Tom Øresland

• Schultz, Johannes Kurt; Sigurdardottir, Johanna M.; Bakstad, Linda Tøften; Thorisson, Arnar; Yaqub, Sheraz & Chabok, Abbas [Vis alle 8 forfattere av denne artikkelen] (2026). Accuracy and reliability of preoperative CT in perforated diverticulitis: Post hoc secondary analysis from the SCANDIV trial. Scandinavian Journal of Surgery. ISSN 1457-4969. doi: 10.1177/14574969261418419. Fulltekst i vitenarkiv
• Martling, Anna; Myrberg, Ida Hed; Nilbert, Mef; Grönberg, Henrik; Granath, Fredrik & Eklund, Martin [Vis alle 50 forfattere av denne artikkelen] (2025). Low-Dose Aspirin for PI3K-Altered Localized Colorectal Cancer. New England Journal of Medicine. ISSN 0028-4793. 393(11), s. 1051–1064. doi: 10.1056/NEJMoa2504650. Fulltekst i vitenarkiv Vis sammendrag

  Background Aspirin reduces the incidence of colorectal adenoma and colorectal cancer among high-risk persons. Observational studies suggest that aspirin may also improve disease-free survival after diagnosis, particularly among patients with tumors harboring somatic PIK3CA mutations. However, data from randomized trials are lacking. Methods We conducted a double-blind, randomized, placebo-controlled trial involving patients with stage I, II, or III rectal cancer or stage II or III colon cancer with somatic alterations in PI3K pathway genes. The patients were assigned in a 1:1 ratio to receive 160 mg of aspirin or matched placebo once daily for 3 years. Patients with prespecified PIK3CA hotspot mutations in exon 9 or 20 (group A alterations) and those with other moderate- or high-impact somatic variants in PIK3CA, PIK3R1, or PTEN (group B alterations) were eligible for randomization. The primary end point was colorectal cancer recurrence, assessed in a time-to-event analysis, in patients with group A alterations. Secondary end points included colorectal cancer recurrence in patients with group B alterations, disease-free survival, and safety. Results Alterations in PI3K pathway genes were detected in 1103 of 2980 patients (37.0%) with complete genomic data. Of 515 patients with group A alterations and 588 patients with group B alterations, 314 and 312, respectively, were assigned to receive aspirin or placebo. The estimated 3-year cumulative incidence of recurrence was 7.7% with aspirin and 14.1% with placebo (hazard ratio, 0.49; 95% confidence interval [CI], 0.24 to 0.98; P=0.04) among patients with group A alterations and 7.7% and 16.8%, respectively (hazard ratio, 0.42; 95% CI, 0.21 to 0.83), among those with group B alterations. The estimated 3-year disease-free survival was 88.5% with aspirin and 81.4% with placebo (hazard ratio, 0.61; 95% CI, 0.34 to 1.08) among patients with group A alterations and 89.1% and 78.7%, respectively (hazard ratio, 0.51; 95% CI, 0.29 to 0.88), among those with group B alterations. Severe adverse events occurred in 16.8% of aspirin recipients and 11.6% of placebo recipients. Conclusions Aspirin led to a significantly lower incidence of colorectal cancer recurrence than placebo among patients with PIK3CA hotspot mutations in exon 9 or 20 and appeared to have a similar benefit among those with other somatic alterations in PI3K pathway genes. (Funded by the Swedish Research Council and others; ALASCCA ClinicalTrials.gov number, NCT02647099; EudraCT number, 2015-004240-19.)

• Hoel, Anders Telle; J., Catherine Teig; Lindam, Anita; Øresland, Tom & Bjørnland, Kristin (2023). Evaluation of a Group-based Patient Education Program Promoting Self-management in Adults with Hirschsprung Disease and Anorectal Malformations. Journal of Pediatric Surgery. ISSN 0022-3468. 58(12), s. 2332–2336. doi: 10.1016/j.jpedsurg.2023.06.015. Fulltekst i vitenarkiv Vis sammendrag

  Introduction Adults with Hirschsprung disease (HD) and anorectal malformations (ARM) may experience persisting and new somatic and psychosocial problems. Patient education programs (PEPs) may improve self-management in patients with chronic illnesses. The aim of this study was to explore HD and ARM adults’ experiences with and evaluation of a group-based PEP. We also looked at factors that might influence the attendance rate. Method Non-intellectually impaired HD and ARM adults were invited to attend a diagnosis specific PEP at a pelvic floor interdisciplinary center. Eight health care professionals lectured. Aspects of the PEP were graded anonymously in a patient reported experience measure (PREM). Ethical approval was obtained. Results 17% (21/125) of invited adults (10HD, 11ARM) attended four PEPs. 19/21 (90%) PREMs were returned. Participants found meeting peers and sharing experiences especially valuable in addition to improved disease knowledge. Lectures by the pediatric and colorectal surgeons, stoma nurse, and sexologist were rated highest by the participants. The majority reported that the PEP would be helpful in managing everyday life. All participants recommended PEP in adolescence. Factors such as gender and travel distance did not affect attendance rate, but participants were older than non-participants, median 37 versus 24 years (p = 0.01). Conclusion Attendance rates were low among HD and ARM adults invited to a PEP, but participants were overall highly satisfied. Peer support, mutual learning, and increased disease knowledge were seen as invaluable assets of the PEP. A web-based PEP was discouraged, while physical PEPs for both adults and adolescents were encouraged.

