Andrea Sylvia Winkler

• McFarlane, Robert; Anneser, Johanna; Al-Chalabi, Ammar; Chiò, Adriano; Mcdermott, Christopher J. & Meyer, Thomas [Vis alle 14 forfattere av denne artikkelen] (2026). The EQ-5D-5L in amyotrophic lateral sclerosis: an international longitudinal exploration as part of ALS-CarE. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. ISSN 2167-8421. doi: 10.1080/21678421.2026.2715921. Fulltekst i vitenarkiv
• Bassetti, Claudio L.A.; Chen, Christopher; Lewis, Steven L.; Bègue, Indrit; Adorjan, Kristina & Aguilar, Diego [Vis alle 49 forfattere av denne artikkelen] (2026). The International Alliance on Brain Health (IABH): Bridging global efforts toward integrated brain and mental health plans and the promotion of local implementations. Journal of the Neurological Sciences. ISSN 0022-510X. 489. doi: 10.1016/j.jns.2026.126069. Fulltekst i vitenarkiv
• Claudia, Robbiati,; Miarisoa, Andriamandroso, Antsa; Heidi, Auerswald,; Berger, González, Mónica; Cediel, Becerra, Natalia & Grazia, Dente, Maria [Vis alle 13 forfattere av denne artikkelen] (2026). Diversity, equity and inclusion in One Health could crucially support functional health security by fostering prevention, but a change in mindset is needed | One Health Outlook | Springer Nature Link. One Health Outlook. doi: 10.1186/s42522-025-00175-3. Fulltekst i vitenarkiv Vis sammendrag

  In recent years, One Health (OH) has taken the lead as a systems-oriented method to foster transdisciplinary, multisectoral, and multi-actor action to promote global health security. However, operationalizing the OH approach is difficult since it requires equitable collaboration, communication and information sharing. The One Health High-Level Expert Panel’s (OHHLEP) definition of OH lists key underlying principles at its core, which align with principles of diversity, equity and inclusion (DEI), and establishes that the application of the definition is incomplete without the adoption of these key principles. In this paper, we argue that, by overcoming the barriers that hamper OH adherence to DEI principles, the operationalization of the OH approach could be significantly enhanced to support global health security. We built on the key underlying principles included in the OHHLEP 2022 definition of OH to map barriers preventing its full-scale implementation and to identify inclusive avenues to promote the compliance of OH with its core principles. A scoping review of the literature and consultations with 10 OH professionals from different disciplinary backgrounds, regions of the world and levels of experience were performed. The barriers to the full adherence of OH to its underlying principles that emerged from this study were grouped into five categories: mindset, behaviors and awareness, conceptual, structural, power dynamics, and governance and implementation. Crucially, the engagement of diverse sectors and disciplines notably the environmental and social sciences; of different actors from communities and young people to donors and OH professionals, including the private sector; and of underrepresented groups, such as Indigenous peoples, farmers, fishers, representatives from low- and middle-income countries, and especially women across these groups, all intimately connected to the drivers of emerging health threats, is not only critical for realizing DEI principles in OH, but also to promote more effective prevention strategies and thus enhance global health security.

• Pupillo, Elisabetta; Leone, Maurizio A.; Amato, Anthony; Bianchi, Elisa; Damian, Maxwell S. & Dyck, James [Vis alle 19 forfattere av denne artikkelen] (2026). Prevalence and trajectories of post-COVID-19 neuromuscular conditions: A systematic-review and meta-analysis - PubMed. Journal of the Neurological Sciences. ISSN 0022-510X. doi: 10.1016/j.jns.2025.125710. Fulltekst i vitenarkiv Vis sammendrag

  NMDs and related symptoms are common following COVID-19, but their general prevalence decreases with time. However, trajectories varied depending on the type of NMD or symptom.

• Hughes, Thomas; Venkatesan, Arun; Hetherington, Claire; Egbe, Franklyn Nkongho; Netravathi, M. & Thakur, Kiran T. [Vis alle 51 forfattere av denne artikkelen] (2025). International evaluation of the SEIZUre Risk in Encephalitis (SEIZURE) score for predicting acute seizure risk. BMJ Open. 15(12). doi: 10.1136/bmjopen-2025-099451. Fulltekst i vitenarkiv
• Njamnshi, Alfred Kongnyu; Ndongo, Jacques Fame; Ngoh, Ferdinand Ngoh; Mbella, Lejeune Mbella; Ghogomu, Paul M. & Fouda, Séraphin M. [Vis alle 139 forfattere av denne artikkelen] (2025). African leadership in brain diplomacy: The Yaoundé declaration advances the global brain economy playbook for better brain health. Neuroscience. ISSN 0306-4522. 577, s. 174–174. doi: 10.1016/j.neuroscience.2025.04.032. Fulltekst i vitenarkiv
• Mucavele, Janny; Elson, Lynne; Nhancupe, Noémia; Monteiro, Gaby Ermelindo Roberto; Miambo, Regina Daniel & Gouveia, Lídia [Vis alle 20 forfattere av denne artikkelen] (2025). Cysticercosis and neurocysticercosis in people from Mocuba district, Zambézia province: A Mozambican community-based study. PLoS Neglected Tropical Diseases. ISSN 1935-2727. 19(5), s. 0013083–0013083. doi: 10.1371/journal.pntd.0013083. Fulltekst i vitenarkiv Vis sammendrag

  Introduction Taenia solium cysticercosis represents a significant public health concern, especially in low-income countries such as Mozambique, where especially the sub form neurocysticercosis can be associated with acute symptomatic seizures, epilepsy and other neurological and psychiatric disorders. Therefore, this study aimed to determine the prevalence of T. solium cysticercosis, neurocysticercosis, seizures and chronic headaches in the Mocuba district, Zambézia province, Mozambique, and to assess their associations. Methods The overall study combined both a community-based and a clinic-based segment, including epidemiological, clinical, laboratory and neuroradiological approaches, to investigate the prevalence and the association of cysticercosis, neurocysticercosis, seizure activity and chronic headaches in the Mocuba district. The community-based study involved 6,932 participants who were asked a questionnaire related to signs/symptoms of neurocysticercosis and who were asked to provide a blood sample for serological testing. Serological tests (Antigen-ELISA and Western blot) were used to detect cysticerci specific antigens and antibodies, respectively, in the participants. The clinic-based study included cerebral computed tomography (CT) of 233 individuals – a subset of those recruited from the community (with and without seizure activity and with and without cysticercosis based on serology). Results The prevalence of seizures and chronic headaches in the community-based study was 6.5% and 46.2% respectively, and the cysticercosis seroprevalence was 9.6%. Seizures and chronic headaches presented significant associations with cysticercosis seropositivity (p < 0.05). The clinic-based study revealed 9 (3.9%) of 233 individuals with neurocysticercosis-typical lesions on CT-scan of whom one case was negative on serology and on screening for seizure activity. Conclusions The community-based prevalence of seizure activity and cysticercosis was high in the Mocuba district. There was also a significant association of seizure activity and chronic headaches with the seroprevalence of cysticercosis and 8 out of 9 people with neurocysticercosis had seizure activity. This highlights the importance of increased awareness and the need for building health literacy within the healthcare workforce and the communities as well as the implementation of targeted interventions, both for people with seizure activity with and without neurocysticercosis. Future research should also assess the impact of preventive measures in reducing disease burden caused by T. solium .

• Reigl, Lisa Sophie; Lange, Isabelle L.; Okan, Orkan; Neema, Stella & Winkler, Andrea Sylvia (2025). Tackling schistosomiasis in fisherfolk communities in Uganda: Enablers and challenges for implementing paediatric schistosomiasis mass drug administration from the perspective of district health authorities. Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz. ISSN 1436-9990. 68(7), s. 786–786. doi: 10.1007/s00103-025-04066-w. Fulltekst i vitenarkiv Vis sammendrag

  Abstract Background Schistosomiasis remains a significant public health issue in Uganda, particularly among fishing communities. This study, nested within a larger community-based study (ADOPT) on introducing a new child-friendly praziquantel formulation for schistosomiasis, arpraziquantel, explored enablers and challenges perceived by district health authorities for implementing a mass drug administration (MDA) programme with arpraziquantel. Methods Respondents in this cross-sectional study were purposively selected in Bugiri and Hoima districts, Uganda. Key informant interviews were conducted in July 2022 and thematically analysed using the World Health Organization health system building blocks framework. Results In general, arpraziquantel is expected to be widely accepted, though some may oppose it for religious or political reasons, belief in witchcraft as a cause of schistosomiasis, or fear of side effects. High awareness of disease burden and the acceptance of the existing schistosomiasis MDA for adults and school-aged children were identified as enablers for successful implementation. Key implementation challenges include limited resources for sustained biannual MDAs, adequate remuneration of village health teams (VHTs), inadequate staff training, time constraints, uneven VHT workload, and weaknesses in the referral systems. Migration, difficulties sensitising mobile parents, and delayed meals due to poverty—complicating drug absorption requiring a full stomach—further hinder efforts. Discussion This study underscores the importance of addressing health systems’ challenges through targeted measures to ensure effective and sustainable MDA of arpraziquantel, including enhanced training of VHTs and other staff, sensitisation of parents and key stakeholders at all levels, and adequate responses to potentially emerging side effects.

• Wijeratne, Tissa; Oh, Jiyeon; Kim, Soeun; Yim, Yesol; Kim, Min Seo & Shin, Jae Il [Vis alle 277 forfattere av denne artikkelen] (2025). Global, regional, and national burden of headache disorders, 1990–2021, with forecasts to 2050: A Global Burden of Disease study 2021. Cell Reports Medicine. 6(10), s. 102348–102348. doi: 10.1016/j.xcrm.2025.102348. Fulltekst i vitenarkiv
• Sternkopf, Leonardo Elias; Prodjinotho, Ulrich Fabien; Gres, Vitka; Repgen, Nikolaus; Steiger, Katja & Schluckebier, Julia [Vis alle 16 forfattere av denne artikkelen] (2025). Helminthic larval stage induces cellular apoptosis via caspase 9-mediated mitochondrial dysfunction. Frontiers in Immunology. 16. doi: 10.3389/fimmu.2025.1603385. Fulltekst i vitenarkiv Vis sammendrag

  Introduction In human neurocysticercosis (NCC), the cellular and molecular mechanisms of host-parasite interactions triggering brain inflammation and epileptic seizures in Sub-Saharan Africa are poorly understood. Emerging evidence indicates that the viability of the cyst of the pork tapeworm Taenia solium determines brain inflammation and, thus, symptom development and disease severity. We have previously shown that while viable cyst-released molecules promote immune regulation and often asymptomatic disease, the fluid from degenerating cysts causes inflammation in microglia and peripheral immune cells, potentially driving immune-mediated pathology. This study aims to elucidate the apoptotic signaling pathways underlying this process and their relevance for symptomatic disease in NCC patients. Materials and methods Human and porcine peripheral immune cells, as well as murine microglia, were exposed to T. solium cyst vesicular fluid (CVF). Apoptosis signaling pathways were analysed using flow cytometric FLICA (fluorochrome-labeled inhibitors of caspases) caspase 8 and 9 assays, while mitochondrial dysfunction was assessed via TMRE and MitoTracker Deep Red and Green fluorescent probes. Apoptosis-inducing CVF molecules were identified by differential mass spectrometry and functionally tested using specific inhibitors. Caspase activity and soluble mediators (FasL, ROS, TNFα) were measured in NCC asymptomatic and symptomatic patients’ sera, and inflammatory T cell infiltrates expressing caspases near viable and degenerating cysts in naturally infected pig brain slices were examined via immunohistology. Results We found that vesicular fluid derived from cysts primarily induced apoptosis and caspase 3 and 9 activity, and only minimal necrosis, in a dose-dependent manner across central and peripheral immune cells. This effect was prominent in CD16 + monocytes, microglia, and in CD3 + T cell-expressing caspase 3 near degenerating brain cysts. Apoptotic signaling was predominantly mediated by a dynamic remodeling of caspase 9 pathway, accompanied by a significant loss of mitochondrial potential and a sharp decrease in Bid and Bcl2 transcription, favoring the intrinsic over the FasL-dependent extrinsic pathway and mechanisms. This process is primarily mediated by small molecules (&lt; 30 kDa), and remained unaffected by heat and proteinase treatment. Notably, symptomatic NCC patients exhibited elevated FasL levels correlating with increased caspase activity, underscoring the potential contribution of apoptosis to disease pathogenesis. Conclusions This study identifies caspase 9-mediated apoptosis as a mechanism of helminth-induced brain inflammation and implicates FasL in symptomatic disease progression. These insights enhance our understanding of NCC immunopathogenesis and may inform future therapeutic strategies targeting apoptotic pathways.

