Faglige interesser
Biokjemiske og hormonelle endringer ved endokrine sykdommer som hormonproduserende hypofysesvulster, diabetes og osteoporose.
Undervisning
- Modul 3 og 8: Blodgasser, syre-/baseforstyrrelser og diabetes.
Bakgrunn og stillinger
- Fra 1. oktober 2007 professor i medisin (klinisk biokjemi) ved UiO og overlege i bistilling (20 %) ved Avdeling for medisinsk biokjemi, OUS HF
- Fra 1. januar 2023 til 29. februar 2024 Fungerende leder for Senter for pandemi og én-helseforskning, SUSTAINIT, Det medisinske fakultet, UiO
- Fra 1. januar 2019 til 31. desember 2022 prodekan for forskning, Det medisinske fakultet, UiO
- Fra 21. oktober 2016 til 31. desember 2018 undervisningsleder i klinisk biokjemi
- Fra 1. oktober 2015 til 31. januar 2019 avdelingsleder (OUS) og fagmiljøleder (UiO) Avdeling for medisinsk biokjemi
- Fra 1. mai 2013 til 30. september 2015 vikar forskningsleder Klinikk for diagnostikk og intervensjon
- Fra 1. januar 2011 til 30. april 2013 fagmiljøleder ved Avdeling for medisinsk biokjemi
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- UHR-Dekanskolen 2021
- Nasjonalt Topplederprogram (spesialisthelsetjenesten) 2018
- Forskningslederprogrammet ved UiO 2007-2008
- Spesialist i medisinsk biokjemi 2004
- Dr. med., UiO 1995.
- Cand. med., UiO 1986.
Verv og oppgaver
Emneord:
Diabetes og hormoner
Publikasjoner
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Næss-Andresen, Marthe-Lise; Jenum, Anne Karen; Berg, Jens Petter; Falk, Ragnhild Sørum & Sletner, Line
(2023).
The impact of recommending iron supplements to women with depleted iron stores in early pregnancy on use of supplements, and factors associated with changes in iron status from early pregnancy to postpartum in a multi-ethnic population-based cohort.
BMC Pregnancy and Childbirth.
ISSN 1471-2393.
23:350(1),
s. 1–13.
doi:
10.1186/s12884-023-05668-5.
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Jansen, Aina; Aaseth, Jan Olav; Lyche, Jan Ludvig; Berg, Jens Petter; Müller, Mette Helen Bjørge & Lydersen, Stian
[Vis alle 7 forfattere av denne artikkelen]
(2022).
Do changes in persistent organic pollutants after bariatric surgery cause endocrine disruption?
Chemosphere.
ISSN 0045-6535.
313,
s. 1–8.
doi:
10.1016/j.chemosphere.2022.137461.
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Background
Bariatric surgery results in weight loss, marked endocrine changes and the release of persistent organic pollutants (POPs). The release of POPs might cause endocrine disruption. The study aimed to explore associations between POPs and adiponectin, leptin and ghrelin in subjects undergoing bariatric surgery. Methods: The study included 63 subjects with severe obesity (men/women: 13/50), age (years): 45.0 (8.5), and BMI (kg/m2) 39.1 (3.4). Analyses of adiponectin, leptin and ghrelin and POPs (hexachlorobenzene (HCB), dichlorodiphenyldichloroethylene (p,p’-DDE), polychlorinated biphenyl (PCB) 118 (dioxin-like compound; dl), and sum 6 PCB (PCB 28, -52, −101, −138, −153, and −180) were performed before and 12 months after bariatric surgery. Results: There were significant increases in adiponectin and all POPs and a fall in leptin after surgery. The main finding was the highly significant associations between adiponectin and all POPs. The increase in HCB explained 38% of the variation in adiponectin. Conclusions: If the POP-associated increase in adiponectin is a causal effect, the release of POPs might have important clinical consequences. Adiponectin has both positive and negative clinical effects exerted by essentially unknown mechanisms. The effects of released POPs on the metabolic functions in subjects undergoing bariatric surgery deserve further evaluation.
© 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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Næss-Andresen, Marthe-Lise; Jenum, Anne Karen; Berg, Jens Petter; Falk, Ragnhild Sørum & Sletner, Line
(2022).
Prevalence of postpartum anaemia and iron deficiency by serum ferritin, soluble transferrin receptor and total body iron, and associations with ethnicity and clinical factors: a Norwegian population-based cohort study.
Journal of Nutritional Science (JNS).
ISSN 2048-6790.
11.
doi:
10.1017/jns.2022.45.
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Øystese, Kristin Astrid Berland; Casar-Borota, Olivera; Berg-Johnsen, Jon; Berg, Jens Petter & Bollerslev, Jens
(2022).
Distribution of E- and N-cadherin in subgroups of non-functioning pituitary neuroendocrine tumours.
Endocrine.
ISSN 1355-008X.
77(1),
s. 151–159.
doi:
10.1007/s12020-022-03051-6.
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Kordt Sundet, Birgitte; Kreyberg, Ina; Staff, Anne Cathrine; Carlsen, Karin Cecilie Lødrup; Bains, Karen Eline Stensby & Berg, Jens Petter
[Vis alle 20 forfattere av denne artikkelen]
(2022).
The effect of nicotine-containing products and fetal sex on placenta-associated circulating midpregnancy biomarkers.
Biology of Sex Differences.
ISSN 2042-6410.
