Kristina Haugaa

• Corrado, Domenico; van Tintelen, Peter J.; McKenna, William J.; Hauer, Richard N.W.; Anastastakis, Aris; Asimaki, Angeliki; Basso, Cristina; Bauce, Barbara; Brunckhorst, Corinna; Bucciarelli-Ducci, Chiara; Duru, Firat; Elliott, Perry; Hamilton, Robert M.; Haugaa, Kristina; James, Cynthia A.; Judge, Daniel; Link, Mark S.; Marchlinski, Francis E.; Mazzanti, Andrea; Mestroni, Luisa; Pantazis, Antonis; Pelliccia, Antonio; Marra, Martina Perazzolo; Pilichou, Kalliopi; Platonov, Pyotr G.; Protonotarios, Alexandros; Rampazzo, Alessandra; Saffitz, Jeffry E.; Saguner, Ardan M.; Schmied, Christian; Sharma, Sanjay; Tandri, Hari; te Riele, Anneline S.J.M.; Thiene, Gaetano; Tsatsopoulou, Adalena; Zareba, Wojciech; Zorzi, Alessandro; Wichter, Thomas; Marcus, Frank I. & Calkins, Hugh (2020). Arrhythmogenic right ventricular cardiomyopathy: Evaluation of the current diagnostic criteria and differential diagnosis. European Heart Journal.  ISSN 0195-668X.  41(14), s 1414- 1427b . doi: 10.1093/eurheartj/ehz669
• Otterstad, Jan Erik; Norum, Ingvild Billehaug; Ruddox, Vidar; Bendz, Bjørn; Haugaa, Kristina & Edvardsen, Thor (2020). The impact of semi-automatic versus manually adjusted assessment of global longitudinal strain in post-myocardial infarction patients. The International Journal of Cardiovascular Imaging.  ISSN 1569-5794. . doi: 10.1007/s10554-020-01826-4
• Ross, Stian Balnagown; Nestaas, Eirik; Kongsgaard, Erik; Odland, Hans Henrik; Haland, Trine F.; Hopp, Einar; Haugaa, Kristina & Edvardsen, Thor (2020). Septal contraction predicts acute haemodynamic improvement and paced QRS width reduction in cardiac resynchronization therapy. European Heart Journal-Cardiovascular Imaging.  ISSN 2047-2404. . doi: 10.1093/ehjci/jez315 Vis sammendrag

  Three distinct septal contraction patterns typical for left bundle branch block may be assessed using echocardiography in heart failure patients scheduled for cardiac resynchronization therapy (CRT). The aim of this study was to explore the association between these septal contraction patterns and the acute haemodynamic and electrical response to biventricular pacing (BIVP) in patients undergoing CRT implantation. Thirty-eight CRT candidates underwent speckle tracking echocardiography prior to device implantation. The patients were divided into two groups based on whether their septal contraction pattern was indicative of dyssynchrony (premature septal contraction followed by various amount of stretch) or not (normally timed septal contraction with minimal stretch). CRT implantation was performed under invasive left ventricular (LV) pressure monitoring and we defined acute CRT response as ≥10% increase in LV dP/dtmax. End-diastolic pressure (EDP) and QRS width served as a diastolic and electrical parameter, respectively. LV dP/dtmax improved under BIVP (737 ± 177 mmHg/s vs. 838 ± 199 mmHg/s, P < 0.001) and 26 patients (68%) were defined as acute CRT responders. Patients with premature septal contraction (n = 27) experienced acute improvement in systolic (ΔdP/dtmax: 18.3 ± 8.9%, P < 0.001), diastolic (ΔEDP: −30.6 ± 29.9%, P < 0.001) and electrical (ΔQRS width: −23.3 ± 13.2%, P < 0.001) parameters. No improvement under BIVP was observed in patients (n = 11) with normally timed septal contraction (ΔdP/dtmax: 4.0 ± 7.8%, P = 0.12; ΔEDP: −8.8 ± 38.4%, P = 0.47 and ΔQRS width: −0.9 ± 11.4%, P = 0.79).   Septal contraction patterns are an excellent predictor of acute CRT response. Only patients with premature septal contraction experienced acute systolic, diastolic, and electrical improvement under BIVP.

• Smistad, Erik; Østvik, Andreas; Salte, Ivar Mjåland; Melichova, Daniela; Nguyen, Thuy Mi; Haugaa, Kristina; Brunvand, Harald; Edvardsen, Thor; Leclerc, Sarah; Bernard, Olivier; Grenne, Bjørnar & Løvstakken, Lasse (2020). Real-Time Automatic Ejection Fraction and Foreshortening Detection Using Deep Learning. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.  ISSN 0885-3010. . doi: 10.1109/TUFFC.2020.2981037
• Stokke, Mathis Korseberg; Castrini, Anna I.; Aneq, Meriam Åström; Jensen, Henrik K.; Madsen, Trine; Hansen, Jim; Bundgaard, Henning; Gilljam, Thomas; Platonov, Pyotr G.; Svendsen, Jesper Hastrup; Edvardsen, Thor & Haugaa, Kristina (2020). Absence of ECG Task Force Criteria does not rule out structural changes in genotype positive ARVC patients. International Journal of Cardiology.  ISSN 0167-5273. . doi: 10.1016/j.ijcard.2020.05.095
• Babic, Aleksandar; Odland, Hans Henrik; Lyseggen, Erik; Holm, Torbjørn; Ross, Stian Balnagown; Hopp, Einar; Haugaa, Kristina; Kongsgård, Erik; Edvardsen, Thor; Olivier, Gerard & Samset, Eigil (2019). An image fusion tool for echo‐guided left ventricular lead placement in cardiac resynchronization therapy: Performance and workflow integration analysis. Echocardiography.  ISSN 0742-2822.  36(10), s 1834- 1845 . doi: 10.1111/echo.14483 Fulltekst i vitenarkiv.
• Baturova, Maria A; Haugaa, Kristina; Jensen, Henrik K; Svensson, Anneli; Gilljam, Thomas; Bundgaard, Henning; Madsen, Trine; Hansen, Jim; Chivulescu, Ana Monica; Christiansen, Morten Krogh; Carlson, Jonas; Edvardsen, Thor; Svendsen, Jesper H. & Platonov, Pyotr G (2019). Atrial fibrillation as a clinical characteristic of arrhythmogenic right ventricular cardiomyopathy: Experience from the Nordic ARVC Registry. International Journal of Cardiology.  ISSN 0167-5273.  (298), s 39- 43 . doi: 10.1016/j.ijcard.2019.07.086 Fulltekst i vitenarkiv. Vis sammendrag

  Abstract BACKGROUND: Recent studies in arrhythmogenic right ventricular cardiomyopathy (ARVC) patients have drawn attention to atrial fibrillation (AF) as an arrhythmic manifestation of ARVC and as an indicator of atrial involvement in the disease progression. We aimed to assess the prevalence of AF in the Scandinavian cohort of ARVC patients and to evaluate its association with disease clinical manifestations. METHODS: Study sample comprised of 293 definite ARVC patients by 2010 Task Force criteria (TFC2010) and 141 genotype-positive family members (total n = 434, 43% females, median age at ARVC diagnosis 41 years [interquartile range (IQR) 28-52 years]). ARVC diagnostic score was calculated as the sum of major (2 points) and minor (1 point) criteria in all categories of the TFC2010. RESULTS: AF was diagnosed in 42 patients (10%): in 41 patients with definite ARVC diagnosis (14%) vs in one genotype-positive family member (1%), p < 0.001. The median age at AF onset was 51 (IQR 38-58) years. The prevalence of AF was related to the ARVC diagnostic score: it significantly increased starting with the diagnostic score 4 (2% in those with score 3 vs 13% in those with score 4, p = 0.023) and increased further with increased diagnostic score (Somer's d value is 0.074, p < 0.001). CONCLUSION: AF is seen in 14% of definite ARVC patients and is related to the severity of disease phenotype thus suggesting AF being an arrhythmic manifestation of this cardiomyopathy indicating atrial myocardial involvement in the disease progression.

