagnoses in a national health registry as compared to research diagnoses based on structured interview. BMC Psychiatry.  ISSN 1471-244X.  17(1) . doi: 10.1186/s12888-017-1256-8 Fulltekst i vitenarkiv.
• Simonsen, Carmen Elisabeth; Færden, Ann; Romm, Kristin Lie; Berg, Akiah Ottesen; Bjella, Thomas; Sundet, Kjetil Søren; Ueland, Torill; Andreassen, Ole Andreas & Melle, Ingrid (2017). Early clinical recovery in first-episode psychosis: Symptomatic remission and its correlates at 1-year follow-up. Psychiatry Research.  ISSN 0165-1781.  254, s 118- 125 . doi: 10.1016/j.psychres.2017.04.050
• Skåtun, Kristina Cecilie; Kaufmann, Tobias; Brandt, Christine Lycke; Doan, Nhat Trung; Alnæs, Dag; Tønnesen, Siren; Biele, Guido; Vaskinn, Anja; Melle, Ingrid; Agartz, Ingrid; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2017). Thalamo-cortical functional connectivity in schizophrenia and bipolar disorder. Brain Imaging and Behavior.  ISSN 1931-7557. . doi: 10.1007/s11682-017-9714-y
• Srinivasan, Saurabh; Bettella, Francesco; Hassani, Sahar; Wang, Yunpeng; Witoelar, Aree; Schork, Andrew J.; Thompson, Wesley Kurt; Collier, David A.; Desikan, Rahul S.; Melle, Ingrid; Dale, Anders; Djurovic, Srdjan & Andreassen, Ole Andreas (2017). Probing the association between early evolutionary markers and schizophrenia. PLoS ONE.  ISSN 1932-6203.  12:e0169227(1), s 1- 15 . doi: 10.1371/journal.pone.0169227
• Trampush, Joey W.; Yang, M.L.Z.; Yu, Jin; Knowles, Emma; Davies, Gail; Liewald, David C.M.; Starr, John M.; Djurovic, Srdjan; Melle, Ingrid; Sundet, Kjetil Søren; Christoforou, Andrea; Reinvang, Ivar; DeRosse, Pamela; Lundervold, Astri; Steen, Vidar Martin; Espeseth, Thomas; Räikkönen, Katri; Widén, Elisabeth; Palotie, Aarno; Eriksson, Johan Gunnar; Giegling, Ina; Konte, Bettina; Roussos, Panos; Giakoumaki, Stella; Burdick, Katherine E.; Payton, Antony; Ollier, William E.R.; Horan, Michael Arthur; Chiba-Falek, Ornit; Attix, Deborah K.; Need, Anna C.; Cirulli, Elizabeth Trilby; Voineskos, Aristotle N.; Stefanis, Nikos C.; Avramopoulos, Dimitrios A.; Hatzimanolis, Alex; Arking, Dan E.; Smyrnis, Nikolaos; Bilder, Robert Martin; Freimer, Nelson A.; Cannon, Tyrone D.; London, Edyth; Poldrack, Russell Alan; Sabb, Fred W.; Congdon, Eliza L.; Conley, Emily Drabant; Scult, Matthew A.; Dickinson, Dwight; Straub, Richard E.; Donohoe, Gary J.; Morris, Derek W.; Corvin, Aiden; Gill, Michael; Hariri, Ahmad; Weinberger, Daniel R.; Pendleton, Neil; Bitsios, Panos; Rujescu, Dan; Lahti, Jari; Le Hellard, Stephanie; Keller, Matthew C.; Andreassen, Ole Andreas; Deary, Ian John; Glahn, David C.; Malhotra, Anil K. & Lencz, Todd (2017). GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report form the COGENT consortium. Molecular Psychiatry.  ISSN 1359-4184.  22(3), s 336- 345 . doi: 10.1038/mp.2016.244
• Walton, Esther Fintan; Hibar, Derrek; Van Erp, Theo G.M.; Potkin, Steven G.; Roiz-Santiáñez, Roberto; Crespo-Facorro, Benedicto; Suarez-Pinilla, Paula; van Haren, Neeltje E.M.; de Zwarte, Sonja M.C.; Kahn, René S.; Cahn, Wiepke; Doan, Nhat Trung; Jørgensen, Kjetil Nordbø; Gurholt, Tiril Pedersen; Agartz, Ingrid; Andreassen, Ole Andreas; Westlye, Lars Tjelta; Melle, Ingrid; Berg, Akiah Ottesen; Mørch-Johnsen, Lynn; Færden, Ann; Flyckt, Lena; Fatouros-Bergman, Helena; Jönsson, Erik Gunnar; Hashimoto, Ryota; Yamamori, Hidenaga; Fukunaga, Masaki; Preda, Adrian; De Rossi, Pietro; Piras, Fabrizio; Banaj, Nerisa; Ciullo, Valentina; Spalletta, Gianfranco; Gur, Raquel E.; Gur, Ruben C.; Wolf, Daniel H.; Satterthwaite, Theaodore D.; Beard, Lauren M.; Sommer, Iris E.; Koops, Sanne; Gruber, Oliver; Richter, Anja; Krämer, B.; Kelly, Sinéad; Donohoe, Gary J.; McDonald, Colm; Cannon, Dara M.; Corvin, Aiden; Gill, Michael; Di Giorgio, Annabella; Bertolino, Alessandro; Lawrie, Stephen M.; Nickson, Thomas; Whalley, Heather Clare; Neilson, Emma; Calhoun, Vince D.; Thompson, Paul Murray; Turner, Jessica A. & Ehrlich, Stefan (2017). Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  135(5), s 439- 447 . doi: 10.1111/acps.12718
• Weibell, Melissa Anne; Hegelstad, Wenche; Auestad, Bjørn Henrik; Bramness, Jørgen Gustav; Evensen, Julie Horgen; Haahr, Ulrik; Joa, Inge; Johannessen, Jan Olav; Larsen, Tor Ketil; Melle, Ingrid; Ilner, Stein E. Opjordsmoen; Rund, Bjørn Rishovd; Simonsen, Erik; Vaglum, Per Jørgen Wiggen; McGlashan, Thomas; McGorry, Patrick & Friis, Svein (2017). The Effect of Substance Use on 10-Year Outcome in First-Episode Psychosis. Schizophrenia Bulletin.  ISSN 0586-7614.  43(4), s 843- 851 . doi: 10.1093/schbul/sbw179
