Inger Ottestad

• Gjevestad, Gyrd Omholt; Holven, Kirsten Bjørklund; Rundblad, Amanda; Flatberg, Arnar; Myhrstad, Mari; Karlsen, Karina; Mutt, Shivaprakash J.; Herzig, Karl-Heinz; Ottestad, Inger & Ulven, Stine Marie (2019). Increased protein intake affects pro-opiomelanocortin (POMC) processing, immune function and IGF signaling in peripheral blood mononuclear cells of home-dwelling old subjects using a genome-wide gene expression approach. Genes & Nutrition.  ISSN 1555-8932.  14:32 . doi: 10.1186/s12263-019-0654-6 Fulltekst i vitenarkiv.
• Rundblad, Amanda; Larsen, Sunniva; Myhrstad, Mari; Ottestad, Inger; Thoresen, Magne; Holven, Kirsten Bjørklund & Ulven, Stine Marie (2019). Differences in peripheral blood mononuclear cell gene expression and triglyceride composition in lipoprotein subclasses in plasma triglyceride responders and non-responders to omega-3 supplementation. Genes & Nutrition.  ISSN 1555-8932.  14(10), s 1- 13 . doi: 10.1186/s12263-019-0633-y Fulltekst i vitenarkiv.
• Ulven, Stine Marie; Christensen, Jacob J.; Nygård, Ottar; Svardal, Asbjørn M.; Leder, Lena; Ottestad, Inger; Lysne, Vegard; Laupsa-Borge, Johnny; Ueland, Per Magne; Midttun, Øivind; Meyer, Klaus; McCann, Adrian; Andersen, Lene Frost & Holven, Kirsten Bjørklund (2019). Using metabolic profiling and gene expression analyses to explore molecular effects of replacing saturated fat with polyunsaturated fat-a randomized controlled dietary intervention study. American Journal of Clinical Nutrition.  ISSN 0002-9165.  109(5), s 1239- 1250 . doi: 10.1093/ajcn/nqy356 Fulltekst i vitenarkiv.
• Henriksen, Christine; Golberg Brenno, Silje; Ulven, Stine Marie; Holven, Kirsten Bjørklund & Ottestad, Inger (2018). Helserelatert livskvalitet og ernæringsstatus blant eldre hjemmeboende over 70 år.. Norsk Tidsskrift for Ernæring.  ISSN 1503-5034.  (2)
• Larsen, Sunniva Veen; Holven, Kirsten Bjørklund; Ottestad, Inger; Dagsland, Kine Margrethe; Myhrstad, Mari & Ulven, Stine Marie (2018). Plasma fatty acid levels and gene expression related to lipid metabolism in peripheral blood mononuclear cells: A cross-sectional study in healthy subjects. Genes & Nutrition.  ISSN 1555-8932.  13(1) . doi: 10.1186/s12263-018-0600-z Fulltekst i vitenarkiv.
• Ottestad, Inger; Ulven, Stine Marie; Øyri, Linn Kristin Lie; Sandvei, Kristin Søfteland; Gjevestad, Gyrd Omholt; Bye, Asta; Sheikh, Navida Akhter; Biong, Anne Sofie; Andersen, Lene Frost & Holven, Kirsten Bjørklund (2018). Reduced plasma concentration of branched-chain amino acids in sarcopenic older subjects: a cross-sectional study. British Journal of Nutrition.  ISSN 0007-1145.  120(4), s 445- 453 . doi: 10.1017/S0007114518001307 Fulltekst i vitenarkiv.
• Gjevestad, Gyrd Omholt; Hamarsland, Håvard; Raastad, Truls; Ottestad, Inger; Christensen, Jacob J.; Eckardt, Kristin; Drevon, Christian A; Biong, Anne Sofie; Ulven, Stine Marie & Holven, Kirsten Bjørklund (2017). Gene expression is differentially regulated in skeletal muscle and circulating immune cells in response to an acute bout of high-load strength exercise. Genes & Nutrition.  ISSN 1555-8932.  12:8, s 1- 11 . doi: 10.1186/s12263-017-0556-4 Vis sammendrag

  Background: High-intensity exercise induces many metabolic responses. In is unknown whether the response in the peripheral blood mononuclear cells (PBMCs) reflects the response in skeletal muscle and whether mRNA expression after exercise can be modulated by nutritional intake. The aims were to (i) investigate the effect of dairy proteins on acute responses to exercise in skeletal muscle and PBMCs measuring gene expression and (ii) compare this response in young and older subjects. Methods: We performed two separate studies in young (20–40 years) and older subjects (≥70 years). Subjects were randomly allocated to a milk group or a whey group. Supplements were provided immediately after a standardized exercise session. We measured mRNA expression of selected genes after a standardized breakfast and 60/120 min after finishing the exercise, using RT-qPCR. Results: We observed no significant differences in mRNA expression between the milk and the whey group; thus, we merged both groups for further analysis. The mRNA expression of IL6, TNF, and CCL2 in skeletal muscle increased significantly after exercise compared with smaller or no increase, in mRNA expression in PBMCs in all participants. The mRNA expression of IL1RN, IL8, and IL10 increased significantly in skeletal muscle and PBMCs. Some mRNA transcripts were differently regulated in older compared to younger participants in PBMCs. Conclusions: An acute bout of heavy-load strength exercise, followed by protein supplementation, caused overlapping, but also unique, responses in skeletal muscle and PBMCs, suggesting tissue-specific functions in response to exercise. However, no different effects of the different protein supplements were observed. Altered mRNA expressions in PBMCs of older participants may affect regenerative mechanisms.