• Bjerring, Anders W.; Landgraff, Hege Elisabeth W.; Stokke, Thomas Muri; Murbræch, Klaus; Leirstein, Svein; Aaeng, Anette; Brun, Henrik; Haugaa, Kristina; Hallén, Jostein; Edvardsen, Thor & Sarvari, Sebastian (2019). The developing athlete's heart: a cohort study in young athletes transitioning through adolescence. European Journal of Preventive Cardiology (EJPC).  ISSN 2047-4873.  s 1- 8 . doi: 10.1177/2047487319862061 Fulltekst i vitenarkiv. Vis sammendrag

  Background Athlete's heart is a term used to describe physiological changes in the hearts of athletes, but its early development has not been described in longitudinal studies. This study aims to improve our understanding of the effects of endurance training on the developing heart. Methods Cardiac morphology and function in 48 cross-country skiers were assessed at age 12 years (12.1 ± 0.2 years) and then again at age 15 years (15.3 ± 0.3 years). Echocardiography was performed in all subjects including two-dimensional speckle-tracking strain echocardiography and three-dimensional echocardiography. All participants underwent cardiopulmonary exercise testing at both ages 12 and 15 years to assess maximal oxygen uptake and exercise capacity. Results Thirty-one (65%) were still active endurance athletes at age 15 years and 17 (35%) were not. The active endurance athletes had greater indexed maximal oxygen uptake (62 ± 8 vs. 57 ± 6 mL/kg/min, P < 0.05) at follow-up. There were no differences in cardiac morphology at baseline. At follow-up the active endurance athletes had greater three-dimensional indexed left ventricular end-diastolic (84 ± 11 mL/m2 vs. 79 ± 10 mL/m2, P < 0.05) and end-systolic volumes (36 ± 6 mL/m2 vs. 32 ± 3 mL/m2, P < 0.05). Relative wall thickness fell in the active endurance athletes, but not in those who had quit (–0.05 ΔmL/m2 vs. 0.00 mL/m2, P = 0.01). Four active endurance athletes had relative wall thickness above the upper reference values at baseline; all had normalised at follow-up. Conclusion After an initial concentric remodelling in the pre-adolescent athletes, those who continued their endurance training developed eccentric changes with chamber dilatation and little change in wall thickness. Those who ceased endurance training maintained a comparable wall thickness, but did not develop chamber dilatation.

• Cadrin-Tourigny, Julia; Bosman, Laurens P.; Nozza, Anna; Wang, Weijia; Tadros, Rafik; Bhonsale, Aditya; Bourfiss, Mimount; Fortier, Annik; Lie, Øyvind Haugen; Saguner, Ardan M.; Svensson, Anneli; Andorin, Antoine; Tichnell, Crystal; Murray, Brittney; Zeppenfeld, Katja; van den Berg, Maarten P.; Asselbergs, Folkert W.; Wilde, Arthur A.M.; Krahn, Andrew D.; Talajic, Mario; Rivard, Lena; Chelko, Stephen; Zimmerman, Stefan L.; Kamel, Ihab R.; Crosson, Jane E.; Judge, Daniel P.; Yap, Sing-Chien; van der Heijden, Jeroen F.; Tandri, Harikrishna; Jongbloed, Jan D.H.; Guertin, Marie-Claude; van Tintelen, J. Peter; Platonov, Pyotr G.; Duru, Firat; Haugaa, Kristina; Khairy, Paul; Hauer, Richard N.W.; Calkins, Hugh; te Riele, Anneline S.J.M. & James, Cynthia A. (2019). A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy. European Heart Journal.  ISSN 0195-668X.  40(23), s 1850- 1858 . doi: 10.1093/eurheartj/ehz103
• Cameli, Matteo; Marsan, Nina Ajmone; D'Andrea, Antonello; Dweck, Mark R.; Fontes-Carvalho, Ricardo; Manka, Robert; Michalski, Blazej; Podlesnikar, Tomaz; Sitges, Marta; Popescu, Bogdan A.; Edvardsen, Thor; Fox, Kevin F. & Haugaa, Kristina (2019). EACVI survey on multimodality training in ESC countries. European Heart Journal-Cardiovascular Imaging.  ISSN 2047-2404.  20(12), s 1332- 1336 . doi: 10.1093/ehjci/jez200 Fulltekst i vitenarkiv.
• Castrini, Anna Isotta; Lie, Øyvind Haugen; Leren, Ida Skrinde; Estensen, Mette-Elise; Stokke, Mathis Korseberg; Klæboe, Lars Gunnar; Edvardsen, Thor & Haugaa, Kristina (2019). Number of pregnancies and subsequent phenotype in a cross-sectional cohort of women with arrhythmogenic cardiomyopathy. European Heart Journal-Cardiovascular Imaging.  ISSN 2047-2404.  20(2), s 192- 198 . doi: 10.1093/ehjci/jey061 Fulltekst i vitenarkiv.
• Christiansen, Morten K; Haugaa, Kristina; Svensson, Anneli; Gilljam, Thomas; Madsen, Trine; Hansen, Jim; Holst, Anders G; Bundgaard, Henning; Edvardsen, Thor; Svendsen, Jesper H.; Platonov, Pyotr G & Jensen, Henrik K (2019). Incidence, Predictors, and Success of Ventricular Tachycardia Catheter Ablation in Arrhythmogenic Right Ventricular Cardiomyopathy (from the Nordic ARVC Registry). American Journal of Cardiology.  ISSN 0002-9149.  125, s 803- 811 Fulltekst i vitenarkiv.
• Conte, Giulio; Belhassen, Bernard; Lambiase, Pier; Ciconte, Giuseppe; de Asmundis, Carlo; Arbelo, Elena; Schaer, Beat; Frontera, Antonio; Burri, Haran; Calo, Leonardo; Letsas, Kostantinos P.; Leyva, Francisco; Porter, Bradley; Saenen, Johan; Zacà, Valerio; Berne, Paola; Ammann, Peter; Zardini, Marco; Luani, Blerim; Rordorf, Roberto; Sarquella Brugada, Georgia; Medeiros-Domingo, Argelia; Geller, Johann-Christoph; de Potter, Tom; Stokke, Mathis Korseberg; Márquez, Manlio F.; Michowitz, Yoav; Honarbakhsh, Shohreh; Conti, Manuel; Sticherling, Christian; Martino, Annamaria; Zegard, Abbasin; Özkartal, Tardu; Caputo, Maria Luce; Regoli, François; Braun-Dullaeus, Rüdiger C.; Notarangelo, Francesca; Moccetti, Tiziano; Casu, Gavino; Rinaldi, Christopher A.; Levinstein, Moises; Haugaa, Kristina; Derval, Nicolas; Klersy, Catherine; Curti, Moreno; Pappone, Carlo; Heidbuchel, Hein; Brugada, Josép; Haïssaguerre, Michel; Brugada, Pedro & Auricchio, Angelo (2019). Out-of-hospital cardiac arrest due to idiopathic ventricular fibrillation in patients with normal electrocardiograms: Results from a multicentre long-term registry. Europace.  ISSN 1099-5129.  21(11), s 1670- 1677 . doi: 10.1093/europace/euz221
• Cosyns, Bernard; Haugaa, Kristina; Gerber, Bernhard L.; Gimelli, Alessia; Donal, Erwan; Maurer, Gerald & Edvardsen, Thor (2019). The year 2018 in the European Heart Journal - Cardiovascular Imaging: Part II. European Heart Journal-Cardiovascular Imaging.  ISSN 2047-2404.  20(12), s 1337- 1344 . doi: 10.1093/ehjci/jez218
• Cuneo, Bettina F.; Kaizer, Alexander M.; Clur, Sally Ann; Swan, Heikki; Herberg, Ulrike; Winbo, Annika; Rydberg, Annika; Haugaa, Kristina; Etheridge, Susan; Ackerman, Michael J.; Dagradi, Federica; Killen, Stacy A.S.; Wacker-Gussmann, Annette; Benson, D. Woodrow; Wilde, Arthur Arnold Maria; Pan, Zhaoxing; Lam, Aimee; Spazzolini, Carla; Horigome, Hitoshi & Schwartz, Peter J. (2019). Mothers with long QT syndrome are at increased risk for fetal death: findings from a multicenter international study. American Journal of Obstetrics and Gynecology.  ISSN 0002-9378.  222(3), s 263.e1- 263.e11 . doi: 10.1016/j.ajog.2019.09.004
• Edvardsen, Thor; Haugaa, Kristina; Petersen, Steffen E.; Gimelli, Alessia; Donal, Erwan; Maurer, Gerald; Popescu, Bogdan A. & Cosyns, Bernard (2019). The year 2018 in the European Heart Journal - Cardiovascular Imaging: Part I. European Heart Journal-Cardiovascular Imaging.  ISSN 2047-2404.  20(8), s 858- 865 . doi: 10.1093/ehjci/jez133 Fulltekst i vitenarkiv.
• Gibbs, Charlotte Christine; Thalamus, Jacob; Kristoffersen, Doris Tove; Svendsen, Martin Veel; Holla, Øystein Lunde; Heldal, Kristian; Haugaa, Kristina & Hysing, Jan (2019). QT prolongation predicts short-term mortality independent of comorbidity. Europace.  ISSN 1099-5129.  21(8), s 1254- 1260 . doi: 10.1093/europace/euz058 Fulltekst i vitenarkiv.
• Haugaa, Kristina & Leren, Ida Skrinde (2019). Prevalence, clinical presentation, and management of channelopathies and cardiomyopathies, long QT syndrome, Brugada syndrome, arrhythmogenic cardiomyopathy, and hypertrophic cardiomyopathy. Current Cardiovascular Risk Reports.  ISSN 1932-9520.  13:16(7), s 1- 7 . doi: 10.1007/s12170-019-0612-2
• Haugaa, Kristina & Lie, Øyvind Haugen (2019). Cardiac amyloidosis: can imaging shed light on mechanisms and prognosis?. European Heart Journal-Cardiovascular Imaging.  ISSN 2047-2404.  20(5), s 500- 501 . doi: 10.1093/ehjci/jez009 Fulltekst i vitenarkiv.
• Haugaa, Kristina; Marsan, Nina Ajmone; Cameli, Matteo; D'Andrea, Antonello; Dweck, Mark R.; Carvalho, Ricardo Fontes; Holte, Espen; Manka, Robert; Michalski, Blazej; Podlesnikar, Tomaz; Popescu, Bogdan A.; Schulz-Menger, Jeanette; Sitges, Marta; Stankovic, Ivan; Maurer, Gerald & Edvardsen, Thor (2019). Criteria for surveys: from the European Association of Cardiovascular Imaging Scientific Initiatives Committee. European Heart Journal-Cardiovascular Imaging.  ISSN 2047-2404.  20(9), s 963- 966 . doi: 10.1093/ehjci/jez193 Fulltekst i vitenarkiv.
• Kawakami, Hiroshi; Nerlekar, Nitesh; Haugaa, Kristina; Edvardsen, Thor & Marwick, Thomas H. (2019). Prediction of Ventricular Arrhythmias With Left Ventricular Mechanical Dispersion: A Systematic Review and Meta-Analysis. JACC Cardiovascular Imaging.  ISSN 1936-878X.  13(2), s 562- 572 . doi: 10.1016/j.jcmg.2019.03.025
• Klæboe, Lars Gunnar; Brekke, Pål Haugar; Lie, Øyvind Haugen; Aaberge, Lars; Haugaa, Kristina & Edvardsen, Thor (2019). Classical mechanical dyssynchrony is rare in transcatheter aortic valve implantation-induced left bundle branch block. European Heart Journal-Cardiovascular Imaging.  ISSN 2047-2404.  20(3), s 271- 278 . doi: 10.1093/ehjci/jey127 Fulltekst i vitenarkiv.
• Kvisvik, Brede Alexander; Aagaard, Erika Nerdrum; Mørkrid, Lars; Røsjø, Helge; Lyngbakken, Magnus; Smedsrud, Marit Kristine; Eek, Christian; Bendz, Bjørn; Haugaa, Kristina; Edvardsen, Thor & Gravning, Jørgen A. (2019). Mechanical dispersion as a marker of left ventricular dysfunction and prognosis in stable coronary artery disease. The International Journal of Cardiovascular Imaging.  ISSN 1569-5794.  35, s 1265- 1275 . doi: 10.1007/s10554-019-01583-z Fulltekst i vitenarkiv.
• Magne, Julien; Bharucha, Tara; Bucciarelli-Ducci, Chiara; Dahl, Jordi S.; Gimelli, Alessia; Haugaa, Kristina; Muraru, Denisa; Donal, Erwan; Edvardsen, Thor & Popescu, Bogdan A. (2019). EuroEcho-imaging 2018: highlights. European Heart Journal-Cardiovascular Imaging.  ISSN 2047-2404.  20(5), s 489- 497 . doi: 10.1093/ehjci/jez042
• Platonov, Pyotr G.; Haugaa, Kristina; Bundgaard, Henning; Svensson, Anneli; Gilljam, Thomas; Hansen, Jim; Madsen, Trine; Holst, Anders Gaarsdal; Carlson, Jonas; Lie, Øyvind Haugen; Kvistholm Jensen, Morten; Edvardsen, Thor; Jensen, Henrik K. & Svendsen, Jesper H. (2019). Primary prevention of sudden cardiac death with implantable cardioverter-defibrillator therapy in patients with arrhythmogenic right ventricular cardiomyopathy. American Journal of Cardiology.  ISSN 0002-9149.  123(7), s 1156- 1162 . doi: 10.1016/j.amjcard.2018.12.049 Fulltekst i vitenarkiv.
• Rootwelt, Christine; Lie, Øyvind Haugen; Dejgaard, Lars; Chivulescu, Ana Monica; Leren, Ida Skrinde; Edvardsen, Thor & Haugaa, Kristina (2019). Life-threatening arrhythmic presentation in patients with arrhythmogenic cardiomyopathy before and after entering the genomic era; a two-decade experience from a large volume center. International Journal of Cardiology.  ISSN 0167-5273.  (279), s 79- 83 . doi: 10.1016/j.ijcard.2018.12.066 Fulltekst i vitenarkiv.
• Scheirlynck, Esther Steffie; Dejgaard, Lars; Skjølsvik, Eystein Theodor Ek; Lie, Øyvind Haugen; Motoc, Andreea; Hopp, Einar; Tanaka, Kaoru; Ueland, Thor; Ribe, Margareth; Collet, Carlos; Edvardsen, Thor; Droogmans, Steven; Cosyns, Bernard & Haugaa, Kristina (2019). Increased levels of sST2 in patients with mitral annulus disjunction and ventricular arrhythmias. Open heart.  ISSN 2053-3624.  6:e001016(1), s 1- 8 . doi: 10.1136/openhrt-2019-001016 Fulltekst i vitenarkiv.
• Van Der Werf, Christian; Lieve, Krystien V; Bos, J. Martijn; Lane, Conor M; Denjoy, Isabelle; Roses-Noguer, Ferran; Aiba, Takeshi; Wada, Yuko; Ingles, Jodie; Leren, Ida Skrinde; Rudic, Boris; Schwartz, Peter J; Maltret, Alice; Sacher, Frederic; Skinner, Jonathan R.; Krahn, Andrew D.; Roston, Thomas M; Tfelt-Hansen, Jacob; Swan, Heikki; Robyns, Tomas; Ohno, Seiko; Roberts, Jason; Van Den Berg, Maarten P; Kammeraad, Janneke A; Probst, Vincent; Kannankeril, Prince J; Blom, Nico A; Behr, Elijah R; Borggrefe, Martin; Haugaa, Kristina; Semsarian, Christopher; Horie, Minoru; Shimizu, Wataru; Till, Janice A; Leenhardt, Antoine; Ackerman, Michael J & Wilde, Arthur AM (2019). Implantable cardioverter-defibrillators in previously undiagnosed patients with catecholaminergic polymorphic ventricular tachycardia resuscitated from sudden cardiac arrest. European Heart Journal.  ISSN 0195-668X.  40(35), s 2953- 2961 . doi: 10.1093/eurheartj/ehz309
• Bjerring, Anders W.; Landgraff, Hege Elisabeth W.; Leirstein, Svein; Aaeng, Anette; Ansari, Hamza; Saberniak, Jørg; Murbræch, Klaus; Brun, Henrik; Stokke, Thomas Muri; Haugaa, Kristina; Hallén, Jostein; Edvardsen, Thor & Sarvari, Sebastian (2018). Morphological changes and myocardial function assessed by traditional and novel echocardiographic methods in preadolescent athlete?s heart. European Journal of Preventive Cardiology (EJPC).  ISSN 2047-4873.  25(9), s 1000- 1007 . doi: 10.1177/2047487318776079 Vis sammendrag

