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Published Aug. 7, 2018 3:11 PM

Binding of growth factors to their receptors is known to cause endocytosis and degradation of the receptors and their ligands by a mechanism that involves the endosomal sorting complex required for transport (ESCRT) machinery. Failure of this mechanism can lead to cancer development. In a recent paper in Nature Communications, a team led by project leaders Eva Wenzel and Camilla Raiborg at Institute for Cancer Research and Centre for Cancer Cell Reprogramming has used advanced microscopy methods to reveal the dynamics of ESCRT recruitment and formation of multivesicular endosomes (MVEs) into which the receptor-ligand complexes are sorted for subsequent degradation.

Published May 18, 2018 10:14 AM

Check out the brand-new CanCell blog where we will post popular science texts about our research on a regular basis. Our blog is intended for a general audience with a special interest for cancer research as well as for other scientists.