• Gjevestad, Gyrd Omholt; Ottestad, Inger; Biong, Anne Sofie; Iversen, Per Ole; Retterstøl, Kjetil; Raastad, Truls; Skålhegg, Bjørn Steen; Ulven, Stine Marie & Holven, Kirsten Bjørklund (2017). Consumption of protein-enriched milk has minor effects on inflammation in older adults?A 12-week double-blind randomized controlled trial. Mechanisms of Ageing and Development.  ISSN 0047-6374.  162, s 1- 8 . doi: 10.1016/j.mad.2017.01.011 Fulltekst i vitenarkiv. Vis sammendrag

  Introduction: Aging is associated with increased levels of circulating inflammatory markers and reduced muscle mass and strength. Objective: We investigated whether intake of protein-enriched milk for 12 weeks would influence markers of inflammation among adults ≥70 years of age with reduced physical strength. Methods: In a double-blind randomized controlled intervention study, subjects were randomly allocated into two groups, receiving a protein-enriched milk (2 × 20 g protein/d, n = 14, mean (±SD) age 76.9 ± 4.9 yrs) or an isocaloric carbohydrate drink (n = 17, age 77.7 ± 4.8 yrs) for 12 weeks. We measured serum and mRNA expression levels of inflammatory markers in PBMCs. Results: Significant differences in the mRNA expression of nuclear receptor subfamily, group H, member 3 (NR1H3, encoding the LXRα transcription factor) and interferon gamma (INFG) were observed between groups. The mRNA level of TNFRSF1A was significantly reduced, while the mRNA level of dipeptidyl-peptidase 4 (DPP4) was significantly increased, in the control group. The serum level of TNFα increased significantly in the control group, while sTNFRSF1A increased significantly in both groups, but with no significant differences between groups. Conclusion: Consumption of a low-fat, protein-enriched milk for 12 weeks had minor effects on inflammatory related markers in older adults compared to an isocaloric carbohydrate drink.

• Narverud, Ingunn; Christensen, Jacob J.; Ottestad, Inger; Ulven, Stine Marie & Holven, Kirsten Bjørklund (2017). Misvisende om kosthold i ny nasjonal retningslinje for forebygging av hjerte- og karsykdommer. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  137(20) . doi: 10.4045/tidsskr.17.0834
• Ottestad, Inger; Løvstad, Arne; Gjevestad, Gyrd Omholt; Hamarsland, Håvard; Saltyte-Benth, Jurate; Frost Andersen, Lene; Bye, Asta; Biong, Anne-Sofie; Retterstøl, Kjetil; Iversen, Per Ole; Raastad, Truls; Ulven, Stine Marie & Holven, Kirsten Bjørklund (2017). Intake of a Protein-Enriched Milk and Effects on Muscle Mass and Strength. A 12-Week Randomized Placebo Controlled Trial among Community-Dwelling Older Adults. The Journal of Nutrition, Health & Aging.  ISSN 1279-7707.  21, s 1160- 1169 . doi: 10.1007/s12603-016-0856-1
• Rundblad, Amanda; Holven, Kirsten Bjørklund; Ottestad, Inger; Myhrstad, Mari & Ulven, Stine Marie (2017). High-quality fish oil has a more favourable effect than oxidised fish oil on intermediate-density lipoprotein and LDL subclasses: a randomised controlled trial. British Journal of Nutrition.  ISSN 0007-1145.  117(9), s 1291- 1298 . doi: 10.1017/S0007114517001167
• Myhrstad, Mari; Ottestad, Inger; Günther, Clara-Cecilie; Ryeng, Einar; Holden, Marit; Nilsson, Astrid; Brønner, Kirsti Wettre; Kohler, Achim; Borge, Grethe Iren Andersen; Holven, Kirsten Bjørklund & Ulven, Stine Marie (2016). The PBMC transcriptome profile after intake of oxidized versus high-quality fish oil: an explorative study in healthy subjects. Genes & Nutrition.  ISSN 1555-8932.  11:16 . doi: 10.1186/s12263-016-0530-6 Fulltekst i vitenarkiv. Vis sammendrag

  Background: Marine long-chain polyunsaturated fatty acids are susceptible to oxidation, generating a range of different oxidation products with suggested negative health effects. The aim of the present study was to utilize sensitive high-throughput transcriptome analyses to investigate potential unfavorable effects of oxidized fish oil (PV: 18 meq/kg; AV: 9) compared to high-quality fish oil (PV: 4 meq/kg; AV: 3). Methods: In a double-blinded randomized controlled study for seven weeks, 35 healthy subjects were assigned to 8 g of either oxidized fish oil or high quality fish oil. The daily dose of EPA+DHA was 1.6 g. Peripheral blood mononuclear cells were isolated at baseline and after 7 weeks and transcriptome analyses were performed with the illuminaHT-12 v4 Expression BeadChip. Results: No gene transcripts, biological processes, pathway or network were significantly changed in the oxidized fish oil group compared to the fish oil group. Furthermore, gene sets related to oxidative stress and cardiovascular disease were not differently regulated between the groups. Within group analyses revealed a more prominent effect after intake of high quality fish oil as 11 gene transcripts were significantly (FDR < 0.1) changed from baseline versus three within the oxidized fish oil group. Conclusion: The suggested concern linking lipid oxidation products to short-term unfavorable health effects may therefore not be evident at a molecular level in this explorative study. Trial registration: ClinicalTrials.gov, NCT01034423

• Ottestad, Inger; Løvstad, Amund T.; Gjevestad, Gyrd Omholt; Hamarsland, Håvard; Saltyte Benth, Jurate; Andersen, Lene Frost; Bye, Asta; Biong, Anne Sofie; Retterstøl, Kjetil; Iversen, Per Ole; Raastad, Truls; Ulven, Stine Marie & Holven, Kirsten Bjørklund (2016). Intake of a protein-enriched milk and effects on muscle mass and strength. A 12-week randomized placebo controlled trial among community-dwelling older adults. The Journal of Nutrition, Health & Aging.  ISSN 1279-7707.  21, s 1160- 1169 . doi: 10.1007/s12603-016-0856-1
• Ottestad, Inger; Nordvi, Berit; Vogt, Kjell Gjermund; Holck, Marianne; Halvorsen, Bente; Brønner, Kirsti Wettre; Retterstøl, Kjetil; Holven, Kirsten Bjørklund; Nilsson, Astrid & Ulven, Stine Marie (2016). Bioavailability of n-3 fatty acids from n-3 enriched foods and fish oil with different oxidative quality in healthy humans – a randomized single meal cross-over study. Journal of Nutritional Science (JNS).  ISSN 2048-6790.  5(e43), s 1- 8 . doi: 10.1017/jns.2016.34 Fulltekst i vitenarkiv. Vis sammendrag

