Kjetil Retterstøl

• Melnes, Torunn; Bogsrud, Martin Prøven; Christensen, Jacob Juel; Rundblad, Amanda; Narverud, Ingunn & Retterstøl, Kjetil [Vis alle 10 forfattere av denne artikkelen] (2024). Gene expression profiling in elderly patients with familial hypercholesterolemia with and without coronary heart disease. Atherosclerosis. ISSN 0021-9150. 392. doi: 10.1016/j.atherosclerosis.2024.117507.
• Gregersen, Ida; Narverud, Ingunn; Christensen, Jacob J.; Hovland, Anders Wilhelm; Øyri, Linn Kristin Lie & Ueland, Thor [Vis alle 11 forfattere av denne artikkelen] (2024). Plasma legumain in familial hypercholesterolemia: associations with statin use and cardiovascular risk markers. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. doi: 10.1080/00365513.2024.2309617.
• Retterstøl, Kjetil & Rosqvist, Fredrik (2024). Fat and fatty acids – a scoping review for Nordic Nutrition Recommendations 2023. Food & Nutrition Research (FNR). ISSN 1654-6628. 68. doi: 10.29219/fnr.v68.9980.
• Olsen, Thomas; Stolt, Emma Theresia Kjelland; Øvrebø, Bente; Elshorbagy, Amany; Tore, Elena C. & Lee-Ødegård, Sindre [Vis alle 20 forfattere av denne artikkelen] (2024). Dietary sulfur amino acid restriction in humans with overweight and obesity: a translational randomized controlled trial. Journal of Translational Medicine. ISSN 1479-5876. 22(1). doi: 10.1186/s12967-023-04833-w.
• Christensen, Jacob J.; Arnesen, Erik Kristoffer; Rundblad, Amanda; Telle-Hansen, Vibeke; Narverud, Ingunn & Blomhoff, Rune [Vis alle 10 forfattere av denne artikkelen] (2023). Dietary fat quality, plasma atherogenic lipoproteins, and atherosclerotic cardiovascular disease: An overview of the rationale for dietary recommendations for fat intake. Atherosclerosis. ISSN 0021-9150. 389. doi: 10.1016/j.atherosclerosis.2023.117433. Fulltekst i vitenarkiv
• Røstad-Tollefsen, Helen Kathrine; Kolset, Svein Olav; Retterstøl, Kjetil; Rendal, Heidi Hesselberg & Nordstrøm, Marianne (2023). Weight reduction and dietary improvements in a cluster-randomised controlled trial for adults with intellectual disabilities. Food & Nutrition Research (FNR). ISSN 1654-6628. 67. doi: 10.29219/fnr.v67.9505. Fulltekst i vitenarkiv
• Vinknes, Kathrine Jørgensen; Olsen, Thomas; Zare, Hasse Khiabani; Bastani, Nasser Ezzatkhah; Stolt, Emma Theresia Kjelland & Dahl, Anja Falkenhaug [Vis alle 11 forfattere av denne artikkelen] (2023). Cysteine-lowering treatment with mesna against obesity: Proof of concept and results from a human phase I, dose-finding study. Diabetes, obesity and metabolism. ISSN 1462-8902. 25(11), s. 3161–3170. doi: 10.1111/dom.15210. Fulltekst i vitenarkiv
• Schreuder, M.M.; Hamkour, S.; Siegers, K.E.; Holven, Kirsten Bjørklund; Johansen, Anja Katrin & van de Ree, de [Vis alle 14 forfattere av denne artikkelen] (2023). LDL cholesterol targets rarely achieved in familial hypercholesterolemia patients: A sex and gender-specific analysis. Atherosclerosis. ISSN 0021-9150. 384. doi: 10.1016/j.atherosclerosis.2023.03.022. Fulltekst i vitenarkiv
• Rodriguez-Borjabad, Celia; Narverud, Ingunn; Christensen, Jacob J.; Ibarretxe, Daiana; Andreychuk, Natalia & Girona, Josefa [Vis alle 13 forfattere av denne artikkelen] (2023). Association between Nordic and Mediterranean diets with lipoprotein phenotype assessed by ¹HNMR in children with familial hypercholesterolemia. Atherosclerosis. ISSN 0021-9150. 373, s. 38–45. doi: 10.1016/j.atherosclerosis.2023.04.009. Fulltekst i vitenarkiv
• Johansen, Anja Katrin; Bogsrud, Martin Prøven; Christensen, Jacob J.; Rundblad, Amanda; Narverud, Ingunn & Ulven, Stine Marie [Vis alle 9 forfattere av denne artikkelen] (2023). Young women with familial hypercholesterolemia have higher LDL-cholesterol burden than men: Novel data using repeated measurements during 12-years follow-up. Atherosclerosis Plus. ISSN 2667-0909. 51, s. 28–34. doi: 10.1016/j.athplu.2023.01.001. Fulltekst i vitenarkiv
• Tore, Elena C.; Eussen, Simone; Bastani, Nasser Ezzatkhah; Dagnelie, Pieter; Elshorbagy, Amany K & Grootswagers, Pol [Vis alle 14 forfattere av denne artikkelen] (2023). The Associations of Habitual Intake of Sulfur Amino Acids, Proteins and Diet Quality with Plasma Sulfur Amino Acid Concentrations: The Maastricht Study. Journal of Nutrition. ISSN 0022-3166. 153(7), s. 2027–2040. doi: 10.1016/j.tjnut.2023.05.008.
• Øyri, Linn K. L.; Christensen, Jacob J.; Sebert, Sylvain; Thoresen, Magne; Michelsen, Trond M. & Ulven, Stine M. [Vis alle 12 forfattere av denne artikkelen] (2023). Maternal prenatal cholesterol levels predict offspring weight trajectories during childhood in the Norwegian Mother, Father and Child Cohort Study. BMC Medicine. ISSN 1741-7015. 21. doi: 10.1186/s12916-023-02742-9. Fulltekst i vitenarkiv Vis sammendrag

  Background Numerous intrauterine factors may affect the offspring’s growth during childhood. We aimed to explore if maternal and paternal prenatal lipid, apolipoprotein (apo)B and apoA1 levels are associated with offspring weight, length, and body mass index from 6 weeks to eight years of age. This has previously been studied to a limited extent. Methods This parental negative control study is based on the Norwegian Mother, Father and Child Cohort Study and uses data from the Medical Birth Registry of Norway. We included 713 mothers and fathers with or without self-reported hypercholesterolemia and their offspring. Seven parental metabolites were measured by nuclear magnetic resonance spectroscopy, and offspring weight and length were measured at 12 time points. Data were analyzed by linear spline mixed models, and the results are presented as the interaction between parental metabolite levels and offspring spline (age). Results Higher maternal total cholesterol (TC) level was associated with a larger increase in offspring body weight up to 8 years of age (0.03 ≤ Pinteraction ≤ 0.04). Paternal TC level was not associated with change in offspring body weight (0.17 ≤ Pinteraction ≤ 0.25). Higher maternal high-density lipoprotein cholesterol (HDL-C) and apoA1 levels were associated with a lower increase in offspring body weight up to 8 years of age (0.001 ≤ Pinteraction ≤ 0.005). Higher paternal HDL-C and apoA1 levels were associated with a lower increase in offspring body weight up to 5 years of age but a larger increase in offspring body weight from 5 to 8 years of age (0.01 ≤ Pinteraction ≤ 0.03). Parental metabolites were not associated with change in offspring height or body mass index up to 8 years of age (0.07 ≤ Pinteraction ≤ 0.99). Conclusions Maternal compared to paternal TC, HDL-C, and apoA1 levels were more strongly and consistently associated with offspring body weight during childhood, supporting a direct intrauterine effect.