  Background: Athlete’s heart is a term used to describe the morphological and functional changes in the hearts of athletes. Recent studies suggest that these changes may occur even in preadolescent athletes. This study aims to improve our understanding of the changes occurring in the preadolescent athlete’s heart. Design and methods: Cardiac morphology and function in 76 preadolescent cross-country skiers (aged 12.1 ± 0.2 years) were compared with 25 age-matched non-competing preadolescents. Echocardiography was performed in all subjects, including 2D speckle-tracking strain echocardiography and 3D echocardiography. All participants underwent cardiopulmonary exercise testing to assess oxygen uptake and exercise capacity. Results: Athletes had greater indexed VO2 max (62 ± 7 vs. 44 ± 5 mL/kg per min, p < 0.001), indexed left ventricular end-diastolic volume (79 ± 7 vs. 68 ± 7 mL/m2, p < 0.001), left ventricular mass (69 ± 12 vs. 57 ± 13 g/m2, p < 0.001), indexed right ventricular basal diameter (28.3 ± 3.0 vs. 25.4 ± 3.5 mm/m2, p < 0.001) and right atrial area (10.6 ± 1.4 vs. 9.7 ± 1.2 cm2/m2, p < 0.01). There was no difference in left ventricular ejection fraction, global longitudinal strain, and global circumferential strain and right ventricular fractional area change between the groups. Controls had higher right ventricular global longitudinal strain (−28.1 ± 3.5 vs. −31.1 ± 3.3%, p < 0.01). VO2 max was highly correlated to left ventricular end-diastolic volume (r = 0.76, p < 0.001). Conclusion: Athletes had greater left ventricular mass and greater left and right ventricular chamber dimensions compared with controls, while left ventricular function did not differ. Interestingly, right ventricular deformation was significantly lower compared with controls. This supports the notion that there is physiological, adaptive remodelling in preadolescent athlete’s heart.