• Østefjells, Tiril; Lystad, June Ullevoldsæter; Berg, Akiah Ottesen; Hagen, Roger; Loewy, R; Sandvik, Leiv; Melle, Ingrid & Røssberg, Jan Ivar (2017). Metacognitive beliefs mediate the effect of emotional abuse on depressive and psychotic symptoms in severe mental disorders. Psychological Medicine.  ISSN 0033-2917.  47(13), s 2323- 2333 . doi: 10.1017/S0033291717000848
• Østefjells, Tiril; Melle, Ingrid; Aminoff, Sofie Ragnhild; Hellvin, Tone; Hagen, Roger; Lagerberg, Trine Vik; Lystad, June Ullevoldsæter & Røssberg, Jan Ivar (2017). An exploration of metacognitive beliefs and thought control strategies in bipolar disorder. Comprehensive Psychiatry.  ISSN 0010-440X.  73, s 84- 92 . doi: 10.1016/j.comppsych.2016.11.008 Vis sammendrag

  Background: Previous studies have shown that individuals with schizophrenia exhibit higher levels of unhelpful metacognitive beliefs than healthy controls, but no studies have explored metacognitive beliefs in early psychosis. Aims: We examined i) differences in levels of unhelpful metacognitive beliefs between psychosis spectrum disorders, and healthy controls, and ii) to what extent demographic and clinical characteristics predicted levels of metacognitive beliefs in the early treated phases of psychotic disorders. Method: Patients were included within two years of first treatment for a psychotic disorder (N=92). They were assessed on premorbid adjustment, psychotic symptoms, anxiety/depression, and self-reported metacognitive beliefs (MCQ-30). Ninety-seven controls also completed MCQ-30. Predictors of metacognitive beliefs were explored with multiple linear regression analyses. Results: Patients scored significantly higher than controls on all metacognitive subscales except positive beliefs about worry. The regression model explained 14—38% of the variance on each metacognitive subscale. Current affective symptoms explained a significant amount of variance on all subscales, except positive beliefs about worry. Childhood (premorbid) social adjustment predicted a significant amount of the variance on all subscales, except cognitive confidence. Duration of untreated psychosis contributed significantly to more unhelpful beliefs about cognitive confidence. Negative symptoms predicted lower scores on cognitive self-consciousness. Conclusion: Affective symptoms and childhood social adjustment could be important predictors of unhelpful metacognitive beliefs in the early treated phases of psychosis, indicating potential psychopathological relationships that warrant further investigation for clinical relevance.

• Aas, Monica; Andreassen, Ole Andreas; Aminoff, Sofie Ragnhild; Færden, Ann; Romm, Kristin Lie; Nesvåg, Ragnar; Berg, Akiah Ottesen; Simonsen, Carmen Elisabeth; Agartz, Ingrid & Melle, Ingrid (2016). A history of childhood trauma is associated with slower improvement rates: Findings from a one-year follow-up study of patients with a first-episode psychosis. BMC Psychiatry.  ISSN 1471-244X.  16 . doi: 10.1186/s12888-016-0827-4 Fulltekst i vitenarkiv.
• Aas, Monica; Henry, Chantal; Andreassen, Ole Andreas; Bellivier, Frank; Melle, Ingrid & Etain, Bruno (2016). The role of childhood trauma in bipolar disorders. International journal of bipolar disorders.  ISSN 2194-7511.  4(2) . doi: 10.1186/s40345-015-0042-0
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• Bjørnestad, Jone Ravndal; Brønnick, Kolbjørn Selvåg; Davidson, Larry; Hegelstad, Wenche; Joa, Inge; Kandal, Øyvind; Larsen, Tor Ketil; Langeveld, Johannes H.; Veseth, Marius; Melle, Ingrid & Johannessen, Jan Olav (2016). The central role of self-agency in clinical recovery from first episode psychosis. Psychosis.  ISSN 1752-2439.  9(2), s 140- 148 . doi: 10.1080/17522439.2016.1198828
• Bjørnestad, Jone Ravndal; Joa, Inge; Larsen, Tor Ketil; Langeveld, Johannes H.; Davidson, Larry; Hegelstad, Wenche; Anda-Ågotnes, Liss Gøril; Veseth, Marius; Melle, Ingrid; Johannessen, Jan Olav & Brønnick, Kolbjørn Selvåg (2016). "Everyone Needs a Friend Sometimes" - social predictors of long-term remission in first episode psychosis. Frontiers in Psychology.  ISSN 1664-1078.  7 . doi: 10.3389/fpsyg.2016.01491 Fulltekst i vitenarkiv.