• Hovland, Anders; Mundal, Liv; Veierød, Marit Bragelien; Holven, Kirsten Bjørklund; Bogsrud, Martin Prøven & Tell, Grethe Seppola [Vis alle 8 forfattere av denne artikkelen] (2022). The risk of various types of cardiovascular diseases in mutation positive familial hypercholesterolemia; a review. Frontiers in Genetics. ISSN 1664-8021. 13. doi: 10.3389/fgene.2022.1072108. Fulltekst i vitenarkiv Vis sammendrag

  Familial hypercholesterolemia (FH) is a common, inherited disease characterized by high levels of low-density lipoprotein Cholesterol (LDL-C) from birth. Any diseases associated with increased LDL-C levels including atherosclerotic cardiovascular diseases (ASCVDs) would be expected to be overrepresented among FH patients. There are several clinical scoring systems aiming to diagnose FH, however; most individuals who meet the clinical criteria for a FH diagnosis do not have a mutation causing FH. In this review, we aim to summarize the literature on the risk for the various forms of ASCVD in subjects with a proven FH-mutation (FH+). We searched for studies on FH+ and cardiovascular diseases and also included our and other groups published papers on FH + on a wide range of cardiovascular and other diseases of the heart and vessels. FH + patients are at a markedly increased risk of a broad range of ASCVD. Acute myocardial infarction (AMI) is the most common in absolute numbers, but also aortic valve stenosis is by far associated with the highest excess risk. Per thousand patients, we observed 3.6 incident AMI per year compared to 1.9 incident aortic valve stenosis, however, standardized incidence ratio (SIR) for incident AMI was 2.3 compared to 7.9 for incident aortic valve stenosis. Further, occurrence of ischemic stroke seems not to be associated with increased risk in FH+. Clinicians should be aware of the excess risk of almost all kind of ASCVD in FH+, and the neutral risk of stroke need to be studied further in FH + patients.

• Svilaas, Tone; Klemsdal, Tor Ole; Bogsrud, Martin Prøven; Græsdal, Asgeir; Vesterbekkmo, Elisabeth Kleivhaug & Asprusten, Emil Andreas [Vis alle 8 forfattere av denne artikkelen] (2022). Høyt nivå av lipoprotein(a) – utredning og behandling. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 143(1). doi: 10.4045/tidsskr.21.0800. Fulltekst i vitenarkiv
• Urke, Eli Bjørnøy; Igland, Jannicke; Mundal, Liv; Holven, Kirsten Bjørklund; Retterstøl, Kjetil & Svendsen, Karianne (2022). Individuals with familial hypercholesterolemia have excess risk of eating disorders: a prospectively matched cohort study. European Journal of Preventive Cardiology (EJPC). ISSN 2047-4873. 30(4). doi: 10.1093/eurjpc/zwac291. Fulltekst i vitenarkiv
• Christensen, Jacob Juel; Bogsrud, Martin Prøven; Holven, Kirsten Bjørklund; Retterstøl, Kjetil; Veierød, Marit Bragelien & Nordeng, Hedvig Marie Egeland (2022). Use of statins and other lipid-modifying agents across pregnancy – a nationwide drug utilization study of 822 071 pregnancies in Norway in 2005-2018. medRxiv. doi: 10.1101/2022.06.28.22276237. Fulltekst i vitenarkiv
• Christensen, Jacob Juel; Bogsrud, Martin Prøven; Holven, Kirsten Bjørklund; Retterstøl, Kjetil; Veierød, Marit Bragelien & Nordeng, Hedvig Marie Egeland (2022). Use of statins and other lipid-modifying agents across pregnancy: A nationwide drug utilization study in Norway in 2005–2018. Atherosclerosis. ISSN 0021-9150. s. 1–10. doi: 10.1016/j.atherosclerosis.2022.11.022. Fulltekst i vitenarkiv Vis sammendrag

  Background and aims Statins are becoming more widely used among women of reproductive age; however, nationwide data on statin use across pregnancy is scarce. We therefore aimed to describe the drug utilization patterns for statins and other lipid-modifying agents (LMAs) before, during, and after pregnancy, for all pregnancies in Norway from 2005 to 2018. Methods We linked individual-level data from four nationwide electronic health care registries in Norway and characterized the prescription fills of statins and other LMAs across pregnancy. We also examined trends in pregnancy-related LMA use, and characterized women using statins and other LMAs on parameters of health status and co-morbidity. Results In total, 822,071 pregnancies for 503,723 women were included. The number of statin prescription fills decreased rapidly during the first trimester and returned to pre-pregnancy levels about one year postpartum. Pregnancy-related statin use increased from 2005 (approx. 0.11% of all pregnancies) to 2018 (approx. 0.29% of all pregnancies); however, in total, few statin prescriptions were filled within any trimester of pregnancy (n = 331, 0.04% of all pregnancies). Statin use was more common in women with higher age, higher weight, smoking, and comorbidities such as hypertension and diabetes mellitus; also, statin users often had co-medication pertinent to these conditions. Conclusions Although statins and other LMAs were increasingly being used around the time of pregnancy among women in Norway, drug use was mostly discontinued during the first trimester. Our results suggest that pregnancy-related statin use should be monitored, and that drug safety analyses for maternal and offspring health outcomes are needed.

• Tore, Elena C.; Elshorbagy, Amany K.; Bakers, Frans CH; Brouwers, Marin C.G.J.; Dagnelie, Pieter & Eussen, Simone J. [Vis alle 17 forfattere av denne artikkelen] (2022). Associations between plasma sulfur amino acids and specific fat depots in two independent cohorts: CODAM and The Maastricht Study. European Journal of Nutrition. ISSN 1436-6207. doi: 10.1007/s00394-022-03041-4. Fulltekst i vitenarkiv
• Telle-Hansen, Vibeke; Gaundal, Line; Bastani, Nasser Ezzatkhah; Rud, Ida; Byfuglien, Marte G. & Gjøvaag, Terje [Vis alle 10 forfattere av denne artikkelen] (2022). Replacing saturated fatty acids with polyunsaturated fatty acids increases the abundance of Lachnospiraceae and is associated with reduced total cholesterol levels-a randomized controlled trial in healthy individuals. Lipids in Health and Disease. ISSN 1476-511X. 21, s. 1–13. doi: 10.1186/s12944-022-01702-1. Fulltekst i vitenarkiv Vis sammendrag

  Improving dietary fat quality strongly affects serum cholesterol levels and hence the risk of cardiovascular diseases (CVDs). Recent studies have identified dietary fat as a potential modulator of the gut microbiota, a central regulator of host metabolism including lipid metabolism. We have previously shown a significant reduction in total cholesterol levels after replacing saturated fatty acids (SFAs) with polyunsaturated fatty acids (PUFAs). The aim of the present study was to investigate the effect of dietary fat quality on gut microbiota, short-chain fatty acids (SCFAs), and bile acids in healthy individuals. In addition, to investigate how changes in gut microbiota correlate with blood lipids, bile acids, and fatty acids.

• Melnes, Torunn; Bogsrud, Martin Prøven; Thorsen, Ida; Fossum, Julie; Christensen, Jacob J. & Narverud, Ingunn [Vis alle 9 forfattere av denne artikkelen] (2022). What characterizes event-free elderly FH patients? A comprehensive lipoprotein profiling. NMCD. Nutrition Metabolism and Cardiovascular Diseases. ISSN 0939-4753. 32(7), s. 1651–1660. doi: 10.1016/j.numecd.2022.03.028. Fulltekst i vitenarkiv Vis sammendrag

  Familial hypercholesterolemia (FH) is a genetic disorder characterized by lifelong elevated low-density lipoprotein cholesterol (LDL-C) and increased risk of pre- mature coronary heart disease (CHD). Cholesterol-lowering therapy (statins) reduces CHD risk, but have been available only in the last 25 years, thus, elderly FH patients have been exposed to elevated LDL-C levels most of their life. Surprisingly, some of these have never experienced any CHD event, raising the question whether they present CHD resistant characteristics. Identifying possible cardioprotective biomarkers could contribute to future CHD preventive treatment, therefore, we aimed to identify metabolic markers in event-free elderly FH subjects. Methods and results: We used a high-throughput nuclear magnetic resonance (NMR) spectroscopy platform to quantify a large number of metabolites in serum samples from 83 FH patients >65 years, and analyze differences between subjects with (n = 39) and without (n = 44) CHD. Mean age was 70 years in both groups (57% and 38% female in the event-free group and CHD group, respectively). The event-free group had significantly higher levels of large and extra-large high-density lipoprotein (HDL) particles, and higher concentration of Apolipoprotein A1 (ApoA1) and cholesterol in HDL and HDL2 particles, compared to the CHD group (p < 0.05 for all). Conclusion: CHD resistant elderly FH patients have higher levels of large HDL particles. The mechanisms behind the event-free survival among these patients remain unclear; hence, a deeper understanding of the metabolic profile in event-free elderly FH subjects may lead to development of novel preventive therapies.