• Azhar, Najia; Lambrichts, Daniël; Lange, Johan; Yakub, Sheraz; Øresland, Tom & Schultz, Johannes Kurt [Vis alle 8 forfattere av denne artikkelen] (2023). Laparoscopic lavage for Hinchey III perforated diverticulitis: factors for treatment failure in two randomized clinical trials. British Journal of Surgery. ISSN 0007-1323. 110(7), s. 846–851. doi: 10.1093/bjs/znad114. Fulltekst i vitenarkiv Vis sammendrag

  Abstract Background The Scandinavian Diverticulitis (SCANDIV) trial and the LOLA arm of the LADIES trial randomized patients with Hinchey III perforated diverticulitis to laparoscopic peritoneal lavage or sigmoid resection. The aim of this analysis was to identify risk factors for treatment failure in patients with Hinchey III perforated diverticulitis. Methods This was a post hoc analysis of the SCANDIV trial and LOLA arm. Treatment failure was defined as morbidity requiring general anaesthesia (Clavien–Dindo grade IIIb or higher) within 90 days. Age, sex, BMI, ASA fitness grade, smoking status, previous episodes of diverticulitis, previous abdominal surgery, time to surgery, and surgical competence were all tested in univariable and multivariable logistic regression analyses using an interaction variable. Results The pooled analysis included 222 patients randomized to laparoscopic lavage and primary resection (116 and 106 patients respectively). Univariable analysis found ASA grade to be associated with advanced morbidity in both groups, and the following factors in the laparoscopic lavage group: smoking, corticosteroid use, and BMI. Significant factors for laparoscopic lavage morbidity in multivariable analysis were smoking (OR 7.05, 95 per cent c.i. 2.07 to 23.98; P = 0.002) and corticosteroid use (OR 6.02, 1.54 to 23.51; P = 0.010). Conclusion Active smoking status and corticosteroid use were risk factors for laparoscopic lavage treatment failure (advanced morbidity) in patients with perforated diverticulitis.

• Deputy, Mohammed; Worley, Guy; Patel, Komal; Fletcher, Jordan; Hart, Ailsa & Block, Mattias [Vis alle 9 forfattere av denne artikkelen] (2021). Long-term outcome and quality of life after continent ileostomy for ulcerative colitis: A systematic review. Colorectal Disease. ISSN 1462-8910. 23(9), s. 2286–2299. doi: 10.1111/codi.15788. Fulltekst i vitenarkiv Vis sammendrag

  Aim The continent ileostomy allows evacuation of an ileal reservoir at a time convenient to the patient. It is a surgical option for patients with ulcerative colitis (UC) when a restorative option is not suitable or has not succeeded and the patient does not want a conventional end ileostomy. Continent ileostomy types include the Kock pouch, Barnett continent intestinal reservoir and T-pouch. All of the published evidence on the long-term outcome and quality of life after continent ileostomy for UC was systematically reviewed. Methods A systematic review was performed in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Studies published between 1990 and 2020 were included. A descriptive synthesis was used due to the clinical heterogeneity. Results The search returned 1655 abstracts and after screening of abstracts and full text review, 19 were included in the final review, involving 1602 patients. Operative mortality is low (0%–3.6%) after all types of continent ileostomy but reoperation rates are high (20.8%–65%) because of valve mechanism failures. Rates of fistulae (0%–25.5%) and stomal stenosis (0%–25%) can be relatively high postoperatively. Quality of life scores improve for most patients undergoing continent ileostomy, especially for patients converted from ileal pouch anal anastomosis. Overall, continent ileostomy retention is high in the long-term. Discussion In the long-term, patients report high satisfaction and a good quality of life with continent ileostomy, despite high reoperation rates and complications. Newer technologies may reinvigorate interest in the continent ileostomy for this population.