• Demmo, Christine; Lagerberg, Trine Vik; Aminoff, Sofie Ragnhild; Hellvin, Tone; Kvitland, Levi Røstad; Simonsen, Carmen Elisabeth; Andreassen, Ole Andreas; Melle, Ingrid & Ueland, Torill (2016). History of psychosis and previous episodes as potential explanatory factors for neurocognitive impairment in first-treatment bipolar I disorder. Bipolar Disorders.  ISSN 1398-5647.  18(2), s 136- 147 . doi: 10.1111/bdi.12377
• Friis, Svein; Melle, Ingrid; Johannessen, Jan Olav; Røssberg, Jan Ivar; Barder, Helene; Evensen, Julie Horgen; Haahr, Ulrik; Hegelstad, Wenche; Joa, Inge; Langeveld, Johannes H.; Larsen, Tor Ketil; Ilner, Stein E. Opjordsmoen; Rund, Bjørn Rishovd; Simonsen, Erik; Vaglum, Per Jørgen Wiggen & McGlashan, Thomas H. (2016). Early Predictors of Ten-Year Course in First-Episode Psychosis.. Psychiatric Services.  ISSN 1075-2730.  67(4), s 438- 443 . doi: 10.1176/appi.ps.201400558
• Gardsjord, Erlend Strand; Romm, Kristin Lie; Friis, Svein; Barder, Helene; Evensen, Julie Horgen; Haahr, Ulrik; Hegelstad, Wenche; Joa, Inge; Johannessen, Jan Olav; Langeveld, Johannes H.; Larsen, Tor Ketil; Ilner, Stein E. Opjordsmoen; Rund, Bjørn Rishovd; Simonsen, Erik; Vaglum, Per Jørgen Wiggen; McGlashan, Thomas; Melle, Ingrid & Røssberg, Jan Ivar (2016). Subjective quality of life in first-episode psychosis. A ten year follow-up study. Schizophrenia Research.  ISSN 0920-9964.  172(1-3), s 23- 28 . doi: 10.1016/j.schres.2016.02.034
• Gunnarsson, Bjarni; Jonsdottir, Gudrun A; Bjornsdottir, Gyda; Konte, Bettina; Sulem, Patrick; Kristmundsdottir, Snædis; Kehr, Birte; Gustafsson, Omar; Helgason, Hannes; Iordache, Paul D; Olafsson, Sigurgeir; Frigge, Michael L; Thorleifsson, Gudmar; Arnarsdottir, Sunna; Stefansdottir, Berglind; Giegling, Ina; Djurovic, Srdjan; Sundet, Kjetil Søren; Espeseth, Thomas; Melle, Ingrid; Hartmann, Annette M.; Thorsteinsdottir, Unnur; Kong, Augustine; Gudbjartsson, Daniel F.; Ettinger, Ulrich; Andreassen, Ole Andreas; Rujescu, Dan; Halldorsson, Jonas G.; Stefansson, Hreinn; Halldorsson, Bjarni V. & Stefánsson, Kári (2016). A sequence variant associating with educational attainment also affects childhood cognition. Scientific Reports.  ISSN 2045-2322.  6 . doi: 10.1038/srep36189
• Haahr, Ulrik Helt; Larsen, Tor Ketil; Simonsen, Erik; Rund, Bjørn Rishovd; Joa, Inge; Røssberg, Jan Ivar; Johannessen, Jan Olav; Langeveld, Johannes H.; Evensen, Julie Horgen; Trauelsen, Anne Marie; Vaglum, Per Jørgen Wiggen; Ilner, Stein E. Opjordsmoen; Hegelstad, Wenche; Friis, Svein; McGlashan, Thomas & Melle, Ingrid (2016). Relation between premorbid adjustment, duration of untreated psychosis and close interpersonal trauma in first-episode psychosis. Early Intervention in Psychiatry.  ISSN 1751-7885.  12(3), s 316- 323 . doi: 10.1111/eip.12315
• Haatveit, Beathe Christin; Jensen, Jimmy; Alnæs, Dag; Kaufmann, Tobias; Brandt, Christine Lycke; Thoresen, Christian; Andreassen, Ole Andreas; Melle, Ingrid; Ueland, Torill & Westlye, Lars Tjelta (2016). Reduced load-dependent default mode network deactivation across executive tasks in schizophrenia spectrum disorders. NeuroImage: Clinical.  ISSN 2213-1582.  12, s 389- 396 . doi: 10.1016/j.nicl.2016.08.012
• Haram, Marit; Bettella, Francesco; Brandt, Christine Lycke; Quintana, Daniel; Nerhus, Mari; Bjella, Thomas; Djurovic, Srdjan; Westlye, Lars Tjelta; Andreassen, Ole Andreas; Melle, Ingrid & Tesli, Martin Steen (2016). Contribution of oxytocin receptor polymorphisms to amygdala activation in schizophrenia spectrum disorders. BJPsych Open.  ISSN 2056-4724.  2(6), s 353- 358 . doi: 10.1192/bjpo.bp.116.003376
• Haug, Elisabeth; Øie, Merete Glenne; Andreassen, Ole Andreas; Bratlien, Unni; Romm, Kristin Lie; Møller, Paul & Melle, Ingrid (2016). The association between anomalous self-experiences, self-esteem and depression in first episode schizophrenia. Frontiers in Human Neuroscience.  ISSN 1662-5161.  10(557) . doi: 10.3389/fnhum.2016.00557
• Haug, Elisabeth; Øie, Merete Glenne; Andreassen, Ole Andreas; Møller, Paul; Melle, Ingrid; Romm, Kristin Lie & Bratlien, Unni (2016). The association between anomalous self-experiences, self-esteem and depression in first episode schizophrenia. Frontiers in Human Neuroscience.  ISSN 1662-5161.  Nov 7 Fulltekst i vitenarkiv.
