Ingrid Melle

• Glastad, Stine Holmstul; Klungsøyr, Ole; Aminoff, Sofie Ragnhild; Hagen, Roger; Bjella, Thomas & Engen, Magnus Johan [Vis alle 11 forfattere av denne artikkelen] (2026). Frequency analysis of mood, sleep, and alcohol and nicotine use: investigating instability in bipolar I and II disorder. Frontiers in Psychiatry. 17, s. 1–12. doi: 10.3389/fpsyt.2026.1810743.
• Solberg, Amalie Christine; Ottesen, Akiah Astral; Barrett, Elizabeth Ann; Mork, Erlend; Qin, Ping & Melle, Ingrid (2026). Characteristics of self-harm in patients with first episode psychosis. Psychiatry Research. ISSN 0165-1781. 364, s. 117278–117278. doi: 10.1016/j.psychres.2026.117278. Fulltekst i vitenarkiv
• Busch, Cecilie; Ueland, Torill; Høegh, Margrethe Collier; Simonsen, Carmen; Aminoff, Sofie R. & Barrett, Elizabeth Ann [Vis alle 11 forfattere av denne artikkelen] (2026). Wish list from people with lived experience of bipolar disorder - for clinicians and researchers. Journal of Affective Disorders Reports. 25, s. 101114–101114. doi: 10.1016/j.jadr.2026.101114. Fulltekst i vitenarkiv
• Slapø, Nora Berz; Jørgensen, Kjetil Nordbø; Nerland, Stener; Mørch-Johnsen, Lynn Egeland; Pettersen, Johanne Hagen & Roelfs, Daniel [Vis alle 23 forfattere av denne artikkelen] (2026). Relationship between N100 amplitude and T1w/T2w-ratio in the auditory cortex in schizophrenia spectrum disorders. Schizophrenia. doi: 10.1038/s41537-025-00715-w. Fulltekst i vitenarkiv Vis sammendrag

  Schizophrenia spectrum disorders (SCZspect) are associated with altered function in the auditory cortex (AC), indicated by lower N100 amplitude of the auditory evoked potential (AEP). Although the neural substrate behind lower N100 amplitude remains elusive, myelination in the AC may play a role. This study compared N100 amplitude and magnetic resonance imaging (MRI) T1 weighted and T2 weighted ratio (T1w/T2w-ratio), as a proxy of myelination, in the primary AC (AC1) and secondary AC (AC2) between SCZspect (n = 33, 48% women) and healthy controls (HC, n = 144, 49% women). We also examined the associations between N100 amplitude and T1w/T2w-ratios across groups. We finally explored N100 amplitude and T1w/T2w-ratios and the N100-T1w/T2w-ratio associations between male and female SCZspect and HC. N100 amplitude was significantly lower in male SCZspect compared to male HC (p = 0.01) and nominally lower in SCZspect compared to HC (p = 0.03). However, T1w/T2w-ratios in AC1/AC2 did not differ between groups, and no association was found between N100 amplitude and T1w/T2w-ratio in either group. These findings suggest that sex-specific effects should be considered in SCZspect neurophysiology research. Our results do not support the hypothesis of an association between lower N100 amplitude and lower T1w/T2w-ratio in the AC1/AC2 in SCZspect. More precise assessments of intracortical myelin are needed to understand the relationship between N100 amplitude and cortical myelination in the AC in SCZspect and in healthy controls.

• Bauer, M.; Glenn, T.; Achtyes, E. D.; Alda, M.; Agaoglu, E. & Altınbaş, K. [Vis alle 164 forfattere av denne artikkelen] (2026). Family History and Solar Insolation in Bipolar I Disorder. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 153(4), s. 270–278. doi: 10.1111/acps.70075. Fulltekst i vitenarkiv
• Høegh, Margrethe Collier; Glastad, Stine Holmstul; Lyngstad, Siv Hege; Engen, Magnus Johan; Aminoff, Sofie Ragnhild & Melle, Ingrid [Vis alle 8 forfattere av denne artikkelen] (2025). The MinDag app for symptom monitoring and feedback to patients and clinicians during the initial treatment of bipolar disorder – a feasibility study. International journal of bipolar disorders. 13(1). doi: 10.1186/s40345-025-00382-x. Fulltekst i vitenarkiv Vis sammendrag