• Mallouli, Salma Zouari; Munblit, Daniel; Iakovleva, Ekaterina; Winkler, Andrea Sylvia; Fornari, Arianna & Helbok, Raimund [Vis alle 21 forfattere av denne artikkelen] (2025). Persistent neurological sequelae in children and adolescents after SARS-CoV-2: a scoping review. Infection. ISSN 0300-8126. 54(1), s. 74–74. doi: 10.1007/s15010-025-02669-8. Fulltekst i vitenarkiv
• Masaku, Janet; Gachohi, John M.; Sinkeet, Alice; Maghanga, Mary; Wakesho, Florence & Omondi, Wyckliff [Vis alle 13 forfattere av denne artikkelen] (2025). Correction: Community preferred drug delivery approaches for pilot roll-out of a potential novel paediatric schistosomiasis treatment option in two endemic counties of Kenya: A mixed methods study. PLOS Global Public Health. 5(12), s. 0005653–0005653. doi: 10.1371/journal.pgph.0005653. Fulltekst i vitenarkiv
• Wilson, Christina; Mestorino, Nora; Nonga, Hezron Emmanuel; Mdegela, Robinson Hammerthon; Makingi, George & Stelzle, Dominik [Vis alle 9 forfattere av denne artikkelen] (2025). Effect of Community Health Education Intervention on Prevalence and Pig Farmers’ Knowledge, Attitudes, and Practices Related to Porcine Cysticercosis in Selected Areas of Tanzania. Veterinary Medicine International. ISSN 2090-8113. 2025(1). doi: 10.1155/vmi/9929531. Fulltekst i vitenarkiv Vis sammendrag

  Porcine cysticercosis (PCC) is a food‐borne zoonotic disease prevalent in resource‐poor rural communities with free‐range pig management systems and low sanitation practices. Various prevention and control strategies have been implemented in Tanzania, with this study highlighting the importance of community‐based health education in controlling the Taenia solium parasite. The study evaluated the effectiveness of community‐based health education using a cocreated health education package (HEP) on the knowledge, attitudes, and practices (KAP) of smallholder farmers, as well as on the prevalence of PCC in Kongwa and Songwe Districts, Tanzania. A cluster‐randomized health education intervention was conducted between June 2019 and December 2021, with pre‐ and postintervention evaluations of PCC prevalence and smallholder farmers’ KAP. A baseline cross‐sectional study was followed by health education training utilizing the HEP, which included brochures, booklets, and posters. The training was provided to trainers (TOT) who, in turn, trained the community. A commercial Ag‐ELISA kit (apDia, Belgium) was used to identify circulating antigens in pig serum and determine the PCC prevalence both before and after the intervention. A total of 692 and 486 respondents participated in face‐to‐face interviews during the baseline and postintervention periods, respectively. Concurrently, 692 and 317 pigs were sampled during these periods. At baseline, the seroprevalence of PCC was 10.2% in the intervention group and 9.1% in the control group. Twelve months following the health education intervention, the study observed significant improvements in knowledge ( β  = 1.779, p = 0.004), attitudes ( β  = 1.024, p = 0.038), and practices ( β  = 0.719, p = 0.023) among participants. Additionally, a reduction in PCC prevalence was observed—3.9% in the intervention group and 0.9% in the control group—though this difference was not statistically significant (OR = 0.70; 95% CI: 0.27–1.83; p = 0.47). The reduction in PCC is a gradual process that likely requires a longer observation period to yield a measurable impact. The limited duration of follow‐up may have constrained the study’s ability to conclusively attribute the observed decline in PCC seroprevalence to the intervention. Evidence suggests that a comprehensive strategy targeting both intermediate and definitive hosts is essential. Therefore, future health education interventions should integrate mass drug administration for pigs and treatment of human taeniosis—an approach that could be effective in disrupting the lifecycle of Taenia solium .

• Lema, Yakobo; Prodjinotho, Ulrich Fabien; Makasi, Charles; Nanyaro, Marrywinnie A.; Asenga, Frank & Kilale, Andrew [Vis alle 13 forfattere av denne artikkelen] (2025). Diagnostic Accuracy of Antigen ELISA and Western Blot IgG for Neurocysticercosis in People Living with HIV/AIDS in Tanzania. Tropical Medicine and Infectious Disease. 10(9), s. 246–246. doi: 10.3390/tropicalmed10090246. Fulltekst i vitenarkiv Vis sammendrag

  Background: Neurocysticercosis (NCC) and HIV co-infection frequently occur in sub-Saharan Africa, yet the accuracy of available serological tests for NCC in immunosuppressed patients is uncertain. Methodology: We performed a cross-sectional diagnostic study on 101 people living with HIV from two endemic districts in Tanzania. Participants provided serum for cysticercosis antigen ELISA and Western Blot IgG; any positive result prompted neuroimaging investigation with cerebral computed tomography. NCC was diagnosed according to the 2017 revised Del Brutto criteria based on cCT according to Del Brutto criteria modified to exclude serology. Sensitivity, specificity, and area under the receiver–operating–characteristic curve (AUC) were calculated and adjusted for CD4 count and HIV stage. Two algorithms were compared: parallel testing (“either-test-positive”) and sequential screening (Ag ELISA screen, western blot IgG confirm). Results: NCC prevalence was 23%. Western Blot IgG outperformed Ag ELISA (sensitivity 57% vs. 30%; specificity 87% vs. 86%; AUC 0.73 vs. 0.57). Western blot IgG sensitivity declined to 54% when CD4 < 500 cells µL−1, while Ag ELISA remained low. Western blot IgG positivity independently predicted NCC (adjusted odds ratio 4.1, 95% CI 1.4–11.9); Ag ELISA did not. When we counted a positive if either test was positive (parallel rule), sensitivity rose to 78% and NPV to 87%. When we ran Ag ELISA only if IgG was negative (sequential rule), we saved 70% of IgG strips, kept specificity at 95%, and PPV at 69%, but sensitivity fell to 39%. Conclusions: Western blot IgG is the most reliable single serological test for NCC in PLHIV. Parallel testing increased sensitivity and NPV and may suit better primary-level facilities without routine imaging. Sequential testing achieved high specificity, PPV, and conserved test kits, making it ideal for centers with limited reagents or scanner access. Tiered use of these assays can streamline NCC diagnosis in T. solium endemic, resource-limited settings.

• Reigl, Lisa Sophie; Anyolitho, Maxson Kenneth; Neema, Stella; Amuyunzu-Nyamongo, Mary; Buhl, Andrea & Carlton, Elizabeth J. [Vis alle 20 forfattere av denne artikkelen] (2025). Socio-cultural and structural barriers influencing parents’ knowledge and access to information on schistosomiasis in children around Ugandan Lakes. PLoS Neglected Tropical Diseases. ISSN 1935-2727. 19(5), s. 0013050–0013050. doi: 10.1371/journal.pntd.0013050. Fulltekst i vitenarkiv Vis sammendrag

  Background In Uganda, the national prevalence of schistosomiasis is 36.1% among the two-to-four-year age group. Knowledge about schistosomiasis and socio-cultural factors have been reported to influence adult participation in mass drug administrations of praziquantel, the standard medication used to treat the disease. In advance and support of the (pilot) introduction of the recently developed paediatric praziquantel formulation (arpraziquantel), we conducted research on parent and other community members’ knowledge about paediatric schistosomiasis, their information sources, and potential perceived barriers that influence knowledge and access to information on schistosomiasis. Methods This cross-sectional qualitative study consisted of 65 in-depth interviews and ten focus group discussions with parents/guardians of preschool-aged children (PSAC), Village Health Teams (VHTs), health professionals, community leading persons and district officials, in addition to direct observations. We collected data concurrently in Hoima District at Lake Albert and Bugiri at Lake Victoria, Uganda, in 2022. The analysis followed both an inductive and a deductive thematic approach. Results Despite high parental awareness of the disease and knowledge of signs and symptoms, we identified less familiarity with its transmission and prevention. With limited communication channels, VHTs emerged as the primary information sources but reflected varied local understandings of schistosomiasis. Parents expressed a desire to be informed about the new paediatric treatment through VHTs, health professionals, and community leaders, and partly through the radio. Other mentioned socio-cultural and structural barriers to information flow included language barriers, illiteracy, high population movement, fears, and resentment from restrictive government fishing laws. Conclusions Carefully designed information campaigns tailored to local circumstances and health literacy needs should be carried out by trained VHTs and preferably supported by health professionals and the local leadership structure. These components are essential to inform parents/guardians of PSAC, enabling them to make well-informed decisions for their children’s health.