13(1).
doi:
10.1186/s13293-022-00443-1.
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In utero exposure to nicotine, largely assessed by smoking, is a risk factor for impaired offspring health, while potential effects of non-combustible nicotine use such as snus (oral moist tobacco), are less well-known. Maternal serum concentrations of placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) may be viewed as “placenta health markers”, known to differ by fetal sex. Maternal smoking during pregnancy has been associated with lower levels of circulating sFlt-1, while the effect of snus on placenta-associated angiogenic factors is unknown. Our aim was to explore if snus and/or smoking exposure was associated with midpregnancy maternal levels of sFlt-1, PlGF and sFlt-1/PlGF ratio if these associations were modified by fetal sex.
Methods
Midpregnancy (16–22 gestational weeks) serum from 2603 Scandinavian women enrolled in the population-based multi-center PreventADALL (Preventing Atopic Dermatitis and ALLergies in children) study was analysed for sFlt-1 and PlGF concentrations by electrochemiluminescence, deriving the sFlt-1/PGF ratio. Nicotine use was assessed by electronic questionnaires at enrollment in 2278 of the women. Univariable and multivariable linear regression models on log transformed outcomes were used to assess the association between nicotine use and biomarker levels. Interaction terms were included to identify whether the associations were modified by fetal sex.
Results
Median sFlt-1, PlGF and sFlt-1/PlGF ratios among women with nicotine exposure information were similar to those of all included women and differed by fetal sex. Current snus use was significantly associated with reduced maternal circulating PlGF levels in adjusted analyses [β − 0.12, (95% CI − 0.20; 0.00) compared to never use, p = 0.020]. A significant interaction between fetal sex and snus exposure was observed for PIGF (p = 0.031). Prior or periconceptional snus use was significantly associated with PIGF in male fetus pregnancies [β − 0.05 (95% CI − 0.09 to (− 0.02)) and β − 0.07 (95% CI − 0.12 to (− 0.02)) compared to never use, p = 0.002]. Smoking was not significantly associated with any circulating biomarkers levels.
Conclusions
Midpregnancy maternal angiogenic profile differed by periconceptional snus use and fetal sex. Snus exposure, perceived as “safe” by users, before or during pregnancy seems to affect midpregnancy placental health in a sex dimorphic manner.
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Johannessen, Karl Arne; Wear, Nina Kristin Steen; Toska, Karin; Hansbø, Morten; Berg, Jens Petter & Fosse, Erik
(2021).
Pathologic Blood Samples Tolerate Exposure to Vibration and High Turbulence in Simulated Drone Flights, but Plasma Samples Should be Centrifuged after Flight.
IEEE Journal of Translational Engineering in Health and Medicine.
ISSN 2168-2372.
9.
doi:
10.1109/JTEHM.2021.3053172.
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Objective. Most of the previous studies of drone transport of blood samples examined normal
blood samples transported under tranquil air conditions. We studied the effects of 1- and 2-hour drone
flights using random vibration and turbulence simulation (10-30 g-force) on blood samples from 16 healthy
volunteers and 74 patients with varying diseased. Methods: Thirty-two of the most common analytes were
tested. For biochemical analytes, we used plasma collected in lithium heparin tubes with and without separator
gel. Gel samples were analyzed for the effect of separation by centrifugation before or after turbulence.
Turbulence was simulated in an LDS V8900 high-force shaker using random vibration (range, 5–200 Hz),
with samples randomly allocated to 1- or 2-hour flights with 25 or 50 episodes of turbulence from 10 to
30 G. Results: For all hematologic and most biochemical analytes, test results before and after turbulence
exposure were similar (bias < 12%, intercepts < 10%). However, aspartate aminotransferase, folate, lactate
dehydrogenase and lipid index increased significantly in samples separated by gel and centrifugation prior to
vibration and turbulence test. These changes increased form 10 G to 30 G, but were not observed when the
samples were separated after vibration and turbulence. Conclusions: Whole blood showed little vulnerability
to turbulence, whereas plasma samples separated from blood cells by gel may be significantly influenced by
turbulence when separated by spinning before the exposure. Centrifugation of plasma samples collected in
tubes with separator gel should be avoided before drone flights that could be subject to turbulence.
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Wendel, Kristina; Pfeiffer, Helle Cecilie; Fugelseth, Drude; Nestaas, Eirik; Domellöf, Magnus & Skålhegg, Bjørn Steen
[Vis alle 42 forfattere av denne artikkelen]
(2021).
Effects of nutrition therapy on growth, inflammation and metabolism in immature infants: a study protocol of a double-blind randomized controlled trial (ImNuT).
BMC Pediatrics.
ISSN 1471-2431.
21.
doi:
10.1186/s12887-020-02425-x.
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Background: Current nutritional management of infants born very preterm results in significant deficiency of the essential fatty acids (FAs) arachidonic acid (ARA) and docosahexaenoic acid (DHA). The impact of this deficit on brain maturation and inflammation mediated neonatal morbidities are unknown. The aim of this study is to determine whether early supply of ARA and DHA improves brain maturation and neonatal outcomes in infants born before 29 weeks of gestation.
