Sigurd Høye

• Blix, Hege Salvesen & Høye, Sigurd (2021). Bruk av antibiotika under covid-19-pandemien. Tidsskrift for Den norske legeforening.  ISSN 0029-2001. . doi: 10.4045/tidsskr.20.1003 Fulltekst i vitenarkiv.
• Blix, Hege Salvesen & Høye, Sigurd (2021). Use of antibiotics during the COVID-19 pandemic. Tidsskrift for Den norske legeforening.  ISSN 0029-2001. . doi: 10.4045/tidsskr.20.1003 Fulltekst i vitenarkiv. Vis sammendrag

  BACKGROUND Interest has been shown in the use of antibiotics during the COVID-19 pandemic. In thisarticle we present the consumption of systemic antibiotics in Norway during the period ofthe pandemic. MATERIAL AND METHOD Total sales of systemic antibiotics in defined daily doses (DDD) were retrieved from thewholesaler-based medicinal product statistics for 2019 and 2020, and sales of antibiotics foruse outside of healthcare institutions were retrieved from the Norwegian prescriptiondatabase. Information was retrieved on the proportion of users (prevalence), doses(measured in DDD) and prescriptions. RESULTS Total sales of systemic antibiotics increased in March 2020, but sales to persons outside ofhealthcare institutions did not. Compared to previous years, both total consumption anduse of antibiotics outside of institutions fell steeply in the months that followed. Thereduction was greatest for antibiotics against respiratory infections and in the youngest agegroups.INTERPRETATIONThe significant reduction in the use of systemic antibiotics during the COVID-19 pandemicis attributed to infection control measures and reduced contact with the health service. In2016, the Norwegian government set a goal for a 30 % reduction in antibiotic use by the endof 2020. The pandemic has contributed to the achievement of that goal

• Lindberg, Bent Håkan; Rebnord, Ingrid Keilegavlen & Høye, Sigurd (2021). Phone triage nurses’ assessment of respiratory tract infections–the tightrope walk between gatekeeping and service providing. A qualitative study. Scandinavian Journal of Primary Health Care.  ISSN 0281-3432.  s 1- 10 . doi: 10.1080/02813432.2021.1908715 Fulltekst i vitenarkiv.
• Eig, Ruth Davey; Harbin, Nicolay Jonassen; Gjelstad, Svein; Høye, Sigurd; Jensen, Siri; Lindbæk, Morten & Blix, Hege Salvesen (2020). RASK – Promoting appropriate use of antibiotics in municipal healthcare institutions, In Gunnar Skov Simonsen; Hege Salvesen Blix; Kari Grave & Anne Margrete Urdahl (ed.),  NORM/NORM-vet 2019. Usage of Antimicrobial Agents and Occurrence of Antimicrobial Resistance in Norway.  NORM/NORM-VET.  Kapittel.  s 42 - 43
• Harbin, Nicolay Jonassen; Eig, Ruth Davey; Høye, Sigurd; Gjelstad, Svein; Jensen, Siri; Lindbæk, Morten & Blix, Hege Salvesen (2020). Antibiotic use in nursing homes, In Gunnar Skov Simonsen; Hege Salvesen Blix; Kari Grave & Anne Margrete Urdahl (ed.),  NORM/NORM-vet 2019. Usage of Antimicrobial Agents and Occurrence of Antimicrobial Resistance in Norway.  NORM/NORM-VET.  Kapittel.  s 42 - 42
• Høye, Sigurd; Brænd, Anja Maria & Spehar, Ivan (2020). Quality improvement and antimicrobial stewardship in general practice – the role of the municipality chief medical officer. A qualitative study. Scandinavian Journal of Primary Health Care.  ISSN 0281-3432.  38(3), s 352- 359 . doi: 10.1080/02813432.2020.1794400 Fulltekst i vitenarkiv.
• Høye, Sigurd; Lindbæk, Morten & Blix, Hege Salvesen (2020). RAK – Promoting appropriate use of antibiotics among general practitioners, In Gunnar Skov Simonsen; Hege Salvesen Blix; Kari Grave & Anne Margrete Urdahl (ed.),  NORM/NORM-vet 2019. Usage of Antimicrobial Agents and Occurrence of Antimicrobial Resistance in Norway.  NORM/NORM-VET.  Kapittel.  s 40 - 41
• Skow, Marius Andre Hybbestad; Vik, Ingvild & Høye, Sigurd (2020). Antibiotic switch after treatment with UTI antibiotics in male patients. Infectious Diseases.  ISSN 2374-4235.  52(6), s 405- 412 . doi: 10.1080/23744235.2020.1736329 Fulltekst i vitenarkiv.
• Sunde, Marthe; Nygaard, Marthe Marie & Høye, Sigurd (2019). General Practitioners’ Attitudes toward Municipal Initiatives to Improve Antibiotic Prescribing — A Mixed-Methods Study. Antibiotics.  ISSN 2079-6382.  8(3), s 1- 8 . doi: 10.3390/antibiotics8030120 Fulltekst i vitenarkiv. Vis sammendrag