• Damme, Inge Van; Fusco,, Daniela; Trevisan, Chiara; Kabululu, Mwemezi; Stelzle, Dominik & Makasi, Charles E. [Vis alle 21 forfattere av denne artikkelen] (2025). Evaluation of a rapid lateral flow assay for the detection of taeniosis and cysticercosis at district hospital level in Tanzania: A prospective multicentre diagnostic accuracy study. PLoS Neglected Tropical Diseases. ISSN 1935-2727. 19(3), s. 0012310–0012310. doi: 10.1371/journal.pntd.0012310. Fulltekst i vitenarkiv Vis sammendrag

  The TS POC test, Taenia solium point-of-care test, is a two-strip lateral flow assay using the recombinant antigen rES33 on the TS POC T test strip, and rT24H on the TS POC CC test strip, to detect antibodies against T. solium taeniosis and cysticercosis, respectively. The objective of this study was to assess the diagnostic performance of the TS POC test for the detection of T. solium taeniosis and cysticercosis in individuals attending district hospitals in Tanzania. In this prospective two-phase diagnostic accuracy study, we recruited participants aged 10 and above, excluding pregnant women and those with acute severe illness. Participants were consecutively recruited in three cohorts according to their signs/symptoms: compatible with neurocysticercosis (cohort 1), intestinal worm infections (cohort 2), and other signs/symptoms (cohort 3). Lacking a gold standard test for both infections, diagnostic accuracy was evaluated using results of two coprological and two serological tests for taeniosis, and three serological tests for cysticercosis, in a Bayesian Latent Class Model approach. The TS POC test was conducted on 601 participants in cohort 1, 1661 participants in cohort 2, and 662 participants in cohort 3. Most individuals tested negative on both TS POC test strips, with proportions of 83% (n = 496), 97% (n = 1613) and 97% (n = 641) in cohorts 1, 2 and 3, respectively. Complete case data were available for 120, 114, and 53 participants for taeniosis, and 126, 122, and 55 participants for cysticercosis. Sensitivity values for the TS POC T test strip were 50.2% [95% credible interval 4.9 - 96.4], 40.8% [2.2 - 95.2], and 40.4% [2.3 – 95.0], while specificity values were 98.6% [97.1 - 99.6], 99.3% [98.7 - 99.7] and 99.4% [98.5 - 99.9], respectively. For the TS POC CC test strip, the sensitivity was 77.5% [37.8 - 99.2], 24.9% [95% CI 6.4 - 52.7] and 44.2% [6.6 - 91.5], and the specificity 92.3% [86.5 - 98.8], 99.1% [97.8 - 100], and 98.1% [96.1 - 99.7] across the respective cohorts. Although the TS POC test has a low sensitivity, it demonstrates a high specificity, which may have clinical utility to guide treatment and diagnostic decisions, or in epidemiological studies. An important strength of this study lies in its assessment of the TS POC test under real-world conditions, revealing divergent estimates across distinct cohorts. The study underscores the suboptimal performance of existing tests under field conditions, emphasizing the need to enhance and validate these tests for better performance in practical real-world settings. Registration number: PACTR201712002788898.

• Kurscheid, Johanna; Buhl, Andrea; Westenberg, Erica; Palmeirim, Marta Sólveig; Winkler, Andrea Sylvia & Steinmann, Peter [Vis alle 7 forfattere av denne artikkelen] (2025). Considerations and expectations for the administration of dispersible arpraziquantel to young children: a landscape analysis. International Health. ISSN 1876-3413. 17(4), s. 534–534. doi: 10.1093/inthealth/ihae092. Fulltekst i vitenarkiv Vis sammendrag

  Abstract Schistosomiasis is a serious public health problem in many African countries and beyond. Preventive chemotherapy with praziquantel is a successful public health intervention that is recommended for all communities at risk, commonly reached through large-scale mass drug administration campaigns. However, preschool-age children are currently not routinely targeted for treatment due to operational challenges related to dosing and administration with the standard drug formulation. In response to the need for a suitable, child-friendly treatment, the multistakeholder Pediatric Praziquantel Consortium has developed a novel dispersible tablet with improved taste and smaller size. To prepare the introduction and inform future uptake of the novel paediatric formulation in endemic countries, we conducted a landscape analysis to explore perspectives, opinions and experiences of key stakeholders on operational and practical issues in relation to drug dosing and administration. Our findings confirm that child-friendly drug formulations mitigate several operational constraints related to the dosing and administration in young children. The introduction of this novel child health intervention into routine platforms and programs requires solid training and careful communication by engaging with communities, caregivers, healthcare workers and decision-makers to ensure acceptance and future uptake of treatment.

• Nyangi, Chacha; Mkupasi, Ernatus Martin; Ngowi, Helena Aminiel; Mahonge, Christopher & Winkler, Andrea Sylvia (2025). Impact of Health Education Interventions for Control of Taenia solium Cysticercosis/Taeniasis in Endemic Countries: A Systematic Review - PubMed. Public Health Challenges. ISSN 2769-2450. doi: 10.1002/puh2.70147. Fulltekst i vitenarkiv Vis sammendrag

  Despite some control efforts, <i>Taenia solium</i> cysticercosis/taeniasis (TSCT) remains widespread in many low-income countries across sub-Saharan Africa, Latin America and Asia. With increased global interaction, the risk of infection also rises in high-income countries (HICs) and middle-income c …

• Sukums, Felix; Ngowi, Bernard; Chaula, Rebecca; Weiszhar, Kim L; Kalinga, Akili & Ivanova, Olena [Vis alle 14 forfattere av denne artikkelen] (2025). Experiences of Health Research Data Sharing Among Researchers in Sub-Saharan Africa: Cross-Sectional Study. JMIR Formative Research. 9. doi: 10.2196/69411. Fulltekst i vitenarkiv Vis sammendrag

  Abstract Background Digital platforms play a vital role in improving the availability and access to health research outputs, enhancing the engagement of policy makers and practitioners in the research processes. Despite their potential, it needs to be explored how digital platforms are used to manage and share health research datasets and publications, and to translate research findings among health networks or institutions in sub-Saharan Africa (SSA). Objective This study aimed to assess the practices of health research data management, including sharing among researchers and their support staff within 3 large research networks for health innovations in SSA. Methods A cross-sectional mixed methods survey was conducted across 3 research networks in SSA, showing experiences of sharing research data using digital platforms among researchers of 3 large research and innovation networks in SSA and affiliated institutions in the Global North. A total of 160 respondents completed a self-administered web-based questionnaire, and following data cleansing, the survey data were analyzed using both descriptive and inferential statistics. Results Most respondents (91/160, 56.9%) used electronic data collection tools to collect research data. Almost half (79/160, 49.4%) of the respondents have a digital research data management platform. More than half of the respondents shared their research datasets (102/160, 63.8%), and 61.3% (98/160) shared research findings with the research community through different channels. Furthermore, most respondents shared their research datasets and research outputs through institutional data repositories (42/160, 26.1%), scientific conferences (123/160, 76.9%), and journal articles (110/160, 68.8%). This study found that parameters such as sex, professional category (health professional, information and communication technology professional, and data managers), and the role (researcher or student) influence health research data sharing within the community. The results show that the roles of the individual have the strongest association with the sharing of research datasets, followed by years of experience in research, then sex, and profession. Females were less likely to share their research datasets than males. Data managers and information and communication technology professionals exchanged datasets less frequently in the professional group, and the researcher’s role was statistically significant in sharing research datasets. Conclusions This study demonstrates that most researchers share research datasets and outputs through various channels. It was further found that digital platforms were essential in managing and sharing research datasets and publications since more than half (85/160, 53.1%) of the respondents have and use digital platforms. In addition, the study identified factors that influenced researchers’ practices of sharing research datasets and publications. Furthermore, key gaps limit the sharing of these research datasets, including inadequate infrastructure, insufficient African dataset sharing platforms, a lack of institutional policy, and limited skills to use available platforms.

