Hilde Kristin Brekke

• Øyri, Linn Kristin Lie; Bogsrud, Martin Prøven; Christensen, Jacob J.; Ulven, Stine Marie; Brantsæter, Anne Lise & Retterstøl, Kjetil [Vis alle 13 forfattere av denne artikkelen] (2021). Novel associations between parental and newborn cord blood metabolic profiles in the Norwegian Mother, Father and Child Cohort Study. BMC Medicine. ISSN 1741-7015. 19(19). doi: 10.1186/s12916-021-01959-w Fulltekst i vitenarkiv Vis sammendrag

  Background:More than one third of Norwegian women and men between 20 and 40 years of age have elevated cholesterol concentration. Parental metabolic health around conception or during pregnancy may affect the offspring’s cardiovascular disease risk. Lipids are important for fetal development, but the determinants of cord blood lipids have scarcely been studied. We therefore aimed to describe the associations between maternal andpaternal peri-pregnancy lipid and metabolic profile and newborn cord blood lipid and metabolic profile. Methods:This study is based on 710 mother–father–newborn trios from the Norwegian Mother, Father and ChildCohort Study (MoBa) and uses data from the Medical Birth Registry of Norway (MBRN). The sample included in thisstudy consisted of parents with and without self-reported hypercholesterolemia the last 6 months before pregnancy and their partners and newborns. Sixty-four cord blood metabolites detected by nuclear magnetic resonance spectroscopy were analyzed by linear mixed model analyses. The false discovery rate procedure wasused to correct for multiple testing. Results:Among mothers with hypercholesterolemia, maternal and newborn plasma high-density lipoproteincholesterol, apolipoprotein A1, linoleic acid, docosahexaenoic acid, alanine, glutamine, isoleucine, leucine, valine,creatinine, and particle concentration of medium high-density lipoprotein were significantly positively associated(0.001≤q≤0.09). Among mothers without hypercholesterolemia, maternal and newborn linoleic acid, valine,tyrosine, citrate, creatinine, high-density lipoprotein size, and particle concentration of small high-density lipoproteinwere significantly positively associated (0.02≤q≤0.08). Among fathers with hypercholesterolemia, paternal andnewborn ratio of apolipoprotein B to apolipoprotein A1 were significantly positively associated (q= 0.04). Amongfathers without hypercholesterolemia, no significant associations were found between paternal and newbornmetabolites. Sex differences were found for many cord blood lipids. Conclusions:Maternal and paternal metabolites and newborn sex were associated with several cord bloodmetabolites. This may potentially affect the offspring’s long-term cardiovascular disease risk.Keywords:MoBa, the Norwegian Mother, Father and Child Cohort Study, MBRN, Medical Birth Registry of Norway,Cholesterol, Metabolic profiling, Cord blood, Sex differences