• Boveda, Serge; Lenarczyk, Radosław; Haugaa, Kristina; Iliodromitis, Konstantinos; Finlay, Malcolm; Lane, Deirdre; Prinzen, Frits W. & Dagres, Nikolaos (2018). Use of leadless pacemakers in Europe: Results of the European Heart Rhythm Association survey. Europace.  ISSN 1099-5129.  20(3), s 555- 559 . doi: 10.1093/europace/eux381
• Chivulescu, Monica; Haugaa, Kristina; Lie, Øyvind Haugen; Edvardsen, Thor; Ginghină, Carmen; Popescu, Bogdan A. & Jurcut, Ruxandra (2018). Right ventricular remodeling in athletes and in arrhythmogenic cardiomyopathy. Scandinavian Cardiovascular Journal.  ISSN 1401-7431.  52(1), s 13- 19 . doi: 10.1080/14017431.2017.1416158
• Danielsen, Tore Kristian; Manotheepan, Ravinea; Sadredini, Mani; Leren, Ida Skrinde; Edwards, Andrew; Vincent, Kevin P.; Lehnart, Stephan .; Sejersted, Ole M; Sjaastad, Ivar; Haugaa, Kristina & Stokke, Mathis Korseberg (2018). Arrhythmia initiation in catecholaminergic polymorphic ventricular tachycardia type 1 depends on both heart rate and sympathetic stimulation. PLOS ONE.  ISSN 1932-6203.  13:e0207100(11), s 1- 21 . doi: 10.1371/journal.pone.0207100 Fulltekst i vitenarkiv.
• Dejgaard, Lars; Håland, Trine Synnøve Fink; Lie, Øyvind Haugen; Ribe, Margareth; Bjune, Thea; Leren, Ida Skrinde; Berge, Knut Erik; Edvardsen, Thor & Haugaa, Kristina (2018). Vigorous exercise in patients with hypertrophic cardiomyopathy. International Journal of Cardiology.  ISSN 0167-5273.  250, s 157- 163 . doi: 10.1016/j.ijcard.2017.07.015 Fulltekst i vitenarkiv.
• Dejgaard, Lars; Skjølsvik, Eystein Theodor Ek; Lie, Øyvind Haugen; Ribe, Margareth; Stokke, Mathis Korseberg; Hegbom, Finn; Scheirlynck, Esther Steffie; Gjertsen, Erik; Andresen, Kristoffer; Helle-Valle, Thomas Michael; Hopp, Einar; Edvardsen, Thor & Haugaa, Kristina (2018). The Mitral Annulus Disjunction Arrhythmic Syndrome. Journal of the American College of Cardiology.  ISSN 0735-1097.  72(14), s 1600- 1609 . doi: 10.1016/j.jacc.2018.07.070 Fulltekst i vitenarkiv.
• Delgado, Victoria; Cardim, Nuno; Cosyns, Bernard; Donal, Erwan; Flachskampf, Frank; Galderisi, Maurizio; Gerber, Bernhard; Gimelli, Alessia; Haugaa, Kristina; Kaufmann, Philipp A.; Lancellotti, Patrizio; Magne, Julien; Masci, Pier Giorgio; Muraru, Denisa; Habib, Gilbert; Edvardsen, Thor & Popescu, Bogdan A. (2018). Criteria for recommendation, expert consensus, and appropriateness criteria papers: Update from the European Association of Cardiovascular Imaging Scientific Documents Committee. European Heart Journal-Cardiovascular Imaging.  ISSN 2047-2404.  19(8), s 835- 837 . doi: 10.1093/ehjci/jey079
• Edvardsen, Thor; Haugaa, Kristina; Gerber, Bernhard L.; Maurovich-Horvat, Pál; Donal, Erwan; Maurer, Gerald & Popescu, Bogdan Alexandru (2018). The year 2017 in the European Heart Journal-Cardiovascular Imaging: Part II. European Heart Journal-Cardiovascular Imaging.  ISSN 2047-2404.  19(11), s 1222- 1229 . doi: 10.1093/ehjci/jey110 Fulltekst i vitenarkiv.
• Fumagalli, Stefano; Pieragnoli, Paolo; Haugaa, Kristina; Potpara, Tatjana S.; Rasero, Laura; Ramacciati, Nicola; Ricciardi, Giuseppe; Solimene, Francesco; Mascia, Giuseppe; Mascioli, Giosuè; Zuo, Giulia; Roberts, Anna T.; Marchionni, Niccolò; Lenarczyk, Radoslaw; Boveda, Serge & Dagres, Nikolaos (2018). The influence of age on the psychological profile of patients with cardiac implantable electronic devices: results from the Italian population in a multicenter study conducted by the European Heart Rhythm Association. Aging Clinical and Experimental Research.  ISSN 1594-0667.  s 1- 8 . doi: 10.1007/s40520-018-1088-5
• Gibbs, Charlotte Christine; Thalamus, Jacob; Tveten, Kristian; Busk, Øyvind; Hysing, Jan; Haugaa, Kristina & Holla, Øystein Lunde (2018). Genetic and phenotypic characterization of community hospital patients with QT prolongation. Journal of the American Heart Association.  ISSN 2047-9980.  7(16), s 1- 11 . doi: 10.1161/JAHA.118.009706 Fulltekst i vitenarkiv.
• Gilljam, Thomas; Haugaa, Kristina; Jensen, Henrik K; Svensson, Anneli; Bundgaard, Henning; Hansen, Jim; Dellgren, Göran; Gustafsson, Finn; Eiskjær, Hans; Andreassen, Arne K.; Sjögren, Johan; Edvardsen, Thor; Holst, Anders G.; Svendsen, Jesper Hastrup & Platonov, Pyotr G. (2018). Heart transplantation in arrhythmogenic right ventricular cardiomyopathy ? Experience from the Nordic ARVC Registry. International Journal of Cardiology.  ISSN 0167-5273.  250, s 201- 206 . doi: 10.1016/j.ijcard.2017.10.076 Fulltekst i vitenarkiv.
• Gonzalez Figuera, Alba Marina; Aurlien, Dag; Haugaa, Kristina & Taubøll, Erik (2018). Epilepsy in patients with long QT syndrome type 1: A Norwegian family. Epilepsy and Behavior Case Reports (EBCR).  ISSN 2213-3232.  10, s 118- 121 . doi: 10.1016/j.ebcr.2018.09.006 Fulltekst i vitenarkiv. Vis sammendrag

  The congenital long QT syndrome (cLQTS) is an inherited cardiac disorder and is associated with sudden cardiac death. We describe a Norwegian family with mutations within the KCNQ1 gene causing cLQTS type 1 (LQT1) and epilepsy. The index patient had Jervell and Lange-Nielsen-syndrome (JLNS) with deafness and recurrent episodes of cardiac arrhythmia. The mother and the brother have Romano-Ward syndrome (RWS) with recurrent arrhythmias. Whereas the father has focal epilepsy and genetically verified LQT1, the sister has both focal epilepsy and RWS. Our findings are consistent with the notion that mutations in the KCNQ1 gene can cause epilepsy.

• Gonzalez Figuera, Alba Marina; Aurlien, Dag; Larsson, Pål Gunnar; Olsen, Ketil Berg; Dahl, Iselin Teresa; Edvardsen, Thor; Haugaa, Kristina & Taubøll, Erik (2018). Seizure-like episodes and EEG abnormalities in patients with long QT syndrome. Seizure.  ISSN 1059-1311.  61, s 214- 220 . doi: 10.1016/j.seizure.2018.08.020
• Hasselberg, Nina Eide; Berge, Knut Erik; Rasmussen, Magnhild; Fruh, Andreas; Ørstavik, Kristin & Haugaa, Kristina (2018). Kardiomyopati ved arvelig skjelettmuskeldystrofi. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  138(1) . doi: 10.4045/tidsskr.16.0683 Vis sammendrag

  En rekke genetiske skjelettmuskeldystrofier er assosiert med kardiomyopati med hjertesviktutvikling og risiko for plutselig død. Grad av kardial affeksjon er ikke nødvendigvis relatert til grad av skjelettmuskelaffeksjon, og plutselig hjertedød kan være første tegn på kardiomyopati. For å iverksette behandling og forebyggende tiltak mot livstruende kardiale hendelser er det nødvendig med økt oppmerksomhet blant allmennleger og spesialister.

