Chromatin Regulation in Adipose Stem Cells
Cell fate decisions are programmed by interactions between multiple layers of regulation of gene expression involving chromatin modifications and a dynamic organization of the genome in the 3-dimensional space of the cell nucleus.
Nuclear foci of histone variant H3.3 and associated chaperones. Illustration: CollasLab
Our laboratory "CollasLab" is interested in understanding chromatin features that pattern the 3-dimensional architecture and differentiation potential of adipose stem cells. To this end we combine cell biological, biochemical, imaging, genomics and computational approaches.