• Thorsen, Yngve; Stimec, Bojan V.; Lindstrom, Jonas Christoffer; Oresland, Tom & Ignjatovic, Dejan (2021). Stool dynamics after extrinsic nerve injury during right colectomy with extended D3-mesenterectomy. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 56(7), s. 770–776. doi: 10.1080/00365521.2021.1918757. Fulltekst i vitenarkiv Vis sammendrag

  Introduction To improve oncological outcome in right colon cancer surgery, an extended mesenterectomy (D3) is under evaluation. In this procedure, all tissue anterior and posterior to the superior mesenteric vessels from the middle colic to ileocolic artery origin is removed, causing injury to the superior mesenteric nerve plexus. The aim was to study the effects of this injury on bowel dynamics and quality of life (QoL). Methods Patients undergoing right colectomy with conventional D2- and extended D3-mesenterectomy were asked to record stool number and consistency for 60 d after surgery and complete questionnaires regarding QoL and bowel function (BF) before and after recovery from surgery. We compared early postoperative stool dynamics and long-term QoL in the groups and presented graphs depicting the temporal profile of stool numbers and consistency. Results Thirty-three patients operated with a D3-resection and 12 patients with a D2-resection participated. The results revealed significantly higher stool numbers in the D3-group until day 26, with significantly more loose-watery stools until day 40. The most pronounced difference was found on day 9 (Mean difference in the total number of stools: 2.25 stools/day, p=.004. Mean difference in loose-watery stools/day: 2.81 p<.001). About 25% in the D2- and 69.7% in the D3-group reported having more than three stools/day in the early postoperative phase. There were no differences in long-term QoL and BF between the groups except in stool consistency (p=.039). Discussion/conclusions Denervation following extended D3-mesenterectomy leads to transitory reduced consistency and increased frequency. It does not affect long-term QoL or BF.

• Hoel, Anders Telle; Tofft, Louise; Bjørnland, Kristin; Gjone, Inger Helene; J., Catherine Teig & Øresland, Tom [Vis alle 8 forfattere av denne artikkelen] (2020). Reaching adulthood with Hirschsprung's disease: Patient experiences and recommendations for transitional care. Journal of Pediatric Surgery. ISSN 0022-3468. doi: 10.1016/j.jpedsurg.2020.05.015. Fulltekst i vitenarkiv Vis sammendrag

  Background/Purpose The need for transitional care has gained increased focus in the treatment of patients with congenital colorectal disorders. We aimed to acquire in-depth knowledge about the experiences of adult patients with Hirschsprung's disease (HD) and their suggestions for transitional care. Methods Binational study applying gender equal focus group interviews (FGI). Results Seventeen (9 men) of 52 invited patients with median age 29 (19–43) years participated. Three themes evolved from the FGI. “Scarred body and soul” describes the somatic and psychosocial challenges the patients experienced and “limited health literacy on HD” refers to the patients' lack of HD knowledge. “Absent transition” depicts missing transitional care and the patients' inability to find adult HD specialists. The adult HD patients strongly recommended transitional care from early teens with focus on information about HD and establishment of a peer-to-peer program. They also emphasized the possibility of being referred to a pelvic floor center. Conclusions HD negatively influences patients' somatic and psychosocial health in childhood, adolescence and adulthood. Adult HD patients strongly recommend transitional care from early teens and the possibility for referral to a center working with pelvic floor dysfunctions. Level of evidence IV Type of research Clinical

• Azhar, Najia; Buchwald, Pamela; Ansari, Hamza; Schyman, Tommy; Yaqub, Sheraz & Øresland, Tom [Vis alle 7 forfattere av denne artikkelen] (2020). Risk of colorectal cancer following CT-verified acute diverticulitis: a nationwide population-based cohort study. Colorectal Disease. ISSN 1462-8910. s. 1406–1414. doi: 10.1111/codi.15073. Fulltekst i vitenarkiv Vis sammendrag

  Aim Routine colonoscopy to exclude colorectal cancer (CRC) after CT‐verified acute diverticulitis is controversial. This study aimed to compare the incidence of CRC in patients with acute diverticulitis with that in the general population. Method Patients with an emergency admission for diverticular disease to any Norwegian hospital between 1 January 2008 and 31 December 2010 were included through identification in the Norwegian Patient Registry using International Classification of Diseases (ICD‐10) codes K57.1‐9. To estimate the age‐specific distribution of CT‐verified acute uncomplicated diverticulitis (AUD) and acute complicated diverticulitis (ACD) in this nationwide study population, numbers from the largest Norwegian emergency hospital were used. Patients diagnosed with CRC within 1 year following their admission for acute diverticulitis were detected through cross‐matching with the Cancer Registry of Norway. Based on both Norwegian age‐specific incidence of CRC and estimated age‐specific distribution of CT‐verified diverticulitis, standard morbidity ratios (SMRs) were calculated. Results A total of 7473 patients with emergency admissions for diverticular disease were identified (estimated CT‐verified AUD n = 3523, ACD n = 1206); of these 155 patients were diagnosed with CRC within 1 year. Eighty had a CT‐verified diverticulitis at index admission [41 AUD (51.3%); 39 ACD (49.7%)]. Compared with the general population, the SMR was 6.6 following CT‐verified AUD and 16.3 following ACD, respectively. Conclusion In the first year after CT‐verified acute diverticulitis, especially after ACD, the risk of CRC is higher than in the general population. This probably represents misdiagnosis of CRC as acute diverticulitis. Follow‐up colonoscopy should be recommended to all patients admitted with acute diverticulitis.