• Aaseth, Jan; Rootwelt, Helge; Retterstøl, Kjetil; Hestad, Knut & Farup, Per Grønaas (2022). Circulating Lipoproteins in Subjects with Morbid Obesity Undergoing Bariatric Surgery with Gastric Bypass or Sleeve Gastrectomy. Nutrients. ISSN 2072-6643. 14(12). doi: 10.3390/nu14122381. Fulltekst i vitenarkiv Vis sammendrag

  The efficacy of various bariatric procedures on the mitigation of the obese dyslipidemia remains debated, and the impact of these measures on lipoprotein(a) (Lp(a)) levels is unknown. In this study we aimed to compare the two most commonly used procedures: gastric bypass (RYGB) and sleeve gastrectomy (SG). Adult patients with morbid obesity were assigned to receive either RYGB or SG. The levels of non-HDL cholesterol, LDL/HDL-ratio and Lp(a) at examinations conducted 6 and 12 months postoperatively were determined and compared to preoperative levels to estimate the efficacy of the two surgical methods. All results 6 and 12 months after surgery were used in the comparisons with the preoperative results. A linear mixed regression model for repeated analyses was used. The Lp(a) and the non-HDL cholesterol levels were considerably reduced in the RYGB group, in contrast to the minor changes in the SG group. In addition, the LDL/HDL ratio was significantly more reduced in the RYGB group when compared to the SG group. Conclusively, RYGB was found to be more efficient than SG for the mitigation of obese dyslipidemia, including preoperative high Lp(a)-levels. This might have important individual and societal implications, especially regarding the potential to reduce the risk of cardiovascular disease and the related societal costs.

• Svendsen, Karianne; Olsen, Thomas; Vinknes, Kathrine Jørgensen; Mundal, Liv; Holven, Kirsten Bjørklund & Bogsrud, Martin Prøven [Vis alle 9 forfattere av denne artikkelen] (2022). Risk of stroke in genetically verified familial hypercholesterolemia: A prospective matched cohort study. Atherosclerosis. ISSN 0021-9150. 358, s. 34–40. doi: 10.1016/j.atherosclerosis.2022.08.015. Fulltekst i vitenarkiv Vis sammendrag

  Background and aims: Individuals with familial hypercholesterolemia (FH), causing severely elevated LDL-C, are expected to have a higher risk of ischemic stroke. The risk of hemorrhagic stroke and impact of statin use are, however, not known. We aimed to investigate the risk of incident total, ischemic and hemorrhagic stroke in individuals with FH compared to controls, and to explore the association between cumulative statin use and risk of total stroke in FH. Methods: This prospective cohort study consists of 4186 individuals with genetically verified FH and 82 180 age and sex matched controls followed from 2008 to 2018 for incident stroke. Daily defined doses (DDD) described cumulative statin exposure: 0–5000 DDD (“low”), 5000–10,000 DDD (“intermediate”), and >10 000 DDD (“high”). Results were presented as hazard ratio (95% CI) derived from Cox proportional hazards models. Results: Individuals with FH did not have a higher risk of total stroke (1.16 (0.95–1.43) nor ischemic stroke (1.11 (0.88–1.38). Excess risk of hemorrhagic stroke was observed (1.63 (1.07, 2.48) but attenuated after adjusting for antithrombotic medication (1.25 (0.81, 1.93). Among individuals with FH, there was no association between statin use and total stroke for intermediate vs. low DDD [0.69 (0.32, 1.48)] or for high vs. low DDD [0.83 (0.41, 1.67)]. Conclusions: No significant excess risk of incident total and ischemic stroke in FH, and no difference in total stroke risk among the FH population with low, intermediate, and high statin exposure were observed. The observed relationship between FH and hemorrhagic stroke was no longer significant after adjusting for use of anti- thrombotic medication.

• Gaundal, Line; Myhrstad, Mari; Rud, Ida; Gjøvaag, Terje; Byfuglien, Marte G. & Retterstøl, Kjetil [Vis alle 9 forfattere av denne artikkelen] (2022). Gut microbiota is associated with dietary intake and metabolic markers in healthy individuals. Food & Nutrition Research (FNR). ISSN 1654-6628. 66. doi: 10.29219/fnr.v66.8580. Fulltekst i vitenarkiv Vis sammendrag

  Background: Metabolic diseases have been related to gut microbiota, and new knowledge indicates that diet impacts host metabolism through the gut microbiota. Identifying specific gut bacteria associated with both diet and metabolic risk markers may be a potential strategy for future dietary disease prevention. However, studies investigating the association between the gut microbiota, diet, and metabolic markers in healthy indi-viduals are scarce.Objective: We explored the relationship between a panel of gut bacteria, dietary intake, and metabolic and anthropometric markers in healthy adults.Design: Forty-nine volunteers were included in this cross-sectional study. Measures of glucose, serum tri-glyceride, total cholesterol, hemoglobin A1c (HbA1c), blood pressure (BP), and body mass index (BMI) were collected after an overnight fast, in addition to fecal samples for gut microbiota analyzes using a targeted approach with a panel of 48 bacterial DNA probes and assessment of dietary intake by a Food Frequency Questionnaire (FFQ). Correlations between gut bacteria, dietary intake, and metabolic and anthropometric markers were assessed by Pearson’s correlation. Gut bacteria varying according to dietary intake and metabolic markers were assessed by a linear regression model and adjusted for age, sex, and BMI.Results: Of the 48 gut bacteria measured, 24 and 16 bacteria correlated significantly with dietary intake and metabolic and/or anthropometric markers, respectively. Gut bacteria including Alistipes, Lactobacillus spp., and Bacteroides stercoris differed according to the intake of the food components, fiber, sodium, saturated fatty acids, and dietary indices, and metabolic markers (BP and total cholesterol) after adjustments. Notably, Bacteroides stercoris correlated positively with the intake of fiber, grain products, and vegetables, and higher Bacteroides stercoris abundance was associated with higher adherence to Healthy Nordic Food Index (HNFI) and lower diastolic BP after adjustment.Conclusion: Our findings highlight the relationship between the gut microbiota, diet, and metabolic mark-ers in healthy individuals. Further investigations are needed to address whether these findings are causally linked and whether targeting these gut bacteria can prevent metabolic diseases.

• Arnesen, Erik Kristoffer & Retterstøl, Kjetil (2022). Secular trends in serum lipid profiles in young adults in Norway, 2001-19. Atherosclerosis Plus. ISSN 2667-0909. 48, s. 60–67. doi: 10.1016/j.athplu.2022.03.006. Fulltekst i vitenarkiv
• Mundal, Liv; Igland, Jannicke; Svendsen, Karianne; Holven, Kirsten Bjørklund; Leren, Trond Paul & Retterstøl, Kjetil (2022). Association of familial hypercholesterolemia and statin use with risk of dementia in Norway. JAMA Network Open. ISSN 2574-3805. 5:e227715(4), s. 1–11. doi: 10.1001/jamanetworkopen.2022.7715. Fulltekst i vitenarkiv Vis sammendrag