Methods: Infants born at Oslo University Hospital are eligible to participate in this double-blind randomized controlled trial. Study participants are randomized to receive an enteral FA supplement of either 0.4 ml/kg MCT-oil™ (medium chain triglycerides) or 0.4 ml/kg Formulaid™ (100 mg/kg of ARA and 50 mg/kg of DHA). The FA supplement is given from the second day of life to 36 weeks' postmenstrual age (PMA). The primary outcome is brain maturation assessed by Magnetic Resonance Imaging (MRI) at term equivalent age. Secondary outcomes include quality of growth, incidence of neonatal morbidities, cardiovascular health and neuro-development. Target sample size is 120 infants (60 per group), this will provide 80% power to detect a 0.04 difference in mean diffusivity (MD, mm2/sec) in major white matter tracts on MRI.
Discussion: Supplementation of ARA and DHA has the potential to improve brain maturation and reduce inflammation related diseases. This study is expected to provide valuable information for future nutritional guidelines for preterm infants.
Trial registration: Clinicaltrials.gov ID: NCT03555019 . Registered 4 October 2018- Retrospectively registered.
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Bornstedt, Mette Eskild; Gjerlaugsen, Nina; Olstad, Ole Kristoffer; Berg, Jens Petter; Bredahl, May K. Lyamouri & Thorsby, Per Medbøe
(2020).
Vitamin D metabolites influence expression of genes concerning cellular viability and function in insulin producing β-cells (INS1E).
Gene.
ISSN 0378-1119.
746:144649,
s. 1–8.
doi:
10.1016/j.gene.2020.144649.
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Background
Studies have shown that vitamin D can enhance glucose-stimulated insulin secretion (GSIS) and change the expression of genes in pancreatic β-cells. Still the mechanisms linking vitamin D and GSIS are unknown.
Material and methods
We used an established β-cell line, INS1E. INS1E cells were pre-treated with 10 nM 1,25(OH)2vitamin D or 10 nM 25(OH)vitamin D for 72 h and stimulated with 22 mM glucose for 60 min. RNA was extracted for gene expression analysis.
Results
Expression of genes affecting viability, apoptosis and GSIS changed after pre-treatment with both 1,25(OH)2vitamin D and 25(OH)vitamin D in INS1E cells. Stimulation with glucose after pre-treatment of INS1E cells with 1,25(OH)2vitamin D resulted in 181 differentially expressed genes, whereas 526 genes were differentially expressed after pre-treatment with 25(OH)vitamin D.
Conclusion
Vitamin D metabolites may affect pancreatic β-cells and GSIS through changed gene expression for genes involved in β-cell function and viability.
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Atukunda, Prudence; Muhoozi, Grace Kyamazima Mehangye; Diep, Lien My; Berg, Jens Petter; Westerberg, Ane Cecilie & Iversen, Per Ole
(2020).
The association of urine markers of iodine intake with development and growth among children in rural Uganda: A secondary analysis of a randomised education trial.
Public Health Nutrition (PHN).
ISSN 1368-9800.
s. 1–10.
doi:
10.1017/S1368980020001603.
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Jansen, Aina; Berg, Jens Petter; Klungsøyr, Ole; Müller, Mette Helen Bjørge; Lyche, Jan Ludvig & Aaseth, Jan
(2019).
The Influence of Persistent Organic Pollutants on Thyroidal, Reproductive and Adrenal Hormones After Bariatric Surgery.
Obesity Surgery.
ISSN 0960-8923.
doi:
10.1007/s11695-019-04273-w.
Vis sammendrag
Persistent organic pollutants (POPs) including organochlorine pesticides, polychlorinated biphenyls (PCBs), and per- and polyfluoroalkylated substances (PFASs) are suspected endocrine disruptors.
AIM:
To evaluate the associations between POPs and thyroidal, reproductive, and adrenal hormones in a study population treated with bariatric surgery.
METHODS:
Blood samples from a cohort of 63 participants before and 1 year after bariatric surgery were analyzed for 16 lipophilic POPs, 17 PFASs, and thyroidal, reproductive, and adrenal hormones. Participants reporting relevant medical conditions or interfering medication were excluded, and plausible confounders were corrected for in multiple regression analyses.
RESULTS:
Free thyroxine (fT4) showed a significant decrease from preoperative to postoperative follow-up, and regression analyses demonstrated that p,p'-dichlorodiphenyldichloroethylene (p,p-DDE) was inversely associated with the ratio free triiodothyronine/free thyroxine (fT3/fT4). Testosterone concentrations in male participants increased significantly in the study period, and sex hormone-binding globulin (SHBG) increased in both gender. Regression analyses showed positive associations between increased levels of lipophilic POPs and the raised postoperative testosterone and SHBG concentrations in males. For females, an inverse association between the sum perfluoroalkyl carboxylic acids (ΣPFCA) and SHBG was seen. Regression analyses of postoperative serum cortisol concentrations on changes in hexachlorobenzene (HCB) showed a non-significant inverse association.
CONCLUSION:
The results suggest that POPs may have an influence on the hypothalamic-pituitary-thyroid (HPT) and the hypothalamic-pituitary-gonadal (HPG) axes after bariatric surgery. Because of small sample sizes and discrepancy in the sampling time points pre- and postoperatively, the observed hormonal impacts of POPs must be interpreted as associative and not causative. Further studies are needed to confirm the findings.
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Næss-Andresen, Marthe-Lise; Eggemoen, Åse Ruth; Berg, Jens Petter; Falk, Ragnhild Sørum & Jenum, Anne Karen
(2019).
Serum ferritin, soluble transferrin receptor, and total body iron for the detection of iron deficiency in early pregnancy: A multiethnic population-based study with low use of iron supplements.
