Diet, cholesterol, inflammation and atherosclerosis
Our primary interest is to study dietary prevention of cholesterol-induced inflammation in early atherosclerosis.
In particular we are focusing on the role of cholesterol-induced inflammation in atherosclerosis in patients with high risk of cardiovascular disease such as familial hypercholesterolemia. Additionally, we investigate how dietary intake ( whole diet, single dietary components or nutrients) may modulate these inflammatory markers and thereby influence cardiovascular risk.
We do translational research and perform clinical intervention studies both with patients and healthy individuals, and investigate the effects at cellular and molecular level. We use peripheral blood mononuclear cells as a model system and study the gene expression level and also culture these patient-derived cells ex vivo. This gives us the possibility to study how dietary components may influence cellular pathways in order to gain a more thorough understanding of the underlying mechanisms as to how food components influence our health. We also use transcriptomics and metabololmics to characterize the effects of different dietary components both at cellular level and in plasma.