• Azhar, Najia; Johanssen, Anette; Sundström, Tove; Folkesson, Joakim; Wallon, Conny & Kørner, Hartwig [Vis alle 12 forfattere av denne artikkelen] (2020). Laparoscopic lavage vs primary resection for acute perforated diverticulitis: Long-term outcomes from the Scandinavian Diverticulitis (SCANDIV) randomized clinical trial. JAMA Surgery. ISSN 2168-6254. s. 1–7. doi: 10.1001/jamasurg.2020.5618. Fulltekst i vitenarkiv
• Gallo, Gaetano; Pata, Francesco; Vennix, S.; Laurberg, S.; Morton, D. & Rubbini, M. [Vis alle 1 087 forfattere av denne artikkelen] (2020). Predictors for anastomotic leak, postoperative complications, and mortality after right colectomy for cancer: Results from an international snapshot audit. Diseases of the Colon & Rectum. ISSN 0012-3706. 63(5), s. 606–618. doi: 10.1097/DCR.0000000000001590. Fulltekst i vitenarkiv
• Tofft, Louise; Hoel, Anders Telle; Håkansson, Carita; Zawadzki, Antoni; Gjone, Inger Helene & Øresland, Tom [Vis alle 8 forfattere av denne artikkelen] (2020). Key components of successful transition for adolescents born with anorectal malformations-a Nordic focus group study. International Journal of Adolescent Medicine and Health. ISSN 0334-0139. s. 1–8. doi: 10.1515/ijamh-2020-0052. Fulltekst i vitenarkiv
• Thorsen, Yngve; Stimec, Bojan Vladimir; Lindstrøm, Jonas Christoffer; Næsgaard, Jens Marius; Øresland, Tom & Ignjatovic, Dejan (2019). Bowel Motility After Injury to the Superior Mesenteric Plexus During D3 Extended Mesenterectomy. Journal of Surgical Research. ISSN 0022-4804. 239, s. 115–124. doi: 10.1016/j.jss.2019.02.004. Fulltekst i vitenarkiv
• Sunde, Marie Louise; Negård, Anne; Øresland, Tom; Bakka, Njål; Geitung, Jonn Terje & Færden, Arne Engebreth (2018). MRI defecography of the ileal pouch-anal anastomosis?contributes little to the understanding of functional outcome. International Journal of Colorectal Disease. ISSN 0179-1958. 33(5), s. 609–617. doi: 10.1007/s00384-018-3011-0. Fulltekst i vitenarkiv
• Augestad, Knut Magne; Keller, Deborah S.; Bakaki, Paul M.; Rose, Johnie; Koroukian, Siran M. & Øresland, Tom [Vis alle 7 forfattere av denne artikkelen] (2018). The impact of rectal cancer tumor height on recurrence rates and metastatic location: A competing risk analysis of a national database. Cancer Epidemiology. ISSN 1877-7821. 53, s. 56–64. doi: 10.1016/j.canep.2018.01.009. Fulltekst i vitenarkiv
• Sunde, Marie Louise; Ricanek, Petr; Øresland, Tom; Jahnsen, Jørgen; Naimy, Nazir & Færden, Arne Engebreth (2018). Determinants of optimal bowel function in ileal pouch-anal-anastomosis - physiological differences contributing to pouch function. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 53(1), s. 8–14. doi: 10.1080/00365521.2017.1390601. Fulltekst i vitenarkiv
• El-Hussuna, Alaa; Pinkney, Thomas; Zmora, Oded; Frasson, Murili Zomer; Bhangu, Aneel & Battersby, Nicholas J. [Vis alle 24 forfattere av denne artikkelen] (2018). Risk factors for unfavourable postoperative outcome in patients with Crohn’s disease undergoing right hemicolectomy or ileocaecal resection. An international audit by ESCP and S-ECCO. Colorectal Disease. ISSN 1462-8910. 20(3), s. 219–227. doi: 10.1111/codi.13889. Fulltekst i vitenarkiv
• Willard, Christer-Daniel; Kjæstad, Erik; Stimec, Bojan; Edwin, Bjørn; Ignjatovic, Dejan & Øresland, Tom [Vis alle 32 forfattere av denne artikkelen] (2018). Preoperative anatomical road mapping reduces variability of operating time, estimated blood loss, and lymph node yield in right colectomy with extended D3 mesenterectomy for cancer. International Journal of Colorectal Disease. ISSN 0179-1958. 34(1), s. 151–160. doi: 10.1007/s00384-018-3177-5. Fulltekst i vitenarkiv
• Bondi, Johan Fridtjof; Avdagic, Jasna; Karlbom, U; Hallbook, O; Kalman, D & Benth, Jurate Saltyte [Vis alle 8 forfattere av denne artikkelen] (2017). Randomized clinical trial comparing collagen plug and advancement flap for trans-sphincteric anal fistula. British Journal of Surgery. ISSN 0007-1323. 104(9), s. 1160–1166. doi: 10.1002/bjs.10549. Fulltekst i vitenarkiv
• Sunde, Marie Louise; Øresland, Tom & Færden, Arne Engebreth (2017). Restorative proctocolectomy with two different pouch designs: few complications with good function. Colorectal Disease. ISSN 1462-8910. 19(4), s. 363–371. doi: 10.1111/codi.13478. Fulltekst i vitenarkiv
• Schultz, Johannes Kurt; Wallon, Conny; Blecic, Liljana; Forsmo, Håvard Mjørud; Folkesson, Joakim & Buchwald, Pamela [Vis alle 10 forfattere av denne artikkelen] (2017). One-year results of the SCANDIV randomized clinical trial of laparoscopic lavage versus primary resection for acute perforated diverticulitis. British Journal of Surgery. ISSN 0007-1323. 104(10), s. 1382–1392. doi: 10.1002/bjs.10567. Fulltekst i vitenarkiv
• Schultz, Johannes Kurt; Yaqub, Sheraz & Øresland, Tom (2016). Management of diverticular disease in scandinavia. Journal of Clinical Gastroenterology. ISSN 0192-0790. 50, s. S50–S52. doi: 10.1097/MCG.0000000000000642. Fulltekst i vitenarkiv
• Thorsen, Yngve; Stimec, Bojan V.; Andersen, Solveig Norheim; Lindstrøm, Jonas Christoffer; Pfeffer, Frank & Øresland, Tom [Vis alle 8 forfattere av denne artikkelen] (2016). Bowel function and quality of life after superior mesenteric nerve plexus transection in right colectomy with D3 extended mesenterectomy. Techniques in Coloproctology. ISSN 1123-6337. s. 1–9. doi: 10.1007/s10151-016-1466-y. Fulltekst i vitenarkiv Vis sammendrag

