Jan Magnus Aronsen

• Frisk, Michael; Le, Christopher; Shen, Xin; Røe, Åsmund Treu; Hou, Yufeng; Manfra, Ornella; Silva, Gustavo Jose Justo; van Hout, Isabelle; Norden, Einar Sjaastad; Aronsen, Jan Magnus; Laasmaa, Martin; Espe, Emil Knut Stenersen; Zouein, Fouad A.; Lambert, Regis P.; Dahl, Christen Peder; Sjaastad, Ivar; Lunde, Ida Gjervold; Coffey, Sean; Cataliotti, Alessandro; Gullestad, Lars; Tønnessen, Theis; Jones, Peter P; Altara, Raffaele & Louch, William Edward (2021). Etiology-dependent impairment of diastolic cardiomyocyte calcium homeostasis in heart failure with preserved ejection fraction. Journal of the American College of Cardiology.  ISSN 0735-1097.  77(4), s 405- 419 . doi: 10.1016/j.jacc.2020.11.044 Fulltekst i vitenarkiv.
• Louwe, Maria Cornelia; Olsen, Maria Belland; Kaasbøll, Ole Jørgen; Yang, Kuan; Fosshaug, Linn Elisabeth Lillerud; Alfsnes, Katrine; Øgaard, Jonas; Rashidi, Azita; Skulberg, Vidar Magne; Yang, Mingyi; Fonseca, Davi de Miranda; Sharma, Animesh; Aronsen, Jan Magnus; Schrumpf, Elisabeth; Ahmed, Muhammad Shakil; Dahl, Christen Peder; Nyman, Tuula Anneli; Ueland, Thor; Melum, Espen; Halvorsen, Bente; Bjørås, Magnar; Attramadal, Håvard; Sjaastad, Ivar; Aukrust, Pål & Yndestad, Arne (2020). Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction. JACC: Basic to Translational Science.  ISSN 2452-302X.  5(12), s 1210- 1224 . doi: 10.1016/j.jacbts.2020.09.013 Fulltekst i vitenarkiv.
• Rønning, Sissel Beate; Carlson, Cathrine Rein; Aronsen, Jan Magnus; Pisconti, Addolorata; Høst, Vibeke; Lunde, Marianne; Liland, Kristian Hovde; Sjaastad, Ivar; Kolset, Svein Olav; Christensen, Geir Arve & Pedersen, Mona Elisabeth (2020). Syndecan-4–/– Mice Have Smaller Muscle Fibers, Increased Akt/mTOR/S6K1 and Notch/HES-1 Pathways, and Alterations in Extracellular Matrix Components.. Frontiers in Cell and Developmental Biology.  ISSN 2296-634X. . doi: 10.3389/fcell.2020.00730 Fulltekst i vitenarkiv. Vis sammendrag

  Background: Extracellular matrix (ECM) remodeling is essential for skeletal muscle development and adaption in response to environmental cues such as exercise and injury. The cell surface proteoglycan syndecan-4 has been reported to be essential for muscle differentiation, but few molecular mechanisms are known. Syndecan-4–/– mice are unable to regenerate damaged muscle, and display deficient satellite cell activation, proliferation, and differentiation. A reduced myofiber basal lamina has also been reported in syndecan-4–/– muscle, indicating possible defects in ECM production. To get a better understanding of the underlying molecular mechanisms, we have here investigated the effects of syndecan-4 genetic ablation on molecules involved in ECM remodeling and muscle growth, both under steady state conditions and in response to exercise. Methods: Tibialis anterior (TA) muscles from sedentary and exercised syndecan-4–/– and WT mice were analyzed by immunohistochemistry, real-time PCR and western blotting. Results: Compared to WT, we found that syndecan-4–/– mice had reduced body weight, reduced muscle weight, muscle fibers with a smaller cross-sectional area, and reduced expression of myogenic regulatory transcription factors. Sedentary syndecan-4–/– had also increased mRNA levels of syndecan-2, decorin, collagens, fibromodulin, biglycan, and LOX. Some of these latter ECM components were reduced at protein level, suggesting them to be more susceptible to degradation or less efficiently translated when syndecan-4 is absent. At the protein level, TRPC7 was reduced, whereas activation of the Akt/mTOR/S6K1 and Notch/HES-1 pathways were increased. Finally, although exercise induced upregulation of several of these components in WT, a further upregulation of these molecules was not observed in exercised syndecan-4–/– mice. Conclusion: Altogether our data suggest an important role of syndecan-4 in muscle development.

