METHODS
The study was a mixed prospective/retrospective national cohort study of 123 Norwegian women in opioid maintenance treatment (OMT) during pregnancy and their neonates. A standardized questionnaire was administered to the women and medical information that could be used for verification was collected from hospitals and municipalities.
RESULTS
Two of the women came off the OMT-medication during pregnancy and another 15% tapered their OMT-medication dose more than 50%. The birth weights of methadone-exposed neonates of the women who tapered more than 50% were significantly higher than for the methadone-exposed neonates of the women tapering between 11 and 50%. No other significant differences were found.
CONCLUSION
Pregnant women in OMT who taper their OMT-medication dose should be monitored closely. We need studies that document the maternal well-being and fetal safety of maternal tapering of the OMT-medication during pregnancy.
Link til artikkel
- Forfattere: Welle-Strand, Gabrielle; Skurtveit, Svetlana; Tanum, Lars; Waal, Helge; Bakstad, Britt Elise; BJARKØ, LISA; Ravndal, Edle.
- Publisert: European Addiction Research 2015 ;Volum 21.(5) s. 253-261