• Gharagozlian, Sedegheh; Mala, Tom; Brekke, Hilde Kristin; Kolbjørnsen, Lisa Cornelia; Ullerud, Åslaug Asgeirsdatter & Johnson, Egil (2020). Nutritional status, sarcopenia, gastrointestinal symptoms and quality of life after gastrectomy for cancer - A cross-sectional pilot study. Clinical Nutrition ESPEN. ISSN 2405-4577. 37, s. 195–201. doi: 10.1016/j.clnesp.2020.03.001 Fulltekst i vitenarkiv
• Nesse, Siri Halland; Ottestad, Inger; Winkvist, Anna; Bertz, Fredrik; Ellegård, Lars & Brekke, Hilde Kristin (2020). Predictive equations for estimating resting energy expenditure in women with overweight and obesity at three postpartum stages. Journal of Nutritional Science (JNS). ISSN 2048-6790. 9. doi: 10.1017/jns.2020.16 Fulltekst i vitenarkiv
• Klingberg, Sofia; Brekke, Hilde Kristin & Ludvigsson, Johnny (2019). Introduction of fish and other foods during infancy and risk of asthma in the All Babies In Southeast Sweden cohort study . European Journal of Pediatrics. ISSN 0340-6199. 178(3), s. 395–402. doi: 10.1007/s00431-018-03312-5 Fulltekst i vitenarkiv
• Hagberg, Lars; Winkvist, Anna; Brekke, Hilde Kristin; Bertz, Fredrik; Hellebø Johansson, Else & Huseinovic, Ena (2019). Cost-effectiveness and quality of life of a diet intervention postpartum: 2-year results from a randomized controlled trial. BMC Public Health. ISSN 1471-2458. 8(19). doi: 10.1186/s12889-018-6356-y Fulltekst i vitenarkiv
• Hansson, Patrik; Holven, Kirsten Bjørklund; Øyri, Linn Kristin Lie; Brekke, Hilde Kristin; Gjevestad, Gyrd Omholt & Thoresen, Magne [Vis alle 7 forfattere av denne artikkelen] (2019). Sex differences in postprandial responses to different dairy products on lipoprotein subclasses: A randomised controlled cross-over trial. British Journal of Nutrition. ISSN 0007-1145. 122(7), s. 780–789. doi: 10.1017/S0007114519001429 Fulltekst i vitenarkiv
• Hansson, Patrik; Holven, Kirsten Bjørklund; Øyri, Linn Kristin Lie; Brekke, Hilde Kristin; Gjevestad, Gyrd Omholt & Rehfeld, Jens Frederik [Vis alle 9 forfattere av denne artikkelen] (2019). Dairy products influence gut hormone secretion and appetite differently: A randomized controlled crossover trial. Journal of Dairy Science (JDS). ISSN 0022-0302. 103(2), s. 1100 –1109. doi: 10.3168/jds.2019-16863 Fulltekst i vitenarkiv
• Hansson, Patrik; Holven, Kirsten Bjørklund; Øyri, Linn Kristin Lie; Brekke, Hilde Kristin; Biong, Anne Sofie & Gjevestad, Gyrd Omholt [Vis alle 10 forfattere av denne artikkelen] (2019). Meals with Similar Fat Content from Different Dairy Products Induce Different Postprandial Triglyceride Responses in Healthy Adults: A Randomized Controlled Cross-Over Trial. Journal of Nutrition. ISSN 0022-3166. 149(3), s. 422–431. doi: 10.1093/jn/nxy291 Fulltekst i vitenarkiv
• Øyri, Linn Kristin Lie; Bogsrud, Martin Prøven; Kristiansen, Anne Lene; Myhre, Jannicke Borch; Retterstøl, Kjetil & Brekke, Hilde Kristin [Vis alle 9 forfattere av denne artikkelen] (2019). Infant cholesterol and glycated hemoglobin concentrations vary widely - associations with breastfeeding, infant diet and maternal biomarkers . Acta Paediatrica. ISSN 0803-5253. 109(1), s. 115–121. doi: 10.1111/apa.14936 Fulltekst i vitenarkiv Vis sammendrag

  Aim: Elevated total cholesterol (TC) and glycated hemoglobin (HbA1c) are risk factors for cardiovascular disease however little is known about their determinants in infants. We aimed to describe TC and HbA1c concentrations in infants aged 8-14 months, and explore the relation between infant TC, HbA1c, breastfeeding, infant diet, and maternal TC and HbA1c. Methods: In this cross-sectional pilot study, mothers of infants aged 6 and 12 months were invited to complete a food frequency questionnaire and to take home-based dried blood spot samples from themselves and their infants. Results: Among the 143 included infants, the mean (SD, range) concentration was 4.1 (0.8, 2.3-6.6) mmol/L for TC and 4.9 (0.4, 3.7-6.0) % for HbA1c. There was no significant difference between age groups or sexes. There was a positive relation between TC concentrations of all infants and mothers (B=0.30 unadjusted, B=0.32 adjusted, P<0.001 for both), and a negative relation between infant TC and intake of unsaturated fatty acids in the oldest age group (B=-0.09, P=0.03 unadjusted, B=-0.08, P=0.06 adjusted). Infant HbA1c was not significantly related to diet or maternal HbA1c. Conclusion: TC and HbA1c concentrations varied widely among infants aged 8-14 months. Infant TC was associated with macronutrient intake and maternal TC.