  Regular consumption of long-chain n-3 fatty acids (LC n-3 FA) reduces postprandial triacylglycerolaemia. Functional foods and supplements are alternative sources of LC n-3 FA; however, emulsification technologies, food matrices and altered lipid oxidation levels affect their bioavailability. Moreover, which functional foods are optimal LC n-3 FA carriers is unknown. The aim of the study was to determine the bioavailability of LC n-3 FA and the postprandial TAG response after the intake of oxidised or non-oxidised cod liver oil and after the intake of emulsified or non-emulsified LC n-3 FA using novel functional food items as LC n-3 FA carriers in a randomised cross-over acute study. A total of twenty-four healthy subjects completed the study in which subjects consumed one of four different test meals containing 1·5 g LC n-3 FA, or a control meal with no LC n-3 FA. Postprandial TAG-rich lipoproteins were isolated and their fatty acid composition was measured. The LC n-3 FA from emulsified foods were more rapidly incorporated into TAG-rich lipoproteins compared with non-emulsified foods. The incorporation of LC n-3 FA was similar for oils emulsified in yogurt or juice and was unaffected by the oxidative status of the oil. Postprandial TAG levels did not differ among the various test meals. In conclusion, emulsification increases the bioavailability of LC n-3 FA through a more rapid incorporation into TAG-rich lipoproteins, and juice and yogurt are equally suited as LC n-3 FA carriers. The acute intake of oxidised cod liver oil does not influence the incorporation of LC n-3 FA into TAG-rich lipoproteins.

• Torvik, Kristin; Narverud, Ingunn; Ottestad, Inger; Svilaas, Arne B; Gran, Jon Michael; Retterstøl, Kjetil; Ellingvåg, Asta; Strøm, Ellen C; Ose, Leiv; Veierød, Marit Bragelien & Holven, Kirsten Bjørklund (2016). Dietary counseling is associated with an improved lipid profile in children with familial hypercholesterolemia. Atherosclerosis.  ISSN 0021-9150.  252, s 21- 27 . doi: 10.1016/j.atherosclerosis.2016.07.913
• Ulven, Stine Marie; Leder, Lena; Elind, Elisabeth; Ottestad, Inger; Christensen, Jacob J.; Telle-Hansen, Vibeke; Skjetne, Anne Juul; Raael, Ellen; Sheikh, Navida Akhter; Holck, Marianne; Torvik, Kristin; Lamglait, Amandine; Thyholt, Kari; Byfuglien, Marte Gjeitung; Granlund, Linda; Andersen, Lene Frost & Holven, Kirsten Bjørklund (2016). Exchanging a few commercial, regularly consumed food items with improved fat quality reduces total cholesterol and LDL-cholesterol: A double-blind, randomised controlled trial. British Journal of Nutrition.  ISSN 0007-1145.  116(8), s 1383- 1393 . doi: 10.1017/S0007114516003445
• Myhrstad, Mari; Ulven, Stine Marie; Günther, Clara-Cecilie; Ottestad, Inger; Holden, Marit; Ryeng, Einar; Borge, Grethe Iren Andersen; Kohler, Achim; Brønner, Kirsti Wettre; Thoresen, Magne & Holven, Kirsten Bjørklund (2014). Fish oil supplementation induces Expression of genes related to cell cycle, endoplasmic reticulum stress and apoptosis in peripheral blood mononuclear cells: a transcriptomic approach. Journal of Internal Medicine.  ISSN 0954-6820.  276(5), s 498- 511 . doi: 10.1111/joim.12217 Fulltekst i vitenarkiv. Vis sammendrag

  Background Fish oil supplementation has been shown to alter gene expression of mononuclear cells both in vitro and in vivo. However, little is known about the total transcriptome profile in healthy subjects after intake of fish oil. We therefore investigated the gene expression profile in peripheral blood mononuclear cells (PBMCs) after intake of fish oil for 7 weeks using transcriptome analyses. Design In a 7-week, double-blinded, randomized, controlled, parallel-group study, healthy subjects received 8 g day−1 fish oil (1.6 g day−1 eicosapentaenoic acid + docosahexaenoic acid) (n = 17) or 8 g day−1 high oleic sunflower oil (n = 19). Microarray analyses of RNA isolated from PBMCs were performed at baseline and after 7 weeks of intervention. Results Cell cycle, DNA packaging and chromosome organization are biological processes found to be upregulated after intake of fish oil compared to high oleic sunflower oil using a moderated t-test. In addition, gene set enrichment analysis identified several enriched gene sets after intake of fish oil. The genes contributing to the significantly different gene sets in the subjects given fish oil compared with the control group are involved in cell cycle, endoplasmic reticulum (ER) stress and apoptosis. Gene transcripts with common motifs for 35 known transcription factors including E2F, TP53 and ATF4 were upregulated after intake of fish oil. Conclusion We have shown that intake of fish oil for 7 weeks modulates gene expression in PBMCs of healthy subjects. The increased expression of genes related to cell cycle, ER stress and apoptosis suggests that intake of fish oil may modulate basic cellular processes involved in normal cellular function.

• Ottestad, Inger; Ose, Leiv; Wennersberg, Marianne Hauge; Granlund, Linda; Kirkhus, Bente & Retterstøl, Kjetil (2013). Phytosterol capsules and serum cholesterol in hypercholesterolemia: a randomized controlled trial. Atherosclerosis.  ISSN 0021-9150.  228(2), s 421- 425 . doi: 10.1016/j.atherosclerosis.2013.03.001
• Ottestad, Inger; Hassani, Sahar; Borge, Grethe iren andersen; Kohler, Achim; Vogt, Kjell gjermund; Hyøtylainen, Tuulia; Oresic, Matej; Brønner, Kirsti Wettre; Holven, Kirsten Bjørklund; Ulven, Stine Marie & Myhrstad, Mari Charlotte (2012). Fish oil supplementation alters the plasma lipidomic profile and increases long-chain PUFAs of phospholipids and triglycerides in healthy subjects. PLOS ONE.  ISSN 1932-6203.  7(8) . doi: 10.1371/journal.pone.0042550 Fulltekst i vitenarkiv. Vis sammendrag