  Background The app “MinDag” (MyDay) was developed as a tool for monitoring mood, symptoms and illness-relevant behaviour in the initial treatment of bipolar disorder. Digital self-monitoring may provide patients and clinicians with valuable data for tailoring treatment interventions. This study aims to evaluate the practical use and clinical implications of integrating MinDag in the early treatment of bipolar disorder from the perspectives of both patients and clinicians. Methods The MinDag app includes six content modules covering mood, sleep, functioning/activities, substance use, emotional reactivity, and psychotic symptoms. Patients were asked to use the app for six months, and automated feedback based on the app registrations was delivered to the patients’ clinicians biweekly. The study involved quantitative evaluations completed by patients (n = 20), as well as interviews with patients (n = 7) and clinicians (n = 2). Results Overall, the patients reported that they felt that MinDag was safe, relevant and easy to use, although technical difficulties such as too many automated reminders and need for reinstallations were reported. The patients appreciated the potential for increased awareness of their mental health, but expressed a desire for direct access to their data. Clinicians found the visual reports and feedback useful for tailoring treatment, even though the alert system for high-risk variables needed refinement. The quantitative evaluations indicated a positive general reception, with suggestions for improvement in usability and accessibility. Conclusion The MinDag app shows promise as a tool for enhancing the treatment of bipolar disorder by facilitating self-monitoring and providing actionable data to clinicians. However, technical issues and the need for direct patient access to data must be addressed. Development of digital tools to support the treatment of bipolar disorder and other mental health conditions is resource demanding, and there is a need to clarify criteria to establish proof of concept to guide the selection of tools for upscaling and implementation.

• Colbert, Sarah M. C.; Monson, Eric T.; Andreassen, Ole; Ayinde, Olatunde O.; Barr, Peter B. & Bejan, Cosmin A. [Vis alle 314 forfattere av denne artikkelen] (2025). Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group. Molecular Psychiatry. ISSN 1359-4184. 30(12), s. 6144–6154. doi: 10.1038/s41380-025-03271-y. Fulltekst i vitenarkiv Vis sammendrag

  Suicidality phenotypes, consisting of suicidal ideation (SI), suicide attempt (SA), and suicide death (SD), are all heritable but present unique challenges in genome-wide association studies (GWAS) due to their individual complexity, overlap with each other and with related self-harm phenotypes, and varying associations with psychiatric disorders. GWAS have uncovered several loci associated with suicidality phenotypes by meta-analyzing data from multiple cohorts. However, combining datasets from many research groups, where each group may use different study designs, phenotyping instruments, and definitions of suicidality phenotypes, presents challenges. Heterogeneity resulting from these differences can limit genetic discovery; harmonizing phenotype definitions to ensure consistency will greatly improve results. Here, we describe a standardized phenotyping protocol that draws on the expertise of a subgroup of clinicians, researchers, and experts from the Psychiatric Genomics Consortium Suicide Working Group to propose consensus definitions for SI, SA, and SD for genetic studies.

• Fischer-Vieler, Thomas; Rokicki, Jaroslav; Kim, Milin; Leonardsen, Esten Høyland; Wolfers, Thomas & Bell, Christina [Vis alle 14 forfattere av denne artikkelen] (2025). Mapping cerebellar subregional volumes and heterogeneity in schizophrenia spectrum disorders and violence. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. doi: 10.1007/s00406-025-02081-1. Fulltekst i vitenarkiv Vis sammendrag

  Cerebellar abnormalities have been linked to schizophrenia and aggressive behaviour. Subregional cerebellar morphology reflects structural organization and function and show great heterogeneity, which may be linked to shared or distinct underlying mechanisms of violence and psychosis but remain unexplored in these marginalized groups. Total and subregional cerebellar volumes were estimated from 3 T MRI scans from persons with schizophrenia spectrum disorders without (SSD-NV; n = 107) or with (SSD-V; n = 36) a history of severe violence, violent offenders without schizophrenia (NPV; n = 20), and 411 healthy controls. Group difference analyses by GLMs were complemented by novel heterogeneity analyses using pre-trained models and norm-charts of lifespan cerebellar volumes to assess individual deviation patterns. We found decreased grey matter volumes in the posterior cerebellar hemispheres and the vermal regions in both SSD-V and SSD-NV, but with a different subregional distribution. Specifically, SSD-V showed differences in the right Crus I (p = .045, Cohen’s d = .62) and Vermis IX (p < .001, Cohen’s d = .81) in the groupwise comparisons. In addition, individual-level extreme negative deviations were detected in the Vermis IX region in 11% of SSD-V and in some subregions of the posterior cerebellum and the vermis in > 10% of NPV. By applying novel analytical tools, we report different patterns of cerebellar subregion volume reductions associated with violence in individuals with or without schizophrenia spectrum disorders. The partly converging results from the group comparisons and the normative modelling analyses demonstrate the usefulness of complemental methodological approaches to disentangle the complex biological associations between violence and psychosis.

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• Andreassen, Ole; Malt, Ulrik Fredrik & Melle, Ingrid (2026). Lærebok i psykiatri | Gyldendal. Gyldendal Forlag. ISBN 9788205599277. 1172 s. Fulltekst i vitenarkiv Vis sammendrag

  Boken er den mest omfattende læreboken i psykiatri i Norge.