• Haukvik, Unn Kristin H.; Hartberg, Cecilie Bhandari; Nerland, Stener; Jørgensen, Kjetil Nordbø; Lange, Elisabeth; Simonsen, Carmen Elisabeth; Nesvåg, Ragnar; Dale, Anders; Andreassen, Ole Andreas; Melle, Ingrid & Agartz, Ingrid (2016). No progressive brain changes during a 1-year follow-up of patients with first-episode psychosis. Psychological Medicine.  ISSN 0033-2917.  46(3), s 589- 598 . doi: 10.1017/S003329171500210X Vis sammendrag

  Background. First-episode psychosis (FEP) patients show structural brain abnormalities. Whether the changes are progressive or not remain under debate, and the results from longitudinal magnetic resonance imaging (MRI) studies are mixed. We investigated if FEP patients showed a different pattern of regional brain structural change over a 1-year period compared with healthy controls, and if putative changes correlated with clinical characteristics and outcome. Method. MRIs of 79 FEP patients [SCID-I-verified diagnoses: schizophrenia, psychotic bipolar disorder, or other psychoses, mean age 27.6 (S.D. = 7.7) years, 66% male] and 82 healthy controls [age 29.3 (S.D. = 7.2) years, 66% male] were acquired from the same 1.5 T scanner at baseline and 1-year follow-up as part of the Thematically Organized Psychosis (TOP) study, Oslo, Norway. Scans were automatically processed with the longitudinal stream in FreeSurfer that creates an unbiased within-subject template image. General linear models were used to analyse longitudinal change in a wide range of subcortical volumes and detailed thickness and surface area estimates across the entire cortex, and associations with clinical characteristics. Results. FEP patients and controls did not differ significantly in annual percentage change in cortical thickness or area in any cortical region, or in any of the subcortical structures after adjustment for multiple comparisons. Within the FEP group, duration of untreated psychosis, age at illness onset, antipsychotic medication use and remission at follow-up were not related to longitudinal brain change. Conclusions. We found no significant longitudinal brain changes over a 1-year period in FEP patients. Our results do not support early progressive brain changes in psychotic disorders.

• Hegelstad, Wenche; Brønnick, Kolbjørn Selvåg; Barder, Helene; Evensen, Julie Horgen; Haahr, Ulrik; Joa, Inge; Johannessen, Jan Olav; Langeveld, Johannes H.; Larsen, Tor Ketil; Melle, Ingrid; Ilner, Stein E. Opjordsmoen; Rund, Bjørn Rishovd; Røssberg, Jan Ivar; Simonsen, Erik; Vaglum, Per Jørgen Wiggen; McGlashan, Thomas & Friis, Svein (2016). Preventing poor vocational functioning in psychosis through early intervention. Psychiatric Services.  ISSN 1075-2730.  68(1), s 100- 103 . doi: 10.1176/appi.ps.201500451
• Helle, Siri; Ringen, Petter Andreas; Melle, Ingrid; Larsen, Tor Ketil; Gjestad, Rolf; Johnsen, Erik; Lagerberg, Trine Vik; Andreassen, Ole Andreas; Kroken, Rune Andreas; Joa, Inge; Hegelstad, Wenche & Løberg, Else-Marie (2016). Cannabis use is associated with 3 years earlier onset of schizophrenia spectrum disorder in a naturalistic, multi-site sample (N = 1119). Schizophrenia Research.  ISSN 0920-9964.  170(1), s 217- 221 . doi: 10.1016/j.schres.2015.11.027
• Howrigan, Dave; Simonson, M.A.; Davies, Gail; Harris, SE; Tenesa, A.; Starr, JM; Liewald, DC; Deary, IJ; McRae, A.; Wright, MJ; Montgomery, GW; Hansell, Narelle K; Martin, NG; Payton, A.; Horan, M.; Ollier, W.; Abdellaoui, A.; Boomsma, DI; Derosse, P; Knowles, Emma; Glahn, David C.; Djurovic, Srdjan; Melle, Ingrid; Andreassen, Ole Andreas; Christoforou, Andrea; Steen, Vidar Martin; Le Hellard, Stephanie; Sundet, Kjetil Søren; Reinvang, Ivar; Espeseth, Thomas; Lundervold, Astri; Giegling, I; Konte, B; Hartmann, AM; Rujesco, D.; Roussos, P; Giakoumaki, S; Burdick, KE; Bitsios, P; Donohoe, G; Corley, Robin P; Visscher, PM; Pendleton, N.; Malhotra, AK; Neale, BM; Lencz, T & Keller, M. (2016). Genome-wide autozygosity is associated with lower general cognitive ability. Molecular Psychiatry.  ISSN 1359-4184.  21(6), s 837- 843 . doi: 10.1038/mp.2015.120
• Jørgensen, Kjetil Nordbø; Nerland, Stener; Norbom, Linn Christin Bonaventure; Doan, Nhat Trung; Nesvåg, Ragnar; Mørch-Johnsen, Lynn; Haukvik, Unn Kristin H.; Melle, Ingrid; Andreassen, Ole Andreas; Westlye, Lars Tjelta & Agartz, Ingrid (2016). Increased MRI-based cortical grey/white-matter contrast in sensory and motor regions in schizophrenia and bipolar disorder. Psychological Medicine.  ISSN 0033-2917.  46(9), s 1971- 1985 . doi: 10.1017/S0033291716000593
• Kvitland, Levi Røstad; Melle, Ingrid; Aminoff, Sofie Ragnhild; Lagerberg, Trine Vik; Andreassen, Ole Andreas & Ringen, Petter Andreas (2016). Cannabis use in first-treatment bipolar I disorder: Relations to clinical characteristics. Early Intervention in Psychiatry.  ISSN 1751-7885.  10(1), s 36- 44 . doi: 10.1111/eip.12138
• Kvitland, Levi Røstad; Ringen, Petter Andreas; Aminoff, Sofie Ragnhild; Demmo, Christine; Hellvin, Tone; Lagerberg, Trine Vik; Andreassen, Ole Andreas & Melle, Ingrid (2016). Duration of untreated illness in first-treatment bipolar I disorder in relation to clinical outcome and cannabis use.. Psychiatry Research.  ISSN 0165-1781.  246, s 762- 768 . doi: 10.1016/j.psychres.2016.07.064