  Background While beneficial health effects of fish and fish oil consumption are well documented, the incorporation of n-3 polyunsaturated fatty acids in plasma lipid classes is not completely understood. The aim of this study was to investigate the effect of fish oil supplementation on the plasma lipidomic profile in healthy subjects. Methodology/Principal Findings In a double-blinded randomized controlled parallel-group study, healthy subjects received capsules containing either 8 g/d of fish oil (FO) (1.6 g/d EPA+DHA) (n = 16) or 8 g/d of high oleic sunflower oil (HOSO) (n = 17) for seven weeks. During the first three weeks of intervention, the subjects completed a fully controlled diet period. BMI and total serum triglycerides, total-, LDL- and HDL-cholesterol were unchanged during the intervention period. Lipidomic analyses were performed using Ultra Performance Liquid Chromatography (UPLC) coupled to electrospray ionization quadrupole time-of-flight mass spectrometry (QTOFMS), where 568 lipids were detected and 260 identified. Both t-tests and Multi-Block Partial Least Square Regression (MBPLSR) analysis were performed for analysing differences between the intervention groups. The intervention groups were well separated by the lipidomic data after three weeks of intervention. Several lipid classes such as phosphatidylcholine, phosphatidylethanolamine, lysophosphatidylcholine, sphingomyelin, phosphatidylserine, phosphatidylglycerol, and triglycerides contributed strongly to this separation. Twenty-three lipids were significantly decreased (FDR<0.05) in the FO group after three weeks compared with the HOSO group, whereas fifty-one were increased including selected phospholipids and triglycerides of long-chain polyunsaturated fatty acids. After seven weeks of intervention the two intervention groups showed similar grouping. Conclusions/Significance In healthy subjects, fish oil supplementation alters lipid metabolism and increases the proportion of phospholipids and triglycerides containing long-chain polyunsaturated fatty acids. Whether the beneficial effects of fish oil supplementation may be explained by a remodeling of the plasma lipids into phospholipids and triglycerides of long-chain polyunsaturated fatty acids needs to be further investigated.

• Ottestad, Inger; Vogt, Kjell Gjermund; Retterstøl, Kjetil; Myhrstad, Mari; Haugen, John-Erik; Nilsson, Astrid; Ravn-Haren, Gitte; Nordvi, Berit; Brønner, Kirsti Wettre; Andersen, Lene Frost; Holven, Kirsten Bjørklund & Ulven, Stine Marie (2012). Oxidised fish oil does not influence established markers of oxidative stress in healthy human subjects: a randomised controlled trial. British Journal of Nutrition.  ISSN 0007-1145. . doi: 10.1017/S0007114511005484
• Myhrstad, Mari; Retterstøl, Kjetil; Telle, Vibeke Helen; Ottestad, Inger; Halvorsen, Bente; Holven, Kirsten Bjørklund & Ulven, Stine Marie (2011). Effect of marine n-3 fatty acids on circulating inflammatory markers in healthy subjects and subjects with cardiovascular risk factors. Inflammation Research.  ISSN 1023-3830.  60(4), s 309- 319 . doi: 10.1007/s00011-010-0302-5
• Bogsrud, Martin Prøven; Ose, Leiv; Langslet, Gisle; Ottestad, Inger; Strøm, Ellen Charlotte; Hagve, Tor-Arne & Retterstøl, Kjetil (2010). HypoCol (red yeast rice) lowers plasma cholesterol - a randomized placebo controlled study. Scandinavian Cardiovascular Journal.  ISSN 1401-7431.  44(4), s 197- 200 . doi: 10.3109/14017431003624123 Vis sammendrag

  Objective. The primary endpoint in our study was to investigate the effect of a red yeast rice (RYR) product on plasma lipids. Design. A randomized, double-blind, placebo controlled study was performed. Patients were randomized to either RYR (HypoCol, 4 capsules/day) (n=22) or placebo (n=20) for 16 weeks. Inclusion criteria were male or female, 18-75 years, LDL-cholesterol between 3.0 and 6.0 mmol/L, fasting triglyceride level less than 4.5 mmol/L. Results. Patients receiving RYR experienced a significant reduction in LDL-cholesterol (23.0%) and total cholesterol (15.5%) compared to placebo after 16 weeks of treatment (p<0.001). Conclusion. The tested red yeast rice product demonstrated a significant cholesterol lowering effect compared to placebo, and was well tolerated in this Caucasian population.

• Langslet, Gisle; Ottestad, Inger; Retterstøl, Kjetil & Ose, Leiv (2010). Klinisk legemiddelutprøvning - hva mener deltakerne? :. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  130(16), s 1606- 1608 . doi: 10.4045/tidsskr.09.0030
• Ottestad, Inger; Halvorsen, Bente; Balstad, Trude Rakel; Otterdal, Kari; Borge, Grethe Iren Andersen; Brosstad, Frank; Myhre, Anne Grete; Ose, Leiv; Nenseter, Marit S. & Holven, Kirsten Bjørklund (2006). Triglyceride-rich HDL3 from patients with familial hypercholesterolemia are less able to inhibit cytokine release or to promote cholesterol efflux. Journal of Nutrition.  ISSN 0022-3166.  136(4), s 877- 881

Se alle arbeider i Cristin

• Holven, Kirsten Bjørklund; Sæther, Thomas; Hjorth, Marit; Dalen, Knut Tomas; Ulven, Stine Marie; Ottestad, Inger & Hustad, Kristin Solheim (2019). Kan fisk utnyttes enda mer og samtidig fremme folkehelsen?. Norsk Tidsskrift for Ernæring.  ISSN 1503-5034.  17(2), s 20- 22
• Kardel, Kristin Reimers; Hägg, Sara B.; Gjevre, Ragnhild; Sævre, Synne Risan; Henriksen, Tore; Roland, Marie Cecilie & Ottestad, Inger (2019). Helseutfall hos gravide kvinner med overvekt og barnet ved fødsel.
• Ottestad, Inger; Ulven, Stine Marie; Sandvei, Kristin Søfteland; Carlsen, Monica Hauger; Gundersen, Thomas; Gjevestad, Gyrd Omholt; Andersen, Lene Frost & Holven, Kirsten Bjørklund (2019). Iodine status and effect of increased intake of milk among older Norwegian adults.
• Rundblad, Amanda; Larsen, Sunniva Veen; Myhrstad, Mari; Ottestad, Inger; Thoresen, Magne; Holven, Kirsten Bjørklund & Ulven, Stine Marie (2019). Characterization of PBMC gene expression and lipoprotein subclasses among plasma TG responders and non-responders.
• Sande, Rikka Frøyen; Thoresen, Lene; Løhre, Erik Torbjørn; Nygard, Astrid Signe; Paulsen, Ørnulf; Ottestad, Inger; Solheim, Tora Skeidsvoll & Balstad, Trude Rakel (2019). Parenteral nutrition therapy in patients with incurable cancer: A retrospective medical chart review of current practice. Vis sammendrag