• Winkler, Andrea Sylvia; Mburu, Christina Brux; Carabin, Hélène; Neves, Carlos Goncalo Rolhas Fernandes Das; Häsler, Barbara & Zinsstag, Jakob [Vis alle 40 forfattere av denne artikkelen] (2025). The Lancet One Health Commission: harnessing our interconnectedness for equitable, sustainable, and healthy socioecological systems. The Lancet. ISSN 0140-6736. 406(10502), s. 501–570. doi: 10.1016/s0140-6736(25)00627-0. Fulltekst i vitenarkiv
• Feigin, Svetlana V; Wiebers, David O; Blumstein, Daniel T; Knight, Andrew; Eshel, Gidon & Lueddeke, George [Vis alle 20 forfattere av denne artikkelen] (2025). Solving climate change requires changing our food systems. Oxford Open Climate Change. doi: 10.1093/oxfclm/kgae024. Fulltekst i vitenarkiv
• Lema, Yakobo Leonard; Prodjinotho, Ulrich Fabien; Makasi, Charles; Nanyaro, Mary-Winnie A.; Kilale, Andrew Martin & Mfinanga, Sayoki Godfrey [Vis alle 12 forfattere av denne artikkelen] (2025). Cytokine profiles and CD4 counts in HIV-positive individuals with cysticercosis: implications for sex-specific immune responses in co-endemic regions of Tanzania. Frontiers in Immunology. 16. doi: 10.3389/fimmu.2025.1521295. Fulltekst i vitenarkiv
• Makasi, Charles Elias; Ngowi, Bernard James; Stelzle, Dominik; Kilale, Andrew Martin; Mahande, Michael Johnson & Welte, Tamara Margarete [Vis alle 8 forfattere av denne artikkelen] (2025). Extensive Inactive Neurocysticercosis: A Case Report in Mbeya, Southern Highlands of Tanzania. International Medical Case Reports Journal. 18, s. 117–124. doi: 10.2147/IMCRJ.S488096. Fulltekst i vitenarkiv
• Kaducu, Joyce Moriku; Mbutiwi, Fiston Ikwa Ndol; Keller, Luise; Escheu, Gabriele; Hauke, Peter & Pfausler, Bettina [Vis alle 11 forfattere av denne artikkelen] (2025). Prevalence of Epilepsy across 25 Sub-Counties in Three Districts of Northern Uganda. Neuroepidemiology. ISSN 0251-5350. doi: 10.1159/000543472. Fulltekst i vitenarkiv
• Feigin, Valery L.; Vos, Theo; Nair, Balakrishnan Sukumaran; Hay, Simon I.; Abate, Yohannes Habtegiorgis & Magied, Abdallah H. A. Abd Al [Vis alle 503 forfattere av denne artikkelen] (2025). Global, regional, and national burden of epilepsy, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet Public Health. ISSN 2468-2667. 10(3), s. e203–e227. doi: 10.1016/S2468-2667(24)00302-5. Fulltekst i vitenarkiv
• Crivelli, Lucia; Winkler, Andrea Sylvia; Keller, Greta; Beretta, Simone; Calandri, Ismael Luis & Groote, Wouter De [Vis alle 15 forfattere av denne artikkelen] (2025). Impact of COVID-19 on functional, cognitive, neuropsychiatric, and health-related outcomes in patients with dementia: A systematic review. eNeurologicalSci. 38. doi: 10.1016/j.ensci.2024.100539. Fulltekst i vitenarkiv
• Zulu, Chibeza; Phiri, Isaac K.; Mwape, Kabemba E.; Simuunza, Martin C.; Sitali, Muloongo C. & Mwenda, Racheal [Vis alle 11 forfattere av denne artikkelen] (2025). Treatment with oxfendazole increased levels of cardiac troponin I in pigs naturally infected with Taenia solium cysticercosis. PLOS ONE. 20(5). doi: 10.1371/journal.pone.0321735. Fulltekst i vitenarkiv
• Masaku, Janet; Gachohi, John M.; Sinkeet, Alice; Maghanga, Mary; Wakesho, Florence & Omondi, Wyckliff [Vis alle 13 forfattere av denne artikkelen] (2024). Community preferred drug delivery approaches for pilot roll-out of a potential novel paediatric schistosomiasis treatment option in two endemic counties of Kenya: A mixed methods study. PLOS Global Public Health. 4(5). doi: 10.1371/journal.pgph.0003221. Fulltekst i vitenarkiv
• Metanmo, Salvatore; Dossa, Djamirou; Ahmat, Djibrine Nassir; Winkler, Andrea Sylvia & Boumediene, Farid (2024). Mapping, Associated Factors, and Pathophysiology of Nodding Syndrome in Africa: A Systematic Review. Neuroepidemiology. ISSN 0251-5350. 58(2), s. 92–119. doi: 10.1159/000536013. Fulltekst i vitenarkiv
• Gupta, Saksham; Aukrust, Camilla Grøver; Bhebhe, Arnold; Winkler, Andrea Sylvia & Park, Kee B. (2024). Neurosurgery and the World Health Organization Intersectoral Global Action Plan for Epilepsy and Other Neurological Disorders 2022–2031. Neurosurgery. ISSN 0148-396X. 95(1), s. e1–e7. doi: 10.1227/neu.0000000000002828. Fulltekst i vitenarkiv
• Masaku, Janet; Gachohi, John M.; Sinkeet, Alice; Maghanga, Mary; Wakesho, Florence & Omondi, Wyckliff [Vis alle 11 forfattere av denne artikkelen] (2024). A qualitative assessment of community perceptions and practices towards schistosomiasis prior to introduction of a potential novel treatment option for preschool-age children in Kenya. Frontiers in Tropical Diseases. 5. doi: 10.3389/fitd.2024.1404634. Fulltekst i vitenarkiv
• Geiselhart, Klaus; Damm, Maik; Jeske, Niklas; Knappmann, Alexia; Nasser, Gabriela Pen & Roth, Laura Franziska [Vis alle 10 forfattere av denne artikkelen] (2024). Sufficiency health-wise: sustainable paths towards planetary and public health. Frontiers in Public Health. 12. doi: 10.3389/fpubh.2024.1497657. Fulltekst i vitenarkiv
• Makasi, Charles E.; Ngowi, Bernard; Mahande, Michael Johnson; Welte, Tamara M.; Stelzle, Dominik & Guga, Godfrey [Vis alle 14 forfattere av denne artikkelen] (2024). Neurocysticercosis and cognitive impairment among people with epilepsy in Taenia solium endemic regions of rural southern Tanzania: A hospital-based cross-sectional study in mental health clinics of selected sites in Tanzania. Epilepsy & Behavior. ISSN 1525-5050. 159. doi: 10.1016/j.yebeh.2024.110010. Fulltekst i vitenarkiv
• Mambo, Richard; Phiri, Andrew M.; Trevisan, Chiara; Zulu, Gideon; Mubanga, Chishimba M. & Mwelwa, Chembensofu [Vis alle 13 forfattere av denne artikkelen] (2024). Gaps in treatment of epileptic seizures in a Zambian rural area. Neurological Sciences. ISSN 1590-1874. doi: 10.1007/s10072-024-07456-1. Fulltekst i vitenarkiv
• Lemaid, Yakobo Leonard; Prodjinotho, Ulrich Fabien; Makasi, Charles; Nanyaro, Mary-Winnie A.; Kilale, Andrew Martin & Mfinanga, Sayoki Godfrey M. [Vis alle 14 forfattere av denne artikkelen] (2024). Evaluating the modulation of peripheral immune profile in people living with HIV and (Neuro)cysticercosis. PLoS Neglected Tropical Diseases. ISSN 1935-2727. 18(8). doi: 10.1371/journal.pntd.0012345. Fulltekst i vitenarkiv
• Zulu, Gideon; Stelzle, Dominik; Gabriël, Sarah; Trevisan, Chiara; Damme, Inge Van & Mubanga, Chishimba [Vis alle 17 forfattere av denne artikkelen] (2024). Neurocysticercosis Prevalence and Characteristics in Communities of Sinda District in Zambia: A Cross-Sectional Study. Journal of Epidemiology and Global Health (JEGH). ISSN 2210-6006. doi: 10.1007/s44197-024-00271-z. Fulltekst i vitenarkiv
• Mlowe, Fredy; Mlangwa, James; Mkupasi, Ernatus; Winkler, Andrea Sylvia; Nyerere, Antony D. & Churi, Ayubu [Vis alle 8 forfattere av denne artikkelen] (2024). Taenia solium Cysticercosis and Taeniosis Reporting in the Current Medical and Veterinary Diseases Reporting Systems in Tanzania: A Cross-Sectional Study. Veterinary Medicine International. ISSN 2090-8113. 2024. doi: 10.1155/2024/5592872. Fulltekst i vitenarkiv
• Zulu, Gideon; Stelzle, Dominik; Mwape, Kabemba E.; Damme, Inge Van; Trevisan, Chiara & Mubanga, Chishimba [Vis alle 20 forfattere av denne artikkelen] (2024). The performance of a point-of-care test for the diagnosis of Neurocysticercosis in a resource-poor community setting in Zambia – a diagnostic accuracy study. EClinicalMedicine. 77. doi: 10.1016/j.eclinm.2024.102893. Fulltekst i vitenarkiv
• Nyangi, Chacha; Mkupasi, Ernatus Martin; Mahonge, Christopher; Churi, Ayubu Jacob; Ngowi, Helena Aminiel & Winkler, Andrea Sylvia (2024). Development and rapid assessment of Community-Based Health Education Package for the Control of Taenia solium Taeniasis/Cysticercosis in Tanzania. Tanzania Journal of Health Research (TJHR). ISSN 1821-6404. 25(3), s. 1066–1084. doi: 10.4314/thrb.v25i3. Fulltekst i vitenarkiv
• Schuster, Joachim; Dreyhaupt, Jens; Dupuis, Luc; Weishaupt, Jochen H.; Kassubek, Jan & Petri, Susanne [Vis alle 18 forfattere av denne artikkelen] (2024). In‐depth analysis of data from the RAS‐ALS study reveals new insights in rasagiline treatment for amyotrophic lateral sclerosis. European Journal of Neurology. ISSN 1351-5101. doi: 10.1111/ene.16204. Fulltekst i vitenarkiv
• Jin, Yingzhao; Guo, Cui; Abbasian, Mohammadreza; Abbasifard, Mitra; Abbott, J. Haxby & Abdullahi, Auwal [Vis alle 50 forfattere av denne artikkelen] (2024). Global pattern, trend, and cross-country inequality of early musculoskeletal disorders from 1990 to 2019, with projection from 2020 to 2050. Med. ISSN 2666-6359. 5, s. 943–962. doi: 10.1016/j.medj.2024.04.009. Fulltekst i vitenarkiv Vis sammendrag

  Background: This study aims to estimate the burden, trends, forecasts, and disparities of early musculoskeletal (MSK) disorders among individuals ages 15 to 39 years. Methods: The global prevalence, years lived with disabilities (YLDs), disability-adjusted life years (DALYs), projection, and inequality were estimated for early MSK diseases, including rheumatoid arthritis (RA), osteoarthritis (OA), low back pain (LBP), neck pain (NP), gout, and other MSK diseases (OMSKDs). Findings: More adolescents and young adults were expected to develop MSK disorders by 2050. Across five age groups, the rates of prevalence, YLDs, and DALYs for RA, NP, LBP, gout, and OMSKDs sharply increased from ages 15–19 to 35–39; however, these were negligible for OA before age 30 but increased notably at ages 30–34, rising at least 6-fold by 35–39. The disease burden of gout, LBP, and OA attributable to high BMI and gout attributable to kidney dysfunction increased, while the contribution of smoking to LBP and RA and occupational ergonomic factors to LBP decreased. Between 1990 and 2019, the slope index of inequality increased for six MSK disorders, and the relative concentration index increased for gout, NP, OA, and OMSKDs mbut decreased for LBP and RA. Conclusions: Multilevel interventions should be initiated to prevent disease burden related to RA, NP, LBP, gout, and OMSKDs among individuals ages 15–19 and to OA among individuals ages 30–34 to tightly control high BMI and kidney dysfunction. Funding: The Global Burden of Disease study is funded by the Bill and Melinda Gates Foundation. The project is funded by the Scientific Research Fund of Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital (2022QN38

• Gupta, Saksham; Patel, Vikram; Bhebhe, Arnold; Fleury, Agnès; Aukrust, Camilla Grøver & Dua, Tarun [Vis alle 10 forfattere av denne artikkelen] (2024). Global brain health-the time to act is now. The Lancet Global Health. ISSN 2572-116X. doi: 10.1016/S2214-109X(23)00602-2. Fulltekst i vitenarkiv
• Arndts, Kathrin; Kegele, Josua; Ritter, Manuel; Costa, Clarissa Prazeres da; Hoerauf, Achim & Winkler, Andrea Sylvia (2024). Active infection with Onchocerca volvulus and the linkage to epilepsy/nodding syndrome. PLoS Neglected Tropical Diseases. ISSN 1935-2727. 18(5), s. e0012076–e0012076. doi: 10.1371/journal.pntd.0012076. Fulltekst i vitenarkiv
• Giussani, Giorgia; Westenberg, Erica; Garcia-Azorin, David; Bianchi, Elisa; Khan, Abdul Hanif Khan Yusof & Allegri, Ricardo Francisco [Vis alle 28 forfattere av denne artikkelen] (2024). Prevalence and Trajectories of Post-COVID-19 Neurological Manifestations: A Systematic Review and Meta-Analysis. Neuroepidemiology. ISSN 0251-5350. 58(2), s. 120–133. doi: 10.1159/000536352. Fulltekst i vitenarkiv
• Kegele, Josua; Wagner, Thomas; Kowenski, Teresa; Wiesmayr, Matthias; Gatterer, Christian & Alber, Michael [Vis alle 10 forfattere av denne artikkelen] (2024). Long-term clinical course and treatment outcomes of individuals with Nodding Syndrome. Journal of the Neurological Sciences. ISSN 0022-510X. 457. doi: 10.1016/j.jns.2024.122893. Fulltekst i vitenarkiv
• Steinmetz, Jaimie D.; Seeher, Katrin Maria; Schiess, Nicoline; Nichols, Emma; Cao, Bochen & Servili, Chiara [Vis alle 1 263 forfattere av denne artikkelen] (2024). Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Neurology. ISSN 1474-4422. 23(4), s. 344–381. doi: 10.1016/S1474-4422(24)00038-3. Fulltekst i vitenarkiv Vis sammendrag

  Background Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021. Methods We estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined. Findings Globally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378–521), affecting 3·40 billion (3·20–3·62) individuals (43·1%, 40·5–45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7–26·7) between 1990 and 2021. Age-standardised rates of deaths per 100 000 people attributed to these conditions decreased from 1990 to 2021 by 33·6% (27·6–38·8), and age-standardised rates of DALYs attributed to these conditions decreased by 27·0% (21·5–32·4). Age-standardised prevalence was almost stable, with a change of 1·5% (0·7–2·4). The ten conditions with the highest age-standardised DALYs in 2021 were stroke, neonatal encephalopathy, migraine, Alzheimer's disease and other dementias, diabetic neuropathy, meningitis, epilepsy, neurological complications due to preterm birth, autism spectrum disorder, and nervous system cancer. Interpretation As the leading cause of overall disease burden in the world, with increasing global DALY counts, effective prevention, treatment, and rehabilitation strategies for disorders affecting the nervous system are needed.

