Diet and atherosclerosis
Our primary interest is the relation between nutrients and inflammatory markers.
In particular we are focusing on the role of inflammation in patients with high risk of cardiovascular disease such as familial hypercholesterolemia. Additionally, we investigate how the intake of a whole diet, single dietary components or nutrients may modulate these inflammatory markers and thereby influence health.
We do translational research and perform clinical intervention studies both with patients and healthy individuals, and investigate the effects at cellular and molecular level. We have many years of experience by using peripheral blood mononuclear cells as a model system because these cells have been shown to be a sensitive modelsystem. We study the gene expression level and also culture these patient-derived cells ex vivo. This gives us the possibility to study how food components may influence cellular pathways in order to gain a more thorough understanding of the underlying mechanisms as to how food components influence our health. We also use new –omics-technology (lipidomics/transcriptomics/metabololmics) to characterize the effects of different dietary components both at cellular level and in plasma.