  Rationale: Indication for use, dose and duration of parenteral nutrition (PN) in patients with incurable cancer is understudied. The aim of the study was to describe current practice of PN treatment in adult patients with incurable cancer at St. Olavs University Hospital, Trondheim, Norway. Methods: A retrospective medical chart review of patients with incurable cancer receiving PN between 2011 and 2017 was conducted. Of 271 identified patients, data from the first 78 patients was included in this preliminary analysis. Medical information was collected from start of PN until patients’ death. Results: The mean (SD) age was 63.5 (12.9) years, 41 women and 37 men. All patients received PN concomitant with anti-cancer treatment at some point in time. The most common indications for PN were “insufficient oral or enteral intake” (n=67) or “gastrointestinal malfunction” (n=17). At start of PN, there were no differences between subgroups in s-albumin, C-reactive protein level, metastatic disease, or ascites. The main reason for discontinuation of PN was imminently dying patient (n=36), patient preferences (n=19), and complications (n=12). The table presents available data on PN treatment and survival in subgroups defined by duration of PN treatment. Data presented as n or median (Q1-Q3). Variables < 2 weeks 2 weeks -1 month 1 month - 2 months > 2 months P1 n Patients (n) 14 20 16 16 66 PN treatment Highest received PN dose, kcal 1100 (612-1600)#,¤ 1600 (1100-2200)# 1600 (1100-1600) 1750 (1450-2200)¤ 0.001 62 Received dose (percentage of estimated energy need) 73 (43-73) 78 (62-101) 69 (50-94) 97 (73-118) 0.03 52 Documented oral food intake, n 9 16 15 15 0.09 55 Survival From start of PN, days 19 (13-74)& 39 (26- 384) 61 (43-115) 168 (88-295)& 0.001 66 From PN termination, days 10 (4-70) 16 (5-358)§ 4.5 (1-70) 2 (1-7)§ 0.016 66 1Kruskal-Wallis test, Dunn’s Post Hoc test; # P=0.04, ¤ p=0.003, & P=0.001, § P=0.02 Conclusion: To our knowledge, this is the first study describing clinical practice with respect to dose, duration and termination of PN in incurable cancer patients. Preliminary data suggest that the use of PN was dynamic and differentiated. Termination of PN was based on expected patient survival, patient preferences, and treatment complications.

