Guro Haugen Fossum

• Fossum, Guro Haugen; Gjelstad, Svein; Kvaerner, Kari Jorunn & Lindbæk, Morten (2018). Prescribing antibiotics when the stakes are higher — do GPs prescribe less when patients are pregnant? A retrospective observational study. British Journal of General Practice Open.  ISSN 2398-3795.  2(2), s 1- 12 . doi: 10.3399/bjgpopen18X101505 Fulltekst i vitenarkiv. Vis sammendrag

  Background Most oral antibiotics are prescribed by GPs, and they are therefore the most important influencers with regard to improving antibiotic prescription patterns. Although GPs’ prescription patterns in general are well-studied, little is known about antibiotic prescription patterns in pregnancy. Aim To study GPs’ antibiotic prescriptions in respiratory tract infections (RTIs) during pregnancy, and assess differences, if any, between pregnant and non-pregnant patients. Design & setting Retrospective observational study combining prescription data from the Norwegian Peer Academic Detailing (Rx-PAD) study database, pregnancy data from the Norwegian birth registry, and pharmacy dispension data from the Norwegian Prescription Database (NorPD). Method Records of patient contacts with 458 GPs, between December 2004 and February 2007, were screened for RTI episodes. Similar diagnoses were grouped together, as were similar antibiotics. Episodes were categorised according to whether the patient was pregnant or not, and included women aged 16–46 years. Logistic regression models were used to assess odds ratios (ORs), and calculated relative risks (cRRs) were produced. The authors also adjusted for clustering at various levels. Results Overall prescription rate for RTI episodes was 30.8% (n = 96 830). The cohort was reduced to include only episodes with women pregnant in the study period (n = 18 890). The antibiotic prescription rate in pregnancy was 25.9% versus 34.2% in the time before and after pregnancy (cRR = 0.66 [95% confidence intervals {CI} = 0.68 to 0.81]). During pregnancy, 83.0% of the antibiotic prescriptions were picked up at a pharmacy, compared to an 86.6% filling rate in non-pregnant patients. The difference was not significant when adjusting for clustering at the patient level. Conclusion Norwegian GPs prescribe fewer antibiotics overall when patients are pregnant and, when they do prescribe, choose more narrow spectrum antibiotics for RTIs. This indicates a possible lower target rate for GP prescriptions to females. A low antibiotic dispension rate during pregnancy may represent a discussion topic in the consultation setting, to address possible reasons and avoid under-treatment.

• Fossum, Guro Haugen; Lindbæk, Morten; Gjelstad, Svein & Kvaerner, Kari Jorunn (2018). Relationship between Maternal and First Year of Life Dispensations of Antibiotics and Antiasthmatics. Antibiotics.  ISSN 2079-6382.  7(3) . doi: 10.3390/antibiotics7030084
• Denstad, Silje Eilertsen; Aasen, Silja; Østrem, Anette; Bakkeheim, Vivi; Fossum, Guro Haugen & Moen, Mette Haase (2017). Hysterektomi ved St. Olavs hospital 1989-2014. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  137(16) . doi: 10.4045/tidsskr.16.0260
• Fossum, Guro Haugen; Lie, Agnes Kathrine; Jebsen, Peter Wilhelm; Sandlie, Lars Eriks & Mork, Jon (2017). Human papillomavirus in oropharyngeal squamous cell carcinoma in South-Eastern Norway: prevalence, genotype, and survival. European Archives of Oto-Rhino-Laryngology.  ISSN 0937-4477.  274(11), s 4003- 4010 . doi: 10.1007/s00405-017-4748-8
• Fossum, Guro Haugen; Lindbæk, Morten; Gjelstad, Svein; Dalen, Ingvild & Kvaerner, Kari Jorunn (2013). Are children carrying the burden of broad-spectrum antibiotics in general practice? Prescription pattern for paediatric outpatients with respiratory tract infections in Norway. BMJ Open.  ISSN 2044-6055.  3(1) . doi: 10.1136/bmjopen-2012-002285

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• Fossum, Guro Haugen (2018). Relationship between maternal antibiotic prescriptions and antibiotic and antiasthmatic prescriptions in children younger than one year.
• Fossum, Guro Haugen (2013). Antibiotika til barn -et spørsmål om smak og behag. Utposten.  ISSN 0800-5680.  2, s 6- 7
• Fossum, Guro Haugen & Hjortdal, Per (2013). Streptokokkhalsinfeksjon og skarlagensfeber, I:  Nasjonale retningslinjer for antibiotikabruk i primærhelsetjenesten.  Helsedirektoratet.  ISBN 978-82-8081-271-1.  8.5.  s 73 - 78

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