  Antimicrobial stewardship (AMS) interventions directed at general practitioners (GPs) contribute to an improved antibiotic prescribing. However, it is challenging to implement and maintain such interventions at a national level. Involving the municipalities’ Chief Medical Officer (MCMO) in quality improvement activities may simplify the implementation and maintenance, but may also be perceived challenging for the GPs. In the ENORM (Educational intervention in NORwegian Municipalities for antibiotic treatment in line with guidelines) study, MCMOs acted as facilitators of an AMS intervention for GPs. We explored GPs’ views on their own antibiotic prescribing, and their views on MCMO involvement in improving antibiotic prescribing in general practice. This is a mixed-methods study combining quantitative and qualitative data from two data sources: e-mail interviews with 15 GPs prior to the ENORM intervention, and online-form answers to closed and open-ended questions from 132 GPs participating in the ENORM intervention. The interviews and open-ended responses were analyzed using systematic text condensation. Many GPs admitted to occasionally prescribing antibiotics without medical indication, mainly due to pressure from patients. Too liberal treatment guidelines were also seen as a reason for overtreatment. The MCMO was considered a suitable and acceptable facilitator of quality improvement activities in general practice, and their involvement was regarded as unproblematic (scale 0 (very problematic) to 10 (not problematic at all): mean 8.2, median 10). GPs acknowledge the need and possibility to improve their own antibiotic prescribing, and in doing so, they welcome engagement from the municipality. MCMOs should be involved in quality improvement and AMS in general practice.

• Skarpeid, Philip Lawrence & Høye, Sigurd (2018). Phenoxymethylpenicillin Versus Amoxicillin for Infections in Ambulatory Care: A Systematic Review. Antibiotics.  ISSN 2079-6382.  7(3) . doi: 10.3390/antibiotics7030081 Fulltekst i vitenarkiv. Vis sammendrag

  Most antibiotics are prescribed in primary care, and commonly for respiratory tract infections (RTIs). Narrow-spectrum phenoxymethylpenicillin is the antibiotic of choice for RTIs in the Scandinavian countries, while broader spectrum amoxicillin is used in most other European countries. This review summarizes the knowledge of the effect of phenoxymethylpenicillin versus amoxicillin for infections treated in ambulatory care. We searched PubMed/Medline and Embase for trials comparing the clinical effect of phenoxymethylpenicillin and amoxicillin. The Norwegian Knowledge Centre for the Health Services’ checklist was used to assess risk of bias. In total, 1687 studies were identified, and 18 of these fulfilled the inclusion criteria. One additional study was found as a reference. The randomized controlled trials revealed no significant differences in clinical effect in acute sinusitis (three RCTs), GAS tonsillitis (11 RCTs) and Lyme borreliosis (two RCTs). One RCT on community-acquired pneumonia found amoxicillin to be superior, while the results were conflicting in the two RCTs on acute otitis. The results suggest that non-Scandinavian countries should consider phenoxymethylpenicillin as the treatment of choice for RTIs because of its narrower spectrum. More studies should be conducted on the clinical effect of phenoxymethylpenicillin versus amoxicillin for acute otitis and lower RTIs.