• Holst, Christine; Tschirhart, Naomi Anne; Ngowi, Bernard James; Noll, Josef & Winkler, Andrea Sylvia (2023). Utilizing community InfoSpots for health education: perspectives and experiences in Migoli and Izazi, Tanzania. Health Promotion International. ISSN 0957-4824. 38(4). doi: 10.1093/heapro/daab187. Fulltekst i vitenarkiv
• Stelzle, D.; Makasi, C.; Welte, T.M.; Ruether, C.; Schmidt, V. & Gabriel, S. [Vis alle 10 forfattere av denne artikkelen] (2023). Report of three patients with extensive neurocysticercosis in rural southern Tanzania: neurological, serological and neuroradiological findings. Journal of Medical Case Reports. 17(1). doi: 10.1186/s13256-023-03974-2. Fulltekst i vitenarkiv Vis sammendrag

  Background Neurocysticercosis (NCC) is common in eastern Africa, but disease presentation varies considerably. Most patients have single or few NCC-typical lesions in their brain but some present with a large number of lesions. We present three patients with positive antibody-based serology for Taenia solium cysticercosis screened at the Vwawa district hospital, Mbozi district, southern Tanzania, in whom extensive NCC was confirmed by neuroimaging. Case presentations Patient 1 was a 55-year-old female from the tribe Malila smallholder farmer who has had four generalized tonic–clonic epileptic seizures over a period of 11 years and one episode of transient left hemiparesis one year before seizure onset. The patient also reported monthly to weekly episodes of severe, progressive, unilateral headache. The computed tomography (CT) scan of the brain showed 25 NCC lesions of which 15 were in the vesicular stage. Patient 2 was a 30-year-old male from tribe Nyha mechanic who reported monthly episodes of moderate to severe, progressive, bilateral headache, but no epileptic seizures. The CT scan showed 63 NCC lesions of which 50 were in the vesicular stage. Patient 3 was a 54-year-old female from the tribe Malila smallholder farmer who suffered from frequent generalized tonic–clonic epileptic seizures with potential signs of focal seizure onset. She also reported weekly to daily episodes of severe, progressive, unilateral headache. The CT scan showed 29 NCC lesions of which 28 were in the vesicular stage. Conclusions Clinical presentation of NCC with multiple brain lesions varies considerably ranging from few epileptic seizures and severe headache to severe epilepsy with frequent epileptic seizures. Individuals with neurological signs/symptoms that may be due to NCC, based for example on epidemiological criteria or serological evidence of cysticercosis, are recommended to undergo neuroimaging before anthelminthic treatment is considered.

• Makingi, George; Ngowi, Bernard James; Mkupasi, Ernatus; Wilson, Christina; Winkler, Andrea Sylvia & Nzalawahe, Jahashi [Vis alle 7 forfattere av denne artikkelen] (2023). Community Health-Education Intervention Trial against Human Taenia solium Taeniasis/Cysticercosis in Central and Southern Zones of Tanzania. Pathogens. ISSN 2076-0817. 12(7). doi: 10.3390/pathogens12070955. Fulltekst i vitenarkiv
• Zulu, Gideon; Sikasunge, Chummy S.; Welte, Tamara M.; Simuunza, Martin C.; Stelzle, Dominik & Schmidt, Veronika [Vis alle 14 forfattere av denne artikkelen] (2023). Epidemiology of intestinal helminthiasis with an emphasis on taeniasis in Chipata district of the Eastern province of Zambia. PLoS Neglected Tropical Diseases. ISSN 1935-2727. 17(11). doi: 10.1371/journal.pntd.0011561. Fulltekst i vitenarkiv
• Asaduzzaman, Muhammad; Mekonnen, Zeleke; Rødland, Ernst Kristian; Sahay, Sundeep; Winkler, Andrea Sylvia & Gradmann, Christoph (2023). District health information system (DHIS2) as integrated antimicrobial resistance surveillance platform: An exploratory qualitative investigation of the one health stakeholders’ viewpoints in Ethiopia. International Journal of Medical Informatics. ISSN 1386-5056. 181. doi: 10.1016/j.ijmedinf.2023.105268. Fulltekst i vitenarkiv Vis sammendrag

  Introduction There is an unmet need for One Health (OH) surveillance and reporting systems for antimicrobial resistance (AMR) in resource poor settings. District health information system, version 2 (DHIS2), is a globally recognized digital surveillance platform which has not been widely utilized for AMR data yet. Our study aimed to understand the local stakeholders’ viewpoints on DHIS2 as OH-AMR surveillance platform in Jimma, Ethiopia which will aid its further context specific establishment. Methods We performed an exploratory qualitative study using semi-structured key informant interviews (KIIs) in Jimma Zone at Southwest Ethiopia. We interviewed 42 OH professionals between November 2020 and February 2021. Following verbatim transcription of the audio recordings of KIIs, we conducted thematic analysis. Results We identified five major themes which are important for understanding the trajectory of OH-AMR surveillance in DHIS2 platform. The themes were: (1) Stakeholders' current knowledge on digital surveillance platforms including DHIS2. (2) Stakeholders' perception on digital surveillance platform including DHIS2. (3) Features suggested by stakeholders to be included in the surveillance platform. (4) Comments from stakeholders on system implementation challenges. (5) Stakeholders' perceived role in the process of implementation. Despite several barriers and challenges, most of the participants perceived and suggested DHIS2 as a suitable OH-AMR surveillance platform and were willing to contribute at their current professional roles. Conclusions Our study demonstrates the potential of the DHIS2 as a user friendly and acceptable interoperable platform for OH-AMR surveillance if the technology designers accommodate the stakeholders’ concerns. Piloting at local level and using performance appraisal tool in all OH disciplines should be the next step before proceeding to workable format.

• Stelzle, D.; Makasi, C.; Schmidt, V.; Trevisan, C.; Damme, Damme Van & Ruether, C. [Vis alle 19 forfattere av denne artikkelen] (2023). Efficacy and safety of antiparasitic therapy for neurocysticercosis in rural Tanzania: a prospective cohort study. Infection. ISSN 0300-8126. doi: 10.1007/s15010-023-02021-y. Fulltekst i vitenarkiv
• Arndts, Kathrin; Kegele, Josua; Massarani, Alain S.; Ritter, Manuel; Wagner, Thomas & Pfarr, Kenneth [Vis alle 17 forfattere av denne artikkelen] (2023). Epilepsy and nodding syndrome in association with an Onchocerca volvulus infection drive distinct immune profile patterns. PLoS Neglected Tropical Diseases. ISSN 1935-2727. 17(8). doi: 10.1371/journal.pntd.0011503. Fulltekst i vitenarkiv
• Boruah, Abhilasha P.; Thakur, Kiran T.; Gadani, Sachin P.; Kothari, Kavita U.; Chomba, Mashina & Guekht, Alla [Vis alle 19 forfattere av denne artikkelen] (2023). Pre-existing neurological conditions and COVID-19 co-infection: Data from systematic reviews, meta-analyses, and scoping reviews. Journal of the Neurological Sciences. ISSN 0022-510X. 455. doi: 10.1016/j.jns.2023.120858. Fulltekst i vitenarkiv
• Schierl, Theresa; Tanaka, Luana Fiengo; Klug, Stefanie J.; Winkler, Andrea Sylvia & Stelzle, Dominik (2023). The Association of Women’s Empowerment with HIV-Related Indicators: A Pooled Analysis of Demographic and Health Surveys in Sub-Saharan Africa. Journal of Epidemiology and Global Health (JEGH). ISSN 2210-6006. doi: 10.1007/s44197-023-00153-w. Fulltekst i vitenarkiv
• Kajuna, Flora; Mwang’onde, Beda; Holst, Christine; Ngowi, Bernard James; Sukums, Felix & Noll, Josef [Vis alle 8 forfattere av denne artikkelen] (2023). Effects of a Digital Health Literacy Intervention on Porcine Cysticercosis Prevalence and Associated Household Practices in Iringa District, Tanzania. Pathogens. ISSN 2076-0817. 12(1). doi: 10.3390/pathogens12010107. Fulltekst i vitenarkiv
• Gaiser, Manuel L.; Winkler, Andrea Sylvia; Klug, Stefanie J.; Nkurunziza, Sandra & Stelzle, Dominik (2023). Determinants of stunting among children under age five in Burundi: Evidence from the 2016–2017 Burundi Demographic and Health Survey (BDHS 2016–17). Food Science & Nutrition. doi: 10.1002/fsn3.3400. Fulltekst i vitenarkiv
• Wilson, Christina; Mdegela, Robinson Hammerthon; Nonga, Hezron Emmanuel; Makingi, George; Churi, Ayubu Jacob & Stelzle, Dominik [Vis alle 11 forfattere av denne artikkelen] (2023). Seroprevalence and risk factors for Taenia spp infection in pigs in Kongwa and Songwe districts, Tanzania: A cross-sectional study. Food and Waterborne Parasitology. ISSN 2405-6766. 33. doi: 10.1016/j.fawpar.2023.e00215. Fulltekst i vitenarkiv
• Makasi, Charles E; Kilale, Andrew Martin; Ngowi, Bernard James; Lema, Yakobo; Katiti, Victor & Mahande, Michael Johnson [Vis alle 10 forfattere av denne artikkelen] (2023). Knowledge and misconceptions about epilepsy among people with epilepsy and their caregivers attending mental health clinics: A qualitative study in Taenia solium endemic pig-keeping communities in Tanzania. Epilepsia Open. 8(2), s. 487–496. doi: 10.1002/epi4.12720. Fulltekst i vitenarkiv
• Tamborska, A.A.; Wood, G.K.; Westenberg, E.; Garcia-Azorin, D.; Webb, G. & Schiess, N. [Vis alle 29 forfattere av denne artikkelen] (2023). Global uncertainty in the diagnosis of neurological complications of SARS-CoV-2 infection by both neurologists and non-neurologists: An international inter-observer variability study. Journal of the Neurological Sciences. ISSN 0022-510X. 449. doi: 10.1016/j.jns.2023.120646. Fulltekst i vitenarkiv
• Zulu, Gideon; Mwape, Kabemba E.; Welte, Tamara M.; Simuunza, Martin C.; Hachangu, Alex & Mutale, Wilbroad [Vis alle 10 forfattere av denne artikkelen] (2023). Community knowledge, attitudes and practices related to Taenia solium taeniosis and cysticercosis in Zambia. PLoS Neglected Tropical Diseases. ISSN 1935-2727. 17(8). doi: 10.1371/journal.pntd.0011375. Fulltekst i vitenarkiv
• Feigin, Valery L; Krishnamurthi, Rita; Medvedev, Oleg; Merkin, Alexander; Nair, Balakrishnan & Kravchenko, Michael [Vis alle 102 forfattere av denne artikkelen] (2023). Usability and feasibility of PreventS-MD web app for stroke prevention. International Journal of Stroke. ISSN 1747-4930. doi: 10.1177/17474930231190745. Fulltekst i vitenarkiv
• Wilson, C.; Nonga, Hezron Emmanuel; Mdegela, R.H.; Churi, A.J.; Mkupasi, E.M. & Winkler, Andrea Sylvia [Vis alle 7 forfattere av denne artikkelen] (2023). Knowledge, attitudes and practices regarding porcine cysticercosis control among smallholder pig farmers in Kongwa and Songwe districts, Tanzania: A cross-sectional study. Veterinary Parasitology: Regional Studies and Reports. 44. doi: 10.1016/j.vprsr.2023.100912. Fulltekst i vitenarkiv
• Hoffmann, Christina; Schneider, Tamara; Wannous, Chadia; Nyberger, Karolina; Haavardsson, Ingeborg Kathrina & Gilmore, Brynne [Vis alle 9 forfattere av denne artikkelen] (2023). Impact of COVID-19 on the private and professional lives of highly educated women working in global health in Europe—A qualitative study. Frontiers in Global Women’s Health. 4. doi: 10.3389/fgwh.2023.1009473. Fulltekst i vitenarkiv
• Zulu, Gideon; Stelzle, Dominik; Mwape, Kabemba E.; Welte, Tamara M.; Strømme, Hilde & Mubanga, Chishimba [Vis alle 13 forfattere av denne artikkelen] (2023). The epidemiology of human Taenia solium infections: A systematic review of the distribution in Eastern and Southern Africa. PLoS Neglected Tropical Diseases. ISSN 1935-2727. 17(3). doi: 10.1371/journal.pntd.0011042. Fulltekst i vitenarkiv
• Ahmed, Osama Ahmed Hassan; Balogh, Katinka de & Winkler, Andrea Sylvia (2023). One Health early warning and response system for zoonotic diseases outbreaks: Emphasis on the involvement of grassroots actors. Veterinary Medicine and Science. doi: 10.1002/vms3.1135. Fulltekst i vitenarkiv
• Wunrow, Han Yong; Bender, Rose G; Vongpradith, Avina ; Sirota, Sarah Brooke ; Swetschinski, Lucien R  & Novotney, Amanda  [Vis alle 51 forfattere av denne artikkelen] (2023). Global, regional, and national burden of meningitis and its aetiologies, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurology. ISSN 1474-4422. 22(8), s. 685–711. doi: 10.1016/S1474-4422(23)00195-3. Fulltekst i vitenarkiv Vis sammendrag