• Tazmini, Kiarash; Frisk, Michael; Lewalle, Alexandre; Laasmaa, Martin; Morotti, Stefano; Lipsett, David Bruce; Manfra, Ornella; Skogestad, Jonas; Aronsen, Jan Magnus; Sejersted, Ole M; Sjaastad, Ivar; Edwards, Andrew G.; Grandi, Eleonora; Niederer, Steven A.; Øie, Erik & Louch, William Edward (2020). Hypokalemia promotes arrhythmia by distinct mechanisms in atrial and ventricular myocytes. Circulation Research.  ISSN 0009-7330.  126(7), s 889- 906 . doi: 10.1161/CIRCRESAHA.119.315641 Fulltekst i vitenarkiv.
• Espe, Emil Knut Stenersen; Aronsen, Jan Magnus; Norden, Einar Sjaastad; Zhang, Lili & Sjaastad, Ivar (2019). Regional right ventricular function in rats: a novel magnetic resonance imaging method for measurement of right ventricular strain. American Journal of Physiology. Heart and Circulatory Physiology.  ISSN 0363-6135.  318(1), s 143- 153 . doi: 10.1152/ajpheart.00357.2019 Fulltekst i vitenarkiv.
• Lipsett, David Bruce; Frisk, Michael; Aronsen, Jan Magnus; Norden, Einar Sjaastad; Buonarati, Olivia R.; Cataliotti, Alessandro; Hell, Johannes W.; Sjaastad, Ivar; Christensen, Geir Arve & Louch, William Edward (2019). Cardiomyocyte substructure reverts to an immature phenotype during heart failure. Journal of Physiology.  ISSN 0022-3751.  597(7), s 1833- 1853 . doi: 10.1113/JP277273 Fulltekst i vitenarkiv.
• Mathiesen, Sabrina Bech; Lunde, Marianne; Aronsen, Jan Magnus; Romaine, Andreas; Kaupang, Anita; Martinsen, Marita; De Souza, Gustavo Antonio; Nyman, Tuula Anneli; Sjaastad, Ivar; Christensen, Geir Arve & Carlson, Cathrine Rein (2019). The cardiac syndecan-4 interactome reveals a role for syndecan-4 in nuclear translocation of muscle LIM protein (MLP). Journal of Biological Chemistry.  ISSN 0021-9258.  294(22), s 8717- 8731 . doi: 10.1074/jbc.RA118.006423 Fulltekst i vitenarkiv. Vis sammendrag

  Costameres are signaling hubs at the sarcolemma and important contact points between the extracellular matrix and cell interior, sensing and transducing biomechanical signals into a cellular response. The transmembrane proteoglycan syndecan-4 localizes to these attachment points and has been shown to be important in the initial stages of cardiac remodeling, but its mechanistic function in the heart remains insufficiently understood. Here, we sought to map the cardiac interactome of syndecan-4 to better understand its function and downstream signaling mechanisms. By combining two different affinity purification methods with MS analysis, we found that the cardiac syndecan-4 interactome consists of 21 novel and 29 previously described interaction partners. Nine of the novel partners were further validated to bind syndecan-4 in HEK293 cells (i.e. CAVIN1/PTRF, CCT5, CDK9, EIF2S1, EIF4B, MPP7, PARVB, PFKM, and RASIP). We also found that 19 of the 50 interactome partners bind differently to syndecan-4 in the left ventricle lysate from aortic-banded heart failure (ABHF) rats compared with SHAM-operated animals. One of these partners was the well-known mechanotransducer muscle LIM protein (MLP), which showed direct and increased binding to syndecan-4 in ABHF. Nuclear translocation is important in MLP-mediated signaling, and we found less MLP in the nuclear-enriched fractions from syndecan-4-/- mouse left ventricles but increased nuclear MLP when syndecan-4 was overexpressed in a cardiomyocyte cell line. In the presence of a cell-permeable syndecan-4-MLP disruptor peptide, the nuclear MLP level was reduced. These findings suggest that syndecan-4 mediates nuclear translocation of MLP in the heart