• Walle-Hansen, Marte & Høye, Sigurd (2018). Geographic Variation in Antibiotic Consumption- Is It Due to Doctors' Prescribing or Patients' Consulting?. Antibiotics.  ISSN 2079-6382.  7(1) . doi: 10.3390/antibiotics7010026 Fulltekst i vitenarkiv.
• Blix, Hege Salvesen; Høye, Sigurd; Blandhol, Mari & Tysland, Thekla (2017). Antibiotic switch during treatment with antibiotics against respiratory tract infections in ambulatory care in Norway. Infectious Diseases.  ISSN 2374-4235.  49(11-12), s 854- 858 . doi: 10.1080/23744235.2017.1350879 Fulltekst i vitenarkiv.
• Lindberg, Bent Håkan; Gjelstad, Svein; Foshaug, Mats & Høye, Sigurd (2017). Antibiotic prescribing for acute respiratory tract infections in Norwegian primary care out-of-hours service. Scandinavian Journal of Primary Health Care.  ISSN 0281-3432.  35(2), s 178- 185 . doi: 10.1080/02813432.2017.1333301
• Nordeng, Stina; Nordeng, Hedvig Marie Egeland & Høye, Sigurd (2016). Bruk av antibiotika i svangerskapet. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  136(4), s 317- 321 . doi: 10.4045/tidsskr.15.0451
• Gjelstad, Svein; Høye, Sigurd; Straand, Jørund; Brekke, Mette; Dalen, Ingvild & Lindbæk, Morten (2013). Improving antibiotic prescribing in acute respiratory tract infections: cluster randomised trial from Norwegian general practice (prescription peer academic detailing (Rx-PAD) study). BMJ. British Medical Journal.  ISSN 0959-8146.  347 . doi: 10.1136/bmj.f4403
• Høye, Sigurd; Gjelstad, Svein & Lindbæk, Morten (2013). Effects on antibiotic dispensing rates of interventions to promote delayed prescribing for respiratory tract infections in primary care. British Journal of General Practice.  ISSN 0960-1643.  63(616), s E777- E786 . doi: 10.3399/bjgp13X674468.
• Høye, Sigurd; Frich, Jan C & Lindbæk, Morten (2011). Use and feasibility of delayed prescribing for respiratory tract infections: A questionnaire survey. BMC Family Practice.  ISSN 1471-2296.  12 . doi: 10.1186/1471-2296-12-34
• Frich, Jan C; Høye, Sigurd; Lindbæk, Morten & Straand, Jørund (2010). General practitioners and tutors' experiences with peer group academic detailing: a qualitative study. BMC Family Practice.  ISSN 1471-2296.  11 . doi: 10.1186/1471-2296-11-12
• Høye, Sigurd; Frich, Jan C & Lindbæk, Morten (2010). Delayed prescribing for upper respiratory tract infections: a qualitative study of GPs' views and experiences. British Journal of General Practice.  ISSN 0960-1643.  60(581), s 907- 912 . doi: 10.3399/bjgp10X544087
• Lærum, Even; Høye, Sigurd; Nordland, Ragnhild; Hegstad, Vegard; Lærum, Synnøve Tafjord & Engvold, Hans Otto (2010). Hva skriver norske aviser og ukeblader om vond rygg? :. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  130(24), s 2465- 2468
• Høye, Sigurd (2008). Vent og se, I: Morten Lindbæk (red.),  Nasjonale faglige retningslinjer for antibiotikabruk i primærhelsetjenesten (Helsedirektoratet bestillingsnummer IS-1593).  Helsedirektoratet og Antibiotikasenteret for primærmedisin (ASP).  ISBN 978-82-8081-112-7.  Kapittel 6.  s 24 - 26
• Høye, Sigurd; Straand, Jørund & Brekke, Mette (2008). Hvordan holder allmennleger seg oppdatert om legemidler?. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  128(23), s 2692- 2695
• Høye, Sigurd & Hjortdahl, Per (2002). "Ny vidunderpille!" – Hva skriver norske aviser om nye legemidler. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  122, s 1671- 1676

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• Høye, Sigurd; Jensen, Siri; Sundseth, Anne Cathrine & Rosvold, Elin Olaug (red.) (2011). Allsangmedisin. Allmennmedisinsk sangbok og festskrift til Jørund Straand og Morten Lindbæk 60 år. Avdeling for allmennmedisin, Universitetet i Oslo.  ISBN 978-82-303-1736-5.  125 s.