  IMPORTANCE Hypercholesterolemia, which is a cardiovascular risk factor, may also be associated with dementia risk. The benefit of statin treatment on dementia risk is controversial. OBJECTIVE To determine whether individuals with familial hypercholesterolemia (FH), who have been exposed to lifelong hypercholesterolemia, have an excess risk of dementia and whether statin use is associated with dementia risk. DESIGN, SETTING, AND PARTICIPANTS This was a prospective cohort study performed from 2008 to 2018 in Norway. Statistical analysis was performed from January 2021 to February 2022. This study included individuals with genetically verified FH and age-matched and sex-matched controls obtained from the general Norwegian population. EXPOSURES Dementia was defined according to International Statistical Classification of Diseases and Related Health Problems, Tenth Revision codes F00-03 and G30. MAIN OUTCOMES AND MEASURES Incident cases of total dementia, vascular dementia, Alzheimer disease–dementia in Alzheimer disease, and data on lipid-lowering medication were obtained from the Norwegian Patient Registry, Cause of Death Registry, and the Norwegian Prescription Database. Hazard ratios (HRs) for risk of dementia for individuals with FH vs matched controls were calculated using Cox regression. The cumulative sum of defined daily doses (DDDs) of statins prescribed during study follow-up was calculated for individuals with FH and was analyzed as a time-varying covariate with 3 levels: 1 to 4999 DDDs, 5000 to 10 000 DDDs, and more than 10 000 DDDs. RESULTS Among the 3520 individuals with FH (1863 women [52.9%]; mean [SD] age at the start of follow-up, 51.8 [11.5] years) and the 69 713 controls (36 958 women [53.0%]; mean [SD] age at the start of follow-up, 51.7 [11.5] years), 62 patients with FH (39 women [62.9%]) and 1294 controls (801 women [61.9%]) had developed dementia over the course of 10 years of follow-up. Most dementia cases occurred among individuals aged 70 years and older (39 patients with FH [62.9%] and 870 patients [67.2%] in the control group). We found no excess risk of dementia in patients with FH vs matched controls (HR for total dementia, 0.9; 95% CI, 0.7-1.2). There was no association between cumulative DDDs of statins and total dementia in patients with FH with HRs of 1.2 (95% CI, 0.4-3.8) for cumulative DDDs of 5000 to 10 000 and 1.9 (95% CI, 0.7-5.0) for cumulative DDDs greater than 10 000. CONCLUSIONS AND RELEVANCE These findings suggest that individuals with FH have no excess risk of dementia compared with age-matched and sex-matched controls and that there is no association between use of statins and risk of dementia in patients with FH

• Langslet, Gisle; Johansen, Anja Katrin; Bogsrud, Martin Prøven; Narverud, Ingunn; Risstad, Hilde & Retterstøl, Kjetil [Vis alle 7 forfattere av denne artikkelen] (2021). Thirty percent of children and young adults with familial hypercholesterolemia treated with statins have adherence issues. American Journal of Preventive Cardiology. 6. doi: 10.1016/j.ajpc.2021.100180.
• Arnesen, Kjell Erik; Phung, Ann Vinh; Randsborg, Karoline; Mork, Irene; Thorvall, Marlene & Langslet, Gisle [Vis alle 10 forfattere av denne artikkelen] (2021). Risk of recurrent coronary events in patients with familial hypercholesterolemia; A 10-years prospective study. Frontiers in Pharmacology. ISSN 1663-9812. 11, s. 1–8. doi: 10.3389/fphar.2020.560958. Fulltekst i vitenarkiv
• Sørlie, Vilde; De Soysa, Ann Kristin Hjelle; Hyldmo, Åsne Ask; Retterstøl, Kjetil; Martins, Catia & Nymo, Siren (2021). Effect of a ketogenic diet on pain and quality of life in patients with lipedema: The LIPODIET pilot study. Obesity Science & Practice. ISSN 2055-2238. doi: 10.1002/osp4.580. Fulltekst i vitenarkiv
• Øyri, Linn Kristin Lie; Bogsrud, Martin Prøven; Kristiansen, Anne Lene; Myhre, Jannicke Borch; Astrup, Helene & Retterstøl, Kjetil [Vis alle 10 forfattere av denne artikkelen] (2021). Cholesterol at ages 6, 12 and 24 months: Tracking and associations with diet and maternal cholesterol in the Infant Cholesterol Study. Atherosclerosis. ISSN 0021-9150. 326, s. 11–16. doi: 10.1016/j.atherosclerosis.2021.04.017. Fulltekst i vitenarkiv
• Berglund, Ida Johnsen; Vesterbekkmo, Elisabeth Kleivhaug; Retterstøl, Kjetil; Anderssen, Sigmund Alfred; Singh, Maria A. Fiatarone & Helge, Jørn Wulff [Vis alle 9 forfattere av denne artikkelen] (2021). The Long-term Effect of Different Exercise Intensities on High-Density Lipoprotein Cholesterol in Older Men and Women Using the Per Protocol Approach: The Generation 100 Study. Mayo Clinic Proceedings: Innovations, Quality & Outcomes (MCP:IQ&O). ISSN 2542-4548. 5(5), s. 859–871. doi: 10.1016/j.mayocpiqo.2021.07.002. Fulltekst i vitenarkiv Vis sammendrag

  Objective: To examine whether 5 years of high-intensity interval training (HIIT) increases high-density lipoprotein cholesterol (HDL-C) concentration more than moderate-intensity continuous training (MICT) and control (CON) in older men and women. Methods: A total of 1567 older adults (790 [50.4%] women) were randomized (2:1:1) to either CON (n=780; asked to follow the national recommendations for physical activity) or 2 weekly sessions of HIIT (10-minute warm-up followed by 4×4-minute intervals at ∼90% of peak heart rate) or MICT (50 minutes of continuous work at ∼70% of peak heart rate). Serum HDL-C concentration was measured by standard procedures at baseline and at 1 year, 3 years, and 5 years. The study took place between August 21, 2012, and June 31, 2018. Linear mixed models were used to determine between-group differences during 5 years using the per protocol approach. Results: Men in HIIT had a smaller reduction in HDL-C (−1.2%) than men in CON (−6.9%) and MICT (−7.8%) after 5 years (P=.01 and P=.03 for CON vs HIIT and MICT vs HIIT, respectively). No effect of exercise intensity on HDL-C was seen in women. Changes in peak oxygen uptake were associated with changes in HDL-C in both men and women, whereas changes in body weight and fat mass were not. Conclusion: In men, HIIT seems to be the best strategy to prevent a decline in HDL-C during a 5-year period. No effect of exercise intensity was seen for older women.

• Christensen, Jacob J.; Narverud, Ingunn; Ruuth, Maija; Heier, Martin; Jauhiainen, Matti & Ulven, Stine Marie [Vis alle 14 forfattere av denne artikkelen] (2021). Children with familial hypercholesterolemia display changes in LDL and HDL function: A cross-sectional study . Journal of Internal Medicine. ISSN 0954-6820. 290(5), s. 1083–1097. doi: 10.1111/joim.13383.
• Klevmoen, Marianne; Bogsrud, Martin Prøven; Retterstøl, Kjetil; Svilaas, Tone; Vesterbekkmo, Elisabeth Kleivhaug & Hovland, Anders [Vis alle 9 forfattere av denne artikkelen] (2021). Loss of statin treatment years during pregnancy and breastfeeding periods in women with familial hypercholesterolemia. Atherosclerosis. ISSN 0021-9150. 335, s. 8–15. doi: 10.1016/j.atherosclerosis.2021.09.003. Fulltekst i vitenarkiv Vis sammendrag

  Background and aims Women with heterozygous familial hypercholesterolemia (FH) are recommended to initiate statin treatment at the same age as men (from 8 to 10 years of age). However, statins are contraindicated when pregnancy is planned, during pregnancy and breastfeeding. The aim of the study was to determine the duration of pregnancy-related off-statin periods and breastfeeding in FH women. Methods A cross-sectional study using an anonymous online self-administered questionnaire was conducted. Women with FH were recruited through Lipid Clinics in Norway and Netherlands and national FH patient organizations. Results 102 women with FH (n = 70 Norwegian and n = 32 Dutch) were included in the analysis. Total length of pregnancy-related off-statin periods was estimated for 80 women where data were available, and was median (min-max) 2.3 (0–14.2) years. Lost statin treatment time was estimated for 67 women where data were available, and was median (min-max) 18 (0–100)% at mean (SD) age of 31 (4.3) years at last pregnancy. More women breastfed in Norway (83%) and for longer time [8.5 [1-42] months] compared to the Netherlands [63%, p = 0.03; 3.6 (0–14) months, p < 0.001]. Eighty-six percent of the women reported need for more information on pregnancy and breastfeeding in relation to FH. Conclusions Young FH women lose years of treatment when discontinuing statins in relation to pregnancy and breastfeeding periods and should be closely followed up to minimize the duration of these off-statin periods. Whether these periods of interrupted treatment increase the cardiovascular risk in FH women needs to be further elucidated.