American Journal of Clinical Nutrition.
ISSN 0002-9165.
109(3),
s. 566–575.
doi:
10.1093/ajcn/nqy366.
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Øystese, Kristin Astrid Berland; Berg, Jens Petter; Normann, Kjersti Ringvoll; Zucknick, Manuela; Casar-Borota, Olivera & Bollerslev, Jens
(2018).
The role of E and N-cadherin in the postoperative course of gonadotroph pituitary tumours.
Endocrine.
ISSN 1355-008X.
62(2),
s. 351–360.
doi:
10.1007/s12020-018-1679-0.
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Øystese, Kristin Astrid Berland; Casar-Borota, Olivera; Normann, Kjersti Ringvoll; Zucknick, Manuela; Berg, Jens Petter & Bollerslev, Jens
(2017).
Estrogen Receptor α, a Sex-Dependent Predictor of Aggressiveness in Nonfunctioning Pituitary Adenomas: SSTR and Sex Hormone Receptor Distribution in NFPA.
Journal of Clinical Endocrinology and Metabolism (JCEM).
ISSN 0021-972X.
102(9),
s. 3581–3590.
doi:
10.1210/jc.2017-00792.
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Gopinathan, Unni; Øvstebø, Reidun; Brusletto, Berit Sletbakk; Olstad, Ole Kristoffer; Kierulf, Peter & Brandtzæg, Petter
[Vis alle 7 forfattere av denne artikkelen]
(2017).
Transcriptomic data from two primary cell models stimulating human monocytes suggest inhibition of oxidative phosphorylation and mitochondrial function by N. meningitidis which is partially up-regulated by IL-10.
BMC Immunology.
ISSN 1471-2172.
18:46,
s. 1–17.
doi:
10.1186/s12865-017-0229-5.
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Hellum, Marit Synnøve; Siebke, Anne-Marie; Berg, Jens Petter; Brandtzæg, Petter; Øvstebø, Reidun & Henriksson, Carola
(2017).
The Neisseria meningitidis lpxL1 mutant induces less tissue factor expression and activity in primary human monocytes and
monocyte-derived microvesicles than the wild type meningococcus.
Innate Immunity.
ISSN 1753-4259.
23(2),
s. 196–205.
doi:
10.1177/1753425916684201.
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Waage, Christin; Jenum, Anne Karen; Mdala, Ibrahimu; Berg, Jens Petter; Richardsen, Kåre Rønn & Birkeland, Kåre I.
(2017).
Associations between gestational diabetes mellitus and elevated HbA1c early postpartum in a multi-ethnic population.
Primary Care Diabetes.
ISSN 1751-9918.
11(2),
s. 132–139.
doi:
10.1016/j.pcd.2016.09.007.
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Jørgenrud, Benedicte Marie; Stene, Lars Christian; Tapia, German; Bøås, Håkon; Pepaj, Milaim & Berg, Jens Petter
[Vis alle 10 forfattere av denne artikkelen]
(2017).
Longitudinal plasma metabolic profiles, infant feeding, and islet autoimmunity in the MIDIA study.
Pediatric Diabetes.
ISSN 1399-543X.
18,
s. 111–119.
doi:
10.1111/pedi.12360.
Vis sammendrag
Aims
The aim of this study was to investigate the longitudinal plasma metabolic profiles in healthy infants and the potential association with breastfeeding duration and islet autoantibodies predictive of type 1 diabetes.
Method
Up to four longitudinal plasma samples from age 3 months from case children who developed islet autoimmunity (n = 29) and autoantibody-negative control children (n = 29) with the HLA DR4-DQ8/DR3-DQ2 genotype were analyzed using two-dimensional gas chromatography coupled to a time-of-flight mass spectrometer for detection of small polar metabolites.
Results
Plasma metabolite levels were found to depend strongly on age, with fold changes varying up to 50% from age 3 to 24 months (p < 0.001 after correction for multiple testing). Tyrosine levels tended to be lower in case children, but this was not significant after correction for multiple testing. Ornithine levels were lower in case children compared with the controls at the time of seroconversion, but the difference was not statistically significant after correcting for multiple testing. Breastfeeding for at least 3 months as compared with shorter duration was associated with higher plasma levels of isoleucine, and lower levels of methionine and 3,4-dihydroxybutyric acid at 3 months of age.
Conclusions
Plasma levels of several small, polar metabolites changed with age during early childhood, independent of later islet autoimmunity status and sex. Breastfeeding was associated with higher levels of branched-chain amino acids, and lower levels of methionine and 3,4-dihydroxybutyric acid.
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Sachse, Daniel; Solevåg, Anne Lee; Berg, Jens Petter & Nakstad, Britt
(2016).
The role of plasma and urine metabolomics in identifying new biomarkers in severe newborn asphyxia: A study of asphyxiated newborn pigs following cardiopulmonary resuscitation.
PLOS ONE.
ISSN 1932-6203.
11:e0161123(8).
doi:
10.1371/journal.pone.0161123.
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Kristensen, Gunn Berit Berge; Rustad, Pål; Berg, Jens Petter & Aakre, Kristin
(2016).
Analytical bias exceeding desirable quality goal in 4 out of 5 common immunoassays: Results of a native single serum sample external quality assessment program for cobalamin, folate, ferritin, thyroid-stimulating hormone, and free t4 analyses.
Clinical Chemistry.
ISSN 0009-9147.