• Lagerberg, Trine Vik; Icick, R.; Andreassen, Ole Andreas; Ringen, Petter Andreas; Etain, B; Aas, Monica; Henry, C; Bjella, Thomas; Melle, Ingrid & Bellivier, F (2016). Cannabis use disorder is associated with greater illness severity in tobacco smoking patients with bipolar disorder. Journal of Affective Disorders.  ISSN 0165-0327.  190, s 286- 293 . doi: 10.1016/j.jad.2015.10.023
• Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Hope, Sigrun; Aas, Monica; Nerhus, Mari; Gardsjord, Erlend Strand; Joa, Inge; Morken, Gunnar; Agartz, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Melle, Ingrid; Ueland, Thor & Andreassen, Ole Andreas (2016). Inflammatory evidence for the psychosis continuum model. Psychoneuroendocrinology.  ISSN 0306-4530.  67, s 189- 197 . doi: 10.1016/j.psyneuen.2016.02.011
• Mørch-Johnsen, Lynn; Nesvåg, Ragnar; Jørgensen, Kjetil Nordbø; Lange, Elisabeth; Hartberg, Cecilie Bhandari; Haukvik, Unn Kristin H.; Kompus, Kristiina; Westerhausen, Rene; Osnes, Kåre; Andreassen, Ole Andreas; Melle, Ingrid; Hugdahl, Kenneth & Agartz, Ingrid (2016). Auditory cortex characteristics in schizophrenia: Associations with auditory hallucinations. Schizophrenia Bulletin.  ISSN 0586-7614.  43(1), s 75- 83 . doi: 10.1093/schbul/sbw130
• Nerhus, Mari; Berg, Akiah Ottesen; Kvitland, Levi Røstad; Dieset, Ingrid; Hope, Sigrun; Dahl, Sandra Rinne; Weibell, Melissa Anne E.a; Romm, Kristin Lie; Færden, Ann; Andreassen, Ole Andreas & Melle, Ingrid (2016). Low vitamin D is associated with negative and depressive symptoms in psychotic disorders. Schizophrenia Research.  ISSN 0920-9964.  178(1-3), s 44- 49 . doi: 10.1016/j.schres.2016.08.024 Fulltekst i vitenarkiv. Vis sammendrag

  BACKGROUND: There are indications that low S-25(OH)D is associated with increased disease severity in psychotic disorder. Our first aim was to investigate the relations between low S-25(OH)D and positive, negative and depressive symptoms. Our second aim was to explore if associations between S-25(OH)D and symptoms were influenced by levels of inflammatory markers. METHODS: Participants (N=358) with a medical history of one or more psychotic episodes were recruited. Current symptomatology was assessed by The Structured Interview for the Positive and Negative Syndrome Scaleanalyzed by a five-factor model. The Calgary Depression Scale for Schizophrenia was used to assess depression and suicidal ideation. Blood samples were analyzed for S-25(OH)D, CRP, sTNF-R1, IL-Ra and OPG. We performed bivariate correlations and multiple regression models to evaluate the effect of S-25(OH)D on the outcomes. RESULTS: Low S-25(OH)D was significantly associated with negative symptoms (adjusted R2=0.113, F(6,357)=8.58, p<0.001) and with depression (adjusted R2=0.045, F(4,357)=5.233, p<0.001) when adjusting for possible confounding factors (i.e. gender, education, diagnose, hospitalization status, ethnicity, season and thyroid status). CRP was correlated with both S-25(OH)D (rho=-0.13, p=0.02) and negative symptoms (rho=0.14, p=0.01), but did not act as a mediator. The correlations between S-25(OH)D and the inflammatory markers sTNF-R1, IL-Ra and OPG were not significant. CONCLUSION: There is a strong association between low S-25(OH)D and higher negative and depressive symptoms in psychotic disorders. Randomized controlled trials should be performed to investigate the effect of vitamin D supplementation as adjuvant treatment strategy in patients with prominent negative or depressive symptoms.

• Ringen, Petter Andreas; Nesvåg, Ragnar; Helle, Siri; Lagerberg, Trine Vik; Lange, Elisabeth; Løberg, Else-Marie; Agartz, Ingrid; Andreassen, Ole Andreas & Melle, Ingrid (2016). Premorbid cannabis use is associated with more symptoms and poorer functioning in schizophrenia spectrum disorder. Psychological Medicine.  ISSN 0033-2917.  46(15), s 3127- 3136 . doi: 10.1017/S0033291716001999 Vis sammendrag

  Cannabis use disorder is associated with an earlier age at onset and a more severe outcome of schizophrenia spectrum disorders. The role of cannabis use before the onset of illness (premorbid cannabis use) has not been fully investigated. We here examined how amount and type of premorbid cannabis use was associated with the later course of illness including current substance use, symptoms and level of functioning in schizophrenia spectrum disorder. We used a naturalistic sample of patients with DSM-IV schizophrenia spectrum disorders with a comprehensive history of illness and substance use. Data on premorbid substance use was obtained from comprehensive self-report. The relationship to outcome was investigated using regression models that included current substance use and premorbid functioning. Pre-schizophrenia cannabis use was significantly associated with more severe psychotic symptoms and impaired functioning. Higher levels of premorbid cannabis use were associated with higher levels of current psychotic symptoms. These associations were independent of current substance use and premorbid functioning. Early use of cannabis (age <17 years) was associated with earlier age at onset of psychosis, independently of potential confounders. Pre-psychosis cannabis use affects illness outcome in schizophrenia spectrum disorders, and is associated with lower age at onset of psychosis. These findings of independent negative effects of premorbid cannabis use in schizophrenia suggest that a limitation of the general use of cannabis may have beneficial health effects.