  Background Although meningitis is largely preventable, it still causes hundreds of thousands of deaths globally each year. WHO set ambitious goals to reduce meningitis cases by 2030, and assessing trends in the global meningitis burden can help track progress and identify gaps in achieving these goals. Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we aimed to assess incident cases and deaths due to acute infectious meningitis by aetiology and age from 1990 to 2019, for 204 countries and territories. Methods We modelled meningitis mortality using vital registration, verbal autopsy, sample-based vital registration, and mortality surveillance data. Meningitis morbidity was modelled with a Bayesian compartmental model, using data from the published literature identified by a systematic review, as well as surveillance data, inpatient hospital admissions, health insurance claims, and cause-specific meningitis mortality estimates. For aetiology estimation, data from multiple causes of death, vital registration, hospital discharge, microbial laboratory, and literature studies were analysed by use of a network analysis model to estimate the proportion of meningitis deaths and cases attributable to the following aetiologies: Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae, group B Streptococcus, Escherichia coli, Klebsiella pneumoniae, Listeria monocytogenes, Staphylococcus aureus, viruses, and a residual other pathogen category. Findings In 2019, there were an estimated 236000 deaths (95% uncertainty interval [UI] 204000–277000) and 2·51 million (2·11–2·99) incident cases due to meningitis globally. The burden was greatest in children younger than 5 years, with 112 000 deaths (87 400–145 000) and 1·28 million incident cases (0·947–1·71) in 2019. Age-standardised mortality rates decreased from 7·5 (6·6–8·4) per 100 000 population in 1990 to 3·3 (2·8–3·9) per 100 000 population in 2019. The highest proportion of total all-age meningitis deaths in 2019 was attributable to S pneumoniae (18·1% [17·1–19·2]), followed by N meningitidis (13·6% [12·7–14·4]) and K pneumoniae (12·2% [10·2–14·3]). Between 1990 and 2019, H influenzae showed the largest reduction in the number of deaths among children younger than 5 years (76·5% [69·5–81·8]), followed by N meningitidis (72·3% [64·4–78·5]) and viruses (58·2% [47·1–67·3]). Interpretation Substantial progress has been made in reducing meningitis mortality over the past three decades. However, more meningitis-related deaths might be prevented by quickly scaling up immunisation and expanding access to health services. Further reduction in the global meningitis burden should be possible through low-cost multivalent vaccines, increased access to accurate and rapid diagnostic assays, enhanced surveillance, and early treatment.

• Frontera, Jennifer A.; Guekht, Alla; Allegri, Ricardo F.; Ashraf, Mariam; Baykan, Betül & Crivelli, Lucía [Vis alle 30 forfattere av denne artikkelen] (2023). Evaluation and treatment approaches for neurological post-acute sequelae of COVID-19: A consensus statement and scoping review from the global COVID-19 neuro research coalition. Journal of the Neurological Sciences. ISSN 0022-510X. 454. doi: 10.1016/j.jns.2023.120827. Fulltekst i vitenarkiv
• Feigin, Svetlana V.; Wiebers, David O.; Lueddeke, George; Morand, Serge; Lee, Kelley & Knight, Andrew [Vis alle 13 forfattere av denne artikkelen] (2023). Proposed solutions to anthropogenic climate change: A systematic literature review and a new way forward. Heliyon. 9(10). doi: 10.1016/j.heliyon.2023.e20544. Fulltekst i vitenarkiv
• Langa, Irene; Padama, Fernando; Nhancupe, Noémia; Pondja, Alberto; Hlashwayo, Delfina & Gouveia, Lidia [Vis alle 11 forfattere av denne artikkelen] (2022). The burden of T. solium cysticercosis and selected neuropsychiatric disorders in Mocuba district, Zambézia province, Mozambique. PLoS Neglected Tropical Diseases. ISSN 1935-2727. 16(7). doi: 10.1371/journal.pntd.0010606. Fulltekst i vitenarkiv
• Stelzle, Dominik; Kaducu, Joyce; Schmidt, Veronika; Welte, Tamara M.; Ngowi, Bernard James & Matuja, William [Vis alle 16 forfattere av denne artikkelen] (2022). Characteristics of people with epilepsy in three Eastern African countries – a pooled analysis. BMC Neurology. 22(1). doi: 10.1186/s12883-022-02813-z. Fulltekst i vitenarkiv Vis sammendrag

  Background Epilepsy is one of the most common neurological disorders worldwide. Yet, its treatment gap is large in some areas and especially in sub-Saharan Africa data on clinical, radiological and semiological characteristics, as well as on treatment of persons with epilepsy (PWE) are still scarce. Methods We pooled data from four cross-sectional studies on epilepsy in eastern Africa. Two studies from Malawi and Uganda were community-based; two studies in Tanzania (urban Dar es Salaam and rural Haydom) were hospital-based. Clinical characteristics of PWE were assessed by the same questionnaire. Additionally, data on treatment were collected and computed tomography (CT) scans were performed. Results Overall, 1179 PWE were included in our analysis (581 (49.3%) female, median age 22 years (IQR 15–32 years)). Up to 25% of the patients had focal onset seizures. Those showed a higher rate of remarkable CT scan findings, with especially post-ischaemic and neurocysticercosis-associated lesions, compared to PWE with generalized onset seizures (35.1% vs. 20%). The majority of the patients experienced tonic–clonic seizures (70–85%). Only 67–78% of PWE received anti-seizure medication (ASM) treatment in the community-based studies, mostly monotherapy with phenobarbital, phenytoin or carbamazepine. Yet, underdosage was frequent and a large proportion of PWE received alternative non-ASM treatment consisting of herbal treatment (up to 83%) and/or scarification (up to 20%). Conclusions Epilepsy is common in sub-Saharan Africa, often caused by neurocysticercosis or ischaemic strokes. PWE suffer from high seizure rates and subsequent injuries, as well as from socio-economic consequences due to insufficient ASM treatment. This pooled analysis illustrates the need for structural programmes for adequate identification, education, assessment and treatment of PWE in sub-Saharan Africa.

• Nyangi, Chacha; Stelzle, Dominik; Mkupasi, Ernatus M.; Ngowi, Helena A.; Churi, Ayubu J. & Schmidt, Veronika [Vis alle 8 forfattere av denne artikkelen] (2022). Knowledge, attitudes and practices related to Taenia solium cysticercosis and taeniasis in Tanzania. BMC Infectious Diseases. 22(1). doi: 10.1186/s12879-022-07408-0. Fulltekst i vitenarkiv Vis sammendrag

  Background Taenia solium cysticercosis/taeniasis (TSCT) is reported to be endemic in pig producing areas around the world, causing significant disease burden and economic losses. Methods This cross-sectional study aimed at assessing Knowledge, Attitudes and Practices (KAP) regarding TSCT in four districts, namely Mbulu, Mpwapwa, Mbinga, and Rungwe in Tanzania. Data on KAP were collected through questionnaire-based interviews and household infrastructure observations. Results Knowledge about porcine cysticercosis was good, particularly among pig keepers across the districts. Many participants had heard about the pork tapeworm (T. solium taeniasis), and the knowledge about signs/symptoms and treatment was fair, but the means of transmission and prevention measures were often unknown. Whilst most participants were familiar with epilepsy, no one knew anything about human cysticercosis and the link between cysticercosis and epileptic seizures. A similar trend is reflected through the attitudes toward the low risk perception of cysticercosis infection. Not surprisingly, the risk perception of the infection with the pork tapeworm was low too. Many participants reported not washing their hands before eating or after using the toilet which highlights potential risks for the development of human cysticercosis. Albeit nearly every participant reported using the toilet always, household observations revealed that toilets were either lacking or had no complete walls. Generally, household observations revealed a discrepancy between questionnaire answers on the one hand and the availability of toilet and handwashing facilities and the confinement of pigs on the other hand. Conclusion This study demonstrates knowledge gaps and adverse practices which may hinder and/or slow down the control/elimination of T. solium in endemic countries. The study results are also useful for appropriate designing of TSCT health interventions that need to be planned carefully, taking into account the local context and designing TSCT in partnership with the local communities from the beginning to the end applying a One Health approach to allow the possible sustained and best impacts. Graphical Abstract

• Bublitz, Sarah K.; Mie, Eva; Wasner, Maria; Hapfelmeier, Alexander; Geiseler, Jens & Lorenzl, Stefan [Vis alle 7 forfattere av denne artikkelen] (2022). Thick Mucus in ALS: A Mixed-Method Study on Associated Factors and Its Impact on Quality of Life of Patients and Caregivers. Brain Sciences. 12(2). doi: 10.3390/brainsci12020252. Fulltekst i vitenarkiv
• Castelpietra, Giulio; Knudsen, Ann Kristin Skrindo; Agardh, Emilie E.; Armocida, Benedetta; Beghi, Massimiliano & Iburg, Kim Moesgaard [Vis alle 52 forfattere av denne artikkelen] (2022). The burden of mental disorders, substance use disorders and self-harm among young people in Europe, 1990–2019: Findings from the Global Burden of Disease Study 2019. The Lancet Regional Health - Europe. 16. doi: 10.1016/j.lanepe.2022.100341. Fulltekst i vitenarkiv Vis sammendrag

  Summary Background Mental health is a public health issue for European young people, with great heterogeneity in resource allocation. Representative population-based studies are needed. The Global Burden of Disease (GBD) Study 2019 provides internationally comparable information on trends in the health status of populations and changes in the leading causes of disease burden over time. Methods Prevalence, incidence, Years Lived with Disability (YLDs) and Years of Life Lost (YLLs) from mental disorders (MDs), substance use disorders (SUDs) and self-harm were estimated for young people aged 10-24 years in 31 European countries. Rates per 100,000 population, percentage changes in 1990-2019, 95% Uncertainty Intervals (UIs), and correlations with Sociodemographic Index (SDI), were estimated. Findings In 2019, rates per 100,000 population were 16,983 (95% UI 12,823 – 21,630) for MDs, 3,891 (3,020 - 4,905) for SUDs, and 89·1 (63·8 - 123·1) for self-harm. In terms of disability, anxiety contributed to 647·3 (432–912·3) YLDs, while in terms of premature death, self-harm contributed to 319·6 (248·9–412·8) YLLs, per 100,000 population. Over the 30 years studied, YLDs increased in eating disorders (14·9%;9·4-20·1) and drug use disorders (16·9%;8·9-26·3), and decreased in idiopathic developmental intellectual disability (–29·1%;23·8-38·5). YLLs decreased in self-harm (–27·9%;38·3-18·7). Variations were found by sex, age-group and country. The burden of SUDs and self-harm was higher in countries with lower SDI, MDs were associated with SUDs. Interpretation Mental health conditions represent an important burden among young people living in Europe. National policies should strengthen mental health, with a specific focus on young people.