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• Lunde, Ketil Berge; Qin, Ping; Mehlum, Lars & Melle, Ingrid (2025). Deliberate Self-Harm (DSH) in Young Adults: Patient Characteristics, Follow-Up Psychiatric Care, and Repetition Risk in Norwegian Public Healthcare. Universitetet i Oslo. Fulltekst i vitenarkiv Vis sammendrag

  Deliberate self-harm (DSH), defined as intentional self-injury or poisoning regardless of intent, is a severe consequence of psychological distress and/or mental illness. It is associated with a range of adverse outcomes; most prominently, suicide. A large proportion of patients who present to hospitals with DSH are young adults 18–35 years old. Efforts to improve followup care for these patients are crucial and should be informed by a solid understanding of patient’s characteristics, current treatment provision, and prospective outcomes. Young adults with hospital-presented DSH represent a highly heterogeneous group. Therefore, it is important to enhance our understanding of the heterogeneity of risk factors in this population as well as how clinical factors such as specific psychiatric morbidities and previous DSH influence both treatment provision and prospective outcomes. Accordingly, the aims of this thesis were: 1) to explore independent and interactive associations of a broad range of sociodemographic and health-related factors with hospitalpresented DSH; 2) to investigate rates of, and factors associated with, direct transferal to psychiatric inpatient services following somatic treatment of DSH; and 3) to describe followup psychiatric care within the first week of discharge from general hospital management of DSH, and its association with DSH relapse within three, six, and 12 months. The thesis comprises three self-contained studies and uses data from national longitudinal registers. Acute somatic treatments of DSH in young adults aged 18–35 years were identified in the Norwegian Patient Registry (NPR). Individual-level data on socioeconomic background and medical treatment were interlinked across registers via an encrypted personal identifier. Paper I was a nested case-control study examining socioeconomic and sick-leaverelated risk factors for DSH. Study cases were young adults with an index episode of hospitalpresented DSH within the study period of 2008–2013. These study cases were compared with age- and gender-matched controls derived from a 25% random sample of all Norwegian residents with no record of hospital-presented DSH at the time. We found that low education, current sick leave due to psychiatric disorders, and being divorced had the greatest effects. Subgroup analyses revealed an association between education and sick leave in which the two subgroups with the highest risk were young adults with low education and young adults with high education and recorded sick leave. Paper II used a retrospective cohort design to examine clinical and sociodemographic correlates of admissions to a psychiatric inpatient unit on the same day of discharge from the general hospital. The cohort included all episodes of hospital-treated DSH in young adult patients within the study period of 2008–2018. We found that 21.4% of these episode patients were directly transferred to psychiatric inpatient services after discharge from a general hospital. Prominent correlates of such transferal or admission were a history of psychiatric treatment and recorded diagnoses of psychotic, mood or personality disorders at a general hospital when DSH occurred. When adjusted for other factors, previous DSH presentations were inversely associated with psychiatric inpatient admissions. Paper III also used a retrospective cohort design, which included all young adults with a hospital-presented DSH within the study period of 2010–2017. The status of follow-up psychiatric care within seven days after discharge from a general hospital was categorized as no follow-up, outpatient attendance, or inpatient admission. The outcome of the study was repetition of hospital-presented DSH within three, six, and 12 months; and observed confounders were adjusted using inverse probability of treatment weighting. We found that 37.2% of these patients received follow-up psychiatric care within seven days of discharge from DSH somatic treatment (17.3% psychiatric outpatient attendance; 19.9% inpatient admissions). Those who received psychiatric follow-up were more likely to have a recorded psychiatric morbidity and were also shown to have a high crude risk of repeated DSH. When adjusting for observed psychiatric confounders and sociodemographic status, this risk was attenuated but remained significant for inpatient admissions. Additional analyses indicated that the increased risks associated with inpatient admissions were confined to certain subgroups: those aged 18– 24 years, those without a recorded mood disorder, and first-time DSH presenters. Overall, this thesis has shown that young adults with hospital-presented DSH often had low education or a history of sick leave. Furthermore, follow-up psychiatric care was most likely provided to those with the most complex and severe psychiatric symptoms and with a high risk of relapse. This was especially prominent among those who were psychiatrically hospitalized, which likely explains the high risk of repeated DSH associated with psychiatric inpatient admissions. Interestingly, although young adults with previous DSH had high psychiatric admission rates, the association between previous DSH and psychiatric inpatient admission reversed in adjusted analyses. Moreover, the increased risk associated with psychiatric inpatient admission was largely confined to certain subgroups of patients with no or limited prior contact with psychiatric services, namely those aged 18–24 years, those without a recorded mood disorder, and first-time DSH presenters. As we were less likely to capture differences in the baseline risk of DSH in these subgroups, this indicates that unmeasured confounders largely explained the risk of DSH relapse associated with inpatient admissions. Finally, young adults who presented to a hospital with DSH faced a multitude of adversities in addition to psychiatric morbidity, including socioeconomic disadvantage and sick leave from work. Although distinct risk factor configurations were found, difficulties in the occupational domain were prominent risk factors for DSH, underscoring the importance of coordinated follow-up from both healthcare services and social services in the DSH aftermath.

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