  Background: The aim of this study was to ascertain the impact of injury to the superior mesenteric nerve plexus caused by right colectomy with D3 extended mesenterectomy as performed in the prospective multicenter trial: “Safe Radical D3 Right Hemicolectomy for Cancer through Preoperative Biphasic Multi-detector Computed Tomography” in which all soft tissue surrounding the superior mesenteric vessels from the level of the middle colic artery to that of the ileocolic artery was removed. Methods: Bowel function and gastrointestinal quality of life in two consecutive cohorts that underwent right colectomy with and without D3 extended mesenterectomy were compared. Main outcome measures were the Diarrhea Assessment Scale (DAS) and Gastrointestinal Quality of Life Index (GIQLI). The data were collected prospectively through telephone interviews. Results: Forty-nine patients per group, comparable for age, sex, length of bowel resected but with significantly shorter follow-up time in the experimental group, were included. There was no difference in total DAS scores, subscores or additional questions except for higher bowel frequency scores in the D3 group (p = 0.02). Comparison of total GIQLI scores and subscales showed no difference between groups. Regression analysis with correction for confounding factors showed 0.48 lower bowel frequency scores in the D2 group (p = 0.022). Within the D3 group presence of jejunal arteries cranial to the D3 dissection area showed 1.78 lower DAS scores and 0.7 lower bowel frequency scores. Conclusions: Small bowel denervation after right colectomy with D3 extended mesenterectomy leads to increased bowel frequency but does not impact gastrointestinal quality of life. Individual anatomical variants can affect postoperative bowel function differently despite standardized surgery.

• Bengtsson, J.; Adlerberth, I.; Östblom, A.; Saksena, P.; Øresland, Tom & Börjesson, L. (2016). Effect of probiotics (Lactobacillus plantarum 299 plus Bifidobacterium Cure21) in patients with poor ileal pouch function: A randomised controlled trial. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 51(9), s. 1087–1092. doi: 10.3109/00365521.2016.1161067. Fulltekst i vitenarkiv
• J., Catherine Teig; Bond, Malcolm J.; Cvancarova, MS; Engh, ME; kjøllesdal, m & Øresland, Tom [Vis alle 8 forfattere av denne artikkelen] (2016). Translation And Validation Of Condition-Specific Quality Of Life Pfdi-20 And Pfiq-7 Questionnaires For Women With Pelvic Floor Dysfunction In The Norwegian Context. Value in Health. ISSN 1098-3015. 19(7). doi: 10.1016/j.jval.2016.09.332. Fulltekst i vitenarkiv
• Brochmann, Nina Dølvik; Schultz, Johannes Kurt; Jakobsen, Gunn Signe & Øresland, Tom (2016). Management of acute uncomplicated diverticulitis without antibiotics: a single-centre cohort study. Colorectal Disease. ISSN 1462-8910. 18(11), s. 1101–1107. doi: 10.1111/codi.13355. Fulltekst i vitenarkiv
• Sunde, Marie Louise; Øresland, Tom & Færden, Arne Engebret (2016). Correlation between pouch function and sexual function in patients with IPAA. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 51(3), s. 295–303. doi: 10.3109/00365521.2015.1093165. Fulltekst i vitenarkiv
• Schultz, Johannes Kurt; Yaqub, Sheraz; Wallon, Conny; Blecic, Liljana; Forsmo, Håvard Mjørud & Folkesson, Joakim [Vis alle 10 forfattere av denne artikkelen] (2015). Laparoscopic lavage vs primary resection for acute perforated diverticulitis: The SCANDIV randomized clinical trial. Journal of the American Medical Association (JAMA). ISSN 0098-7484. 314(13), s. 1364–1375. doi: 10.1001/jama.2015.12076. Fulltekst i vitenarkiv Vis sammendrag