• Svendsen, Karianne; Torheim, Liv E.; Fjellberg, Vibeke; Sorprud, Anita; Narverud, Ingunn & Retterstøl, Kjetil [Vis alle 10 forfattere av denne artikkelen] (2021). Gender differences in nutrition literacy levels among university students and employees: a descriptive study. Journal of Nutritional Science (JNS). ISSN 2048-6790. 10, s. 1–7. doi: 10.1017/jns.2021.47. Fulltekst i vitenarkiv Vis sammendrag

  The impact of nutrition information on public health is partly determined by the population’s level of nutrition literacy (NL), which involves functional NL (such as knowledge of dietary guidelines) and critical NL (such as the ability to distinguish between evidence-based nutrition information and alternative facts). The aim of this cross-sectional study was to describe aspects of functional and critical NL and predictors of NL scores among university students and employees. We recruited at different university campuses, 414 students and 112 employees, of which 80 % were females and 69 % were in the ages of 18–30 years. In total, 82 % reported knowledge about where to find information on nutrition issues, and 70 % were familiar with Norwegian dietary guidelines. Being female, having higher age, being highly physically active and studying or working within health sciences were significant predictors of higher levels of functional nutrition knowledge. Significantly more women than men found it difficult to judge if media information on nutritional issues could be trusted (69 v. 54 %) and found it hard to distinguish between scientific and non-scientific information about diet (60 v. 42 %). Our findings indicate that for a sample of university students and employees, affiliation with health sciences, being female, having a higher age and being physically active were associated with higher functional NL. Women did, however, seem to have lower levels of some aspects of critical NL, e.g. how to critically judge nutrition information. A more thorough assessment of NL in university students and employees should therefore be conducted.

• Øyri, Linn Kristin Lie; Bogsrud, Martin Prøven; Christensen, Jacob J.; Ulven, Stine Marie; Brantsæter, Anne Lise & Retterstøl, Kjetil [Vis alle 13 forfattere av denne artikkelen] (2021). Novel associations between parental and newborn cord blood metabolic profiles in the Norwegian Mother, Father and Child Cohort Study. BMC Medicine. ISSN 1741-7015. 19. doi: 10.1186/s12916-021-01959-w. Fulltekst i vitenarkiv Vis sammendrag

  Background:More than one third of Norwegian women and men between 20 and 40 years of age have elevated cholesterol concentration. Parental metabolic health around conception or during pregnancy may affect the offspring’s cardiovascular disease risk. Lipids are important for fetal development, but the determinants of cord blood lipids have scarcely been studied. We therefore aimed to describe the associations between maternal andpaternal peri-pregnancy lipid and metabolic profile and newborn cord blood lipid and metabolic profile. Methods:This study is based on 710 mother–father–newborn trios from the Norwegian Mother, Father and ChildCohort Study (MoBa) and uses data from the Medical Birth Registry of Norway (MBRN). The sample included in thisstudy consisted of parents with and without self-reported hypercholesterolemia the last 6 months before pregnancy and their partners and newborns. Sixty-four cord blood metabolites detected by nuclear magnetic resonance spectroscopy were analyzed by linear mixed model analyses. The false discovery rate procedure wasused to correct for multiple testing. Results:Among mothers with hypercholesterolemia, maternal and newborn plasma high-density lipoproteincholesterol, apolipoprotein A1, linoleic acid, docosahexaenoic acid, alanine, glutamine, isoleucine, leucine, valine,creatinine, and particle concentration of medium high-density lipoprotein were significantly positively associated(0.001≤q≤0.09). Among mothers without hypercholesterolemia, maternal and newborn linoleic acid, valine,tyrosine, citrate, creatinine, high-density lipoprotein size, and particle concentration of small high-density lipoproteinwere significantly positively associated (0.02≤q≤0.08). Among fathers with hypercholesterolemia, paternal andnewborn ratio of apolipoprotein B to apolipoprotein A1 were significantly positively associated (q= 0.04). Amongfathers without hypercholesterolemia, no significant associations were found between paternal and newbornmetabolites. Sex differences were found for many cord blood lipids. Conclusions:Maternal and paternal metabolites and newborn sex were associated with several cord bloodmetabolites. This may potentially affect the offspring’s long-term cardiovascular disease risk.Keywords:MoBa, the Norwegian Mother, Father and Child Cohort Study, MBRN, Medical Birth Registry of Norway,Cholesterol, Metabolic profiling, Cord blood, Sex differences

• Rodriguez-Borjabad, Celia; Narverud, Ingunn; Christensen, Jacob J.; Ulven, Stine Marie; Malo, Ana Irene & Ibarretxe, Daiana [Vis alle 13 forfattere av denne artikkelen] (2021). Dietary intake and lipid levels in Norwegian and Spanish children with familial hypercholesterolemia. NMCD. Nutrition Metabolism and Cardiovascular Diseases. ISSN 0939-4753. 31(4), s. 1299–1307. doi: 10.1016/j.numecd.2020.12.002.
• Stolt, Emma Theresia Kjelland; Olsen, Thomas; Elshorbagy, Amany; Kozich, Viktor; Van Greevenbroek, Marleen M.J. & Øvrebø, Bente [Vis alle 10 forfattere av denne artikkelen] (2021). Sulfur amino acid restriction, energy metabolism and obesity: a study protocol of an 8-week randomized controlled dietary intervention with whole foods and amino acid supplements. Journal of Translational Medicine. ISSN 1479-5876. 19. doi: 10.1186/s12967-021-02824-3. Fulltekst i vitenarkiv
• Norum, Kaare Reidar; Remaley, Alan T.; Miettinen, Helena E; Strøm, Erik Heyerdahl; Balbo, Bruno E P & Sampaio, Carlos A T L [Vis alle 15 forfattere av denne artikkelen] (2020). Lecithin:cholesterol acyltransferase: symposium on 50 years of biomedical research from its discovery to latest findings. Journal of Lipid Research. ISSN 0022-2275. 61(8), s. 1142–1149. doi: 10.1194/JLR.S120000720.
• Mundal, Liv; Hovland, Anders; Igland, Jannicke; Vetrhus, Morten; Veierød, Marit Bragelien & Holven, Kirsten Bjørklund [Vis alle 10 forfattere av denne artikkelen] (2020). Increased risk of peripheral artery disease in persons with familial hypercholesterolaemia: a prospective registry study. European Journal of Preventive Cardiology (EJPC). ISSN 2047-4873. 28(18). doi: 10.1093/eurjpc/zwaa024. Fulltekst i vitenarkiv
• Svendsen, Karianne; Krogh, Henriette Walaas; Igland, Jannicke; Tell, Grethe S.; Mundal, Liv & Holven, Kirsten Bjørklund [Vis alle 9 forfattere av denne artikkelen] (2020). 2.5-fold increased risk of recurrent acute myocardial infarction with familial hypercholesterolemia. Atherosclerosis. ISSN 0021-9150. 319, s. 28–34. doi: 10.1016/j.atherosclerosis.2020.12.019. Fulltekst i vitenarkiv
• Røstad-Tollefsen, Helen K.; Kolset, Svein Olav; Retterstøl, Kjetil; Hesselberg, Heidi & Nordstrøm, Marianne (2020). Factors influencing the opportunities of supporting staff to promote a healthy diet in adults with intellectual disabilities. JARID: Journal of applied research in intellectual disabilities. ISSN 1360-2322. s. 1–9. doi: 10.1111/jar.12846. Fulltekst i vitenarkiv
• Hovland, Anders; Narverud, Ingunn; Øyri, Linn Kristin Lie; Bogsrud, Martin Prøven; Aagnes, Inger & Ueland, Thor [Vis alle 17 forfattere av denne artikkelen] (2020). Subjects with familial hypercholesterolemia have lower aortic valve area and higher levels of inflammatory biomarkers. Journal of Clinical Lipidology. ISSN 1933-2874. s. 1–8. doi: 10.1016/j.jacl.2020.12.006. Fulltekst i vitenarkiv
• Svendsen, Karianne; Langslet, Gisle; Krogh, Henriette Walaas; Brinck, Jonas; Stenehjem, Jo S. & Holven, Kirsten Bjørklund [Vis alle 8 forfattere av denne artikkelen] (2020). Genetic testing is essential for initiating statin therapy in children with familial hypercholesterolemia: Examples from Scandinavia. Atherosclerosis. ISSN 0021-9150. 316, s. 48–52. doi: 10.1016/j.atherosclerosis.2020.11.027. Fulltekst i vitenarkiv
• Bakka, Anna Lillehammer; Telle-Hansen, Vibeke; Garstad, Kjersti W.; Mørch-Reiersen, Lisa T.; Jacobs Jr., David R. & Retterstøl, Kjetil [Vis alle 7 forfattere av denne artikkelen] (2020). Kva er dei regionale skilnadene i totalkolesterol og kroppsmasseindeks – resultat frå risikokartlegging i apotek . Norsk Farmaceutisk Tidsskrift. ISSN 0029-1935. 8, s. 34–39.
• Christensen, Jacob J.; Narverud, Ingunn; Ruuth, Maija; Heier, Martin; Ulven, Stine Marie & Bogsrud, Martin Prøven [Vis alle 12 forfattere av denne artikkelen] (2020). Children with familial hypercholesterolemia display changes in LDL and HDL function: a cross-sectional study. medRxiv. doi: 10.1101/2020.11.11.20214247. Vis sammendrag