• Hasselberg, Nina Eide; Håland, Trine Synnøve Fink; Saberniak, Jørg; Brekke, Pål Haugar; Berge, Knut Erik; Leren, Trond Paul; Edvardsen, Thor & Haugaa, Kristina (2018). Lamin A/C cardiomyopathy: Young onset, high penetrance, and frequent need for heart transplantation. European Heart Journal.  ISSN 0195-668X.  39(10), s 853- 860 . doi: 10.1093/eurheartj/ehx596 Fulltekst i vitenarkiv.
• Haugaa, Kristina; Dan, Gheorghe-Andrei; Iliodromitis, Konstantinos; Lenarczyk, Radosław; Marinskis, Germanas; Osca, Joaquin; Scherr, Daniel & Dagres, Nikolaos (2018). Management of patients with ventricular arrhythmias and prevention of sudden cardiac death-translating guidelines into practice: results of the European Heart Rhythm Association survey. Europace.  ISSN 1099-5129.  20(2), s f249- f253 . doi: 10.1093/europace/euy112
• Haugaa, Kristina; Potpara, Tatjana S.; Boveda, Serge; Deharo, Jean-Claude; Chen, Jian; Dobreanu, Dan; Fumagalli, Stefano; Lenarczyk, Radoslaw; Hernandez Madrid, Antonio; Larsen, Torben Bjerregaard; Sciarrafia, Elena; Taborsky, Milos; Tilz, Roland Richard; Pieragnoli, Paolo; Przybylski, Andrzej & Dagres, Nikolaos (2018). Patients' knowledge and attitudes regarding living with implantable electronic devices: Results of a multicentre, multinational patient survey conducted by the European Heart Rhythm Association. Europace.  ISSN 1099-5129.  20(2), s 386- 391 . doi: 10.1093/europace/eux365 Fulltekst i vitenarkiv.
• Lenarczyk, Radoslaw; Boveda, Serge; Haugaa, Kristina; Potpara, Tatjana S.; Syska, Pawel; Jędrzejczyk-Patej, Ewa; Chauvin, Michel; Sadoul, Nicolas & Dagres, Nikolaos (2018). Peri-procedural routines, implantation techniques, and procedure-related complications in patients undergoing implantation of subcutaneous or transvenous automatic cardioverter-defibrillators: Results of the European Snapshot Survey on S-ICD Implantation (ESSS-SICDI). Europace.  ISSN 1099-5129.  20(7), s 1218- 1224 . doi: 10.1093/europace/euy092
• Lie, Øyvind Haugen; Dejgaard, Lars; Saberniak, Jørg; Rootwelt, Christine; Stokke, Mathis Korseberg; Edvardsen, Thor & Haugaa, Kristina (2018). Harmful effects of exercise intensity and exercise duration in patients with arrhythmogenic cardiomyopathy. JACC: Clinical Electrophysiology.  ISSN 2405-500X.  4(6), s 744- 753 . doi: 10.1016/j.jacep.2018.01.010 Fulltekst i vitenarkiv.
• Lie, Øyvind Haugen; Rootwelt, Christine; Dejgaard, Lars; Leren, Ida Skrinde; Stokke, Mathis Korseberg; Edvardsen, Thor & Haugaa, Kristina (2018). Prediction of Life-Threatening Ventricular Arrhythmia in Patients With Arrhythmogenic Cardiomyopathy: A Primary Prevention Cohort Study. JACC Cardiovascular Imaging.  ISSN 1936-878X.  11(10), s 1377- 1386 . doi: 10.1016/j.jcmg.2018.05.017 Fulltekst i vitenarkiv.
• Linde, Cecilia; Bongiorni, Maria Grazia; Birgersdotter-Green, Ulrika; Curtis, Anne B.; Deisenhofer, Isabel; Furokawa, Tetsushi; Gillis, Anne M.; Haugaa, Kristina; Lip, Gregory Y.H.; van Gelder, Isabelle; Malik, Marek; Poole, Jeannie; Potpara, Tatjana; Savelieva, Irina & Sarkozy, Andrea (2018). Sex differences in cardiac arrhythmia: a consensus document of the European Heart Rhythm Association, endorsed by the Heart Rhythm Society and Asia Pacific Heart Rhythm Society. Europace.  ISSN 1099-5129.  20:1565(10), s 1565a- 1565o . doi: 10.1093/europace/euy067
• Popescu, Bogdan A.; Petersen, Steffen E.; Maurovich-Horvat, Pál; Haugaa, Kristina; Donal, Erwan; Maurer, Gerald & Edvardsen, Thor (2018). The year 2017 in the European Heart Journal - Cardiovascular Imaging: Part i. European Heart Journal-Cardiovascular Imaging.  ISSN 2047-2404.  19(10), s 1099- 1106 . doi: 10.1093/ehjci/jey109
• Tilz, Roland Richard; Lenarczyk, Radosław; Scherr, Daniel; Haugaa, Kristina; Iliodromitis, Konstantinos; Purerfellner, Helmut; Kiliszek, Marek & Dagres, Nikolaos (2018). Management of ventricular tachycardia in the ablation era: Results of the European Heart Rhythm Association Survey. Europace.  ISSN 1099-5129.  20(1), s 209- 213 . doi: 10.1093/europace/eux332
• Broch, Kaspar; Leren, Ida Skrinde; Saberniak, Jørg; Ueland, Thor; Edvardsen, Thor; Gullestad, Lars & Haugaa, Kristina (2017). Soluble ST2 is associated with disease severity in arrhythmogenic right ventricular cardiomyopathy. Biomarkers.  ISSN 1354-750X.  22(3-4), s 367- 371 . doi: 10.1080/1354750X.2016.1278266
• Dejgaard, Lars; Håland, Trine Synnøve Fink; Lie, Øyvind Haugen; Ribe, Margareth; Bjune, Thea; Leren, Ida Skrinde; Berge, Knut Erik; Edvardsen, Thor & Haugaa, Kristina (2017). Data on exercise and cardiac imaging in a patient cohort with hypertrophic cardiomyopathy. Data in Brief.  ISSN 2352-3409.  15, s 30- 39 . doi: 10.1016/j.dib.2017.08.018
• Fumagalli, Stefano; Potpara, Tatjana S; Bjerregaard Larsen, Torben; Haugaa, Kristina; Dobreanu, Dan; Proclemer, Alessandro & Dagres, Nicolaus (2017). Frailty syndrome: An emerging clinical problem in the everyday management of clinical arrhythmias. the results of the European Heart Rhythm Association survey. Europace.  ISSN 1099-5129.  19(11), s 1896- 1902 . doi: 10.1093/europace/eux288
• Gibbs, Charlotte; Thalamus, Jacob; Heldal, Kristian; Holla, Øystein Lunde; Haugaa, Kristina & Hysing, Jan (2017). Predictors of mortality in high-risk patients with QT prolongation in a community hospital. Europace.  ISSN 1099-5129.  20(1), s f99- f107 . doi: 10.1093/europace/eux286
• Haugaa, Kristina; Basso, Cristina; Badano, Luigi P; Bucciarelli-Ducci, Chiara; Cardim, Nuno; Gaemperli, Oliver; Galderisi, Maurizio; Habib, Gilbert; Knuuti, Juhani; Lancellotti, Patrizio; Mckenna, William; Neglia, Danilo; Popescu, Bogdan A. & Edvardsen, Thor (2017). Comprehensive multi-modality imaging approach in arrhythmogenic cardiomyopathy - an expert consensus document of the European Association of Cardiovascular Imaging. European Heart Journal-Cardiovascular Imaging.  ISSN 2047-2404.  18(3), s 237- 253 . doi: 10.1093/ehjci/jew229
• Haugaa, Kristina; Tilz, Roland Richard; Boveda, Serge; Dobreanu, Dan; Sciaraffia, Elena; Mansourati, Jacques; Papiashvili, Giorgi & Dagres, Nikolaos (2017). Implantable cardioverter defibrillator use for primary prevention in ischaemic and non-ischaemic heart disease - Indications in the post-DANISH trial era: Results of the European Heart Rhythm Association survey. Europace.  ISSN 1099-5129.  19(4), s 660- 664 . doi: 10.1093/europace/eux089
• Hetland, Sveinung Arild; Haugaa, Kristina; Vistnes, Maria; Liland, Kristian Hovde; Olseng, Margareth; Jacobsen, Morten & Edvardsen, Thor (2017). A retrospective analysis of cardiovascular outcomes in patients treated with ASV. Scandinavian Cardiovascular Journal.  ISSN 1401-7431.  51(2), s 106- 113 . doi: 10.1080/14017431.2016.1262546
• Hetland, Sveinung Arild; Lerum, Tøri Vigeland; Haugaa, Kristina & Edvardsen, Thor (2017). Patients with Cheyne-Stokes respiration and heart failure: patient tolerance after three-month discontinuation of treatment with adaptive servo-ventilation. Heart and Vessels.  ISSN 0910-8327.  Published ahead of print, s 1- 7 . doi: 10.1007/s00380-017-0951-1
• Håland, Trine Synnøve Fink; Hasselberg, Nina Eide; Almaas, Vibeke Marie; Dejgaard, Lars; Saberniak, Jørg; Leren, Ida Skrinde; Berge, Knut Erik; Haugaa, Kristina & Edvardsen, Thor (2017). The systolic paradox in hypertrophic cardiomyopathy. Open heart.  ISSN 2053-3624.  4(1) . doi: 10.1136/openhrt-2016-000571
• Håland, Trine Synnøve Fink; Saberniak, Jørg; Leren, Ida Skrinde; Edvardsen, Thor & Haugaa, Kristina (2017). Echocardiographic comparison between left ventricular non-compaction and hypertrophic cardiomyopathy. International Journal of Cardiology.  ISSN 0167-5273.  228, s 900- 905 . doi: 10.1016/j.ijcard.2016.11.162 Fulltekst i vitenarkiv.
• Klæboe, Lars Gunnar; Håland, Trine Synnøve Fink; Leren, Ida Skrinde; ter Bekke, Rachel M. A.; Brekke, Pål Haugar; Røsjø, Helge; Omland, Torbjørn; Gullestad, Lars; Aakhus, Svend; Haugaa, Kristina & Edvardsen, Thor (2017). Prognostic Value of Left Ventricular Deformation Parameters in Patients with Severe Aortic Stenosis: A Pilot Study of the Usefulness of Strain Echocardiography. Journal of the American Society of Echocardiography.  ISSN 0894-7317.  30(8), s 727- 735.e1 . doi: 10.1016/j.echo.2017.04.009 Fulltekst i vitenarkiv.
• Lenarczyk, Radosław; Potpara, Tatjana S.; Haugaa, Kristina; Deharo, Jean-Claude; Hernández-Madrid, Antonio; Del Carmen Exposito Pineda, Maria; Kiliszek, Marek & Dagres, Nikolaos (2017). Approach to cardio-oncologic patients with special focus on patients with cardiac implantable electronic devices planned for radiotherapy: Results of the European Heart Rhythm Association survey. Europace.  ISSN 1099-5129.  19(9), s 1579- 1584 . doi: 10.1093/europace/eux195
• Leren, Ida Skrinde; Saberniak, Jørg; Håland, Trine Synnøve Fink; Edvardsen, Thor & Haugaa, Kristina (2017). Combination of ECG and Echocardiography for Identification of Arrhythmic Events in Early ARVC. JACC Cardiovascular Imaging.  ISSN 1936-878X.  10(5), s 503- 513 . doi: 10.1016/j.jcmg.2016.06.011 Fulltekst i vitenarkiv. Vis sammendrag