62(9),
s. 1255–1263.
doi:
10.1373/clinchem.2016.258962.
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Hov, Karen Roksund; Berg, Jens Petter; Frihagen, Frede Jon; Ræder, Johan; Hall, Roanna J. & Wyller, Torgeir Bruun
[Vis alle 7 forfattere av denne artikkelen]
(2016).
Blood-cerebrospinal fluid barrier integrity in delirium determined by Q-Albumin.
Dementia and Geriatric Cognitive Disorders.
ISSN 1420-8008.
41(3-4),
s. 192–198.
doi:
10.1159/000443789.
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Kringen, Marianne K.; Stormo, Camilla; Berg, Jens Petter; Terry, Sharon F.; Vocke, Christine M. & Rizvi, Samar
[Vis alle 8 forfattere av denne artikkelen]
(2015).
Copy number variation in the ATP-binding cassette transporter ABCC6 gene and ABCC6 pseudogenes in patients with pseudoxanthoma elasticum.
Molecular Genetics & Genomic Medicine.
ISSN 2324-9269.
3(3),
s. 233–237.
doi:
10.1002/mgg3.137.
Vis sammendrag
Single mutations in the ATP-binding cassette transporter (ABCC6) gene (OMIM 603234) are known to cause the rare autosomal recessive disease pseudoxanthoma elasticum (PXE). Recently, we have found that copy number variations (CNVs) in pseudogenes of the ABCC6 gene are quite common. The aim of this study was to investigate the frequency and possible contribution of CNV in ABCC6 and its pseudogenes in PXE. Genomic DNA from 212 PXE individuals were examined for copy number by pyrosequencing and quantitative polymerase chain reaction (PCR) and compared with healthy individuals. The frequency of PXE individuals with any CNV was higher than in healthy individuals. The majority of variation comprised known and possibly new deletions in the ABCC6 gene and duplications of the ABCC6P1 and ABCC6P2 genes. ABCC6 deletions and ABCC6P2 duplications were not observed in 142 healthy individuals. In conclusion, by pyrosequencing and quantitative PCR, we were able to detect known and possibly new deletions in the ABCC6 gene that may have caused the PXE phenotype. Pyrosequencing may be used in PXE patients who have obtained incomplete genotype from conventional techniques. The frequency of ABCC6P2 pseudogene duplication was more common in PXE patients than healthy individuals and may affect the PXE phenotype.
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Lekva, Tove; Berg, Jens Petter; Lyle, Robert; Heck, Ansgar; Bollerslev, Jens & Ueland, Thor
(2015).
Alternative splicing of placental lactogen (CSH2) in somatotroph pituitary adenomas.
Neuro - endocrinology letters.
ISSN 0172-780X.
36(2),
s. 136–142.
Vis sammendrag
OBJECTIVES:
Somatotroph adenomas secrete supraphysiological amounts of GH, causing acromegaly. We have previously shown epithelial splicing regulator 1 (ESRP1) to play a role in epithelial mesenchymal transition (EMT) progression in these adenomas and account for poor treatment response. We evaluated if the mRNA levels of the GH/CSH gene cluster in somatotroph adenomas are associated with an epithelial phenotype and response to SA treatment.
METHODS:
We investigated the associations between ESRP1 and the growth hormone/chorionic somatomammotropin (GH/CSH) gene cluster by RNA sequencing (RNAseq). CSH2 isoform 3 mRNA was further evaluated in 65 somatotroph adenomas and associations with disease severity and treatment response.
RESULTS:
mRNA for all genes in the GH/CSH cluster were expressed, however, only chorionic somatomammotropin 2/placental lactogen 2 (CSH2) displayed an alternative splicing pattern. CSH2 isoform 3 was associated with a dense granulation pattern and an epithelial phenotype with high levels of ESRP1 and E-cadherin expression. Further, CSH2 isoform 3 was associated with reduced serum GH and IGF-I levels after somatostatin analog treatment.
CONCLUSIONS:
Attenuated CSH2 isoform 3 was associated with mesenchymal phenotype and a blunted clinical response to somatostatin analog treatment in patients with acromegaly.
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Sachse, Daniel; Bærug, Anne Bergljot; Sletner, Line; Birkeland, Kåre I.; Nakstad, Britt & Jenum, Anne Karen
[Vis alle 7 forfattere av denne artikkelen]
(2014).
Urine NMR metabolomics analysis of breastfeeding biomarkers during and after pregnancy in a large prospective cohort study.
Scandinavian Journal of Clinical and Laboratory Investigation.
ISSN 0036-5513.
74(3),
s. 264–272.
doi:
10.3109/00365513.2014.884240.
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Vikøren, Thea Berge; Berg, Jens Petter & Berg, Tore Julsrud
(2014).
Feilkilder ved bruk av hemoglobin A1C.
Tidsskrift for Den norske legeforening.
ISSN 0029-2001.
134(4),
s. 417–421.
doi:
10.4045/tidsskr.13.0938.
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Hellum, Marit Synnøve; Øvstebø, Reidun; Brusletto, Berit Sletbakk; Berg, Jens Petter; Brandtzæg, Petter & Henriksson, Carola
(2014).
Microparticle-associated tissue factor activity correlates with plasma levels of bacterial lipopolysaccharides in meningocoocal septic shock.
Thrombosis Research.
ISSN 0049-3848.
133(3),
s. 507–514.
doi:
10.1016/j.thromres.2013.12.031.