  Background The functional status of lipoprotein particles contributes to atherogenesis. The tendency of plasma LDL particles to aggregate and the ability of HDL particles to induce and mediate reverse cholesterol transport associate with high and low risk for cardiovascular disease in adult patients, respectively. However, it is unknown whether children with familial hypercholesterolemia (FH) display lipoprotein function alterations. Hypothesis We hypothesized that FH children had disrupted lipoprotein function. Methods We analyzed LDL aggregation susceptibility and HDL-apoA-I exchange to apoA-I ratio (HAE/apoA-I ratio), and activity of four proteins that regulate lipoprotein metabolism (CETP, LCAT, PLTP and PON1) in plasma samples derived from children with FH (n = 47) and from healthy children (n = 56). Potential biological mechanisms behind any variation in lipoprotein functionalities were explored using an NMR-based metabolomics profiling approach. Results LDL aggregation was higher and HAE/apoA-I ratio was lower in FH children than in healthy children. LDL aggregation associated positively with LDL-C and negatively with triglycerides, and HAE/apoA-I ratio associated negatively with LDL-C. Generally, the metabolomic profile for LDL aggregation was a mirror image of that for HAE/apoA-I ratio. Conclusions FH children displayed increased atherogenicity of LDL and disrupted HDL function. These newly observed functional alterations in LDL and HDL may increase the risk for atherosclerotic cardiovascular disease in FH children.

• Schmidt, Erik B.; Hedegaard, Berit Storgaard & Retterstøl, Kjetil (2020). Familial hypercholesterolaemia: history, diagnosis, screening, management and challenges. Heart. ISSN 1355-6037. 106, s. 1940–1946. doi: 10.1136/heartjnl-2019-316276.
• Gaundal, Line; Myhrstad, Mari; Leder, Lena; Byfuglien, Marte Gjeitung; Gjøvaag, Terje & Rud, Ida [Vis alle 10 forfattere av denne artikkelen] (2020). Beneficial effect on serum cholesterol levels, but not glycaemic regulation, after replacing SFA with PUFA for three days: a randomised crossover trial. British Journal of Nutrition. ISSN 0007-1145. s. 1–11. doi: 10.1017/S0007114520003402. Fulltekst i vitenarkiv Vis sammendrag

  Replacing intake of SFA with PUFA reduces serum cholesterol levels and CVD risk. The effect on glycaemic regulation is, however, less clear. The main objective of the present study was to investigate the short-term effect of replacing dietary SFA with PUFA on glycaemic regulation. Seventeen healthy, normal-weight participants completed a 25-d double-blind, randomised and controlled two-period crossover study. Participants were allocated to either interventions with PUFA products or SFA products (control) in a random order for three consecutive days, separated by a 1·5-week washout period between the intervention periods. Glucose, insulin and TAG were measured before and after an oral glucose tolerance test. In addition, fasting total cholesterol, NEFA and plasma total fatty acid profile were measured before and after the 3-d interventions. Fasting and postprandial glucose, insulin, and TAG levels and fasting levels of NEFA and plasma fatty acid profile did not differ between the groups. However, replacing dietary SFA with PUFA significantly reduced total cholesterol levels by 8 % after 3 d (P = 0·002). Replacing dietary SFA with PUFA for only 3 d has beneficial cardio-metabolic effects by reducing cholesterol levels in healthy individuals.

• Hovland, Anders; Retterstøl, Kjetil; Mollnes, Tom Eirik; Halvorsen, Bente Evy; Aukrust, Pål & Lappegård, Knut Tore (2020). Anti-inflammatory effects of non-statin low-density lipoprotein cholesterol-lowering drugs: an unused potential? Scandinavian Cardiovascular Journal. ISSN 1401-7431. s. 1–7. doi: 10.1080/14017431.2020.1775878. Fulltekst i vitenarkiv
• Nordstrøm, Marianne; Retterstøl, Kjetil; Hope, Sigrun & Kolset, Svein Olav (2020). Nutritional challenges in children and adolescents with Down syndrome. The Lancet Child and Adolescent Health. ISSN 2352-4642. 4(6), s. 455–464. doi: 10.1016/S2352-4642(19)30400-6. Fulltekst i vitenarkiv
• Svendsen, Karianne; Jacobs Jr., David R.; Mørch-Reiersen, Lisa Therese; Garstad, Kjersti W.; Henriksen, Hege Berg & Telle-Hansen, Vibeke [Vis alle 7 forfattere av denne artikkelen] (2020). Evaluating the use of the heart age tool in community pharmacies: a 4-week cluster-randomized controlled trial. European Journal of Public Health. ISSN 1101-1262. 30(6), s. 1139–1145. doi: 10.1093/eurpub/ckaa048. Fulltekst i vitenarkiv Vis sammendrag

  Background: Joint British Societies have developed a tool that utilizes information on cardiovascular disease (CVD) risk factors to estimate an individual's 'heart age'. We studied if using heart age as an add-on to conventional risk communication could enhance the motivation for adapting to a healthier lifestyle resulting in improved whole-blood cholesterol and omega-3 status after 4 weeks. Methods: A total of 48 community pharmacies were cluster-randomized to use heart age+conventional risk communication (intervention) or only conventional risk communication (control) in 378 subjects after CVD risk-factor assessment. Dried blood spots were obtained with a 4-week interval to assay whole-blood cholesterol and omega-3 fatty acids. We also explored pharmacy-staff's (n=27) perceived utility of the heart age tool. Results: Subjects in the intervention pharmacies (n=137) had mean heart age 64 years and chorological age 60 years. In these, cholesterol decreased by median (interquartile range) -0.10 (-0.40, 0.35) mmol/l. Cholesterol decreased by -0.20 (-0.70, 0.30) mmol/l (P difference =0.24) in subjects in the control pharmacies (n=120) with mean chronological age 60 years. We observed increased concentrations of omega-3 fatty acids after 4 weeks, non-differentially between groups. Pharmacy-staff (n=27) agreed that heart age was a good way to communicate CVD risk, and most (n=25) agreed that it appeared to motivate individuals to reduce elevated CVD risk factors. Conclusions: The heart age tool was considered a convenient and motivating communication tool by pharmacy-staff. Nevertheless, communicating CVD risk as heart age was not more effective than conventional risk communication alone in reducing whole-blood cholesterol levels and improving omega-3 status.