  OBJECTIVES: The aim of this study was to investigate early markers of arrhythmic events (AEs) and improve risk stratification in early arrhythmogenic right ventricular cardiomyopathy (ARVC). BACKGROUND: AEs are frequent in patients with ARVC, but risk stratification in subjects with early ARVC is challenging. METHODS: Early ARVC disease was defined as possible or borderline ARVC diagnosis according to the ARVC Task Force Criteria 2010. We performed resting and signal averaged electrocardiogram (ECG). Using echocardiography, we assessed right ventricular (RV) outflow tract diameter and right ventricular basal diameter (RV diameter). Global longitudinal strain and mechanical dispersion (MD) from strain echocardiography were assessed in both the right and left ventricle. AEs were defined as documented ventricular tachycardia, cardiac syncope, or aborted cardiac arrest. RESULTS: Of 162 included subjects with ARVC (41 ± 16 years of age, 47% female), 73 had early ARVC, including mutation positive family members not fulfilling definite ARVC diagnosis. AEs occurred in 15 (21%) subjects with early ARVC. Those with AEs in early disease had larger RV diameter (40 ± 4 mm vs. 37 ± 5 mm), more pronounced RVMD (39 ± 15 ms vs. 26 ± 11 ms), and more pathological signal averaged ECGs compared with those without AEs (all p ≤ 0.05). Adding measurements of RV diameter and RVMD to electrical parameters improved identification of subjects with AEs compared with electrical parameters alone (p = 0.05). CONCLUSIONS: ECG parameters, RV diameter, and RVMD were markers of previous arrhythmic events in patients with early ARVC. A combination of electrical and echocardiographic parameters improved identification of subjects with AEs in early ARVC disease. Copyright © 2017 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. KEYWORDS: arrhythmic risk; arrhythmogenic right ventricular cardiomyopathy; echocardiography; signal averaged ECG; ventricular arrhythmias

• Nestaas, Eirik; Shih, Jhih-Yuan; Smedsrud, Marit Kristine; Gjesdal, Ola; Hopp, Einar; Haugaa, Kristina & Edvardsen, Thor (2017). Comparison of Electrocardiography Markers and Speckle Tracking Echocardiography for Assessment of Left Ventricular Myocardial Scar Burden in Patients With Previous Myocardial Infarction. American Journal of Cardiology.  ISSN 0002-9149.  119(9), s 1307- 1312 . doi: 10.1016/j.amjcard.2017.01.020 Fulltekst i vitenarkiv.
• Stokke, Thomas Muri; Hasselberg, Nina Eide; Smedsrud, Marit Kristine; Sarvari, Sebastian Imre; Haugaa, Kristina; Smiseth, Otto A.; Edvardsen, Thor & Remme, Espen W. (2017). Geometry as a Confounder When Assessing Ventricular Systolic Function: Comparison Between Ejection Fraction and Strain. Journal of the American College of Cardiology.  ISSN 0735-1097.  70(8), s 942- 954 . doi: 10.1016/j.jacc.2017.06.046
• Tilz, Roland Richard; Potpara, Tatjana; Chen, Jian; Dobreanu, Dan; Larsen, Torben Bjerregaard; Haugaa, Kristina & Dagres, Nikolaos (2017). Left atrial appendage occluder implantation in Europe: Indications and anticoagulation post-implantation. Results of the European Heart Rhythm Association Survey. Europace.  ISSN 1099-5129.  19(10), s 1737- 1742 . doi: 10.1093/europace/eux254
• Timmermann, Viviane; Dejgaard, Lars; Haugaa, Kristina; Edwards, Andrew; Sundnes, Joakim; McCulloch, Andrew D. & Wall, Samuel Thomas (2017). An integrative appraisal of mechano-electric feedback mechanisms in the heart. Progress in Biophysics and Molecular Biology.  ISSN 0079-6107.  130, s 404- 417 . doi: 10.1016/j.pbiomolbio.2017.08.008
• Turkowski, Kari L.; Tester, David J.; Bos, J. Martijn; Haugaa, Kristina & Ackerman, Michael J. (2017). Whole exome sequencing with genomic triangulation implicates CDH2-encoded N-cadherin as a novel pathogenic substrate for arrhythmogenic cardiomyopathy. Congenital Heart Disease.  ISSN 1747-079X.  12(2), s 226- 235 . doi: 10.1111/chd.12462
• Barros, Marcio V.L.; Leren, Ida Skrinde; Edvardsen, Thor; Haugaa, Kristina; Carmo, Andre A.L.; Lage, Thais A.R.; Nunes, Maria Carmo P.; Rocha, Manoel O.C. & Ribeiro, Antonio L.P. (2016). Mechanical dispersion assessed by strain echocardiography is associated with malignant arrhythmias in chagas cardiomyopathy. Journal of the American Society of Echocardiography.  ISSN 0894-7317.  29(4), s 368- 374 . doi: 10.1016/j.echo.2015.12.008 Vis sammendrag

  Background Sudden death is one of the characteristics of Chagas disease (ChD). With the development of strategies for the prevention of malignant arrhythmias, especially with implantable cardioverter-defibrillators (ICDs), there is interest in developing strategies to predict sudden cardiac death. The aim of this study was to test the hypothesis that global longitudinal strain (GLS) and mechanical dispersion (MD) may be associated with malignant ventricular arrhythmias in patients with ChD. Methods A cross-sectional study was conducted including 62 patients with ChD who were separated into two groups according to ICD implantation status. Group 0 consisted of 34 patients with ChD without ICDs, and group 1 comprised 28 patients with ICDs. Complete echocardiographic studies, including GLS and MD measurements, were performed in all patients. Results Chamber dimensions, ejection fraction, and diastolic function showed no significant differences between patients with and those without ICDs. GLS was reduced in patients with ChD with ICDs compared with those without (P = .02). By receiver operating characteristic curve analyses, GLS identified patients with ChD with ICDs with sensitivity of 67% and specificity of 69%. MD was more pronounced in patients with ChD with ICDs compared with those without (P < .001), with a C statistic of 0.83 (95% CI, 0.71–0.91). MD > 57 msec detected ICD presence with sensitivity of 79% and specificity of 71% and was superior to GLS and ejection fraction (P < .05). In multivariate analysis, New York Heart Association functional class (odds ratio, 3.02; 95% CI, 1.09–8.39; P = .03), MD (odds ratio, 1.11; 95% CI, 1.04–1.19; P = .001), and GLS (odds ratio, 0.72; 95% CI, 0.54–0.96; P = .026) were significant and independently associated with malignant arrhythmic events. Conclusions GLS and MD may add important information in the risk stratification of patients with ChD. The use of MD by strain echocardiography could be an attractive tool in the decision making for ICD placement as primary prevention for sudden cardiac death in patients with ChD.