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Reppe, Sjur; Sachse, Daniel; Olstad, Ole Kristoffer; Gautvik, Vigdis Teig; Sanderson, Paul & Datta, Harish K
[Vis alle 8 forfattere av denne artikkelen]
(2013).
Identification of transcriptional macromolecular associations in human bone using browser based in silico analysis in a giant correlation matrix.
Bone.
ISSN 8756-3282.
53(1),
s. 69–78.
doi:
10.1016/j.bone.2012.11.015.
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Moltu, Sissel; Strømmen, Kenneth; Blakstad, Elin Wahl; Almaas, Astrid; Westerberg, Ane Cecilie & Brække, Kristin
[Vis alle 13 forfattere av denne artikkelen]
(2013).
Enhanced feeding in very-low-birth-weight infants may cause electrolyte disturbances and septicemia - A randomized, controlled trial.
Clinical Nutrition.
ISSN 0261-5614.
32(2),
s. 207–212.
doi:
10.1016/j.clnu.2012.09.004.
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Berg, Jens Petter
(2013).
Hba1c as a diagnostic tool in diabetes mellitus.
Norsk Epidemiologi.
ISSN 0803-2491.
23(1),
s. 5–8.
doi:
10.5324/nje.v23i1.1596.
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Lekva, Tove; Berg, Jens Petter; Heck, Ansgar; Fougner, Stine Lyngvi; Olstad, Ole Kristoffer & Ringstad, Geir Andre
[Vis alle 8 forfattere av denne artikkelen]
(2013).
Attenuated RORC expression in the presence of EMT progression in somatotroph adenomas following treatment with somatostatin analogs is associated with poor clinical recovery.
PLOS ONE.
ISSN 1932-6203.
8(6).
doi:
10.1371/journal.pone.0066927.
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Evang, Johan Arild; Bollerslev, Jens; Casar-Borota, Olivera; Lekva, Tove; Ramm-Pettersen, Jon-Terje & Berg, Jens Petter
(2013).
Different levels of various glucocorticoid-regulated genes in corticotroph adenomas.
Endocrine.
ISSN 1355-008X.
44(1),
s. 220–227.
doi:
10.1007/s12020-012-9871-0.
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Sakhi, Amrit Kaur; Berg, Jens Petter & Berg, Tore Julsrud
(2013).
Glyoxalase 1 enzyme activity in erythrocytes and Ala111Glu polymorphism in type 1-diabetes patients.
Scandinavian Journal of Clinical and Laboratory Investigation.
ISSN 0036-5513.
73(2),
s. 175–181.
doi:
10.3109/00365513.2013.765028.
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Sachse, Daniel; Sletner, Line; Mørkrid, Kjersti; Jenum, Anne Karen; Birkeland, Kåre I. & Rise, Frode
[Vis alle 8 forfattere av denne artikkelen]
(2012).
Metabolic Changes in Urine during and after Pregnancy in a Large, Multiethnic Population-Based Cohort Study of Gestational Diabetes.
PLOS ONE.
ISSN 1932-6203.
7(12).
doi:
10.1371/journal.pone.0052399.
Fulltekst i vitenarkiv
Vis sammendrag
This study aims to identify novel markers for gestational diabetes (GDM) in the biochemical profile of maternal urine using NMR metabolomics. It also catalogs the general effects of pregnancy and delivery on the urine profile. Urine samples were collected at three time points (visit V1: gestational week 8–20; V2: week 28±2; V3:10–16 weeks post partum) from participants in the STORK Groruddalen program, a prospective, multiethnic cohort study of 823 healthy, pregnant women in Oslo, Norway, and analyzed using 1H-NMR spectroscopy. Metabolites were identified and quantified where possible. PCA, PLS-DA and univariate statistics were applied and found substantial differences between the time points, dominated by a steady increase of urinary lactose concentrations, and an increase during pregnancy and subsequent dramatic reduction of several unidentified NMR signals between 0.5 and 1.1 ppm. Multivariate methods could not reliably identify GDM cases based on the WHO or graded criteria based on IADPSG definitions, indicating that the pattern of urinary metabolites above micromolar concentrations is not influenced strongly and consistently enough by the disease. However, univariate analysis suggests elevated mean citrate concentrations with increasing hyperglycemia. Multivariate classification with respect to ethnic background produced weak but statistically significant models. These results suggest that although NMR-based metabolomics can monitor changes in the urinary excretion profile of pregnant women, it may not be a prudent choice for the study of GDM.
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Gopinathan, Unni; Øvstebø, Reidun; Olstad, Ole Kristoffer; Brusletto, Berit Sletbakk; Aass, Hans Christian & Kierulf, Peter
[Vis alle 8 forfattere av denne artikkelen]
(2012).
Global Effect of Interleukin-10 on the Transcriptional Profile Induced by Neisseria meningitidis in Human Monocytes.
Infection and Immunity.
ISSN 0019-9567.
80(11),
s. 4046–4054.
doi:
10.1128/IAI.00386-12.
-
Hellum, Marit Synnøve; Øvstebø, Reidun; Siebke, Anne-Marie; Berg, Jens Petter; Brandtzæg, Petter & Henriksson, Carola
(2012).
Microparticle-associated tissue factor activity measured with the Zymuphen MP-TF kit and the calibrated automated thrombogram assay.
Blood Coagulation and Fibrinolysis.
ISSN 0957-5235.