• Rund, Bjørn Rishovd; Barder, Helene; Evensen, Julie Horgen; Haahr, Ulrik; Hegelstad, Wenche; Joa, Inge; Johannessen, Jan Olav; Langeveld, Johannes H.; Larsen, Tor Ketil; Melle, Ingrid; Ilner, Stein E. Opjordsmoen; Røssberg, Jan Ivar; Simonsen, Erik; Sundet, Kjetil Søren; Vaglum, Per Jørgen Wiggen; McGlashan, Thomas & Friis, Svein (2016). Neurocognition and Duration of Psychosis: A 10-year Follow-up of First-Episode Patients. Schizophrenia Bulletin.  ISSN 0586-7614.  42(1), s 87- 95 . doi: 10.1093/schbul/sbv083
• Skåtun, Kristina Cecilie; Kaufmann, Tobias; Doan, Nhat Trung; Alnæs, Dag; Còrdova Palomera, Aldo; Jönsson, Erik Gunnar; Fatouros-Bergman, Helena; Flyckt, Lena; Melle, Ingrid; Andreassen, Ole Andreas; Agartz, Ingrid & Westlye, Lars Tjelta (2016). Consistent functional connectivity alterations in schizophrenia spectrum disorder: a multisite study. Schizophrenia Bulletin.  ISSN 0586-7614.  43(4), s 914- 924 . doi: 10.1093/schbul/sbw145
• Skåtun, Kristina Cecilie; Kaufmann, Tobias; Tønnesen, Siren; Biele, Guido; Melle, Ingrid; Agartz, Ingrid; Alnæs, Dag; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2016). Global brain connectivity alterations in persons with schizophrenia and bipolar spectrum disorders. Journal of Psychiatry & Neuroscience.  ISSN 1180-4882.  41(5), s 331- 341 . doi: 10.1503/jpn.150159
• Steen, Nils Eiel; Aas, Monica; Simonsen, Carmen Elisabeth; Dieset, Ingrid; Tesli, Martin Steen; Nerhus, Mari; Gardsjord, Erlend Strand; Mørch, Ragni Helene; Agartz, Ingrid; Melle, Ingrid; Ueland, Torill; Spigset, Olav & Andreassen, Ole Andreas (2016). Serum levels of second-generation antipsychotics are associated with cognitive function in psychotic disorders. World Journal of Biological Psychiatry.  ISSN 1562-2975.  18(6), s 471- 482 . doi: 10.1080/15622975.2016.1245441
• Steen, Nils Eiel; Aas, Monica; Simonsen, Carmen Elisabeth; Dieset, Ingrid; Tesli, Martin Steen; Nerhus, Mari; Gardsjord, Erlend Strand; Mørch, Ragni Helene; Agartz, Ingrid; Melle, Ingrid; Vaskinn, Anja; Spigset, Olav & Andreassen, Ole Andreas (2016). Serum concentrations of mood stabilizers are associated with memory, but not other cognitive domains in psychosis spectrum disorders; explorative analyses in a naturalistic setting. International journal of bipolar disorders.  ISSN 2194-7511.  4(24) . doi: 10.1186/s40345-016-0067-z
• Steinan, Mette Kvisten; Morken, Gunnar; Lagerberg, Trine Vik; Melle, Ingrid; Andreassen, Ole Andreas; Vaaler, Arne Einar & Scott, Jan (2016). Delayed sleep phase: An important circadian subtype of sleep disturbance in bipolar disorders. Journal of Affective Disorders.  ISSN 0165-0327.  191, s 156- 163 . doi: 10.1016/j.jad.2015.11.025
• Sønmez, Nasrettin; Røssberg, Jan Ivar; Evensen, Julie Horgen; Barder, Helene; Haahr, Ulrik; Hegelstad, Wenche; Joa, Inge; Johannessen, Jan Olav; Langeveld, Johannes H.; Larsen, Tor Ketil; Melle, Ingrid; Ilner, Stein E. Opjordsmoen; Rund, Bjørn Rishovd; Simonsen, Erik; Vaglum, Per Jørgen Wiggen; McGlashan, Thomas & Friis, Svein (2016). Depressive symptoms in first-episode psychosis: A 10-year follow-up study. Early Intervention in Psychiatry.  ISSN 1751-7885.  10(3), s 227- 233 . doi: 10.1111/eip.12163
• Tesli, Martin Steen; Wirgenes, Katrine Verena; Hughes, Timothy; Bettella, Francesco; Athanasiu, Lavinia; Hoseth, Eva Zsuzsanna; Nerhus, Mari; Lagerberg, Trine Vik; Steen, Nils Eiel; Agartz, Ingrid; Melle, Ingrid; Dieset, Ingrid; Djurovic, Srdjan & Andreassen, Ole Andreas (2016). VRK2 gene expression in schizophrenia, bipolar disorder and healthy controls. British Journal of Psychiatry.  ISSN 0007-1250.  209(2), s 114- 120 . doi: 10.1192/bjp.bp.115.161950
• Vaskinn, Anja; Sundet, Kjetil Søren; Østefjells, Tiril; Nymo, Katharina Sørvang; Melle, Ingrid & Ueland, Torill (2016). Reading emotions from body movement: A generalized impairment in schizophrenia. Frontiers in Psychology.  ISSN 1664-1078.  6 . doi: 10.3389/fpsyg.2015.02058 Fulltekst i vitenarkiv.