  IMPORTANCE Perforated colonic diverticulitis usually requires surgical resection, which is associated with significant morbidity. Cohort studies have suggested that laparoscopic lavage may treat perforated diverticulitis with less morbidity than resection procedures. OBJECTIVE To compare the outcomes from laparoscopic lavage with those for colon resection for perforated diverticulitis. DESIGN, SETTING, AND PARTICIPANTS Multicenter, randomized clinical superiority trial recruiting participants from 21 centers in Sweden and Norway from February 2010to June 2014. The last patient follow-upwas in December 2014 and final review and verification of the medical records was assessed in March 2015. Patients with suspected perforated diverticulitis, a clinical indication for emergency surgery, and free air on an abdominal computed tomography scanwere eligible. Of 509 patients screened, 415were eligible and 199were enrolled. INTERVENTIONS Patients were assigned to undergo laparoscopic peritoneal lavage (n = 101) or colon resection (n = 98) based on a computer-generated, center-stratified block randomization. All patients with fecal peritonitis (15 patients in the laparoscopic peritoneal lavage group vs 13 in the colon resection group) underwent colon resection. Patients with a pathology requiring treatment beyond that necessary for perforated diverticulitis (12 in the laparoscopic lavage group vs 13 in the colon resection group) were also excluded from the protocol operations and treated as required for the pathology encountered. MAIN OUTCOMES AND MEASURES The primary outcomewas severe postoperative complications (Clavien-Dindo score >IIIa) within 90 days. Secondary outcomes included other postoperative complications, reoperations, length of operating time, length of postoperative hospital stay, and quality of life. RESULTS The primary outcome was observed in 31 of 101 patients (30.7%) in the laparoscopic lavage group and 25 of 96 patients (26.0%) in the colon resection group (difference, 4.7% [95%CI, −7.9%to 17.0%]; P = .53). Mortality at 90 days did not significantly differ between the laparoscopic lavage group (14 patients [13.9%]) and the colon resection group (11 patients [11.5%]; difference, 2.4%[95%CI, −7.2%to 11.9%]; P = .67). The reoperation rate was significantly higher in the laparoscopic lavage group (15 of 74 patients [20.3%]) than in the colon resection group (4 of 70 patients [5.7%]; difference, 14.6%[95%CI, 3.5%to 25.6%]; P = .01) for patients who did not have fecal peritonitis. The length of operating time was significantly shorter in the laparoscopic lavage group; whereas, length of postoperative hospital stay and quality of life did not differ significantly between groups. Four sigmoid carcinomas were missed with laparoscopic lavage. CONCLUSIONS AND RELEVANCE Among patients with likely perforated diverticulitis and undergoing emergency surgery, the use of laparoscopic lavage vs primary resection did not reduce severe postoperative complications and led toworse outcomes in secondary end points. These findings do not support laparoscopic lavage for treatment of perforated diverticulitis. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT01047462