23(6),
s. 520–526.
doi:
10.1097/MBC.0b013e328354a256.
-
-
Lekva, Tove; Berg, Jens Petter; Fougner, Stine Lyngvi; Olstad, Ole Kristoffer; Ueland, Thor & Bollerslev, Jens
(2012).
Gene Expression Profiling Identifies ESRP1 as a Potential Regulator of Epithelial Mesenchymal Transition in Somatotroph Adenomas from a Large Cohort of Patients with Acromegaly.
Journal of Clinical Endocrinology and Metabolism (JCEM).
ISSN 0021-972X.
97(8),
s. E1506–E1514.
doi:
10.1210/jc.2012-1760.
-
-
Fougner, Stine Lyngvi; Borota, Olivera Casar; Heck, Ansgar; Berg, Jens Petter & Bollerslev, Jens
(2012).
Adenoma granulation pattern correlates with clinical variables and effect of somatostatin analogue treatment in a large series of patients with acromegaly.
Clinical Endocrinology.
ISSN 0300-0664.
76(1),
s. 96–102.
doi:
10.1111/j.1365-2265.2011.04163.x.
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Jonassen, Rune; Endestad, Tor; Neumeister, Alexander; Foss, Kari Bente; Berg, Jens Petter & Landrø, Nils Inge
(2012).
The effects of the serotonin transporter polymorphism and age on frontal white matter integrity in healthy adult women.
Frontiers in Human Neuroscience.
ISSN 1662-5161.
6.
doi:
10.3389/fnhum.2012.00019.
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Jonassen, Rune; Endestad, Tor; Neumeister, Alexander; Haug, Kari Bente Foss; Berg, Jens Petter & Landrø, Nils Inge
(2012).
Serotonin Transporter Polymorphism Modulates N-Back Task Performance and fMRI BOLD Signal Intensity in Healthy Women.
PLOS ONE.
ISSN 1932-6203.
7(1).
doi:
10.1371/journal.pone.0030564.
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Kristiansen, Marianne; Stormo, Camilla; Grimholt, Runa Marie; Berg, Jens Petter & Piehler, Armin
(2012).
Copy number variations of the ATP-binding cassette transporter ABCC6 gene and its pseudogenes.
BMC Research Notes.
ISSN 1756-0500.
5.
doi:
10.1186/1756-0500-5-425.
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Stormo, Camilla; Kristiansen, Marianne; Grimholt, Runa Marie; Berg, Jens Petter & Piehler, Armin
(2012).
A novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) splice variant with an alternative exon 1 potentially encoding an extended N-terminus.
BMC Molecular Biology.
ISSN 1471-2199.
13.
doi:
10.1186/1471-2199-13-29.
-
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Aass, Hans Christian D.; Øvstebø, Reidun; Trøseid, Anne-Marie S.; Kierulf, Peter; Berg, Jens Petter & Henriksson, Carola Elisabeth
(2011).
Fluorescent particles in the antibody solution result in false TF- and CD14-positive microparticles in flow cytometric analysis.
Cytometry Part A.
ISSN 1552-4922.
79A(12),
s. 990–999.
doi:
10.1002/cyto.a.21147.
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Steen, Nils Eiel; Methlie, Paal; Lorentzen, Steinar; Hope, Sigrun; Barrett, Elisabeth Ann & Larsson, Sara
[Vis alle 13 forfattere av denne artikkelen]
(2011).
Increased systemic cortisol metabolism in patients with schizophrenia and bipolar disorder: a mechanism for increased stress vulnerability?
Journal of Clinical Psychiatry.
ISSN 0160-6689.
72(11),
s. 1515–1521.
doi:
10.4088/JCP.10m06068yel.
-
-
-
-
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Kristiansen, Marianne; Foss, Kari Bente; Grimholt, Runa Marie; Stormo, Camilla; Narum, Sigrid & Opdal, Mimi S.
[Vis alle 12 forfattere av denne artikkelen]
(2011).
Genetic Variation of VKORC1 and CYP4F2 Genes Related to Warfarin Maintenance Dose in Patients with Myocardial Infarction.
Journal of Biomedicine and Biotechnology.
ISSN 1110-7243.
2011.
doi:
10.1155/2011/739751.
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Piehler, Armin; Grimholt, Runa Marie; Øvstebø, Reidun & Berg, Jens Petter
(2010).
Gene expression results in lipopolysaccharide-stimulated monocytes depend significantly on the choice of reference genes.
BMC Immunology.
ISSN 1471-2172.
11.
doi:
10.1186/1471-2172-11-21.
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Fougner, Stine Lyngvi; Lekva, Tove; Borota, Olivera Casar; Hald, John K; Bollerslev, Jens & Berg, Jens Petter
(2010).
The Expression of E-Cadherin in Somatotroph Pituitary Adenomas Is Related to Tumor Size, Invasiveness, and Somatostatin Analog Response.
Journal of Clinical Endocrinology and Metabolism (JCEM).
ISSN 0021-972X.
95(5),
s. 2334–2342.
doi:
10.1210/jc.2009-2197.
Se alle arbeider i Cristin
-
Storsul, Tanja; Berg, Jens Petter; Urdal, Henrik; Sivertsen, Gunnar & Røeggen, Vidar
(2023).
Hvordan bør framtidas indikator for publisering være?
Khrono.no.
ISSN 1894-8995.
-
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Berg, Jens Petter & Gladhaug, Ivar Prydz
(2020).