• Huseinovic, Ena; Bertz, Fredrik; Brekke, Hilde Kristin & Winkvist, Anna (2018). Two-year follow-up of a postpartum weight loss intervention: Results from a randomized controlled trial. Maternal & Child Nutrition. ISSN 1740-8695. 14(2). doi: 10.1111/mcn.12539
• Klingberg, Sofia; Ludvigsson, Johnny & Brekke, Hilde Kristin (2017). Introduction of complementary foods in Sweeden and impact of maternal education on feeding practices. Public Health Nutrition. ISSN 1368-9800. 20(6), s. 1054–1062. doi: 10.1017/S1368980016003104
• Klingberg, Sofia; Brekke, Hilde Kristin; Winkvist, Anna; Engström, Gunnar; Hedblad, B & Drake, Isabel (2017). Parity, weight change, and maternal risk of cardiovascular events. American Journal of Obstetrics and Gynecology. ISSN 0002-9378. 216(2), s. 172.e1–172.e15. doi: 10.1016/j.ajog.2016.09.105
• Karin, Jonsson; Malin, Barman; Brekke, Hilde Kristin; Hasselmar, B; Johansen, S & Sandberg, AS [Vis alle 7 forfattere av denne artikkelen] (2017). Late introduction of fish and eggs is associated with increased risk of allergy development - results from the FARMFLORA birth cohort. Food & Nutrition Research. ISSN 1654-6628. 6(1). doi: 10.1080/16546628.2017.1393306
• Huseinovic, Ena; Ohlin, M.; Winkvist, A; Bertz, F; Sonesson, U. & Brekke, Hilde Kristin (2017). Does diet intervention in line with nutrition recommendations affect dietary carbon footprint? Results from a weight loss trial among lactating women. European Journal of Clinical Nutrition. ISSN 0954-3007. 71(10), s. 1241–1245. doi: 10.1038/ejcn.2017.63
• Lignell, Sanna; Winkvist, Anna; Bertz, Fredrik; Rasmussen, Kathleen M.; Glynn, Anders & Aune, Marie [Vis alle 7 forfattere av denne artikkelen] (2016). Environmental organic pollutants in human milk before and after weight loss. Chemosphere. ISSN 0045-6535. 159, s. 96–102. doi: 10.1016/j.chemosphere.2016.05.077
• Huseinovic, Ena; Bertz, Fredrik; Agelii, Monica Leu; Johansson, Else Hellebo; Winkvist, Anna & Brekke, Hilde Kristin (2016). Effectiveness of a weight loss intervention in postpartum women: Results from a randomized controlled trial in primary health care. American Journal of Clinical Nutrition. ISSN 0002-9165. 104(2), s. 362–370. doi: 10.3945/ajcn.116.135673
• Jonsson, Karin; Barman, Malin; Moberg, S; Sjöberg, Agneta; Brekke, Hilde Kristin & Hasselmar, B [Vis alle 8 forfattere av denne artikkelen] (2016). Serum fatty acids in infants, reflecting family fish consumption, were inversely associated with allergy development but not related to farm residence. Acta Paediatrica. ISSN 0803-5253. 105(12), s. 1462–1471. doi: 10.1111/apa.13592
• Ellegård, Lasse; Bertz, F; Winkvist, A; Bosaeus, I & Brekke, Hilde Kristin (2016). Body composition in overweight and obese women postpartum: Bioimpedance methods validated by dual energy X-ray absorptiometry and doubly labeled water. European Journal of Clinical Nutrition. ISSN 0954-3007. 70(10), s. 1181–1188. doi: 10.1038/ejcn.2016.50
• Jönsson, Karin; Green, My; Barman, Malin; Sjöberg, Agneta; Brekke, Hilde Kristin & Wold, Agnes E [Vis alle 7 forfattere av denne artikkelen] (2016). Diet in 1-year-old farm and control children and allergy development: Results from the FARMFLORA birth cohort. Food & Nutrition Research. ISSN 1654-6628. 60. doi: 10.3402/fnr.v60.32721
• Huseinovic, Ena; Winkvist, Anna; Bertz, Fredrik; Hellebö Johansson, Else & Brekke, Hilde Kristin (2016). Dietary assessment among women with overweight and obesity in early postpartum. Journal of human nutrition and dietetics. ISSN 0952-3871. 29(4), s. 411–417.
• Bärebring, Linnea; Brembeck, Petra; Löf, Marie; Brekke, Hilde Kristin; Winkvist, Anna & Augustin, Hanna (2016). Food intake and gestational weight gain in Swedish women. SpringerPlus. ISSN 2193-1801. 29(5). doi: 10.1186/s40064-016-2015-x
• Fredriksson, E; Brekke, Hilde Kristin & Ellegård, Lars (2016). Dietary intake in Swedish medical students during 2007-2012. Scandinavian Journal of Public Health. ISSN 1403-4948. 44(1), s. 77–83. doi: 10.1177/1403494815611767
• Jonsson, Karin; Barman, Malin; Moberg, S; Sjöberg, Agneta; Brekke, Hilde Kristin & Hesselmar, B [Vis alle 9 forfattere av denne artikkelen] (2016). Fat intake and breast milk fatty acid composition in farming and nonfarming women and allergy development in the offspring. Pediatric Research. ISSN 0031-3998. 79, s. 114–123. doi: 10.1038/pr.2015.187
• Granfors, Maria; Augustin, Hanna; Ludvigsson, Johnny & Brekke, Hilde Kristin (2016). No association between use of multivitamin supplement containing vitamin D during pregnancy and risk of Type 1 Diabetes in the child. Pediatric Diabetes. ISSN 1399-543X. 17(7), s. 525–530. doi: 10.1111/pedi.12334