• Svendsen, Karianne; Olsen, Thomas; Nordstrand Rusvik, Tove Caroline; Ulven, Stine Marie; Holven, Kirsten Bjørklund & Retterstøl, Kjetil [Vis alle 7 forfattere av denne artikkelen] (2020). Fatty acid profile and estimated desaturase activities in whole blood are associated with metabolic health. Lipids in Health and Disease. ISSN 1476-511X. 19. doi: 10.1186/s12944-020-01282-y. Fulltekst i vitenarkiv

Se alle arbeider i Cristin

• Melnes, Torunn; Bogsrud, Martin Prøven; Christensen, Jacob J.; Rundblad, Amanda; Narverud, Ingunn & Retterstøl, Kjetil [Vis alle 10 forfattere av denne artikkelen] (2023). Difference in PBMC gene expression between elderly event-free FH patients and FH patients with CHD.
• Melnes, Torunn; Bogsrud, Martin Prøven; Christensen, Jacob J.; Rundblad, Amanda; Narverud, Ingunn & Retterstøl, Kjetil [Vis alle 10 forfattere av denne artikkelen] (2023). Difference in PBMC gene expression between elderly event-free FH patients and FH patients with CHD.
• Melnes, Torunn; Bogsrud, Martin Prøven; Thorsen, Ida; Fossum, Julie; Christensen, Jacob J. & Narverud, Ingunn [Vis alle 9 forfattere av denne artikkelen] (2023). What characterizes event-free elderly FH patients? A comprehensive lipoprotein profiling.
• Melnes, Torunn; Bogsrud, Martin Prøven; Christensen, Jacob J.; Rundblad, Amanda; Narverud, Ingunn & Retterstøl, Kjetil [Vis alle 10 forfattere av denne artikkelen] (2023). Difference in PBMC gene expression between elderly event-free FH patients and FH patients with CHD.
• Retterstøl, Kjetil & Angelsen, Madeleine Elisabeth (2023). Dyslipidemi.
• Retterstøl, Kjetil & Angelsen, Madeleine Elisabeth (2023). hyperkolesterolemi .
• Rundblad, Amanda; Hansen, Anna Lena; Christensen, Jacob Juel; Melnes, Torunn; Ottestad, Inger Olaug & Narverud, Ingunn [Vis alle 12 forfattere av denne artikkelen] (2023). Patients with familial hypercholesterolemia have shorter telomeres than controls in older, but not in young subjects: a cross-sectional study.
• Svilaas, Tone & Retterstøl, Kjetil (2023). Tema - Lipider. Indremedisineren. ISSN 1891-1617. s. 17–17.
• Retterstøl, Kjetil & Langslet, Gisle (2023). Høye triglyserider-patofysiologi og risiko. Indremedisineren. ISSN 1891-1617. s. 24–26.
• Svilaas, Tone & Retterstøl, Kjetil (2023). LDL-kolesterolsenkende behandling i dag og i fremtide. Indremedisineren. ISSN 1891-1617. 4(4), s. 18–20.
• Vinnes, Erik Wilhelm; Retterstøl, Kjetil & Renstrøm, Renate (2023). Lipoprotein(a) – en kort oversikt over målemetoder, indikasjoner og kliniske beslutningsgrenser. Klinisk Biokemi i Norden. ISSN 1101-2013. 30(4), s. 30–34.
• Troensegaard, Hannibal; Khoury, Janette; Westerberg, Ane Cecilie; Tonstad, Serena; Roeters van Lennep, Jeanine & Veierød, Marit Bragelien [Vis alle 9 forfattere av denne artikkelen] (2023). Protocol for a 20-year follow-up after a randomized controlled trial of a Mediterranean diet in pregnancy: maternal and offspring risk factors for cardiovascular disease. Frontiers in pediatrics. ISSN 2296-2360. 11. doi: 10.3389/fped.2023.1256815. Fulltekst i vitenarkiv
• semb, anne grete; Vesterbekk, Elisabeth Kleivhaug; Retterstøl, Kjetil; Atar, Dan; Solberg, Erik E. & Schirmer, Henrik [Vis alle 11 forfattere av denne artikkelen] (2023). PCSK9-hemmere på blå resept for hvem? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 143(8). doi: 10.4045/tidsskr.23.0191.
• Melnes, Torunn; Bogsrud, Martin Prøven; Thorsen, Ida; Fossum, Julie; Christensen, Jacob J. & Narverud, Ingunn [Vis alle 9 forfattere av denne artikkelen] (2022). What characterizes event-free elderly FH patients? A comprehensive lipoprotein profiling.
• Bastani, Nasser Ezzatkhah; Refsum, Helga; Olsen, Thomas; Vinknes, Kathrine Jørgensen; Retterstøl, Kjetil & Zare, Hasse Khiabani (2022). Determination of plasma thiols using LC-MS/MS: Cysteine-lowering treatment with mesna against obesity: Preliminary results from a phase I dose-finding stud.
• Aaseth, Jan; Rootwelt, Helge; Retterstøl, Kjetil; Hestad, Knut & Farup, Per Grønaas (2022). Reply to Paredes et al. Comment on “Aaseth et al. Circulating Lipoproteins in Subjects with Morbid Obesity Undergoing Bariatric Surgery with Gastric Bypass or Sleeve Gastrectomy. Nutrients 2022, 14, 2381”. Nutrients. ISSN 2072-6643. 15(1). doi: 10.3390/nu15010053.
• Klevmoen, Marianne; Bogsrud, Martin Prøven; Retterstøl, Kjetil; Svilaas, Tone; Vesterbekkmo, Elisabeth Kleivhaug & Hovland, Anders Wilhelm [Vis alle 9 forfattere av denne artikkelen] (2022). Loss of statin treatment years during pregnancy and breastfeeding periods in women with familial hypercholesterolemia.
• Aaseth, Jan Olav; Rootwelt, Helge; Retterstøl, Kjetil; Hestad, Knut & Farup, Per Grønaas (2022). Reply to Paredes et al. Comment on "Aaseth et al. Circulating Lipoproteins in Subjects with Morbid Obesity Undergoing Bariatric Surgery with Gastric Bypass or Sleeve Gastrectomy. Nutrients 2022, 14, 2381". Nutrients. ISSN 2072-6643. 15(1). doi: 10.3390/nu15010053.. Fulltekst i vitenarkiv
• Svendsen, Karianne; Olsen, Thomas; Vinknes, Kathrine Jørgensen; Mundal, Liv; Holven, Kirsten Bjørklund & Bogsrud, Martin Prøven [Vis alle 9 forfattere av denne artikkelen] (2022). No increased risk of stroke in genetically verified familial hypercholesterolemia: a prospective matched cohort study.
• Urke, Eli Bjørnøy; Igland, Jannicke; Mundal, Liv; Holven, Kirsten Bjørklund; Retterstøl, Kjetil & Svendsen, Karianne (2022). REGISTRY DATA INDICATE HIGHER RISK OF EATING DISORDERS IN INDIVIDUALS WITH FAMILIAL HYPERCHOLESTEROLEMIA COMPARED WITH AGE AND SEX MATCHED CONTROLS .
• Svendsen, Karianne; Mundal, Liv; Holven, Kirsten Bjørklund; Bogsrud, Martin Prøven; Igland, Jannicke & Leren, Trond Paul [Vis alle 7 forfattere av denne artikkelen] (2022). UNCHANGED HAZARD RATIOS OF INCIDENT ACUTE MYOCARDIAL INFARCTION IN PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA DURING 2001-2017.
• Svendsen, Karianne; Mundal, Liv; Holven, Kirsten Bjørklund; Igland, Jannicke; Bogsrud, Martin Prøven & Leren, Trond Paul [Vis alle 7 forfattere av denne artikkelen] (2022). Diseases occuring frequently in a “genetic high LDL-cholesterol (LDL-C) model disease” may be caused by LDL-C itself, or by the treatment of a high LDL-C. .
• Svendsen, Karianne; Urke, Eli Bjørnøy; Igland, Jannicke; Mundal, Liv; Holven, Kirsten Bjørklund & Retterstøl, Kjetil (2022). Can disease-related diet treatment from childhood result in eating disorders in adulthood?
• Mundal, Liv; Igland, Jannicke; Svendsen, Karianne; Holven, Kirsten Bjørklund; Leren, Trond Paul & Retterstøl, Kjetil (2022). No excess risk of dementia in individuals with familial hypercholesterolemia compared with age and sex matched controls .
• Svendsen, Karianne; Vinknes, Kathrine Jørgensen; Retterstøl, Kjetil & Olsen, Thomas (2022). Why we can probably trust public policy dietary guidelines for prevention. European Journal of Preventive Cardiology (EJPC). ISSN 2047-4873. 29(6), s. e209–e210. doi: 10.1093/eurjpc/zwaa008.