• Aminoff, Sofie Ragnhild; Tesli, Martin Steen; Bettella, Franscesco; Aas, Monica; Lagerberg, Trine Vik; Djurovic, Srdjan; Andreassen, Ole Andreas & Melle, Ingrid (2015). Polygenic risk scores in bipolar disorders subgroups. Journal of Affective Disorders.  ISSN 0165-0327.  183, s 310- 314 . doi: 10.1016/j.jad.2015.05.021
• Barder, Helene; Sundet, Kjetil Søren; Rund, Bjørn Rishovd; Evensen, Julie Horgen; Haahr, Ulrik; Hegelstad, Wenche; Joa, Inge; Johannessen, Jan Olav; Langeveld, Johannes H.; Larsen, Tor Ketil; Melle, Ingrid; Ilner, Stein E. Opjordsmoen; Røssberg, Jan Ivar; Simonsen, Erik; Vaglum, Per Jørgen Wiggen; McGlashan, Thomas & Friis, Svein (2015). Ten year course of IQ in first-episode psychosis: relationship between duration of psychsis and long-term intellectual trajectories. Psychiatry Research.  ISSN 0165-1781.  225(3), s 515- 521 . doi: 10.1016/j.psychres.2014.11.054
• Barrett, Elizabeth Ann; Mork, Erlend; Færden, Ann; Nesvåg, Ragnar; Agartz, Ingrid; Andreassen, Ole Andreas & Melle, Ingrid (2015). The development of insight and its relationship with suicidality over one year follow-up in patients with first episode psychosis. Schizophrenia Research.  ISSN 0920-9964.  162(1-3), s 97- 102 . doi: 10.1016/j.schres.2015.01.004
• Bauer, Michael; Glenn, T; Alda, M; Andreassen, Ole Andreas; Angelopoulos, E; Ardau, R; Baethge, C; Bauer, R; Bellivier, F; Belmaker, RH; Berk, M; Bjella, Thomas; Bossini, L; Bersudsky, Y; Cheung, EYW; Conell, J; Del Zompo, M; Dodd, S; Etain, B; Fagiolini, A; Frye, MA; Fountoulakis, KN; Garneau-Fournier, J; Gonzalez-Pinto, A; Harima, H; Hassel, S; Henry, C; Iacovides, A; Isometsä, ET; Kapczinski, F; Kliwicki, S; König, B; Krogh, R; Kunz, M; Lafer, B; Larsen, ER; Lewitzka, U; Lopez-Jaramillo, C; MacQueen, G; Manchia, M; Marsh, W; Martinez-Cengotitabengoa, M; Melle, Ingrid; Monteith, S; Morken, Gunnar; Munoz, R; Nery, FG; O'Donovan, C; Osher, Y; Pfennig, A; Quiroz, D; Ramesar, R; Rasgon, N; Reif, A; Ritter, P; Rybakowski, JK; Sagduyu, K; Scippa, AM; Severus, E; Simhandl, C; Stein, DJ; Strejilevich, S; Hatim Sulaiman, A; Suominen, K; Tagata, H; Tatebayashi, Y; Torrent, C; Vieta, E; Viswanath, B; Wanchoo, MJ; Zetin, M & Whybrow, PC (2015). Influence of birth cohort on age of onset cluster analysis in bipolar I disorder. European psychiatry.  ISSN 0924-9338.  30(1), s 99- 105 . doi: 10.1016/j.eurpsy.2014.10.005
• Bauer, Michael; Glenn, Tasha; Alda, Martin; Andreassen, Ole Andreas; Angelopoulos, Elias; Ardau, Raffaella; Baethge, Christopher; Bauer, Rita; Baune, Bernhard T.; Bellivier, Frank; Belmaker, Robert H.; Berk, Michael; Bjella, Thomas; Bossini, Letizia; Bersudsky, Yuly; Wo Cheung, Eric Yat; Conell, Jörn; Del Zompo, Maria; Dodd, Seetal; Etain, Bruno; Fagiolini, Andrea; Frye, Mark A.; Fountoulakis, Kostas N; Garneau-Fournier, Jade; Gonzalez-Pinto, Ana; Gottlieb, John F; Harima, Hirohiko; Hassel, Stefanie; Henry, Chantal; Iacovides, Apostolos; Isometsä, Erkki T.; Kapczinski, Flavio; Kliwicki, Sebastian; König, Barbara; Krogh, Rikke; Kunz, Mauricio; Lafer, Beny; Larsen, Erik R.; Lewitzka, Ute; Lopez-Jaramillo, Carlos; MacQueen, Glenda; Manchia, Mirko; Marsh, Wendy; Martinez-Cengotitabengoa, Monica; Melle, Ingrid; Monteith, Scott; Morken, Gunnar; Munoz, Rodrigo; Nery, Fabiano G.; O'Donovan, Claire; Osher, Yamima; Pfennig, Andrea; Quiroz, Danilo; Ramesar, Raj; Rasgon, Natalie; Reif, Andreas; Ritter, Philipp; Rybakowski, Janusz K.; Sagduyu, Kemal; Miranda-Scippa, Angela; Severus, Emanuel; Simhandl, Christian; Stein, Dan J.; Strejilevich, Sergio; Sulaiman, Ahmad Hatim; Suominen, Kirsi; Tagata, Hiromi; Tatebayashi, Yoshitaka; Torrent, Carla; Vieta, Eduard; Viswanath, Biju; Wanchoo, Mihir J.; Zetin, Mark & Whybrow, Peter C. (2015). Influence of light exposure during early life on the age of onset of bipolar disorder. Journal of Psychiatric Research.  ISSN 0022-3956.  64, s 1- 8 . doi: 10.1016/j.jpsychires.2015.03.013
• Berg, Akiah Ottesen; Aas, Monica; Larsson, Sara; Nerhus, Mari; Hauff, Edvard; Andreassen, Ole Andreas & Melle, Ingrid (2015). Childhood trauma mediates the association between ethnic minority status and more severe hallucinations in psychotic disorder. Psychological Medicine.  ISSN 0033-2917.  45(01), s 133- 142 . doi: 10.1017/S0033291714001135 Fulltekst i vitenarkiv.