• Boveda, Serge; Lenarczyk, Radoslaw; Haugaa, Kristina; Fumagalli, Stefano; Madrid, Antonio Hernández; Defaye, Pascal; Broadhurst, Paul & Dagres, Nikolaos (2016). Implantation of subcutaneous implantable cardioverter defibrillators in Europe: Results of the European Heart Rhythm Association survey. Europace.  ISSN 1099-5129.  18(9), s 1434- 1439 . doi: 10.1093/europace/euw258
• Di Marco, A; Anguera, I; Schmitt, M; Klem, I; Neilan, T; White, JA; Sramko, M; Masci, PG; Barison, A; McKenna, P; Mordi, I; Haugaa, Kristina; Leyva, F; Rodriguez Capitan, J; Satoh, H; Nabeta, T; Dallaglio, PD; Campbell, NG; Sabate, X & Cequier, Angel (2016). Late Gadolinium Enhancement and the Risk for Ventricular Arrhythmias or Sudden Death in Dilated Cardiomyopathy: Systematic Review and Meta-Analysis. JACC. Heart failure.  ISSN 2213-1779.  5(1), s 28- 38 . doi: 10.1016/j.jchf.2016.09.017
• Edvardsen, Thor; Cardim, Nuno; Cosyns, Bernard; Delgado, Victoria; Donal, Erwan; Dulgheru, Raluca; Galderisi, Maurizio; Haugaa, Kristina; Kaufmann, Philipp A.; Lancellotti, Patrizio; Lombardi, Massimo; Muraru, Denisa; Plein, Sven; Maurer, Gerald; Popescu, Bogdan A. & Habib, Gilbert (2016). Criteria for recommendation and expert consensus papers: From the European Association of Cardiovascular Imaging Scientific Documents Committee. European Heart Journal-Cardiovascular Imaging.  ISSN 2047-2404.  17(10), s 1098- 1100 . doi: 10.1093/ehjci/jew157
• Edvardsen, Thor; Sarvari, Sebastian Imre & Haugaa, Kristina (2016). Strain imaging–from Scandinavian research to global deployment. Scandinavian Cardiovascular Journal.  ISSN 1401-7431.  50(5-6), s 266- 275 . doi: 10.1080/14017431.2016.1239836
• Fruh, Andreas; Siem, Geir; Holmstrøm, Henrik; Døhlen, Gaute & Haugaa, Kristina (2016). The Jervell and Lange-Nielsen syndrome; atrial pacing combined with ß-blocker therapy, a favorable approach in young high-risk patients with long QT syndrome?. Heart Rhythm.  ISSN 1547-5271.  13(11), s 2186- 2192 . doi: 10.1016/j.hrthm.2016.07.020
• Glover, BM; Chen, Jian; Hong, KL; Boveda, S.; Baranchuk, A; Haugaa, Kristina; Dorian, Paul; Potpara, TS; Crystal, Eugene; Mitchell, B; Tilz, Roland; Leong-Sit, P & Dagres, Nikolaos (2016). Catheter ablation for atrial flutter: a survey by the European Heart Rhythm Association and Canadian Heart Rhythm Society. Europace.  ISSN 1099-5129.  18(12), s 1880- 1885 . doi: 10.1093/europace/euw402
• Hasselberg, Nina Eide; Haugaa, Kristina; Bernard, Anne; Ribe, Margareth; Kongsgård, Erik; Donal, Erwan & Edvardsen, Thor (2016). Left ventricular markers of mortality and ventricular arrhythmias in heart failure patients with cardiac resynchronization therapy. European Heart Journal-Cardiovascular Imaging.  ISSN 2047-2404.  17(3), s 343- 350 . doi: 10.1093/ehjci/jev173
• Haugaa, Kristina; Håland, Trine Synnøve Fink; Leren, Ida Skrinde; Saberniak, Jørg & Edvardsen, Thor (2016). Arrhythmogenic right ventricular cardiomyopathy, clinical manifestations, and diagnosis. Europace.  ISSN 1099-5129.  18(7), s 965- 972 . doi: 10.1093/europace/euv340
• Håland, Trine Synnøve Fink; Almaas, Vibeke Marie; Hasselberg, Nina Eide; Saberniak, Jørg; Leren, Ida Skrinde; Hopp, Einar; Edvardsen, Thor & Haugaa, Kristina (2016). Strain echocardiography is related to fibrosis and ventricular arrhythmias in hypertrophic cardiomyopathy. European Heart Journal-Cardiovascular Imaging.  ISSN 2047-2404.  17(6), s 613- 621 . doi: 10.1093/ehjci/jew005 Vis sammendrag

  Aims Hypertrophic cardiomyopathy (HCM) patients are at risk of ventricular arrhythmias (VAs). We aimed to explore whether systolic function by strain echocardiography is related to VAs and to the extent of fibrosis by cardiac magnetic resonance imaging (CMR). Methods and results We included 150 HCM patients and 50 healthy individuals. VAs were defined as non-sustained and sustained ventricular tachycardia and aborted cardiac arrest. Left ventricular function was assessed by ejection fraction (EF) and by global longitudinal strain (GLS) assessed by speckle tracking echocardiography. Mechanical dispersion was calculated as standard deviation (SD) of time from Q/R on ECG to peak longitudinal strain in 16 left ventricular segments. Late gadolinium enhancement (LGE) was assessed by CMR. HCM patients had similar EF (61 ± 5% vs. 61 ± 8%, P = 0.77), but worse GLS (−15.7 ± 3.6% vs. −21.1 ± 1.9%, P < 0.001) and more pronounced mechanical dispersion (64 ± 22 vs. 36 ± 13 ms, P < 0.001) compared with healthy individuals. VAs were documented in 37 (25%) HCM patients. Patients with VAs had worse GLS (−14.1 ± 3.6% vs. −16.3 ± 3.4%, P < 0.01), more pronounced mechanical dispersion (79 ± 27 vs. 59 ± 16 ms, P < 0.001), and higher %LGE (6.1 ± 7.8% vs. 0.5 ± 1.4%, P < 0.001) than patients without VAs. Mechanical dispersion correlated with %LGE (R = 0.52, P < 0.001) and was independently associated with VAs (OR 1.6, 95% CI 1.1–2.3, P = 0.02) and improved risk stratification for VAs. Conclusion GLS, mechanical dispersion, and LGE were markers of VAs in HCM patients. Mechanical dispersion was a strong independent predictor of VAs and related to the extent of fibrosis. Strain echocardiography may improve risk stratification of VAs in HCM.

• Lancellotti, Patrizio; Price, Susanna; Edvardsen, Thor; Cosyns, Bernard; Neskovic, Aleksandar N.; Dulgheru, Raluca; Flachskampf, Frank A.; Hassager, Christian; Pasquet, Agnès; Gargani, Luna; Galderisi, Maurizio; Cardim, Nuno; Haugaa, Kristina; Ancion, Arnaud; Zamorano, Jose-Luis; Donal, Erwan; Bueno, Héctor & Habib, Gilbert (2016). Akut kardiyovasköler bakimda ekokardiyografinin kullanimi: Avrupa Kardiyovasköler Göröntöleme Birliǧi ile Akut Kardiyovasköler Bakim Birliǧi'nin önerileri. Turk Kardiyoloji Dernegi Arsivi.  ISSN 1016-5169.  44, s 53- 80 . doi: 10.1093/ehjci/jeu210
• Leren, Ida Skrinde; Saberniak, Jørg; Håland, Trine Synnøve Fink; Majid, Eman; Edvardsen, Thor & Haugaa, Kristina (2016). Nadolol decreases the incidence and severity of ventricular arrhythmias during exercise stress testing compared with β&lt;sub&gt;1&lt;/sub&gt;-selective β-blockers in patients with catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm.  ISSN 1547-5271.  13(2), s 432- 440 . doi: 10.1016/j.hrthm.2015.09.029
• Mcleod, Kristin; Wall, Samuel Thomas; Leren, Ida Skrinde; Saberniak, Jørg & Haugaa, Kristina (2016). Ventricular structure in ARVC: Going beyond volumes as a measure of risk. Journal of cardiovascular magnetic resonance.  ISSN 1097-6647.  18:73, s 1- 14 . doi: 10.1186/s12968-016-0291-9 Vis sammendrag

  Background Altered right ventricular structure is an important feature of Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), but is challenging to quantify objectively. The aim of this study was to go beyond ventricular volumes and diameters and to explore if the shape of the right and left ventricles could be assessed and related to clinical measures. We used quantifiable computational methods to automatically identify and analyse malformations in ARVC patients from Cardiovascular Magnetic Resonance (CMR) images. Furthermore, we investigated how automatically extracted structural features were related to arrhythmic events. Methods A retrospective cross-sectional feasibility study was performed on CMR short axis cine images of 27 ARVC patients and 21 ageing asymptomatic control subjects. All images were segmented at the end-diastolic (ED) and end-systolic (ES) phases of the cardiac cycle to create three-dimensional (3D) bi-ventricle shape models for each subject. The most common components to single- and bi-ventricular shape in the ARVC population were identified and compared to those obtained from the control group. The correlations were calculated between identified ARVC shapes and parameters from the 2010 Task Force Criteria, in addition to clinical outcomes such as ventricular arrhythmias. Results Bi-ventricle shape for the ARVC population showed, as ordered by prevalence with the percent of total variance in the population explained by each shape: global dilation/shrinking of both ventricles (44 %), elongation/shortening at the right ventricle (RV) outflow tract (15 %), tilting at the septum (10 %), shortening/lengthening of both ventricles (7 %), and bulging/shortening at both the RV inflow and outflow (5 %). Bi-ventricle shapes were significantly correlated to several clinical diagnostic parameters and outcomes, including (but not limited to) correlations between global dilation and electrocardiography (ECG) major criteria (p = 0.002), and base-to-apex lengthening and history of arrhythmias (p = 0.003). Classification of ARVC vs. control using shape modes yielded high sensitivity (96 %) and moderate specificity (81 %). Conclusion We presented for the first time an automatic method for quantifying and analysing ventricular shapes in ARVC patients from CMR images. Specific ventricular shape features were highly correlated with diagnostic indices in ARVC patients and yielded high classification sensitivity. Ventricular shape analysis may be a novel approach to classify ARVC disease, and may be used in diagnosis and in risk stratification for ventricular arrhythmias.