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• Eig, Ruth Davey & Høye, Sigurd (2020). Varighet av antibiotikakurer i allmennpraksis - kort er godt?. Utposten.  ISSN 0800-5680.
• Fossum, Guro Haugen; Heltveit-Olsen, Silje Rebekka & Høye, Sigurd (2020). Experiences of patients and primary health care professionals during the COVID-19 epidemic in Norway.
• Martiniussen, Erik & Høye, Sigurd (2020). Kan koronaen bli et vendepunkt også for antibiotikaresistens?. Aftenposten (morgenutg. : trykt utg.).  ISSN 0804-3116.
• Fossum, Guro Haugen; Brænd, Anja Maria; Høye, Sigurd & Minge, Christina (2019). European Treatment Guidelines for Otitis, Sinusitis and Tonsillitis in Primary Care.
• Høye, Sigurd; Lindbæk, Morten & Blix, Hege Salvesen (2019). Effects of an easy-to-implement, sustainable antimicrobial stewardship intervention in primary care – the ENORM (Educational intervention in NORwegian Municipalities for antibiotic treatment in line with guidelines) study.
• Høye, Sigurd (2018). Antibiotikabruk i primærhelsetjenesten - hva kan kommuneoverlegen gjøre?.
• Høye, Sigurd (2018, 31. mai). Disse kommunene bruker minst og mest antibiotika.  Dagens Medisin.
• Høye, Sigurd (2018, 22. januar). Enkle grep reduserte bruken av antibiotika med femten prosent. [Fagblad].  Apollon.
• Høye, Sigurd (2018). How to use less and more optimal antibiotics.
• Lindberg, Bent Håkan; Rebnord, Ingrid Keilegavlen & Høye, Sigurd (2018). Effect of a Clinical Training Program on Respiratory Tract Infections for Phone Triage Nurses in Out-of-hours Primary Care Centres.
• Høye, Sigurd (2017). Antibiotikabruk i legevakt.
• Høye, Sigurd (2017). Antibiotikabruk i primærhelsetjenesten.
• Høye, Sigurd (2017). Antibiotikabruk i primærhelsetjenesten.
• Høye, Sigurd (2017, 01. juli). Har du bronkitt?. [Internett].  ABC Nyheter.
• Høye, Sigurd (2017). Kommunens antibiotikabuk - hva kan smittevernansvarlig kommunelege bidra med?.
• Høye, Sigurd (2017). Myteknusing tar tid / Myth-busting takes time. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  137(10), s 680- 680 . doi: 10.4045/tidsskr.17.0330
• Høye, Sigurd (2017). "Riktigere antibiotikabruk i kommunene" - kommer snart til ditt fylke. Utposten.  ISSN 0800-5680.  46(7), s 16- 19
• Lindberg, Bent Håkan; Gjelstad, Svein; Foshaug, Mats & Høye, Sigurd (2017). Antibiotic prescribing for acute respiratory tract infections in Norwegian primary care out-of-hours service.
• Høye, Sigurd (2016). Ta dette og et det! : hva er likheten mellom en tablett og en oblat?. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  136(5), s 375 . doi: 10.4045/tidsskr.16.0225
• Lindberg, Bent Håkan & Høye, Sigurd (2016). Antibiotika-forskrivning ved akutte luftveisinfeksjoner på interkommunal legevakt.
• Høye, Sigurd (2015). Bak lukkede dører. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  135(17), s 1527- 1527 . doi: 10.4045/tidsskr.15.0963
• Høye, Sigurd (2015). Kommuniserbar sykdom. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  135(3), s 209 . doi: 10.4045/tidsskr.15.0149
• Høye, Sigurd (2015). Uvanlig om det vanlige. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  135(12/13), s 1147- 1148 . doi: 10.4045/tidsskr.15.0630
• Høye, Sigurd (2014, 01. desember). Allmennlegen – hipp hurra og nam nam! Per Fugelli intervjuet av Sigurd Høye. [Fagblad].  Utposten - blad for allmenn- og samfunnsmedisin.
• Høye, Sigurd (2014). Ikke spør legen. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  134(14), s 1341 . doi: 10.4045/tidsskr.14.0864
• Høye, Sigurd (2013). Delayed prescribing - a feasible strategy to lower antibiotic use for respiratory tract infections in primary care?.
• Høye, Sigurd (2013). Heller sprettert enn kanon. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  133, s 2117- 2117
• Høye, Sigurd (2012). Symptomer og sykdommer - Øre, I: Ingrid Hjulstad Johansen; Jesper Blinkenberg; Cecilie Arentz-Hansen & Kåre Moen (red.),  Legevakthåndboken.  Gyldendal Akademisk.  ISBN 9788205304826.  Symptomer og sykdommer - Øre.
• Høye, Sigurd (2011). Gode erfaringer med å vente og se. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  131, s 216- 216
• Høye, Sigurd (2010). Bruk av vent og se-resept - presentasjon under PMU 2010.
• Høye, Sigurd (2008). Vent og se - om jeg tør be. Utposten.  ISSN 0800-5680.  37(2), s 20- 23
• Rosvold, Elin Olaug & Høye, Sigurd (2008). Presentasjon av sammendragene fra forskningsdagen på Primærmedisinsk uke, 29.10.08. Utposten.  ISSN 0800-5680.  (6), s 38- 41
• Høye, Sigurd; Straand, Jørund & Brekke, Mette (2006). Hva gjør allmennleger for å holde seg oppdatert om legemidler – en spørreundersøkelse. (Muntlig presentasjon på forskningsdagen, PMU 2006 ved Sigurd Høye).
• Høye, Sigurd (2002). Den innbilt syke. VG : Verdens gang.  ISSN 0805-5203.

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