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• Reinan, Thomas Kvitvang; Feuerherm, Astrid Jullumstrø; Kolberg, Marit; Brekke, Hilde Kristin; Thoresen, Lene & Mostad, Ingrid Løvold (2020). HIGH PREVALENCE OF MALNUTRITION AMONG INPATIENTS AT A NORWEGIAN UNIVERSITY HOSPITAL ASSOCIATED WITH ORAL HEALTH PROBLEMS.
• Reinan, Thomas Kvitvang; Feuerherm, Astrid Jullumstrø; Kolberg, Marit; Brekke, Hilde Kristin; Thoresen, Lene & Mostad, Ingrid Løvold (2019). Funn av høy forekomst av underernæring blant innlagte pasienter på St. Olavs hospital, assosiert med dårlig munnhelse. . Vis sammendrag

  Tittel: Funn av høy forekomst av underernæring blant innlagte pasienter på St. Olavs hospital, assosiert med dårlig munnhelse. Et masterprosjekt i regi av Ernæringsutvalget og Kompetansesenteret Tannhelse Midt. Studiesykepleiere fra Forskningsposten ved St. Olavs hospital bidro i prosjektet. Bakgrunn/introduksjon: Hver tredje pasient i norske sykehus er anslått å være underernært eller i ernæringsmessig risiko, med påfølgende helsemessige og helseøkonomiske konsekvenser. Det foreligger begrenset kunnskap om innlagte pasienters munnhelse. På denne bakgrunn ønsket vi å undersøke forekomsten av underernæring, munntørrhet og andre munnhelseproblemer blant innlagte pasienter ved St. Olavs hospital og om/hvordan disse forekomstene var assosiert med hverandre. Videre om pasienter kategorisert som underernærte i studien var blitt funnet å være i ernæringsmessig risiko gjennom sykehusets rutinemessige ernæringsscreening. Metode/design: En tverrsnittstudie på voksne pasienter innlagt ved somatiske og psykiatriske sengeområder ved St. Olavs hospital. Ernæringsstatus ble vurdert av masterstudenten med The Scored Patient-Generated Subjective Global Assessment (PG-SGA), som kategoriserer pasientene som velernærte (A), moderat (B) eller alvorlig underernærte (C). Munnhelse ble vurdert av studiesykepleierne med Revised Oral Assessment Guide (ROAG) i tillegg til pasientrapporterte data. Munntørrhet ble målt objektivt med spyttprøve. Resultater fra ernæringsscreeningen (NRS 2002) ble hentet fra elektronisk pasientjournal. Odds Ratio (OR) for assosiasjonene ble beregnet med logistisk regresjon, korrigert for alder og kjønn. Resultat: Fra oktober 2018 til mars 2019 ble 118 pasienter (56% menn) i alderen 21-94 (median 68) år fra 15 somatiske og 3 psykiatriske avdelinger inkludert i studien. Blant disse var 57 % underernærte (kategori B eller C), 93% hadde minst ett munnhelseproblem, 19% hadde redusert spyttutskillelse og 36% hadde selvrapportert munntørrhet. Signifikante assosiasjoner mellom underernæring og munnhelse ble funnet, de høyeste for røde eller såre munnslimhinner (OR 4.67), sår på lepper (OR 4.22) og dårlig tannstatus (OR 3.62). Ernæringsscreening var blitt utført på 97 av 118 pasienter, hvorav 11 ble funnet å være i ernæringsmessig risiko. I samme utvalg (de 97 screenede) var det 58 underernærte, som tilsier at 47 underernærte ikke ble fanget opp som risikopasienter gjennom ernæringsscreeningen. Diskusjon/konklusjon: Studien påviser en høy forekomst av underernæring og munnhelseproblemer som ikke ble avdekket gjennom sykehusets rutiner. Resultatene kan bidra til at underernæring, dårlig munnhelse og forholdet mellom disse ikke blir oversett i framtida.