• Øresland, Tom (2015). Validation of the Inflammatory Bowel Disease Disability Index in a population-based cohort. Gut. ISSN 0017-5749. doi: 10.1136/gutjnl-2015-310151. Fulltekst i vitenarkiv
• Øresland, Tom & Færden, Arne Engebret (2015). Surgery in the age of biological treatment. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 50(1), s. 121–127. doi: 10.3109/00365521.2014.972445. Fulltekst i vitenarkiv
• Myrelid, P & Øresland, Tom (2015). A reappraisal of the ileo-rectal anastomosis in ulcerative colitis. Journal - Crohn's and Colitis Foundation of Canada. ISSN 1197-4982. 9(6), s. 433–438. doi: 10.1093/ecco-jcc/jjv060. Fulltekst i vitenarkiv
• Øresland, Tom; Bemelman, Willem A.; Sampietro, Gianluca; Spinelli, Antonio; Windsor, Alastair & Ferrante, Marc [Vis alle 26 forfattere av denne artikkelen] (2015). European evidence based consensus on surgery for ulcerative colitis. Journal - Crohn's and Colitis Foundation of Canada. ISSN 1197-4982. s. 4–25. doi: 10.1016/j.crohns.2014.08.012. Fulltekst i vitenarkiv
• Gower-Rousseauc, C; Savoye, G; Tavernier, N; Fumery, M; Sandborn, William J. & Feagan, BG [Vis alle 9 forfattere av denne artikkelen] (2015). Validation of the Infl ammatory Bowel Disease Disability Index in a population-based cohort. Gut. ISSN 0017-5749. doi: 10.1136/gutjnl-2015-310151. Fulltekst i vitenarkiv
• Dignass, Axel; Eliakim, R; Magro, F; Maaser, C; Chowers, Y & Geboes, K [Vis alle 42 forfattere av denne artikkelen] (2014). Segundo Consenso Europeo basado en evidencia sobre el diagnóstico y tratamiento de la colitis ulcerosa crónica idiopática Parte 1: Definiciones y diagnóstico (versión española) (Spanish version). Revista de Gastroenterologia de Mexico. ISSN 0375-0906. 79(4), s. 263–289. doi: 10.1016/j.rgmx.2014.10.001. Fulltekst i vitenarkiv
• Øresland, Tom; Bemelman, Willem A.; Sampietro, Gianluca; Spinelli, Antonio; Windsor, Alastair & Tiret, Emmanuel [Vis alle 25 forfattere av denne artikkelen] (2014). European evidence based consensus on surgery for ulcerative colitis. Journal - Crohn's and Colitis Foundation of Canada. ISSN 1197-4982. 1, s. 4–25. doi: 10.1016/j.crohns.2014.08.012. Fulltekst i vitenarkiv
• Myrelid, P; Marti-Gallostra, M; Ashraf, S; Sunde, Marie Louise; Tholin, M & Øresland, Tom [Vis alle 10 forfattere av denne artikkelen] (2014). Complications in surgery for Crohn's disease after preoperative antitumour necrosis factor therapy. British Journal of Surgery. ISSN 0007-1323. 101(5), s. 539–545. doi: 10.1002/bjs.9439. Fulltekst i vitenarkiv
• Block, M; Jørgensen, Kristin Kaasen; Øresland, Tom; Lindholm, E; Grzyb, Krzysztof & Småstuen, Milada Cvancarova [Vis alle 9 forfattere av denne artikkelen] (2014). Colectomy for patients with ulcerative colitis and primary sclerosing cholangitis - What next? Journal of Crohn's and Colitis. ISSN 1873-9946. 8(5), s. 421–430. doi: 10.1016/j.crohns.2013.10.008. Fulltekst i vitenarkiv
• Strigard, K; Øresland, Tom; Rutegard, J & Gunnarsson, U (2011). Transcutaneous implant evacuation system: a new approach to continent stoma construction. Colorectal Disease. ISSN 1462-8910. 13(11), s. E379–E382. doi: 10.1111/j.1463-1318.2011.02739.x. Fulltekst i vitenarkiv
• Pariente, Benjamin; Cosnes, Jacques; Danese, Silvio; Sandborn, William J.; Lewin, Maïté & Fletcher, Joel G. [Vis alle 31 forfattere av denne artikkelen] (2011). Development of the Crohn's Disease Digestive Damage Score, the Lemann Score. Inflammatory Bowel Diseases. ISSN 1078-0998. 17(6), s. 1415–1422. doi: 10.1002/ibd.21506. Fulltekst i vitenarkiv
• Bengtsson, Jonas; Lindholm, Elisabeth; Nordgren, Svante; Berndtsson, Ina; Øresland, Tom & Börjesson, Lars (2011). Sexual function after failed ileal pouch-anal anastomosis. Journal - Crohn's and Colitis Foundation of Canada. ISSN 1197-4982. 5(5), s. 407–414. doi: 10.1016/j.crohns.2011.04.002. Fulltekst i vitenarkiv
• Woude, C. Janneke van der; Kolacek, Sanja; Dotan, Iris; Øresland, Tom; Vermeire, Severine & Munkholm, Pia [Vis alle 9 forfattere av denne artikkelen] (2010). European evidenced-based consensus on reproduction in inflammatory bowel disease. Journal - Crohn's and Colitis Foundation of Canada. ISSN 1197-4982. 4(5), s. 493–510. doi: 10.1016/j.crohns.2010.07.004. Fulltekst i vitenarkiv
• Dignass, Axel; Assche, Gert van; Lindsay, JO; Lemann, M; Soderholm, J & Colombel, JF [Vis alle 17 forfattere av denne artikkelen] (2010). The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management. Journal - Crohn's and Colitis Foundation of Canada. ISSN 1197-4982. 4(1), s. 28–62. doi: 10.1016/j.crohns.2009.12.002. Fulltekst i vitenarkiv
• Angenete, E; Øresland, Tom; Falk, P; Breimer, M; Hultborn, R & Ivarsson, ML (2009). Preoperative radiotherapy and extracellular matrix remodeling in rectal mucosa and tumour matrix metalloproteinases and plasminogen components. Acta Oncologica. ISSN 0284-186X. 48(8), s. 1144–1151. doi: 10.3109/02841860903150510. Fulltekst i vitenarkiv
• Block, M; Borjesson, L; Lindholm, E & Øresland, Tom (2009). Pouch design and long-term functional outcome after ileal pouch-anal anastomosis. British Journal of Surgery. ISSN 0007-1323. 96(5), s. 527–532. doi: 10.1002/bjs.6590. Fulltekst i vitenarkiv
• Juillerat, P; Vader, JP; Felley, C; Pittet, V; Gonvers, JJ & Mottet, C [Vis alle 12 forfattere av denne artikkelen] (2009). Appropriate maintenance treatment for Crohn's disease: Results of a multidisciplinary international expert panel - EPACT II. Journal - Crohn's and Colitis Foundation of Canada. ISSN 1197-4982. 3(4), s. 241–249. doi: 10.1016/j.crohns.2009.05.002. Fulltekst i vitenarkiv
• Angenete, E; Langenskiold, Marcus; Palmgren, Ingrid; Falk, P; Øresland, Tom & Ivarsson, ML (2009). uPA and PAI-1 in Rectal Cancer - Relationship to Radiotherapy and Clinical Outcome. Journal of Surgical Research. ISSN 0022-4804. 153(1), s. 46–53. doi: 10.1016/j.jss.2008.02.043. Fulltekst i vitenarkiv
• Elkjaer, M; Moser, G; Reinisch, W; Durovicova, D; Lukas, M & Vucelic, B [Vis alle 18 forfattere av denne artikkelen] (2008). IBD patients need in health quality of care ECCO consensus. Journal - Crohn's and Colitis Foundation of Canada. ISSN 1197-4982. 2(2), s. 181–188. doi: 10.1016/j.crohns.2008.02.001. Fulltekst i vitenarkiv