• Munkhaugen, John; Kristiansen, Oscar; Sverre, Elise Christine Bjørkholen; Retterstøl, Kjetil & Tonstad, Serena (2022). Statiner gir sjelden bivirkninger. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 2. doi: 10.4045/tidsskr.21.0885.
• Munkhaugen, John; Kristiansen, Oskar; Sverre, Elise Christine Bjørkholen; Retterstøl, Kjetil & Tonstad, Serena (2022). Statiner gir sjelden bivirkninger. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 142(2). doi: 10.4045/tidsskr.21.0885.
• Christensen, Jacob Juel; Bogsrud, Martin Prøven; Holven, Kirsten Bjørklund; Retterstøl, Kjetil; Veierød, Marit Bragelien & Nordeng, Hedvig Marie Egeland (2021). Maternal use of statins in pregnancy: a population based registry study.
• Christensen, Jacob Juel; Narverud, Ingunn; Ruuth, Maija; Heier, Martin; Jauhiainen, Matti & Ulven, Stine Marie [Vis alle 14 forfattere av denne artikkelen] (2021). Children with FH display changes in LDL and HDL function: a cross-sectional study.
• Christensen, Jacob Juel; Bogsrud, Martin P.; Holven, Kirsten B.; Retterstøl, Kjetil; Veierød, Marit B. & Nordeng, Hedvig Marie Egeland (2021). Maternal use of statins in pregnancy: a population-based registry study.
• Melnes, Torunn; Bogsrud, Martin Prøven; Thorsen, Ida; Fossum, Julie; Christensen, Jacob J. & Narverud, Ingunn [Vis alle 9 forfattere av denne artikkelen] (2021). Event-free FH patients >65 years of age are characterized by higher concentration of large HDL particles.
• Melnes, Torunn; Bogsrud, Martin Prøven; Thorsen, Ida; Fossum, Julie; Christensen, Jacob J. & Narverud, Ingunn [Vis alle 9 forfattere av denne artikkelen] (2021). Event-free FH patients ≥65 years of age are characterized by higher concentration of large HDL particles.
• Hope, Sigrun; Terje, Nærland,; Nordstrøm, Marianne; Kolset, Svein Olav; Retterstøl, Kjetil & Aanonsen, Nils Olav [Vis alle 7 forfattere av denne artikkelen] (2021). Store utfordringer med kosthold ved autisme. Forskning.no. ISSN 1891-635X.
• Retterstøl, Kjetil (2021). Hva med reaksjoner etter covid-19-infeksjon eller vaksine? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 141(12). doi: 10.4045/tidsskr.21.0582.
• Svendsen, Karianne & Retterstøl, Kjetil (2021). e-læring om aterosklerose.
• Retterstøl, Kjetil; Munkhaugen, John; Ingul, Charlotte Björk; Grimsmo, Jostein; Kask, Anne & Schirmer, Henrik [Vis alle 8 forfattere av denne artikkelen] (2021). Lavere behandlingsmål for LDLkolesterol bør innføres. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 141(2), s. 1–6. doi: 10.4045/tidsskr.20.0761.
• Johansen, Anja Katrin; Bogsrud, Martin Prøven; van Lennep, Jeanine Roeters; Narverud, Ingunn; Langslet, Gisle & Retterstøl, Kjetil [Vis alle 7 forfattere av denne artikkelen] (2021). Long term follow-up of children with familial hypercholesterolemia and relatively normal LDL-cholesterol at diagnosis. Journal of Clinical Lipidology. ISSN 1933-2874. s. 1–4. doi: 10.1016/j.jacl.2021.01.007.
• Telle-Hansen, Vibeke & Retterstøl, Kjetil (2021). Kolesterolfellene du må unngå. Dagbladet. ISSN 0805-3766. s. 16–17.
• Retterstøl, Kjetil (2021). Kolesterolfellene du må unngå. Dagbladet. ISSN 0805-3766. s. 16–17.
• Mundal, Liv; Igland, Jannicke; Leren, Trond Paul & Retterstøl, Kjetil (2021). Excess Aortic Pathology Risk in Patients with Genetically Verified Familial Hypercholesterolaemia: A Prospective Norwegian Registry Study. European Journal of Vascular and Endovascular Surgery. ISSN 1078-5884. 61(4), s. 712–713. doi: 10.1016/j.ejvs.2020.12.019.
• Mach, Francois; Baigent, Colin; Catapano, Alberico L.; Koskinas, Konstantinos C.; Casula, Manuela & Badimon, Lina [Vis alle 96 forfattere av denne artikkelen] (2020). Erratum to “2019 ESC/EAS guidelines for the management of dyslipidemias: Lipid modification to reduce cardiovascular risk” (Atherosclerosis (2019) 290 (140–205), (S0021915019314595), (10.1016/j.atherosclerosis.2019.08.014)). Atherosclerosis. ISSN 0021-9150. 292, s. 160–162. doi: 10.1016/j.atherosclerosis.2019.11.020.
• Mach, Francois; Baigent, Colin; Catapano, Alberico L.; Koskinas, Konstantinos C.; Casula, Manuela & Badimon, Lina [Vis alle 96 forfattere av denne artikkelen] (2020). Corrigendum to “2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk” (Atherosclerosis (2019) 290 (140–205), (S0021915019314595), (10.1016/j.atherosclerosis.2019.08.014)). Atherosclerosis. ISSN 0021-9150. 294, s. 80–82. doi: 10.1016/j.atherosclerosis.2019.12.004.
• Narverud, Ingunn; Christensen, Jacob Juel; Bakke, Siril Skaret; Ulven, Stine Marie; Rundblad, Amanda & Aukrust, Pål [Vis alle 12 forfattere av denne artikkelen] (2020). Profiling of immune‐related gene expression in children with familial hypercholesterolaemia.
• Gaundal, Line; Myhrstad, Mari; Leder, Lena; Byfuglien, Marte Gjeitung; Gjøvaag, Terje & Rud, Ida [Vis alle 10 forfattere av denne artikkelen] (2020). Beneficial effect on serum cholesterol levels, but not glycaemic regulation, after replacing SFA with PUFA for 3 days: a randomized crossover trial.
• Svendsen, Karianne; Krogh, Henriette Walaas; Igland, Jannicke; Tell, Grethe Seppola; Mundal, Liv & Holven, Kirsten Bjørklund [Vis alle 9 forfattere av denne artikkelen] (2020). Individuals with familial hypercholesterolemia have increased risk of re-hospitalization after acute myocardial infarction compared with controls.
• Svendsen, Karianne; Igland, Jannicke; Krogh, Henriette Walaas; Tell, Grethe S.; Mundal, Liv & Holven, Kirsten Bjørklund [Vis alle 9 forfattere av denne artikkelen] (2020). Sex-differences in Coronary Heart Disease Between Individuals With Familial Hypercholesterolemia and Controls in Norway During 1992-2017. Circulation Journal. ISSN 1346-9843. 142, s. A15749–A15749. doi: 10.1161/circ.142.suppl_3.15749w.ahajournals.org/doi/10.1161/circ.142.suppl_3.15749.
• Svendsen, Karianne; Igland, Jannicke; Mundal, Liv; Urke, EB; Krogh, Henriette Walaas & Holven, Kirsten Bjørklund [Vis alle 9 forfattere av denne artikkelen] (2020). No increased risk of cognitive impairment in familial hypercholesterolemia compared with controls. Atherosclerosis. ISSN 0021-9150. 315. doi: 10.1016/j.atherosclerosis.2020.10.128.
• Svendsen, Karianne; Vinknes, Kathrine; Retterstøl, Kjetil & Olsen, Thomas (2020). Why we can probably trust public policy dietary guidelines for prevention. European Journal of Preventive Cardiology (EJPC). ISSN 2047-4873. doi: 10.1093/eurjpc/zwaa008.
• Svendsen, Karianne; Vinknes, Kathrine; Retterstøl, Kjetil & Olsen, Thomas (2020). Why we can probably trust public policy dietary guidelines for prevention. European Journal of Preventive Cardiology (EJPC). ISSN 2047-4873. doi: 10.1093/EURJPC/ZWAA008.
• Kolset, Svein Olav; Heier, Martin & Retterstøl, Kjetil (2020). Retensjon av lipoproteiner i arevegg-mulig mal for behandling? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 140(10), s. 1–5. doi: 10.4045/tidsskr.19.0803.

Se alle arbeider i Cristin