• Øyri, Linn Kristin Lie; Bogsrud, Martin Prøven; Christensen, Jacob J.; Ulven, Stine Marie; Brantsæter, Anne Lise & Retterstøl, Kjetil [Vis alle 12 forfattere av denne artikkelen] (2019). Novel and comprehensive metabolite profiling in cord blood reveal sex differences: A sub-study from the Norwegian Mother, Father and Child Cohort study.
• Hansson, Patrik; Holven, Kirsten Bjørklund; Øyri, Linn Kristin Lie; Brekke, Hilde Kristin; Biong, Anne Sofie & Gjevestad, Gyrd Omholt [Vis alle 8 forfattere av denne artikkelen] (2018). Postprandial effects of different dairy products on triglycerides in lean and overweight subjects: a randomized controlled cross-over study.
• Hansson, Patrik; Holven, Kirsten Bjørklund; Øyri, Linn Kristin Lie; Brekke, Hilde Kristin; Biong, Anne Sofie & Gjevestad, Gyrd Omholt [Vis alle 8 forfattere av denne artikkelen] (2018). Postprandial effects of different dairy products on triglycerides in lean and overweight subjects: a randomized controlled cross-over study.
• Hansson, Patrik; Holven, Kirsten Bjørklund; Øyri, Linn Kristin Lie; Brekke, Hilde Kristin; Gjevestad, Gyrd Omholt & Thoresen, Magne [Vis alle 7 forfattere av denne artikkelen] (2018). SEX DIFFERENCES IN POSTPRANDAL RESPONSE TO DIFFERENT DAIRY PRODUCTS ON LIPOPROTEIN SUBCLASSES: A RANDOMIZED CONTROLLED CROSS-OVER TRIAL.
• Hansson, Patrik; Holven, Kirsten Bjørklund; Øyri, Linn Kristin Lie; Brekke, Hilde Kristin; Biong, Anne Sofie & Gjevestad, Gyrd Omholt [Vis alle 8 forfattere av denne artikkelen] (2017). Postprandial effects of different dairy products on blood lipids in lean and overweight subjects.
• Hansson, Patrik; Brekke, Hilde Kristin; Christensen, Jacob J.; Gjevestad, Gyrd Omholt; Larsen, Sunniva Veen & Narverud, Ingunn [Vis alle 11 forfattere av denne artikkelen] (2017). Vegetarkost - bedre helse ved å kutte kjøttet? (Artikkel publisert på FH-Norge sin Facebook-side 10.05.2017 i samarbeid med FH-Norge).
• Brekke, Hilde Kristin (2017). Effectiveness of the LEVA protocol among postpartum women: results from the randomized controlled LEVA in Real Life trial.
• Bus Holth, Cathrine; Høisæther, Elisabeth Adolfsen & Brekke, Hilde Kristin (2017). An evaluation of the suggested ESPEN malnutrition criteria in light of the criteria for malnutrition as presented in the Norwegian National guidelines .
• Bus Holth, Cathrine; Høisæther, Elisabeth Adolfsen & Brekke, Hilde Kristin (2017). An evaluation of the suggested ESPEN malnutrition criteria in light of the criteria for malnutrition as presented in the Norwegian National guideline.
• Høyer, Anne; Høisæther, Elisabeth Adolfsen & Brekke, Hilde Kristin (2017). Body composition in cancer patients Validity of bioelectrical impedance analysis in a clinical setting.
• Ottestad, Inger; Narverud, Ingunn; Christensen, Jacob J.; Rundblad, Amanda; Øyri, Linn Kristin Lie & Larsen, Sunniva Veen [Vis alle 11 forfattere av denne artikkelen] (2017). Ost - venn eller fiende for hjertehelsa?
• Narverud, Ingunn; Ottestad, Inger; Gjevestad, Gyrd Omholt; Christensen, Jacob J.; Rundblad, Amanda & Hansson, Patrik [Vis alle 12 forfattere av denne artikkelen] (2016). Vidundermiddel eller klin kokos.
• Hamrin, Margaretha; Christensen, Jacob J.; Ottestad, Inger; Narverud, Ingunn; Gjevestad, Gyrd Omholt & Rundblad, Amanda [Vis alle 13 forfattere av denne artikkelen] (2016). Fra Beverly Hills-dietten til Nordisk kost – hva virker? FH-magasinet.

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