• Garcia-Azorin, David; Baykan, Betül; Beghi, Ettore; Doheim, Mohamed F; Fernandez-de-las-Penas, Cesar & Gezegen, Hasim [Vis alle 15 forfattere av denne artikkelen] (2022). Timing of headache after COVID-19 vaccines and its association with cerebrovascular events: An analysis of 41,700 VAERS reports. Cephalalgia. ISSN 0333-1024. doi: 10.1177/03331024221099231. Fulltekst i vitenarkiv
• Aukrust, Camilla Grøver; Parikh, Karishma; Smart, Luke R.; Mdala, Ibrahimu; Fjeld, Heidi E & Lubuulwa, James [Vis alle 9 forfattere av denne artikkelen] (2022). Pediatric Hydrocephalus in Northwest Tanzania: A Descriptive Cross-Sectional Study of Clinical Characteristics and Early Surgical Outcomes from the Bugando Medical Centre. World Neurosurgery. ISSN 1878-8750. 161, s. e339–e346. doi: 10.1016/j.wneu.2022.02.003. Fulltekst i vitenarkiv
• Stelzle, Dominik; Schmidt, Veronika; Keller, Luise; Matuja, William; Ngowi, Bernard James & Escheu, Gabrielle [Vis alle 15 forfattere av denne artikkelen] (2022). Characteristics of people with epilepsy and Neurocysticercosis in three eastern African countries-A pooled analysis. PLoS Neglected Tropical Diseases. ISSN 1935-2727. 16(11), s. e0010870–e0010870. doi: 10.1371/journal.pntd.0010870. Fulltekst i vitenarkiv
• Begley, Charles; Wagner, Ryan G.; Abraham, Annette Gabriela; Beghi, Ettore; Newton, Charles & Kwon, Churl-Su [Vis alle 8 forfattere av denne artikkelen] (2022). The global cost of epilepsy: A systematic review and extrapolation. Epilepsia. ISSN 0013-9580. 63(4), s. 892–903. doi: 10.1111/epi.17165. Fulltekst i vitenarkiv
• Cousin, Ewerton; Duncan, Bruce B.; Stein, Caroline; Ong, Kanyin Liane; Vos, Theo & Abbafati, Cristiana [Vis alle 50 forfattere av denne artikkelen] (2022). Diabetes mortality and trends before 25 years of age: an analysis of the Global Burden of Disease Study 2019. The Lancet Diabetes and Endocrinology. ISSN 2213-8587. 10(3), s. 177–192. doi: 10.1016/S2213-8587(21)00349-1. Fulltekst i vitenarkiv Vis sammendrag

  Background: Diabetes, particularly type 1 diabetes, at younger ages can be a largely preventable cause of death with the correct health care and services. We aimed to evaluate diabetes mortality and trends at ages younger than 25 years globally using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Methods: We used estimates of GBD 2019 to calculate international diabetes mortality at ages younger than 25 years in 1990 and 2019. Data sources for causes of death were obtained from vital registration systems, verbal autopsies, and other surveillance systems for 1990–2019. We estimated death rates for each location using the GBD Cause of Death Ensemble model. We analysed the association of age-standardised death rates per 100 000 population with the Socio-demographic Index (SDI) and a measure of universal health coverage (UHC) and described the variability within SDI quintiles. We present estimates with their 95% uncertainty intervals. Findings: In 2019, 16 300 (95% uncertainty interval 14 200 to 18 900) global deaths due to diabetes (type 1 and 2 combined) occurred in people younger than 25 years and 73·7% (68·3 to 77·4) were classified as due to type 1 diabetes. The age-standardised death rate was 0·50 (0·44 to 0·58) per 100000 population, and 15 900 (97·5%) of these deaths occurred in low to high-middle SDI countries. The rate was 0·13 (0·12 to 0·14) per 100 000 population in the high SDI quintile, 0·60 (0·51 to 0·70) per 100 000 population in the low-middle SDI quintile, and 0·71 (0·60 to 0·86) per 100 000 population in the low SDI quintile. Within SDI quintiles, we observed large variability in rates across countries, in part explained by the extent of UHC (r²=0·62). From 1990 to 2019, age-standardised death rates decreased globally by 17·0% (–28·4 to –2·9) for all diabetes, and by 21·0% (–33·0 to –5·9) when considering only type 1 diabetes. However, the low SDI quintile had the lowest decline for both all diabetes (–13·6% [–28·4 to 3·4]) and for type 1 diabetes (–13·6% [–29·3 to 8·9]). Interpretation: Decreasing diabetes mortality at ages younger than 25 years remains an important challenge, especially in low and low-middle SDI countries. Inadequate diagnosis and treatment of diabetes is likely to be major contributor to these early deaths, highlighting the urgent need to provide better access to insulin and basic diabetes education and care. This mortality metric, derived from readily available and frequently updated GBD data, can help to monitor preventable diabetes-related deaths over time globally, aligned with the UN’s Sustainable Development Targets, and serve as an indicator of the adequacy of basic diabetes care for type 1 and type 2 diabetes across nations.

• Wiebers, David O.; Feigin, Valery L. & Winkler, Andrea Sylvia (2022). All Life Protection and Our Collective Future. Neuroepidemiology. ISSN 0251-5350. 56(3), s. 147–150. doi: 10.1159/000525021. Fulltekst i vitenarkiv
• Tan, Yi-Roe; Agrawal, Anurag; Matsoso, Malebona Precious; Katz, Rebecca; Davis, Sara L M & Winkler, Andrea Sylvia [Vis alle 28 forfattere av denne artikkelen] (2022). A call for citizen science in pandemic preparedness and response: Beyond data collection. BMJ Global Health. 7(6). doi: 10.1136/bmjgh-2022-009389. Fulltekst i vitenarkiv
• Stelzle, Dominik; Abraham, Annette Gabriela; Kaminski, Miriam; Schmidt, Veronika; Meijere, Robert De & Winkler, Andrea Sylvia (2022). Clinical characteristics and management of neurocysticercosis patients: a retrospective assessment of case reports from Europe. Journal of Travel Medicine (JTM). ISSN 1195-1982. 30(1). doi: 10.1093/jtm/taac102. Fulltekst i vitenarkiv
• Klein, Ana; Berger, Toni Christoph; Hapfelmeier, Alexander; Schaffert, Matthias; Matuja, William & Schmutzhard, Erich [Vis alle 7 forfattere av denne artikkelen] (2022). Does the presence of a specialist doctor reduce the burden of disease in people with epilepsy in low-resource settings? A comparison of two epilepsy clinics in rural Tanzania. Epilepsy & Behavior. ISSN 1525-5050. 139(109030). doi: 10.1016/j.yebeh.2022.109030. Fulltekst i vitenarkiv
• Nichols, Emma; Steinmetz, Jaimie D; Vollset, Stein Emil; Fukutaki, Kai; Chalek, Julian & Abd-Allah, Foad [Vis alle 35 forfattere av denne artikkelen] (2022). Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019. The Lancet Public Health. ISSN 2468-2667. 7(2), s. 2105–e125. doi: 10.1016/S2468-2667(21)00249-8. Fulltekst i vitenarkiv Vis sammendrag

  Background Given the projected trends in population ageing and population growth, the number of people with dementia is expected to increase. In addition, strong evidence has emerged supporting the importance of potentially modifiable risk factors for dementia. Characterising the distribution and magnitude of anticipated growth is crucial for public health planning and resource prioritisation. This study aimed to improve on previous forecasts of dementia prevalence by producing country-level estimates and incorporating information on selected risk factors. Methods We forecasted the prevalence of dementia attributable to the three dementia risk factors included in the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 (high body-mass index, high fasting plasma glucose, and smoking) from 2019 to 2050, using relative risks and forecasted risk factor prevalence to predict GBD risk-attributable prevalence in 2050 globally and by world region and country. Using linear regression models with education included as an additional predictor, we then forecasted the prevalence of dementia not attributable to GBD risks. To assess the relative contribution of future trends in GBD risk factors, education, population growth, and population ageing, we did a decomposition analysis. Findings We estimated that the number of people with dementia would increase from 57·4 (95% uncertainty interval 50·4–65·1) million cases globally in 2019 to 152·8 (130·8–175·9) million cases in 2050. Despite large increases in the projected number of people living with dementia, age-standardised both-sex prevalence remained stable between 2019 and 2050 (global percentage change of 0·1% [–7·5 to 10·8]). We estimated that there were more women with dementia than men with dementia globally in 2019 (female-to-male ratio of 1·69 [1·64–1·73]), and we expect this pattern to continue to 2050 (female-to-male ratio of 1·67 [1·52–1·85]). There was geographical heterogeneity in the projected increases across countries and regions, with the smallest percentage changes in the number of projected dementia cases in high-income Asia Pacific (53% [41–67]) and western Europe (74% [58–90]), and the largest in north Africa and the Middle East (367% [329–403]) and eastern sub-Saharan Africa (357% [323–395]). Projected increases in cases could largely be attributed to population growth and population ageing, although their relative importance varied by world region, with population growth contributing most to the increases in sub-Saharan Africa and population ageing contributing most to the increases in east Asia. Interpretation Growth in the number of individuals living with dementia underscores the need for public health planning efforts and policy to address the needs of this group. Country-level estimates can be used to inform national planning efforts and decisions. Multifaceted approaches, including scaling up interventions to address modifiable risk factors and investing in research on biological mechanisms, will be key in addressing the expected increases in the number of individuals affected by dementia.