• Larsen, Sunniva Veen; Holven, Kirsten Bjørklund; Ottestad, Inger; Dagsland, Kine Margrethe; Myhrstad, Mari & Ulven, Stine Marie (2018). Plasma fatty acid levels and gene expression related to lipid metabolism in peripheral blood mononuclear cells: a cross-sectional study in healthy subjects.
• Larsen, Sunniva Veen; Holven, Kirsten Bjørklund; Ottestad, Inger; Dagsland, Kine Margrethe; Myhrstad, Mari & Ulven, Stine Marie (2018). Plasma fatty acid levels and gene expression related to lipid metabolism in peripheral blood mononuclear cells: a cross-sectional study in healthy subjects.
• Larsen, Sunniva Veen; Holven, Kirsten Bjørklund; Ottestad, Inger; Dagsland, Kine Margrethe; Myhrstad, Mari & Ulven, Stine Marie (2018). Plasma fatty acid levels and gene expression related to lipid metabolism in peripheral blood mononuclear cells: a cross-sectional study in healthy subjects.
• Larsen, Sunniva Veen; Holven, Kirsten Bjørklund; Ottestad, Inger; Dagsland, Kine Næss; Myhrstad, Mari & Ulven, Stine Marie (2018). Correction: Plasma fatty acid levels and gene expression related to lipid metabolism in peripheral blood mononuclear cells: A cross-sectional study in healthy subjects [Genes Nutr., 13, (2018) (9)] DOI: 10.1186/s12263-018-0600-z. Genes & Nutrition.  ISSN 1555-8932.  13(1) . doi: 10.1186/s12263-018-0604-8
• Rundblad, Amanda; Holven, Kirsten Bjørklund; Ottestad, Inger; Myhrstad, Mari & Ulven, Stine Marie (2018). High-quality fish oil has a more favourable effect than oxidised fish oil on intermediate density lipoprotein and LDL subclasses: a randomised controlled trial.
• Rundblad, Amanda; Larsen, Sunniva Veen; Myhrstad, Mari; Ottestad, Inger; Thoresen, Magne; Holven, Kirsten Bjørklund & Ulven, Stine Marie (2018). Gene expression changes in plasma triglyceride responders and non-responders to omega-3 supplementation.
• Ulven, Stine Marie; Christensen, Jacob J.; nygaard, ottar; Svardal, Asbjørn M.; Leder, Lena; Ottestad, Inger; Andersen, Lene Frost & Holven, Kirsten Bjørklund (2018). Using metabolic profiling and gene expression analyses to explore molecular effects of replacing saturated fat with polyunsaturated fat- a randomized controlled dietary intervention study.
• Ulven, Stine Marie; Christensen, Jacob J.; Nygård, Ottar; Svardal, Asbjørn M.; Leder, Lena; Ottestad, Inger; Lysne, Vegard; Laugstad-Borge, Johnny; Ueland, Per Magne; Midttun, Øivind; Andersen, Lene Frost & Holven, Kirsten B. (2018). Using metabolic profiling to explore molecular effects of replacing saturated fat with polyunsaturated fat- a randomized controlled dietary intervention study.
• Ulven, Stine Marie; Christensen, Jacob J.; Nygård, Ottar; Svardal, Asbjørn M.; Leder, Lena; Ottestad, Inger; Lysne, Vegard; Laugstad-Borge, Johnny; Ueland, Per Magne; Midttun, Øivind; Andersen, Lene Frost & Holven, Kirsten Bjørklund (2018). Using metabolic profiling to explore molecular effects of replacing saturated fat with polyunsaturated fat- a randomized controlled dietary intervention study.
• Brynildsen, Åslaug; Narverud, Ingunn; Christensen, Jacob J. & Ottestad, Inger (2017). Så enkelt får barnet ditt rett type fett.
• Brynildsen, Åslaug; Narverud, Ingunn; Christensen, Jacob J. & Ottestad, Inger (2017). Så enkelt får barnet ditt rett type fett. www.forskning.no.
• Brynildsen, Åslaug; Narverud, Ingunn; Christensen, Jacob J. & Ottestad, Inger (2017). Så enkelt får barnet ditt rett type fett. http://www.uio.no/.
• Hägg, Sara B.; Gjevre, Ragnhild; Kardel, Kristin Reimers; Roland, Marie Cecilie; Henriksen, Tore & Ottestad, Inger (2017). Obesity and pregnancy: Are changes in weight, blood lipids and glucose levels during pregnancy associated with health status of mother and child?.
• Hansson, Patrik; Brekke, Hilde Kristin; Christensen, Jacob J.; Gjevestad, Gyrd Omholt; Larsen, Sunniva Veen; Narverud, Ingunn; Ottestad, Inger; Rundblad, Amanda; Øyri, Linn Kristin Lie; Ulven, Stine Marie & Holven, Kirsten Bjørklund (2017). Vegetarkost - bedre helse ved å kutte kjøttet? (Artikkel publisert på FH-Norge sin Facebook-side 10.05.2017 i samarbeid med FH-Norge).
• Larsen, Sunniva Veen; Holven, Kirsten Bjørklund; Ottestad, Inger; Dagsland, Kine Næss; Myhrstad, Mari & Ulven, Stine Marie (2017). Plasma fatty acid levels and gene expression related to lipid metabolism in peripheral blood mononuclear cells: a cross-sectional study in healthy subjects.
• Narverud, Ingunn; Christensen, Jacob J. & Ottestad, Inger (2017). Klin kokos fra Berit Nordstrand. Facebook.
• Ottestad, Inger (2017). Har økt inntak av protein en gunstig effekt på muskelmasse og muskelstyrke hos eldre hjemmeboende over70 år?.
• Ottestad, Inger & Gjevestad, Gyrd Omholt (2017). Eldre anbefales mer protein – har mer protein betydning for sarkopeni?.
• Ottestad, Inger; Narverud, Ingunn; Christensen, Jacob J.; Rundblad, Amanda; Øyri, Linn Kristin Lie; Larsen, Sunniva Veen; Hansson, Patrik; Brekke, Hilde Kristin; Gjevestad, Gyrd Omholt; Ulven, Stine Marie & Holven, Kirsten Bjørklund (2017). Ost - venn eller fiende for hjertehelsa?.
• Rognø, Linn merete; Ottestad, Inger; Christensen, Jacob J. & Narverud, Ingunn (2017). Mye fett i kostholdet er sunt. klikk.no.
• Rundblad, Amanda; Holven, Kirsten Bjørklund; Ottestad, Inger; Myhrstad, Mari & Ulven, Stine Marie (2017). High quality fish oil has a more favourable effect than oxidized fish oil on intermediate and low density lipoprotein subclasses.
• Rundblad, Amanda; Holven, Kirsten Bjørklund; Ottestad, Inger; Myhrstad, Mari & Ulven, Stine Marie (2017). High quality fish oil has a more favourable effect than oxidized fish oil on intermediate and low density lipoprotein subclasses.