Disputasen er en del av doktorgradsproven.
Tidsskrift for Den norske legeforening.
ISSN 0029-2001.
140(9),
s. 1–3.
doi:
10.4045/tidsskr.20.0328.
-
Berg, Jens Petter
(2019).
Utredning av sykdom i binyrene,
Klinisk biokjemi og fysiologi, 6. utgave.
Gyldendal Akademisk.
ISSN 978-82-05-52788-1.
s. 382–393.
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Berg, Jens Petter & Tazmini, Kiarash
(2019).
Utredning av sykdom i hypofysen,
Klinisk biokjemi og fysiologi, 6. utgave.
Gyldendal Akademisk.
ISSN 978-82-05-52788-1.
s. 370–381.
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Berg, Jens Petter & Gladhaug, Ivar Prydz
(2019).
Viktig at prøveforelesningens hensikt blir oppfylt.
Tidsskrift for Den norske legeforening.
ISSN 0029-2001.
139(16),
s. 1534–1534.
doi:
10.4045/tidsskr.19.0646.
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Schwettmann, Lutz; Berg, Jens Petter & Sandberg, Sverre
(2018).
HbA1c skal angis i mmol/mol.
Tidsskrift for Den norske legeforening.
ISSN 0029-2001.
138(15),
s. 1404–1405.
doi:
10.4045/tidsskr.18.0633.
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Mårild, Karl; Vistnes, Maria; Tapia, German; Midttun, Øivind; Ueland, Per Magne & Viken, Marte K
[Vis alle 10 forfattere av denne artikkelen]
(2017).
Midpregnancy and cord blood immunologic biomarkers, HLA genotype, and pediatric celiac disease.
Journal of Allergy and Clinical Immunology.
ISSN 0091-6749.
139(5),
s. 1696–1698.
doi:
10.1016/j.jaci.2016.10.016.
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Berg, Jens Petter & Halse, Johan
(2015).
Fenylketonuri.
I Godal, Anne Marit (Red.),
Store norske leksikon (snl.no 2015).
Store norske leksikon AS.
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Berg, Jens Petter & Øye, Ivar
(2015).
Dopingmidler.
I Godal, Anne Marit (Red.),
Store norske leksikon (snl.no 2015).
Store norske leksikon AS.
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Berg, Jens Petter & Øye, Ivar
(2015).
Dopingkontroll.
I Godal, Anne Marit (Red.),
Store norske leksikon (snl.no 2015).
Store norske leksikon AS.
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Berg, Jens Petter & Opdahl, Helge
(2015).
Diabeteskoma.
I Godal, Anne Marit (Red.),
Store norske leksikon (snl.no 2015).
Store norske leksikon AS.
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Berg, Jens Petter & Vaaler, Stein
(2015).
Diabetes.
I Godal, Anne Marit (Red.),
Store norske leksikon (snl.no 2015).
Store norske leksikon AS.
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Berg, Jens Petter
(2015).
Aromatase.
I Godal, Anne Marit (Red.),
Store norske leksikon (snl.no 2015).
Store norske leksikon AS.
-
Berg, Jens Petter
(2015).
antinukleære faktorer.
I Godal, Anne Marit (Red.),
Store norske leksikon (snl.no 2015).
Store norske leksikon AS.
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Berg, Jens Petter
(2015).
Androstenedion.
I Godal, Anne Marit (Red.),
Store norske leksikon (snl.no 2015).
Store norske leksikon AS.
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Vereshchagina, Elizaveta; Jensen, Geir Uri; Mielnik, Michal Marek; Berg, Jens Petter & Øvstebø, Reidun
(2015).
A versatile fabrication and assembly approach for microfluidic capturing of extracellular vesicles
.
Vis sammendrag
Cells communicate by means of "messengers" known as extracellular vesicles, i.e. small (30‐1000 nm) cell derived
vesicles released from almost all eukaryotic cells into their extracellular environment and containing a variety of
proteins and RNAs [1]. It has been foreseen that the next generation of biomarkers for disease diagnostics and
prognostics may strongly depend on the vesicles being efficiently isolated, quantified and analyzed by e.g. reliable,
high‐throughput and possibly easy‐to‐operate microfluidic devices.
The results reported here extend the previously reported work by Chen et al. [2]: (i) the fabrication approach is
based on silicon as a micromolding master, which offers better dimensional control and durability than SU‐8
masters, (ii) a staggered herringbone micromixer [3] is introduced in three different channel configurations , (iii) the
device assembly allows straightforward integration of a large variety of surface chemistries by introducing prefunctionalized
glass slides; (iv) individual functionalization of the glass slide and the PDMS replica prior to assembly
permits combination of two differently biofunctionalized surfaces within the same fluidic device; (v) isolated
extracellular vesicles can be accessed directly for a variety of post‐analyses by opening the device assembly.
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Jansen, Aina; Skaug, Marit Aralt; Berg, Jens Petter & Aaseth, Jan
(2014).
Overvekt og miljøgifter.
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Berg, Jens Petter
(2011).
Kapittel 17 Sykdommer i endokrine organer.
I Ørn, Stein; Mjell, Johnny & Bach-Gansmo, Edvin (Red.),
Sykdom og behandling.
Gyldendal Akademisk.
ISSN 9788205323605.
s. 363–378.
Se alle arbeider i Cristin
Publisert
13. apr. 2011 11:36
- Sist endret
5. mars 2024 07:34