• Saberniak, Jørg; Leren, Ida Skrinde; Håland, Trine Synnøve Fink; Beitnes, Jan Otto; Hopp, Einar; Borgquist, Rasmus; Edvardsen, Thor & Haugaa, Kristina (2016). Comparison of patients with early-phase arrhythmogenic right ventricular cardiomyopathy and right ventricular outflow tract ventricular tachycardia. European Heart Journal-Cardiovascular Imaging.  ISSN 2047-2404.  18(1), s 62- 69 . doi: 10.1093/ehjci/jew014 Fulltekst i vitenarkiv.
• Sarvari, Sebastian Imre; Haugaa, Kristina; Stokke, Thomas Muri; Ansari, Hamza; Leren, Ida Skrinde; Hegbom, Finn; Smiseth, Otto A. & Edvardsen, Thor (2016). Strain echocardiographic assessment of left atrial function predicts recurrence of atrial fibrillation. European Heart Journal-Cardiovascular Imaging.  ISSN 2047-2404.  17(6), s 660- 667 . doi: 10.1093/ehjci/jev185
• Smiseth, Otto A.; Torp, Hans; Opdahl, Anders; Haugaa, Kristina & Urheim, Stig (2016). Myocardial strain imaging: How useful is it in clinical decision making?. European Heart Journal.  ISSN 0195-668X.  37(15), s 1196- 1207b . doi: 10.1093/eurheartj/ehv529

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• Dalen, Håvard; Forfang, Kolbjørn; Haugaa, Kristina; Istad, Helge & Wiseth, Rune (red.) (2019). Kardiologi - Klinisk veileder, 3.utgave. Gyldendal Akademisk.  ISBN 9788205523951.  454 s.

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• Donal, Erwan; Delgado, Victoria; Bucciarelli-Ducci, Chiara; Galli, Elena; Haugaa, Kristina; Charron, Philippe; Voigt, Jens-Uwe; Cardim, Nuno; Masci, Pier Giorgio; Galderisi, Maurizio; Gaemperli, Oliver; Gimelli, Alessia; Pinto, Yigal M.; Lancellotti, Patrizio; Habib, Gilbert; Elliott, Perry; Edvardsen, Thor; Cosyns, Bernard & Popescu, Bogdan A. (2019). Multimodality imaging in the diagnosis, risk stratification, and management of patients with dilated cardiomyopathies: An expert consensus document from the European Association of Cardiovascular Imaging. European Heart Journal-Cardiovascular Imaging.  ISSN 2047-2404.  20(10), s 1075- 1093 . doi: 10.1093/ehjci/jez178
• Edvardsen, Thor & Haugaa, Kristina (2019). Stretch and Rebound in the Search for Cardiac Resynchronization Therapy Candidates. JACC Cardiovascular Imaging.  ISSN 1936-878X.  12(9), s 1753- 1754 . doi: 10.1016/j.jcmg.2018.08.008
• Haugaa, Kristina & Stokke, Mathis Korseberg (2019). Cardiac electrical and mechanical alterations - united in the long QT syndrome. International Journal of Cardiology.  ISSN 0167-5273.  274, s 190- 191 . doi: 10.1016/j.ijcard.2018.09.048 Fulltekst i vitenarkiv.
• Werf, Christian van der; Lieve, Krystien V; Bos, J. Martijn; Lan, Conor M; Denjoy, Isabelle; Roses-Noguer, Ferran; Aiba, Takeshi; Wada, Yuko; Ingles, Jodie; Leren, Ida Skrinde; Rudic, Boris; Schwartz, Peter J.; Maltret, Alice; Sacher, Frederic; Skinner, Jonathan R.; Krahn, Andrew D.; Roston, Thomas M; Tfelt-Hansen, Jacob; Swan, Heikki; Robyns, Tomas; Ohno, Seiko; Roberts, Jason D; Berg, Maarten P van der; Kammeraad, Janneke A; Probst, Vincent; Kannankeril, Prince J; Blom, Nico A; Behr, Elijah R; Borggrefe, Martin; Haugaa, Kristina; Semsarian, Christopher; Horie, Minoru; Shimizu, Wataru; Till, Janice A.; Leenhardt, Antonie; Ackerman, Michael J. & Wilde, Arthur A.M. (2019). Implantable cardioverter-defibrillators inpreviously undiagnosed patients withcatecholaminergic polymorphicventricular tachycardia resuscitatedfrom sudden cardiac arrest. European Heart Journal.  ISSN 0195-668X.  40, s 2953- 2961 . doi: 10.1093/eurheartj/ehz309
• Haugaa, Kristina & Dejgaard, Lars (2018). Global longitudinal strain: Ready for clinical use and guideline implementation. Journal of the American College of Cardiology.  ISSN 0735-1097.  71(18), s 1958- 1959 . doi: 10.1016/j.jacc.2018.03.015
• Haugaa, Kristina & Lie, Øyvind Haugen (2018). Reveal the concealed. The quest for early disease detection in family members at risk of developing arrhythmogenic cardiomyopathy. JACC Cardiovascular Imaging.  ISSN 1936-878X.  s 1- 2 . doi: 10.1016/j.jcmg.2018.02.007
• Jurcut, Ruxandra; Haugaa, Kristina & La Gerche, Andre (2018). The right ventricle: From bench to bedside. BioMed Research International.  ISSN 2314-6133.  2018:2868437, s 1- 3 . doi: 10.1155/2018/2868437
• Magne, Julien; Bucciarelli-Ducci, Chiara; Dahl, Jordi S.; Gimelli, Alessia; Haugaa, Kristina; Miller, Owen; Muraru, Denisa; Donal, Erwan; Edvardsen, Thor & Popescu, Bogdan A. (2018). EuroEcho-imaging 2017: Highlights. European Heart Journal-Cardiovascular Imaging.  ISSN 2047-2404.  19(5), s 482- 489 . doi: 10.1093/ehjci/jey037
• Gorcsan, John & Haugaa, Kristina (2017). Ventricular arrhythmias and reduced echocardiographic inferior wall strain: is regional function an important risk marker?. Circulation Cardiovascular Imaging.  ISSN 1941-9651.  10:e005900(1) . doi: 10.1161/CIRCIMAGING.116.005900
• Haugaa, Kristina; Edvardsen, Thor & Smiseth, Otto A. (2017). Mechanical dyssynchrony - Resurrected as a flashing and rocking parameter to predict prognosis after cardiac resynchronization therapy. European Heart Journal-Cardiovascular Imaging.  ISSN 2047-2404.  18(10), s 1118- 1119 . doi: 10.1093/ehjci/jex198
• Danielsen, Tore Kristian; Manotheepan, Ravinea; Sadredini, Mani; Leren, I.S.; Edwards, Andrew; Vincent, K.; Lehnart, Stefan; Sejersted, Ole M; Sjaastad, Ivar; Haugaa, Kristina & Stokke, Mathis Korseberg (2016). Mechanisms underlying the frequency-dependence of triggered arrhythmias in catecholaminergic polymorphic ventricular tachycardia type 1.
• Haugaa, Kristina & Edvardsen, Thor (2016). Global longitudinal strain: the best biomarker for predicting prognosis in heart failure?. European Journal of Heart Failure.  ISSN 1388-9842.  18(11), s 1340- 1341 . doi: 10.1002/ejhf.632
• Manotheepan, Ravinea; Danielsen, Tore Kristian; Saberniak, Jorg; Sadredini, Mani; Anderson, Mark e.; Carlson, Cathrine Rein; Edvardsen, Thor; Lehnart, Stefan; Sjaastad, Ivar; Haugaa, Kristina & Stokke, Mathis Korseberg (2016). Exercise training as anti-arrhythmic therapy in cathecholaminergic polymorphic ventricular tachycardia type 1.
• Nestaas, Eirik; Sarvari, Sebastian Imre; Hopp, Einar; Gjesdal, Ola; Smedsrud, Marit Kristine; Haugaa, Kristina & Edvardsen, Thor (2016). The timing of the post systolic shortening in prediction of scarred myocardium..

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