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Published Nov. 18, 2021 3:58 PM

This November, Milena Pavlović and Lonneke Scheffer, PhD students in the group of prof. Geir Kjetil Sandve at the Department of Informatics (UiO) published their computational framework Immune ML in Nature Machine Intelligence. ImmuneML is a freely available tool that allows researchers to tackle complex computational questions related to studies of adaptive immune receptor repertoires. This tool will be an important resource for all studies that link B cell receptor and T cell receptor sequence data to antigen recognition and disease. For celiac disease, this represents one step closer towards the goal of detecting genes of gluten specific T cells directly in blood. 

Published Sep. 29, 2021 10:44 AM

Transglutaminase 2 (TG2) activity is essential to induce a pathogenic immune response towards gluten in coeliac disease. In a Phase 2 clinical trial, a daily dose of an irreversible TG2-inhibitor prevented gluten-induced mucosal destruction in coeliac patients that consumed gluten daily for 6 weeks. These findings represents a milestone in the search for treatment options for patients with coeliac disease. 

Published Feb. 17, 2021 10:52 PM

Proteomics analysis of intestinal tissue biopsies finds that some patients with celiac disease considered to be well treated by regular gluten free diet have ongoing low-level inflammation in the intestine suggestive of ongoing low-level anti-gluten immunity. These patients developed strong intestinal response following 14 -day gluten challenge. We are now investigating whether some patients may still have activated gluten-specific T-cells despite long-term gluten free diet.

Published July 2, 2018 2:40 PM

Since January 2018, Det Glutenfrie Verksted by Monica Hellmann, Nordic Refreshment Company AS, has donated 1 NOK per bag of gluten free baking mix to research on coeliac disease. The donation is supporting research under the management by Prof Ludvig M. Sollid and Knut E.A. Lundin who are very grateful for this generous gift.

Published May 24, 2018 10:52 AM

The patients weren't crazy—Knut Lundin was sure of that. But their ailment was a mystery. They were convinced gluten was making them sick. Yet they didn't have celiac disease, an autoimmune reaction to that often-villainized tangle of proteins in wheat, barley, and rye. And they tested negative for a wheat allergy. They occupied a medical no man's land. (Servick, Science News, 2018)

Published Feb. 22, 2018 12:51 PM

All J CoDiRC members, associated members, Scientific Advisory Board and Patient Advisory Council enjoyed a two-day seminar at Kleivstua February 13-14 to present and discuss current research on coeliac disease in the Centre.

Published Nov. 19, 2017 10:52 PM

Our member Gry Skodje (clinical dietician) from the research group of professor Knut Lundin, and with collaborators from Monash University in Melbourne, Australia, has published a study showing that fructans, rather than gluten, might be the villain of non-coeliac gluten sensitivity. This was covered in the national broadcast channel NRK news November 17th.