• Berg, Akiah Ottesen; Barrett, Elizabeth Ann; Nerhus, Mari; Buchmann, Camilla Bakkalia; Simonsen, Carmen Elisabeth; Færden, Ann; Andreassen, Ole Andreas & Melle, Ingrid (2015). Psychosis: clinical insight and beliefs in immigrants in their first episode. Early Intervention in Psychiatry.  ISSN 1751-7885.  12(2), s 185- 192 . doi: 10.1111/eip.12297 Vis sammendrag

  Aim: Lack of insight into illness is frequent in psychotic disorders and seen as part of their primary pathology. The recognition of symptoms as psychotic, and beliefs about treatment alternatives, is also influenced by socio-cultural factors. Here we examined clinical insight into illness and beliefs about psychosis in immigrants in their first episode of psychosis compared to a reference group. Methods: 277 first episode psychosis participants were recruited to this cross-sectional study; 40 first- and 40 second-generation immigrants from Europe, Americas and Oceania (n=37), Asia including Turkey (n=28), or Africa (n=15). The Birchwood Insight Scale was used to measure clinical insight and “The Attitudes and Beliefs about Mental Health Problems”, schizophrenia version to assess socio-cultural beliefs. Results: Immigrants did not differ from the reference sample in clinical insight. After controlling for education level first generation immigrants were less likely to recognize psychotic symptoms (OR 2.9; Wald = 8.977, df 1, p =.003) and viewed hospitalization (OR 5.2; Wald = 20.388, df 1, p =.001) and treatment by a psychiatrist (OR 4.9; Wald = 6.609, df 1, p =.01)) as less beneficial than the reference group. Immigrants from Asia held more alternative explanations (OR 0.3; Wald = 6.567, df 1, p=.010). There were significantly stronger associations between clinical insight and socio-cultural beliefs in the reference group. Conclusions: Socio-cultural beliefs about psychosis in immigrants in first episode psychosis calls for more tailored information to this group, and emphasize the importance of treatment interventions involving both a cultural and personal perspective of insight.

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• Malt, Ulrik Fredrik; Andreassen, Ole Andreas; Malt, Eva Albertsen; Melle, Ingrid & Aarsland, Dag (red.) (2018). Lærebok i psykiatri. Gyldendal Akademisk.  ISBN 978-82-05-49463-3.  1060 s.
• Aminoff, Sofie Ragnhild; Berg, Akiah Ottesen; Lagerberg, Trine Vik; Melle, Ingrid; Simonsen, Carmen Elisabeth; Ueland, Torill & Aas, Monica (2015). Psykose og Samfunn. Universitetsforlaget.  ISBN 978-82-15-02469-1.  210 s.
• Aminoff, Sofie Ragnhild; Lagerberg, Trine Vik; Melle, Ingrid; Berg, Akiah Ottesen; Simonsen, Carmen Elisabeth; Ueland, Toril & Aas, Monica (2015). Psykose og samfunn. Universitetsforlaget.  ISBN 9788215024691.  208 s.

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• Andreassen, Ole Andreas; Malt, Eva Albertsen; Malt, Ulrik Fredrik; Aarsland, Dag & Melle, Ingrid (2018). Biopsykososial forståelsesmodell, I: Ulrik Fredrik Malt; Ole Andreas Andreassen; Eva Albertsen Malt; Ingrid Melle & Dag Aarsland (red.),  Lærebok i psykiatri.  Gyldendal Akademisk.  ISBN 978-82-05-49463-3.  Kapittel 6.  s 135 - 142
• Svendsen, Ingrid Hartveit; Øie, Merete Glenne; Møller, Paul; Nelson, Barnaby; Melle, Ingrid & Haug, Elisabeth (2018). Self-disturbances and diagnostic stability in first episode psychosis- a seven year follow-up study.
• Gurholt, Tiril Pedersen; Nerhus, Mari; Osnes, Kåre; Jørgensen, Kjetil Nordbø; Berg, Akiah Ottesen; Andreassen, Ole Andreas; Melle, Ingrid & Agartz, Ingrid (2017). Age-Related Effect of Vitamin D on Hippocampus Volume in Schizophrenia and Bipolar Disorder.
• Nerland, Stener; Jørgensen, Kjetil Nordbø; Jahren, Bjørn; Melle, Ingrid; Andreassen, Ole Andreas & Agartz, Ingrid (2016). A Topological Characterisation of Cortical Folding in Schizophrenia and Bipolar Disorder.
• Aminoff, Sofie Ragnhild; Lagerberg, Trine Vik; Aas, Monica; Bjella, Thomas; Henry, Chantal; Leboyer, Marion; Bellivier, Frank; Andreassen, Ole Andreas; Etain, Bruno & Melle, Ingrid (2015). Affective lability is Associated With Alcohol use disorders in Bipolar disorder.

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