• Mcginley, Gary George; Bendiksen, Bård Andre; Zhang, Lili; Aronsen, Jan Magnus; Norden, Einar Sjaastad; Sjaastad, Ivar & Espe, Emil Knut Stenersen (2019). Accelerated magnetic resonance imaging tissue phase mapping of the rat myocardium using compressed sensing with iterative soft-thresholding. PLOS ONE.  ISSN 1932-6203.  14:e0218874(7), s 1- 17 . doi: 10.1371/journal.pone.0218874 Fulltekst i vitenarkiv.
• Mohammadzadeh, Naiyereh; Lunde, Ida Gjervold; Andenæs, Kine; Strand, Mari Elen; Aronsen, Jan Magnus; Skrbic, Biljana; Marstein, Henriette; Bandlien, Caroline; Nygård, Ståle; Gorham, Joshua; Sjaastad, Ivar; Chakravarti, Shukti; Christensen, Geir Arve; Engebretsen, Kristin V Thunheim & Tønnessen, Theis (2019). The extracellular matrix proteoglycan lumican improves survival and counteracts cardiac dilatation and failure in mice subjected to pressure overload. Scientific Reports.  ISSN 2045-2322.  9:9206, s 1- 13 . doi: 10.1038/s41598-019-45651-9 Fulltekst i vitenarkiv.
• Røe, Åsmund Treu; Ruud, Marianne; Espe, Emil Knut Stenersen; Manfra, Ornella; Longobardi, S; Aronsen, Jan Magnus; Norden, Einar Sjaastad; Husebye, T.; Kolstad, Terje R Selnes; Cataliotti, Alessandro; Christensen, Geir Arve; Sejersted, Ole M; Niederer, Steven A.; Andersen, Geir Øystein; Sjaastad, Ivar & Louch, William Edward (2019). Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression. Cardiovascular Research (CVR).  ISSN 0008-6363.  115(4), s 752- 764 . doi: 10.1093/cvr/cvy257
• Skogestad, Jonas; Aronsen, Jan Magnus; Tovsrud, Nils; Wanichawan, Pimthanya; Hougen, Karina; Stokke, Mathis Korseberg; Carlson, Cathrine Rein; Sjaastad, Ivar; Sejersted, Ole M & Swift, Fredrik (2019). Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes. Cardiovascular Research (CVR).  ISSN 0008-6363.  116(1), s 78- 90 . doi: 10.1093/cvr/cvz087
• Skogestad, Jonas; Lines, Glenn; Louch, William Edward; Sejersted, Ole M; Sjaastad, Ivar & Aronsen, Jan Magnus (2019). Evidence for heterogeneous subsarcolemmal Na+ Levels in rat ventricular myocytes. American Journal of Physiology. Heart and Circulatory Physiology.  ISSN 0363-6135.  316(5) . doi: 10.1152/ajpheart.00637.2018
• Sokolova, Marina; Sjaastad, Ivar; Louwe, Maria Cornelia; Alfsnes, Katrine; Aronsen, Jan Magnus; Zhang, Lili; Haugstad, Solveig Bjærum; Bendiksen, Bård Andre; Øgaard, Jonas; Bliksøen, Marte; Lien, Egil; Berge, Rolf Kristian; Aukrust, Pål; Ranheim, Trine & Yndestad, Arne (2019). NLRP3 inflammasome promotes myocardial remodeling during diet-induced obesity. Frontiers in Immunology.  ISSN 1664-3224.  10:1621(JULY), s 1- 13 . doi: 10.3389/fimmu.2019.01621 Fulltekst i vitenarkiv.
• Andenæs, Kine; Lunde, Ida Gjervold; Mohammadzadeh, Naiyereh; Dahl, Christen Peder; Aronsen, Jan Magnus; Strand, Mari Elen; Palmero, Sheryl; Sjaastad, Ivar; Christensen, Geir Arve; Engebretsen, Kristin V Thunheim & Tønnessen, Theis (2018). The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling. PLOS ONE.  ISSN 1932-6203.  13(7), s 1- 20 . doi: 10.1371/journal.pone.0201422 Fulltekst i vitenarkiv.
• Kolstad, Terje R Selnes; Brink, Jonas van Den; Macquaide, Niall; Lunde, Per Kristian; Frisk, Michael; Aronsen, Jan Magnus; Norden, Einar Sjaastad; Cataliotti, Alessandro; Sjaastad, Ivar; Sejersted, Ole M; Edwards, Andrew; Lines, Glenn Terje & Louch, William Edward (2018). Ryanodine receptor dispersion disrupts Ca2+ release in failing cardiac myocytes. eLIFE.  ISSN 2050-084X.  7 . doi: 10.7554/eLife.39427 Fulltekst i vitenarkiv.

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• Aronsen, Jan Magnus; De Smedt, Koenraad; Heggland, Ingrid; Dingsør, Liv; Tronstad, Stein; Pedersen, Ole Petter; Ørstavik, Inger Berg & Mahler, Tobias (2020). Hvordan få økt deling og gjenbruk av forskningsdata?. Khrono.no.  ISSN 1894-8995.
• Rønning, Sissel Beate; Carlson, Cathrine Rein; Aronsen, Jan Magnus; Høst, Vibeke; Pisconti, Addolorate; Lunde, Marianne; Liland, Kristian Hovde; Sjaastad, Ivar; Kolset, Svein Olav; Christensen, Geir Arve & Pedersen, Mona Elisabeth (2019). Extracellular Matrix remodeling and multiple signaling pathways are regulated by syndecan-4 during myogenesis.
• Aronsen, Jan Magnus (2018). Molecular mediators of chronic heart disease.
• Aronsen, Jan Magnus & Jensenius, Alexander Refsum (2018). «Røvertidsskriftene» er bare toppen av isfjellet. Aftenposten (morgenutg. : trykt utg.).  ISSN 0804-3116. Vis sammendrag

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• Bratland-Sanda, Solfrid; Blikstad-Balas, Marte; De Moor, Katrien; Eriksen, Marianne Hem; Falkum, Ingrid Lossius; Holmen, Heidi & Aronsen, Jan Magnus (2018). Akademia må satse på undervisningskarrierer. Khrono.no.  ISSN 1894-8995.

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