• Crivelli, Lucia; Palmer, Katie; Calandri, Ismael; Guekht, Alla; Beghi, Ettore & Carroll, WM [Vis alle 13 forfattere av denne artikkelen] (2022). Changes in cognitive functioning after COVID-19: A systematic review and meta-analysis. Alzheimer's & Dementia. ISSN 1552-5260. doi: 10.1002/alz.12644. Fulltekst i vitenarkiv
• Mlowe, Fredy; Karimuribo, Esron; Mkupasi, Ernatus; Churi, Ayubu; Nyerere, Antony D. & Schmidt, Veronika [Vis alle 9 forfattere av denne artikkelen] (2022). Challenges in the Diagnosis of Taenia solium Cysticercosis and Taeniosis in Medical and Veterinary Settings in Selected Regions of Tanzania: A Cross-Sectional Study. Veterinary Medicine International. ISSN 2090-8113. 2022. doi: 10.1155/2022/7472051. Fulltekst i vitenarkiv
• Sitali, Muloongo C.; Schmidt, Veronika; Mwenda, Racheal; Sikasunge, Chummy S.; Mwape, Kabemba E. & Simuunza, Martin C. [Vis alle 9 forfattere av denne artikkelen] (2022). Experimental animal models and their use in understanding cysticercosis: A systematic review. PLOS ONE. 17(7). doi: 10.1371/journal.pone.0271232. Fulltekst i vitenarkiv
• Dupont, Fabian; Trevisan, Chiara; Kaducu, Joyce Moriku; Ovuga, Emilio; Schmidt, Veronika & Winkler, Andrea Sylvia [Vis alle 7 forfattere av denne artikkelen] (2022). Human health and economic impact of neurocysticercosis in Uganda. Tropical medicine & international health. ISSN 1360-2276. 27(1), s. 99–109. doi: 10.1111/tmi.13703. Fulltekst i vitenarkiv
• Huber, Annalena; Klug, Stefanie J.; Abraham, Annette Gabriela; Westenberg, Erica; Schmidt, Veronika & Winkler, Andrea Sylvia (2022). Animal-Assisted Interventions Improve Mental, But Not Cognitive or Physiological Health Outcomes of Higher Education Students: a Systematic Review and Meta-analysis. International Journal of Mental Health and Addiction. ISSN 1557-1874. doi: 10.1007/s11469-022-00945-4. Fulltekst i vitenarkiv
• Clarsen, Benjamin Matthew; Nylenna, Magne; Klitkou, Søren Toksvig; Vollset, Stein Emil; Baravelli, Carl Michael & Bølling, Anette Kocbach [Vis alle 31 forfattere av denne artikkelen] (2022). Changes in life expectancy and disease burden in Norway, 1990–2019: an analysis of the Global Burden of Disease Study 2019. The Lancet Public Health. ISSN 2468-2667. 7(7), s. e593–e605. doi: 10.1016/S2468-2667(22)00092-5. Fulltekst i vitenarkiv Vis sammendrag

  Background: Geographical differences in health outcomes are reported in many countries. Norway has led an active policy aiming for regional balance since the 1970s. Using data from the Global Burden of Disease Study (GBD) 2019, we examined regional differences in development and current state of health across Norwegian counties. Methods: Data for life expectancy, healthy life expectancy (HALE), years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) in Norway and its 11 counties from 1990 to 2019 were extracted from GBD 2019. County-specific contributors to changes in life expectancy were compared. Inequality in disease burden was examined by use of the Gini coefficient. Findings: Life expectancy and HALE improved in all Norwegian counties from 1990 to 2019. Improvements in life expectancy and HALE were greatest in the two counties with the lowest values in 1990: Oslo, in which life expectancy and HALE increased from 71·9 years (95% uncertainty interval 71·4-72·4) and 63·0 years (60·5-65·4) in 1990 to 81·3 years (80·0-82·7) and 70·6 years (67·4-73·6) in 2019, respectively; and Troms og Finnmark, in which life expectancy and HALE increased from 71·9 years (71·5-72·4) and 63·5 years (60·9-65·6) in 1990 to 80·3 years (79·4-81·2) and 70·0 years (66·8-72·2) in 2019, respectively. Increased life expectancy was mainly due to reductions in cardiovascular disease, neoplasms, and respiratory infections. No significant differences between the national YLD or DALY rates and the corresponding age-standardised rates were reported in any of the counties in 2019; however, Troms og Finnmark had a higher age-standardised YLL rate than the national rate (8394 per 100 000 [95% UI 7801-8944] vs 7536 per 100 000 [7391-7691]). Low inequality between counties was shown for life expectancy, HALE, all level-1 causes of DALYs, and exposure to level-1 risk factors. Interpretation: Over the past 30 years, Norway has reduced inequality in disease burden between counties. However, inequalities still exist at a within-county level and along other sociodemographic gradients. Because of insufficient Norwegian primary data, there remains substantial uncertainty associated with regional estimates for non-fatal disease burden and exposure to risk factors.

• Stelzle, Dominik; Makasi, Charles; Schmidt, Veronika; Trevisan, Chiara; Damme, Inge van & Welte, Tamara M. [Vis alle 16 forfattere av denne artikkelen] (2022). Epidemiological, clinical and radiological characteristics of people with neurocysticercosis in Tanzania-A cross-sectional study. PLoS Neglected Tropical Diseases. ISSN 1935-2727. 16(11), s. e0010911–e0010911. doi: 10.1371/journal.pntd.0010911. Fulltekst i vitenarkiv
• Prodjinotho, Ulrich Fabien; Gres, Vitka; Henkel, Fiona; Lacorcia, Matthew; Dandl, Ramona & Haslbeck, Martin [Vis alle 13 forfattere av denne artikkelen] (2022). Helminthic dehydrogenase drives PGE<inf>2</inf> and IL-10 production in monocytes to potentiate Treg induction. EMBO Reports. ISSN 1469-221X. 23(5). doi: 10.15252/embr.202154096. Fulltekst i vitenarkiv
• Aukrust, Camilla Grøver; McNicholas, Roisin; Winkler, Andrea Sylvia; Johnson, Walter; Pattisapu, Jogi & White, Colette [Vis alle 9 forfattere av denne artikkelen] (2022). Comprehensive and equitable approaches to the management of neurological conditions in low-and middle-income countries-A call to action. Brain and Spine. 2. doi: 10.1016/j.bas.2022.101701. Fulltekst i vitenarkiv

Se alle arbeider i NVA

• Amuasi, john H & Winkler, Andrea Sylvia (2025). Future trajectories for One Health - PubMed. The Lancet. ISSN 0140-6736. doi: 10.1016/S0140-6736(25)01453-9. Fulltekst i vitenarkiv Vis sammendrag

  Future trajectories for One Health

• Mostert, Cyprian M.; Udeh-Momoh, Chinedu; Winkler, Andrea Sylvia; McLaughlin, Connor; Eyre, Harris & Salama, Mohamed [Vis alle 28 forfattere av denne artikkelen] (2025). Broadening dementia risk models: building on the 2024 Lancet Commission report for a more inclusive global framework - PubMed. EBioMedicine. doi: 10.1016/j.ebiom.2025.105950. Fulltekst i vitenarkiv Vis sammendrag

  The 2024 Lancet Commission Report on dementia prevention has identified 14 modifiable risk factors that account for approximately 45% of global dementia cases. We used a global multidimensional approach that integrates gender equity considerations, poverty, wealth shocks, income inequality and HIV i …

• Metanmo, Salvatore & Winkler, Andrea Sylvia (2024). Response to "Nodding Syndrome Associated with Onchocerciasis". Neuroepidemiology. ISSN 0251-5350. doi: 10.1159/000538697. Fulltekst i vitenarkiv
• Alders, Robyn; Amuasi, John H; Ashraf, Sania; Becker, Daniel; Bukachi, Salome A & Burza, Sakib [Vis alle 30 forfattere av denne artikkelen] (2024). Draft of WHO Pandemic Agreement plays down primary prevention. The Lancet. ISSN 0140-6736. 403(10426), s. 525–526. doi: 10.1016/S0140-6736(24)00066-7. Fulltekst i vitenarkiv
• Tamborska, A.A.; Wood, G.K.; Westenberg, E.; Garcia-Azorin, D.; Webb, G. & Schiess, N. [Vis alle 29 forfattere av denne artikkelen] (2023). Corrigendum to “Global uncertainty in the diagnosis of neurological complications of SARS-CoV-2 infection by both neurologists and non-neurologists: An international inter-observer variability study” [Journal of the Neurological Sciences. 2023 Jun 15;449:120646] (Journal of the Neurological Sciences (2023) 449, (S0022510X23001065), (10.1016/j.jns.2023.120646)). Journal of the Neurological Sciences. ISSN 0022-510X. 451. doi: 10.1016/j.jns.2023.120709. Fulltekst i vitenarkiv
• Stelzle, Dominik; Kaducu, Joyce; Schmidt, Veronika; Welte, Tamara M.; Ngowi, Bernard James & Matuja, William [Vis alle 16 forfattere av denne artikkelen] (2022). Correction: Characteristics of people with epilepsy in three Eastern African countries – a pooled analysis (BMC Neurology, (2022), 22, 1, (321), 10.1186/s12883-022-02813-z). BMC Neurology. 22(1). doi: 10.1186/s12883-022-03034-0. Fulltekst i vitenarkiv
• Asaduzzaman, Muhammad; Rødland, Ernst Kristian; Mekonnen, Zeleke; Gradmann, Christoph & Winkler, Andrea Sylvia (2022). Understanding transmission pathways and integrated digital surveillance potential of antimicrobial resistance in Ethiopia in a One Health approach: a mixed-method study protocol. BMJ Open. 12(6). doi: 10.1136/bmjopen-2021-051022. Fulltekst i vitenarkiv Vis sammendrag

  Introduction Antimicrobial resistance (AMR) has a critical global impact, mostly affecting low- and middle-income countries. A major knowledge gap exists in understanding the transmission pathway of the gut colonisation with AMR bacteria between healthy humans and their animals in addition to the presence of those AMR bacteria in the surrounding environment. A One Health (OH) approach is necessary to address this multisectoral problem. Methods and analysis This cross-sectional, mixed-method OH study design will use both quantitative and qualitative methods of data collection. Quantitative methods will be carried out to assess the prevalence and risk factors associated with multidrug resistant Gram-negative bacteria and vancomycin-resistant enterococci in humans, animals (cattle) and the environment. The focus will be on cattle rearing as an exposure risk for AMR among humans. The assessment of AMR in the population of Jimma, Ethiopia with or without exposure to cattle will reinforce the importance of OH research to identify the impending exchange of resistance profile between humans and animals as well as its ultimate dissemination in the surrounding environment. The targeted semistructured key stakeholder interviews will aid to strengthen the OH-AMR surveillance in Ethiopia by understanding the acceptability of an integrated AMR surveillance platform based on the District Health Information Software-2 and the feasibility of its context-specific establishment. Ethics and dissemination The study has been approved by the Regional Ethics Committee, Norway, and the Institutional Review Board of Jimma University, Ethiopia. The study’s data will be stored on a secure server known as Services for Sensitive Data hosted by the University of Oslo. In addition, the new European Union Global Data Protection Guidelines for data sharing, storage and protection will be followed. We will publish the results in peer-reviewed journals and present the findings at national and international conferences.

Se alle arbeider i NVA