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• Øresland, Tom (2017). Coloproctology: Indeterminate Colitis. Springer. ISBN 9783662532102. 447 s. Fulltekst i vitenarkiv

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• Remzi, Feza H.; Panis, Yves; Spinelli, Antonino; Kotze, Paulo G.; Mantzaris, Gerassimos J. & Söderholm, Johan D. [Vis alle 13 forfattere av denne artikkelen] (2020). International Organization for the Study of IBD Recommendations for Surgery in Patients with IBD during the Coronavirus Disease 2019 Pandemic. Diseases of the Colon & Rectum. ISSN 0012-3706. 63(7), s. 870–873. doi: 10.1097/DCR.0000000000001718. Fulltekst i vitenarkiv
• Øresland, Tom & Færden, Arne Engebreth (2019). The transcutaneous implant evacuation system, the TIES device. Colorectal Disease. ISSN 1462-8910. 21(6), s. 723–724. doi: 10.1111/codi.14625. Fulltekst i vitenarkiv
• Alsøe, Lene; Wennerström, Anna Berit; Liu, Yan; Esbensen, Qin Ying; Bjørset, Randi & Penz, Christine [Vis alle 10 forfattere av denne artikkelen] (2018). Do APOBEC proteins contribute to genomic instability in colitis-associated colorectal cancer? Fulltekst i vitenarkiv
• Alsøe, Lene; Wennerstrøm, Anna; Liu, Yan; Esbensen, Qin Ying; Bjørseth, Randi & Penz, Christine [Vis alle 10 forfattere av denne artikkelen] (2017). Do APOBEC proteins contribute to genomic instability in colitis-associated colorectal cancer? Fulltekst i vitenarkiv
• Alsøe, Lene; Wennerstrøm, Anna; Liu, Yan; Esbensen, Qin Ying; Bjørseth, Randi & Penz, Christine [Vis alle 10 forfattere av denne artikkelen] (2017). Do APOBEC proteins contribute to genomic instability in colitis-associated colorectal cancer? Fulltekst i vitenarkiv
• Schultz, Johannes Kurt; Yaqub, Sheraz & Øresland, Tom (2016). Privacy policies of android diabetes apps and sharing of health information: In reply. Journal of the American Medical Association (JAMA). ISSN 0098-7484. 315(10), s. 1053–1054. Fulltekst i vitenarkiv
• Planke, Catherine; Martini, A; Engh, Marie Ellström; Øresland, Tom; Cvancarova, M & Grotle, M [Vis alle 8 forfattere av denne artikkelen] (2015). TRANSLATION AND VALIDATION OF CONDITION-SPECIFIC QUALITY OF LIFE QUESTIONNAIRES FOR WOMEN WITH PELVIC ORGAN PROLAPSE IN THE NORWEGIAN CONTEXT. Fulltekst i vitenarkiv
• Øresland, Tom (2010). Ulcerative colitis: failed tacrolimus - infliximab or surgery? Alimentary Pharmacology and Therapeutics. ISSN 0269-2813. 32(2), s. 308–309. doi: 10.1111/j.1365-2036.2010.04343.x. Fulltekst i vitenarkiv

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