• Rundblad, Amanda; Holven, Kirsten Bjørklund; Ottestad, Inger; Myhrstad, Mari & Ulven, Stine Marie (2017). High-quality fish oil has a more favourable effect than oxidised fish oil on intermediate density lipoprotein and LDL subclasses.
• Rundblad, Amanda; Holven, Kirsten Bjørklund; Ottestad, Inger; Myhrstad, Mari & Ulven, Stine Marie (2017). High-quality fish oil has a more favourable effect than oxidized fish oil on intermediate-density lipoprotein and LDL subclasses: a randomised controlled trial.
• Rundblad, Amanda; Holven, Kirsten Bjørklund; Ottestad, Inger; Myhrstad, Mari & Ulven, Stine Marie (2017). Quality of fish oil has an impact on lipid composition in intermediate and low density lipoprotein subclasses.
• Ulven, Stine Marie; Christensen, Jacob J.; Leder, Lena; Ottestad, Inger & Holven, Kirsten Bjørklund (2017). Using metabolic profiling to explore mechanisms that cause LDL cholesterol to decrease following replacement of saturated fat with polyunsaturated fat– a randomized controlled dietary intervention study.
• Ulven, Stine Marie; Holven, Kirsten Bjørklund; Christensen, Jacob J.; Leder, Lena & Ottestad, Inger (2017). Use of metabolomics in the NOMA study.
• Gjevestad, Gyrd Omholt; Ottestad, Inger; Biong, Anne Sofie; Iversen, Per Ole; Retterstøl, Kjetil; Raastad, Truls; Skålhegg, Bjørn Steen; Ulven, Stine Marie & Holven, Kirsten Bjørklund (2016). Consumption of protein-enriched milk does not affect inflammation in elderly subjects - a 12 week double-blind randomized controlled trial.
• Hamrin, Margaretha; Christensen, Jacob J.; Ottestad, Inger; Narverud, Ingunn; Gjevestad, Gyrd Omholt; Rundblad, Amanda; Hansson, Patrik; Øyri, Linn Kristin Lie; Larsen, Sunniva Veen; Brekke, Hilde Kristin; Sheikh, Navida Akhter; Ulven, Stine Marie & Holven, Kirsten Bjørklund (2016). Fra Beverly Hills-dietten til Nordisk kost – hva virker?. FH-magasinet.
• Kolbjørnsen, Lisa & Ottestad, Inger (2016). Effekter av helfete meieriprodukter på LDL-kolesterol: En oppsummering av nyere randomiserte kontrollerte studier. Norsk Tidsskrift for Ernæring.  ISSN 1503-5034.
• Narverud, Ingunn; Ottestad, Inger; Gjevestad, Gyrd Omholt; Christensen, Jacob J.; Rundblad, Amanda; Hansson, Patrik; Øyri, Linn Kristin Lie; Larsen, Sunniva Veen; Brekke, Hilde Kristin; Sheikh, Navida Akhter; Ulven, Stine Marie & Holven, Kirsten Bjørklund (2016). Vidundermiddel eller klin kokos.
• Ottestad, Inger; Christensen, Jacob J. & Narverud, Ingunn (2016). Forskere villeder om mettet fett. http://www.uio.no/.
• Ottestad, Inger; Løvstad, Amund; Gjevestad, Gyrd Omholt; Hamarsland, Håvard; Benth, Jurate Saltyte; Andersen, Lene Frost; Bye, Asta; Biong, Anne Sofie; Retterstøl, Kjetil; Iversen, Per Ole; Raastad, Truls; Ulven, Stine Marie & Holven, Kirsten Bjørklund (2016). Intake of a protein-enriched milk and effects on muscle mass and strength. A 12-week randomized placebo controlled trial among community-dwelling older adults.
• Gjevestad, Gyrd Omholt; Hamarsland, Håvard; Ottestad, Inger; Biong, Anne Sofie; Truls, Raastad; Ulven, Stine Marie & Holven, Kirsten Bjørklund (2015). PBMC gene expression of inflammatory markers after an acute bout of resistance exercise in young and elderly subjects.
• Ulven, Stine Marie; Leder, Lena; Elind, Elisabeth; Ottestad, Inger; Christensen, Jacob Juel; Telle-Hansen, Vibeke Helen; Skjetne, Anne Juul; Torvik, Kristin; Raael, Ellen; Sheikh, Navida Akhter; Holck, Marianne; Lamglait, Amandine; Thyholt, Kari; Byfuglien, Marte Gjeitung; Granlund, Linda; Andersen, Lene Frost & Holven, Kirsten Bjørklund (2015). Replacing dietary saturated fat with polyunsaturated fat reduces total cholesterol and LDL cholesterol in healthy subjects with moderate hypercholesterolaemia - a randomized controlled trial.
• Ulven, Stine Marie; Leder, Lena; Elind, Elisabeth; Ottestad, Inger; Christensen, Jacob Juel; Telle-Hansen, Vibeke Helen; Skjetne, Anne Juul; Torvik, Kristin; Raael, Ellen; Sheikh, Navida Akhter; Holck, Marianne; Lamglait, Amandine; Thyholt, Kari; Byfuglien, Marte Gjeitung; Granlund, Linda; Andersen, Lene Frost & Holven, Kirsten Bjørklund (2015). Replacing dietary saturated fat with polyunsaturated fat reduces total cholesterol and LDL cholesterol in healthy subjects with moderate hypercholesterolaemia - a randomized controlled trial.
• Ulven, Stine Marie; Leder, Lena; Elind, Elisabeth; Ottestad, Inger; Christensen, Jacob Juel; Telle-Hansen, Vibeke; Byfuglien, marthe; Granlund, Linda; Andersen, Lene Frost & Holven, Kirsten Bjørklund (2015). EXCHANGING KEY FOOD ITEMS IN DAILY DIET IMPROVES FAT QUALITY AND REDUCES TOTAL CHOLESTEROL AND LDL CHOLESTEROL– A RANDOMIZED CONTROLLED TRIAL.
• Ulven, Stine Marie; Leder, Lena; Elind, Elisabeth; Ottestad, Inger; Christensen, Jacob Juel; Telle-Hansen, Vibeke; Skjetne, Anne Juul; Torvik, Kristin; Raael, Ellen; Sheikh, Navida Akhter; Holck, Marianne; Thyholt, Kari; Byfuglien, marthe; Granlund, Linda; Andersen, Lene Frost & Holven, Kirsten Bjørklund (2015). REPLACING DIETARY SATURATED FAT WITH POLYUNSATURATED FAT REDUCES TOTAL CHOLESTEROL AND LDL CHOLESTEROL IN HEALTHY SUBJECTS WITH MODERATE HYPERCHOLESTEROLAEMIA – A RANDOMIZED CONTROLLED TRIAL.
• Torvik, Krstin; Narverud, Ingunn; Retterstøl, Kjetil; Svilaas, Arne B; Andersen, Lene Frost; Veierød, Marit Bragelien; Ottestad, Inger; Ellingvåg, Asta; Strøm, Ellen C; Ulven, Stine Marie; Ose, Leiv & Holven, Kirsten Bjørklund (2014). Relation between diet and lipids in children with familial hypercholesterolemia (FH).
• Gjevestad, Gyrd Omholt; Ottestad, Inger; Hamarsland, Håvard; Biong, Anne Sofie; Ulven, Stine Marie; Raastad, Truls & Holven, Kirsten Bjørklund (2013). Postprandial inflammatory response after strength exercise followed by consumption of different dairy proteins.
• Ottestad, Inger; Retterstøl, Kjetil; Myhrstad, Mari Charlotte; Andersen, Lene Frost; Vogt, Kjell Gjermund; Nilsson, Astrid; Borge, Grethe Iren Andersen; Nordvi, B.; Brønner, Kirsti Wettre; Ulven, Stine Marie & Holven, Kirsten Bjørklund (2013). Intake of oxidised fish oil does not affect circulating levels of oxidised LDL or inflammatory markers in healthy subjects. NMCD. Nutrition Metabolism and Cardiovascular Diseases.  ISSN 0939-4753.  23(1), s E3- E4 . doi: 10.1016/j.numecd.2012.08.009
• Ottestad, Inger; Retterstøl, Kjetil; Myhrstad, Mari Charlotte; Andersen, Lene Frost; Vogt, Kjell gjermund; Nilsson, Astrid; Borge, Grete; Nordvi, Berit; Brønner, Kirsti; Ulven, Stine Marie & Holven, Kirsten Bjørklund (2012). Oxidised fish oil does not affect circulating levels of oxidised LDL or inflammatory markers in healthy subjects. NMCD. Nutrition Metabolism and Cardiovascular Diseases.  ISSN 0939-4753. . doi: 10.1016/j.numecd.2012.08.009
• Ottestad, Inger; Vogt, Kjell Gjermund; Myhrstad, Mari; Borge, Grethe Iren Andersen; Hassani, Sahar; Kohler, Achim; Retterstøl, Kjetil; Haugen, John-Erik; Nilsson, Astrid; Ravn-Haren, Gitte; Oresic, Matej; Nordvi, Berit; Brønner, Kirsti Wettre; Andersen, Lene Frost; Holven, Kirsten Bjørklund & Ulven, Stine Marie (2012). Effect of oxidized fish oil on oxidative stress markers and plasma lipidome profile.A randomized controlled trial in healthy subjects.
• Ottestad, Inger (2011). Fiskeolje for bedre helse - har kvaliteten noe å si? Et eksempel på et vellykket samarbeidsprosjekt mellom næringslivet og HiAk.
• Ottestad, Inger (2011). Forsker grand prix.
• Ottestad, Inger (2011, 24. mai). Forsker grand prix. [Radio].  P2 Ekko.
• Ottestad, Inger (2011). Health effects of oxidized cod liver oil - a human intervention study.
• Ottestad, Inger (2011). Helseeffekter av oksidert fiskeolje. En intervensjonsstudie på friske personer.
• Ottestad, Inger (2011). Må fiskeoljen være fersk for å gi helseeffekt av omega-3?.
• Ottestad, Inger; Vogt, Gjermund; Retterstøl, Kjetil; Myhrstad, Mari; Haugen, John-erik; Nilsson, Astrid; Ravn-Haren, Gitte; Nordvi, Berit; Brønner, Kirsti Wettre; Andersen, Lene Frost; Holven, Kirsten Bjørklund & Ulven, Stine Marie (2011). Health effects of oxidized cod liver oil in healthy subjects: a randomized controlled trial.
• Ottestad, Inger; Vogt, Gjermund; Retterstøl, Kjetil; Myhrstad, Mari; Haugen, John-Erik; Nilsson, Astrid; Ravn-Haren, Gitte; Nordvi, Berit; Brønner, Kirsti Wettre; Andersen, Lene Frost; Holven, Kirsten Bjørklund & Ulven, Stine Marie (2011). Intake of oxidized cod liver oil and health effects. A randomized control trial.
• Ottestad, Inger; Vogt, Kjell Gjermund; Myhrstad, Mari; Retterstøl, Kjetil; Nilsson, Astrid; Haugen, John-Erik; Ravn-Haren, Gitte; Brønner, Kirsti Wettre; Andersen, Lene Frost; Holven, Kirsten Bjørklund & Ulven, Stine Marie (2011). HEALTH EFFECTS OF OXIDIZED COD LIVER OIL IN HEALTHY SUBJECTS: A RANDOMIZED CONTROLLED TRIAL. Atherosclerosis Supplements.  ISSN 1567-5688.  12(1), s 60- 60
• Ulven, Stine Marie & Ottestad, Inger (2011, 11. november). Ufarlig fiskeolje i kosttilskudd. [Internett].  Forskning.no.
• Vogt, Gjermund; Thorkildsen, T.; Ottestad, Inger; Haugen, J. E. & Nilsson, A. (2011). Oxidation status in omega-3 oils in the Norwegian health care market.
• Ottestad, Inger (2010). Gjennomføring av en fullkostkontrollert studie.
• Ottestad, Inger (2010). Health effects of oxidized fish oil - a randomized controlled trial.
• Ottestad, Inger (2010). Omega-3 index.
• Ottestad, Inger; Sundstøl, Anne Kristin; Retterstøl, Kjetil; Andersen, Lene Frost; Vogt, Gjermund; Astrid, Nilsson; Brønner, Kirsti Wettre; Holven, Kirsten Bjørklund & Ulven, Stine Marie (2010). Effect of cod liver oil with different quality on the omeg-3 index. A randomized controlled trial.
• Ottestad, Inger; Sundstøl, Anne-Kristin; Vogt, Gjermund; Nilsson, Astrid; Brønner, Kirsti Wettre; Retterstøl, Kjetil; Holven, Kirsten & Ulven, Stine Marie (2010). Changes in omega-3 index in healthy individuals after intake of cod liver oil with different quality: a randomized controlled trial, In  ISSFAL 2010: 9th Congress of the International Society for the Study of Fatty Acids & Lipids incorporating the 8th International Congress on Essential Fatty Acids and Eicosanoids and the 5th PUFA in Maternal and Infant Health meeting.  International Society for the Study of Fatty Acids & Lipids.  s 185
• Thorkildsen, Trine; Ottestad, Inger & Vogt, Gjermund (2010). Quality of marine omega-3 oils on the Norwegian health care market, In  First International Marine Ingredients Conference Norway: Programme, abstracts for oral presentations, abstracts for posters.  First International Marine Ingredients Conference.  s 64
• Borge, Grethe Iren Andersen; Myhrstad, Mari C.W.; Holven, Kirsten; Brønner, Kirsti Wettre; Biong, Anne Sofie; Nilsson, Astrid; Vogt, Kjell Gjermund; Kohler, Achim; Oresic, Matej; Ottestad, Inger & Ulven, Stine Marie (2009). Marine omega-3 fatty acids and health use of systems biology in controlled dietary intervention studies.
• Ottestad, Inger; Vogt, Gjermund; Nordvi, Berit; Holck, Marianne; Nilsson, Astrid; Borge, Grethe Iren Andersen; Brønner, Kirsti Wettre; Retterstøl, Kjetil; Holven, Kirsten & Ulven, Stine Marie (2009). Absorption of EPA and DHA from functional food, In  25th Lipid Forum Symposium : June 15-17, Elsinore, Denmark.  Lipid Forum: Nordic Forum for Lipid Research and Technology.  s 38

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